Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Endothelial Cell Heterogeneity
Discussion Leader: Hellmut Augustin (European Center for Angioscience (ECAS), Heidelberg University and German Cancer Research Center, Germany)
7:40 pm - 7:45 pm
Opening Remarks
7:45 pm - 8:00 pm
Introduction by Discussion Leader
8:00 pm - 8:20 pm
Ralf Adams (Max Planck Institute for Molecular Biomedicine, Germany)
"Regulation of Arterial Endothelial Cell Specification and Artery Formation"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
Victoria Bautch (University of North Carolina at Chapel Hill, United States)
"BMP and Blood Vessels: New Insights from Negative Regulators"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
Christiana Ruhrberg (University College London, United Kingdom)
"Single Cell RNAseq Analysis of Endothelial Cell Phenotypes"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Molecular Regulation of Endothelial Phenotypes
Discussion Leader: Karina Yaniv (Weizmann Institute of Science, Israel)
9:00 am - 9:15 am
Introduction by Discussion Leader
9:15 am - 9:35 am
Martin Schwartz (Yale School of Medicine, United States)
"Regulation of Endothelial Phenotype by Fluid Shear Stress"
9:35 am - 9:45 am
Discussion
9:45 am - 9:55 am
Nicholas Chavkin (University of Virginia, United States)
"Endothelial Cell Cycle State Determines Propensity for Arterial-Venous Fate"
9:55 am - 10:00 am
Discussion
10:00 am - 10:20 am
Natasha Harvey (University of South Australia, Australia)
"Control of Endothelial Cell Identity by a GATA2-Bound Enhancer Element"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Mark Kahn (University of Pennsylvania, United States)
"Genetic Investigation of Diverse Vascular Beds"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
Anaïs Briot (Metabolic and Cardiovascular Research Institute (I2MC), Inserm U1297, France)
"Microvascular Endothelial Cells in the Adaptation to Energy Transition State: DLL4 as an Adipose Depot-Specific Metabolic Hub"
11:40 am - 11:45 am
Discussion
11:45 am - 12:05 pm
Anne Eichmann (Yale School of Medicine, United States)
"Guidance of Vascular Barrier Formation"
12:05 pm - 12:15 pm
Discussion
12:15 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hour™
The GRC Power Hour™ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
Organizers: Luisa Iruela-Arispe (Northwestern University, United States) and Katie Bentley (Kings college london /The Francis Crick Institute , United Kingdom)
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Congenital Defects and Clinical Therapy
Discussion Leader: Elizabeth Crouch (University of California, San Francisco, United States)
6:00 pm - 6:15 pm
Introduction by Discussion Leader
6:15 pm - 6:35 pm
Pia Ostergaard (St George's, University of London, United Kingdom)
"Genetic Basis of Primary Lymphoedema"
6:35 pm - 6:45 pm
Discussion
6:45 pm - 6:55 pm
Akiko Mammoto (Medical College of Wisconsin, United States)
"Mutations, Models and Targeted Treatment of Vascular Anomalies"
6:55 pm - 7:00 pm
Discussion
7:00 pm - 7:10 pm
Nathalie Burg (Hospital for Special Surgery, United States)
"Enhancing Endothelial Cell Barrier Function via Sphingosine -1 Phosphate Receptor 1 (S1PR1) – a Novel Target for Experimental Arthritis"
7:10 pm - 7:15 pm
Discussion
7:15 pm - 7:25 pm
Maximiliano Arce (Uppsala University, Sweden)
"High Throughput Drug Screen Reveals a Novel Pharmacological Agent for the Treatment of Cerebral Cavernous Malformation"
7:25 pm - 7:30 pm
Discussion
7:30 pm - 7:50 pm
Susan Quaggin (Northwestern University, United States)
"Vascular Therapies Targeting the TEK Pathway"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Endothelial Cell Damage, Repair and Regeneration
Discussion Leader: Joyce Bischoff (Boston Children's Hospital and Harvard Medical School, United States)
9:00 am - 9:15 am
Introduction by Discussion Leader
9:15 am - 9:35 am
Luisa Iruela-Arispe (Northwestern University, United States)
"Endothelial Cell Replication In Vivo"
9:35 am - 9:45 am
Discussion
9:45 am - 9:55 am
Gabriela D'AMICO (UCL Institute of Ophthalmology, University College London, United Kingdom)
"NRP1 Promotes Cell-Cell Adhesion for Brain Vascularization"
9:55 am - 10:00 am
Discussion
10:00 am - 10:20 am
Katie Bentley (Kings college london /The Francis Crick Institute , United Kingdom)
"Temporal Adaptation of Vascular Patterning"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Kari Alitalo (University of Helsinki and Wihuri Research Institute, Finland)
"Hardwiring Between the Angiopoietin and VEGF Signaling Systems"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
Rebecca Craig-Schapiro (Weill Cornell Medicine, United States)
"NKX2-3 Dependent Specification of Pancreatic Endothelial Cells for Pre-Vascularized Islet Transplantation"
11:40 am - 11:45 am
Discussion
11:45 am - 12:05 pm
Shahin Rafii (Weill Cornell Medicine, United States)
"Molecular Basis of Vascular Heterogeneity in Mediating Tissue-Specific Regulation"
12:05 pm - 12:15 pm
Discussion
12:15 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Aging Endothelium and Impact on Disease Progression
Discussion Leader: Brian Annex (Medical College of Georgia, United States)
6:00 pm - 6:15 pm
Introduction by Discussion Leader
6:15 pm - 6:35 pm
Jaime Grutzendler (Yale School of Medicine, United States)
"In Vivo Optical Interrogation of Neurovascular Function and Pathology"
6:35 pm - 6:45 pm
Discussion
6:45 pm - 7:05 pm
Ebba Brakenhielm (Normandy University and INSERM U1096, France)
"Regulation of Cardiac Lymphangiogenesis in Cardiovascular Diseases – Impact on Myocardial Edema, Inflammation and Cardiac Function"
7:05 pm - 7:15 pm
Discussion
7:15 pm - 7:25 pm
Francoise Lenfant (DR Occitanie Pyrénées- INSERM U1297-Institut des maladies cardiovasculaires et métaboliques, France)
"Overview of Actions of Tamoxifen on Endothelial Cells: Vascular Diseases and Tumor Angiogenesis"
7:25 pm - 7:30 pm
Discussion
7:30 pm - 7:50 pm
Yun Fang (University of Chicago, United States)
"Precision Nanomedicine Targeting Novel Endothelial Mechano-Sensing Mechanisms"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Hematovascular Interactions in Development and Disease
Discussion Leader: Christiana Ruhrberg (University College London, United Kingdom)
9:00 am - 9:15 am
Introduction by Discussion Leader
9:15 am - 9:35 am
Stefania Nicoli (Yale University, United States)
"New Insights into the Regulation of the Endothelial to Hematopoietic Transition"
9:35 am - 9:45 am
Discussion
9:45 am - 9:55 am
Olin Liang (Brown University, United States)
"RUNX1 is Required for the Development of Pulmonary Arterial Hypertension"
9:55 am - 10:00 am
Discussion
10:00 am - 10:20 am
Clint Miller (University of Virginia, United States)
"Cis-Regulatory Architecture of Coronary Vascular Cells During Disease"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Taija Makinen (Uppsala University, Sweden)
"Vessel Type-Specific Mechanisms of Lymphatic Development and Disease"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
Alessandro Fantin (Universita' Degli Studi di Milano, Italy)
"Comparing Roles for KIT in Vascular and Hematopoietic Development"
11:40 am - 11:45 am
Discussion
11:45 am - 12:05 pm
Kenneth Walsh (University of Virginia, United States)
"Clonal Hematopoiesis: Acquired Mutations in Hematopoietic Stem Cells that Contribute to Vascular Disease"
12:05 pm - 12:15 pm
Discussion
12:15 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Advances in Vascular Imaging and Bioengineering
Discussion Leader: Maria Bernabeu (EMBL Barcelona, Spain)
6:00 pm - 6:15 pm
Introduction by Discussion Leader
6:15 pm - 6:35 pm
Friedemann Kiefer (European Institute for Molecular Imaging (EIMI) / University of Münster, Germany)
"Imaging Lymph Vessel Development and Heterogeneity"
6:35 pm - 6:45 pm
Discussion
6:45 pm - 7:05 pm
Rui Benedito (Centro Nacional de Investigaciones Cardiovasculares (CNIC), Spain)
"Ratiometric Multispectral Mosaics Reveal Exclusionary Zoning During Angiogenesis"
7:05 pm - 7:15 pm
Discussion
7:15 pm - 7:25 pm
Florence Tatin (Inserm, France)
"Spatial Organization of Lymphatic Vessels and Adipocyte Microenvironment"
7:25 pm - 7:30 pm
Discussion
7:30 pm - 7:50 pm
Julien Vermot (Imperial College London, United Kingdom)
"Live Imaging of Mechanosensitive Signals in the Developing Endocardium"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Discuss Future Dates and Venue; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Vascular Metabolism
Discussion Leaders: Katrien De Bock (ETH Zurich, Switzerland)
9:00 am - 9:15 am
Introduction by Discussion Leader
9:15 am - 9:35 am
Timothy Hla (Boston Children's Hospital and Harvard Medical School, United States)
"Circulating Bioactive Lipid Chaperones in Endothelial Cell Resilience"
9:35 am - 9:45 am
Discussion
9:45 am - 9:55 am
Massimo Santoro (University of Padua, Italy)
"Metabolic-Control of Translation During Angiogenesis"
9:55 am - 10:00 am
Discussion
10:00 am - 10:20 am
Mariona Graupera (Bellvitge Biomedical Research Institute (IDIBELL), Spain)
"Angiocrine Metabolic Signaling Regulates Adiposity"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Michael Potente (Berlin Institute of Health, Germany)
"Vascular Metabolism: Role and Regulation During Quiescence and Growth"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
Martina Rudnicki (York University (Canada) and University College London (UK), United Kingdom)
"Sex-Related Pathophysiological Differences in Endothelial Cells"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
Elizabeth Jones (KU Leuven, Belgium)
"Pericyte Loss and Active Vessel Regression Drive Early Events in Diastolic Heart Failure"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
Michael Simons (Yale University School of Medicine, United States)
"Metabolic Control of Cell Signaling"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Emerging Approaches to Understanding Cellular Diversity
Discussion Leaders: Hong Chen (Harvard Medical School, United States)
6:00 pm - 6:15 pm
Introduction by Discussion Leader
6:15 pm - 6:35 pm
Ellie Tzima (University of Oxford, United Kingdom)
"Principles and Regulation of Vascular Remodeling – the Junction in Focus"
6:35 pm - 6:45 pm
Discussion
6:45 pm - 7:05 pm
Mauro Siragusa (Goethe University Frankfurt, Germany)
"High-Throughput Proteo-Genomic Identification of Endothelial Microproteins Encoded by Non-Canonical Small Open Reading Frames"
7:05 pm - 7:15 pm
Discussion
7:15 pm - 7:25 pm
Reinhold Medina (Queen's University Belfast, United Kingdom)
"Identification of Molecular Targets to Modulate Endothelial Senescence"
7:25 pm - 7:30 pm
Discussion
7:30 pm - 7:50 pm
Patric Turowski (University College London, United Kingdom)
"Understanding the Multiple Functions of Endothelial Caveolae at Blood-Neural Barriers"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure