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Endothelial Cell Phenotypes in Health and Disease

Gordon Research Conference

Endothelial Pathogenic Pathways: Challenges and Opportunities for Translation

July 6 - 11, 2014
Chair S. Ananth Karumanchi
Vice Chair Victoria L. Bautch

Conference Description

The 2014 Gordon Research Conference on "Endothelial Cell Phenotypes in Health and Disease" will bring together leading scientists with a common interest in understanding the role of the endothelium in health and in disease. Topics covered will include novel endothelial signaling pathways, imaging studies, organ regeneration, vascular inflammation, tumor angiogenesis, and translational research in ocular and cardiovascular diseases. The cross-disciplinary nature of this meeting is widely acclaimed and will allow attendees exposure to cutting edge research in endothelial biology. All attendees are encouraged to submit an abstract for poster presentation. Several "late-breaking topic" abstracts will be selected for oral presentations during the main program. Applicants will be accepted from a diverse mix of established investigators, junior PIs, postdocs and graduate students.

Related Meeting

This GRC will be held in conjunction with the "Endothelial Cell Phenotypes in Health and Disease" Gordon Research Seminar (GRS). Those interested in attending both meetings must submit an application for the GRS in addition to an application for the GRC. Refer to the associated GRS program page for more information.

Conference Program

SUNDAY
4:00 pm - 8:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmMetabolism and Vascular Health
Discussion Leader: Ed Conway (University of British Columbia, Vancouver, Canada)
7:45 pm - 8:30 pmKeynote Speaker: Peter Carmeliet (University of Leuven, Belgium)
"Targeting Vascular Metabolism: Principles and Strategies"
8:30 pm - 8:45 pmDiscussion
8:45 pm - 9:00 pmAudrey Cleuren (University of Michigan, Ann Arbor, USA)
"Characterizing Endothelial Cell Heterogeneity: In Vivo Approach"
9:00 pm - 9:10 pmDiscussion
9:10 pm - 9:25 pmKeqing Wang (Aston University, Birmingham, UK)
"Dysregulation of Placental Cystathione-β-Synthase Promotes Fetal Growth Restriction"
9:25 pm - 9:30 pmDiscussion
MONDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmAdvances in Angiopoietin and Tie Signaling
Discussion Leader: Samir Parikh (Beth Israel Deaconess Medical Center, Boston, USA)
9:00 am - 9:30 amSusan Quaggin (Northwestern University, Chicago, USA)
"Angiopoietins in Vascular Permeability"
9:30 am - 9:40 amDiscussion
9:40 am - 10:10 amHelmut Augustin (German Cancer Research Center, Heidelberg, Germany)
"Mechanisms of Liver Regeneration"
10:10 am - 10:20 amDiscussion
10:20 amCoffee Break
10:45 am - 11:15 amSamir Parikh (Beth Israel Deaconess Medical Center, Boston, USA)
"Tie2 Signaling Axis in Severe Infections"
11:15 am - 11:25 amDiscussion
11:25 am - 11:55 amKari Alitalo (University of Helsinki, Helsinki, Finland)
"Mechanistic and Translational Insights to Endothelial Growth Factors"
11:55 am - 12:05 pmDiscussion
12:05 pm - 12:20 pmBarbara Lavina Siemsen (Uppsala University, Uppsala, Sweden)
"New Transgenic Reporter Mouse line: New Tool to Study Vascular Biology and Dynamics"
12:20 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:30 pmFree Time
4:30 pm - 6:00 pmPoster Session
6:00 pm - 8:00 pmBuilding and Maintaining Blood Vessels
Discussion Leader: Merv Yoder (Indiana University, Indianapolis, USA)
6:00 pm - 6:30 pmMike Simons (Yale University, New Haven, USA)
"Vascular Fate Decisions"
6:30 pm - 6:40 pmDiscussion
6:40 pm - 7:10 pmMerv Yoder (Indiana University, Indianapolis, USA)
"Pro-Angiogenic Hemoatopoietic Cells and Vascular Repair"
7:10 pm - 7:20 pmDiscussion
7:20 pm - 7:50 pmEli Keshet (Hebrew University-Hadassah Medical School, Jerusalem, Israel)
"Vascular Stem Cell Niches"
7:50 pm - 8:00 pmDiscussion
8:00 pmDinner
TUESDAY
7:30 am - 8:30 amBreakfast
8:30 amGroup Photo
9:00 am - 12:30 pmGases and Lipids in the Vasculature
Discussion Leader: Asif Ahmed (Aston University, Birmingham, United Kingdom)
9:00 am - 9:30 amTim Hla (Cornell University, New York, USA)
"Sphingosine 1 Phosphate Signaling"
9:30 am - 9:40 amDiscussion
9:40 am - 10:10 amDipak Panigrahy (Beth Israel Deaconess Medical Center, Boston, USA)
"Suppression of Cell Debris-Stimulated Tumor Growth by Resolvin Mediated Clearance"
10:10 am - 10:20 amDiscussion
10:20 amCoffee Break
10:45 am - 11:15 amRui Wang (Lakehead University, Ontario, Canada)
"Novel Insights into Hydrogen Sulfide Signaling in the Vasculature"
11:15 am - 11:25 amDiscussion
11:25 am - 11:55 amAsrar Malik (University of Illinois, Chicago, USA)
"Nitric Oxide and Related Pathways in Vascular Permeability"
11:55 am - 12:05 pmDiscussion
12:05 pm - 12:20 pmMasataka Majima (Kitasato University School of Medicine, Kanagawa, Japan)
"Roles of Arachidonic Acid Metabolites in Angiogenesis"
12:20 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:30 pmFree Time
4:30 pm - 6:00 pmPoster Session
6:00 pm - 8:00 pmTumor Angiogenesis
Discussion Leader: Laura Benjamin (Eli Lilly and Company, New York, USA)
6:00 pm - 6:30 pmGabriele Bergers (University of California San Francisco, USA)
"Escape Mechanisms from Anti-Angiogenic Therapy"
6:30 pm - 6:40 pmDiscussion
6:40 pm - 7:10 pmLaura Benjamin (Eli Lilly and Company, New York, USA)
"Insights from VEGFR1 and VEGFR2 Antibody Cancer Trials"
7:10 pm - 7:20 pmDiscussion
7:20 pm - 7:50 pmPhil Marsden (University of Toronto, Toronto, Canada)
"Non-Coding RNAs in Tumor Angiogenesis and Hypoxia"
7:50 pm - 8:00 pmDiscussion
8:00 pmDinner
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmNovel Endothelial Signaling Pathways
Discussion Leader: Christiana Ruhrberg (Institute of Ophthalmology-UCL, London, UK)
9:00 am - 9:30 amRalf Adams (Max Planck Institute, Munster, Germany)
"Mechanisms of Endothelial Cell Heterogeneity"
9:30 am - 9:40 amDiscussion
9:40 am - 10:10 amTeresa Sanchez (Harvard Medical School, Boston, USA)
"Sphingosine-1-Phosphate Receptor 2 as a Novel Therapeutic Target for Acute Cerebrovascular Protection"
10:10 am - 10:20 amDiscussion
10:20 amCoffee Break
10:45 am - 11:15 amJohn Greenwood (University College London, London, UK)
"Regulators of TGF-Beta Actions in the Vasculature"
11:15 am - 11:25 amDiscussion
11:25 am - 11:55 amChristiana Ruhrberg (Institute of Ophthalmology-UCL, London, UK)
"Neuropilin Signaling"
11:55 am - 12:05 pmDiscussion
12:05 pm - 12:20 pmHana Totary-Jain (University of South Florida, Tampa, USA)
"MicroRNA Based Strategy to Restore Endothelial Function After Angioplasty"
12:20 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:30 pmFree Time
4:30 pm - 6:00 pmPoster Session
6:00 pm - 8:00 pmKeynote Session: Characterization of Therapeutic Targets for Vascular Disorders
Discussion Leader: Victoria Bautch (University of North Carolina, Chapel Hill, USA)
6:00 pm - 6:45 pmDavid Cheresh (University of California San Diego, USA)
"Targeting Pathways of Vessel Proliferation and Maturation in Disease"
6:45 pm - 7:00 pmDiscussion
7:00 pm - 7:45 pmElisabetta Dejana (IFOM, University of Milan, Milan, Italy)
"Functional and Structural Modification of the Brain Microvasculature in Pathological Conditions"
7:45 pm - 8:00 pmDiscussion
8:00 pmDinner
THURSDAY
7:30 am - 8:30 amBreakfast
8:30 am - 9:00 amBusiness Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
9:00 am - 12:30 pmOcular Vasculopathies - Molecular Mechanisms and Targeted Therapies
Discussion Leader: Jayakrishna Ambati (University of Kentucky, Lexington, USA)
9:00 am - 9:30 amJayakrishna Ambati (University of Kentucky, Lexington, USA)
"A Generic Anti-Angiogenic Class Effect of a Widely Used Therapeutic"
9:30 am - 9:40 amDiscussion
9:40 am - 10:10 amRichard Lang (Cincinnati Children's Hospital Medical Center, Cincinnati, USA)
"Wnt and Light in the Regulation of Vascular Development"
10:10 am - 10:20 amDiscussion
10:20 amCoffee Break
10:45 am - 11:15 amLois Smith (Children's Hospital, Boston, USA)
Omega Fatty Acids and Retinal Neovascularization
11:15 am - 11:25 amDiscussion
11:25 am - 11:55 amBala Ambati (University of Utah, Salt Lake City, USA)
"Normalizing Retinal Vascular Endothelium in Diabetes"
11:55 am - 12:05 pmDiscussion
12:05 pm - 12:20 pmLindsey Keir (Scripps Research Institute, San Diego, USA)
"Vascular Endothelial Growth Factor Regulates Expression of Protective Complement Regulators at Fenestrated Microvascular Beds in the Eye and the Kidney"
12:20 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:30 pmFree Time
4:30 pm - 6:00 pmPoster Session
6:00 pm - 8:00 pmThe Endothelium in Cardiovascular Diseases
Discussion Leader: Zoltan Arany (Beth Israel Deaconess Medical Center, Boston, USA)
6:00 pm - 6:25 pmYury Miller (University of California San Diego, USA)
"Cholesterol Efflux in Angiogenesis and Endothelial Inflammation"
6:25 pm - 6:30 pmDiscussion
6:30 pm - 6:55 pmZoltan Arany (Beth Israel Deaconess Medical Center, Boston, USA)
"Peripartum Cardiomyopathy - A Vascular Disorder"
6:55 pm - 7:00 pmDiscussion
7:00 pm - 7:25 pmJoey Granger (University of Mississippi, Jackson, USA)
"Endothelin Signaling in Hypertension and Preeclampsia"
7:25 pm - 7:30 pmDiscussion
7:30 pm - 7:55 pmEd Conway (University of British Columbia, Vancouver, Canada)
"Coagulation and Complement in Vascular Disorders"
7:55 pm - 8:00 pmDiscussion
8:00 pmDinner
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDeparture

Contributors

Conference Links

Conference History Endothelial Cell Phenotypes in Health and Disease (GRS)
Additional Fee Info

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August 4 - 9, 2024
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January 12 - 17, 2025


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