Saturday
1:30 pm - 4:30 pm
Arrival and Check-in
3:00 pm - 3:15 pm
Introductory Comments by GRC Site Staff / Welcome from the GRS Chair
3:15 pm - 4:00 pm
Keynote Session: Skin Development, Homeostasis, and Function
Discussion Leader: Matthias Ruebsam (University of Cologne, Germany)
3:15 pm - 3:50 pm
Kathleen Green (Northwestern University, USA)
"Evolutionary Repurposing of Cadherins to Create a Better Skin Barrier"
3:50 pm - 4:00 pm
Discussion
4:00 pm - 5:30 pm
Poster Session
5:30 pm - 7:30 pm
Development of Skin and Its Niches / Mechanisms Underlying Epidermal Homeostasis and Regeneration
Discussion Leaders: Katie Cockburn (Yale University, USA), Marja Mikkola (University of Helsinki, Finland), Paola Arcidiacono (Queen Mary University of London, United Kingdom) and Pantelis Rompolas (University of Pennsylvania, USA)
5:30 pm - 5:45 pm
Jillian Pattison (Stanford University, USA)
"Identification of the Dynamic Epigenetic Landscape Guiding Stratified Epithelial Commitment"
5:45 pm - 5:50 pm
Discussion
5:50 pm - 6:05 pm
Marianne Andersen (Biotech Research and Innovation Center, University of Copenhagen, Denmark) and Svetlana Ulyanchenko (Biotech Research and Innovation Center, University of Copenhagen, Denmark)
"Defining the Mode of Growth and Replenishment During Epidermal Appendage Formation"
6:05 pm - 6:10 pm
Discussion
6:10 pm - 6:25 pm
Blair Jenkins (Columbia University, USA)
"Mechanisms of Merkel Cell Innervation During Development"
6:25 pm - 6:30 pm
Discussion
6:30 pm - 6:45 pm
Kai Mesa (Yale University, USA)
"Live Imaging of Coordinated Epidermal Stem Cell Differentiation and Self-Renewal in Mice"
6:45 pm - 6:50 pm
Discussion
6:50 pm - 7:05 pm
Emmi Wachsmuth (CECAD, University of Cologne, Germany)
"Regulation of Epidermal Barrier Function: Roles for Insulin/IGF-1R and p38 Stress Kinase Signaling"
7:05 pm - 7:10 pm
Discussion
7:10 pm - 7:25 pm
Rosa Ventrella (Northwestern University, USA)
"EphA2 Transmembrane Domain Governs Receptor Membrane Distribution and Differentiation-Associated Signaling in Keratinocytes"
7:25 pm - 7:30 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Sunday
7:30 am - 8:30 am
Breakfast
9:00 am - 11:00 am
Crosstalk Between Epithelia and Other Niches / Epithelial Disease, Cancer, and Novel Therapeutic Approaches
Discussion Leaders: Jamie Schwendinger-Schreck (University of California, Berkeley, USA), Sandra Iden (University of Cologne, Germany), Markus Eberl (University of Michigan, USA) and Aron Jaffe (Novartis Institutes for BioMedical Research, USA)
9:00 am - 9:15 am
Samantha Larsen (The Rockefeller University, USA) and Shruti Naik (The Rockefeller University, USA)
"Memory of Inflammation in Epidermal Stem Cells"
9:15 am - 9:20 am
Discussion
9:20 am - 9:35 am
Emanuel Rognoni (Centre for Stem Cells and Regenerative Medicine, King's College London, United Kingdom)
"Dissecting the Fibroblast Subpopulations During Dermal Maturation and Wound Healing"
9:35 am - 9:40 am
Discussion
9:40 am - 9:55 am
Brett Shook (Yale University, USA)
"Dermal Adipocyte Lipolysis Is Required for Multiple Aspects of Skin Regeneration"
9:55 am - 10:00 am
Discussion
10:00 am - 10:15 am
Ana Sastre-Perona (New York University School of Medicine, USA)
"Defining a Transcriptional Network that Governs Self-Renewal and Differentiation in Squamous Cell Carcinoma"
10:15 am - 10:20 am
Discussion
10:20 am - 10:35 am
Ankur Sharma (Genome Institute of Singapore, Singapore)
"Single-Cell RNA-seq Reveals Divergent Evolutionary Modes of Drug Resistance in Oral SCC"
10:35 am - 10:40 am
Discussion
10:40 am - 10:55 am
Wenbo Wu (National Institute of Biological Sciences, Beijing, China)
"Efficient In Vivo Gene Editing Using Ribonucleoproteins in Skin Stem Cells of Recessive Dystrophic Epidermolysis Bullosa Mouse Model"
10:55 am - 11:00 am
Discussion
11:00 am - 12:30 pm
Poster Session
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm
Lunch
1:30 pm - 2:30 pm
Mentorship Component: Career Panel
Discussion Leader: Aaron Mertz (Rockefeller University, USA)
1:30 pm - 2:30 pm
Panel Discussion
Careers and Diversity in Science in Academia and Industry
Sandra Iden (University of Cologne, Germany)
Aron Jaffe (Novartis Institutes for BioMedical Research, USA)
Marja Mikkola (University of Helsinki, Finland)
Pantelis Rompolas (University of Pennsylvania, USA)
Kathleen Green (Northwestern University, USA)
2:30 pm - 3:00 pm
Evaluation Period
Fill in GRS Evaluation Forms
3:00 pm
Seminar Concludes