Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Keynote Session: Synaptic, Plasticity and Behavior
Discussion Leader: Alison Barth (Carnegie Mellon University, United States)
7:40 pm - 8:20 pm
Gina Turrigiano (brandeis university, United States)
"The Ups and Downs of Firing Rate Homeostasis"
8:20 pm - 8:35 pm
Discussion
8:35 pm - 9:15 pm
Christian Lüscher (University of Geneva, Switzerland)
"Plasticity of Excitatory Transmission in Drug Addiction"
9:15 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Excitatory Synapses as Key Regulators of Neural Circuits
Discussion Leader: Christian Lüscher (University of Geneva, Switzerland)
9:00 am - 9:20 am
Manuel Mameli (The University of Lausanne, Switzerland)
"Habenular Neuronal Dynamics Supporting Negative Affective States"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Stephan Lammel (University of California, Berkeley, United States)
"Neural Dynamics and Synaptic Function in Reward Learning and Motivated Behavior"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
Ofer Yizhar (Weizmann Institute of Science, Israel)
"Cortical Cartography: The Organization of Cell Type-Specific Synaptic Connectivity in The Prefrontal Cortex"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Marisela Morales (National Institute on Drug Abuse, NIH, United States)
"Regulation of Prefrontal Cortex Neuronal Activity by VTA Glutamatergic Afferents"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
ChangHui Pak (University of Massachusetts Amherst, United States)
"Dissecting the Neurodevelopmental role of Schizophrenia Gene Variant NRXN1 at Single-Cell Resolution in iPSC-Derived Human Brain Organoid Model"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
Pedro Espinosa (University of Geneva, Switzerland)
"Insular Cortex to Ventral Striatum Synapses Encode Valence of Social Interaction"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Sharon Swanger (Virginia Tech, United States)
"Target-Specific Tuning of Corticothalamic Excitation Through NMDA Receptor Functional Diversity"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Jai Polepalli (National University of Singapore, Singapore)
"Cerebellin-4 in the Prefrontal Cortex Facilitates Remote Recall of Contextual Memories"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Group Photo / Lunch
1:30 pm - 4:30 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hourâ„¢
The GRC Power Hourâ„¢ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
Organizer: Hey-Kyoung Lee (Johns Hopkins University, United States)
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Excitatory Synapses in Learning and Memory
Discussion Leader: Xiang Yu (Peking University, China)
6:00 pm - 6:20 pm
Peter Scheiffele (Biozentrum, University of Basel, Switzerland)
"Control of Neuronal Excitation-Inhibition Balance by BMP-SMAD1 Signaling"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:50 pm
Yingxi Lin (SUNY Upstate Medical University, United States)
"Active Neuronal Ensembles During Early Brain Development"
6:50 pm - 7:00 pm
Discussion
7:00 pm - 7:20 pm
Attila Losonczy (Columbia University, United States)
"Synaptic Integration and Plasticity in Dendrites of Hippocampal Pyramidal Cells During Spatial Learning"
7:20 pm - 7:30 pm
Discussion
7:30 pm - 7:50 pm
Christophe Mulle (CNRS / Université de Bordeaux, France)
"Functional and Behavioral Implication of Presynaptic Facilitation in the Hippocampus"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Experience-Dependent Synaptic Plasticity
Discussion Leader: Gina Turrigiano (brandeis university, United States)
9:00 am - 9:20 am
Alison Barth (Carnegie Mellon University, United States)
"Input- and Target-Specific Synaptic Plasticity in Neocortical Networks During Sensory Learning"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Jackie Schiller (Rappaport Faculty of Medicine, Technion - Israel Institute of Technology, Israel)
"Mechanisms of Learning and Plasticity in Motor Cortex"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
Haruo Kasai (The University of Tokyo, Japan)
"The Force of Dendritic-Spine Enlargement Facilitating Presynaptic Exocytosis"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Xiang Yu (Peking University, China)
"The Effects of Sensory Experience and Oxytocin on Neural Circuit Development and Plasticity"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
Judit Makara (Institute of Experimental Medicine, Hungary)
"Diversity and Modulation of Input-Output Transformation in Hippocampal Pyramidal Cells"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Coralie Berthoux (Albert Einstein College of Medicine, United States)
"Endocannabinoid Signaling in the Dentate Gyrus: A Brake that Controls Synaptic Strength, Spatial Memory and Seizure Activity"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Tara LeGates (University of Maryland, Baltimore County (UMBC), United States)
"Pathway Convergence and Coordinated Plasticity at Hippocampus : Nucleus Accumbens Synapses"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
New Imaging Tools to Study Synapses
Discussion Leader: Daniel Choquet (CNRS, France)
6:00 pm - 6:20 pm
Na Ji (University of California, Berkeley, United States)
"In Vivo imaging of Excitatory Synaptic Transmission at High Spatiotemporal Resolution"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:50 pm
Valentin Nägerl (University of Bordeaux / CNRS, France)
"Mind the gap! Super-Resolution Imaging of the Extracellular Space of Brain Tissue"
6:50 pm - 7:00 pm
Discussion
7:00 pm - 7:20 pm
Joshua Levitz (Weill Cornell Medicine, United States)
"Optical Probing of Synaptic G Protein-Coupled Receptors"
7:20 pm - 7:30 pm
Discussion
7:30 pm - 7:40 pm
David Wong-Campos (Harvard University, United States)
"In Vivo Voltage Imaging and Optogenetics Reveal Rules of Dendritic Back-Propagation and Coupling"
7:40 pm - 7:45 pm
Discussion
7:45 pm - 7:55 pm
Pushpa Kumari (Northwestern University, United States)
"Biosensors for Excitatory Synapse Plasticity"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Synaptic Dysfunction in Brain Disorders
Discussion Leader: Isabel Perez-Otaño (Institute of Neurosciences , Spain)
9:00 am - 9:20 am
Ana Luisa Carvalho (University of Coimbra, Portugal)
"Stargazin in The Etiology of Neurodevelopmental Disorders"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Tara Spires-Jones (The University of Edinburgh, United Kingdom)
"Synapse Degeneration in Alzheimer's Disease"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
Mauro Costa-Mattioli (Altos Labs, United States)
"Unraveling The Role of mTOR Complexes in Neuronal Function and Disease"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Hailan Hu (Zhejiang University, China)
"NMDARs in The Sustained and Brain Region-Specific Actions of Ketamine"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
Claudia Bagni (University of Lausanne, Switzerland)
"Developmental Changes in Structural Plasticity and Mental Illness"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Oakleigh Folkes (Yale University, United States)
"Investigations of Social Behavior and Nucleus Accumbens Dysfunction in a Shank3 Mouse Model of Autism"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Silvia Viana da Silva (DZNE-Berlin, Germany)
"Localized APP Pathology Results in Progressive Network Dysfunction by Disorganizing Spike Timing"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Glutamate Receptors: Structure and Function
Discussion Leader: Hailan Hu (Zhejiang University, China)
6:00 pm - 6:20 pm
Pierre Paoletti (Ecole Normale Superieure / CNRS / INSERM, France)
"Excitatory Glycine Receptors: New Players in The Brain"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:50 pm
Fabrizio Gardoni (University of Milan, Italy)
"NMDA Receptor Synaptic Retention: From Synaptic Plasticity to Neurodevelopmental and Neurodegenerative Disorders"
6:50 pm - 7:00 pm
Discussion
7:00 pm - 7:20 pm
Gabriela Popescu (University at Buffalo, SUNY, United States)
"NMDA Receptors As Molecular Targets for Fast-Acting Antidepressants"
7:20 pm - 7:30 pm
Discussion
7:30 pm - 7:50 pm
Karen Zito (University of California, Davis, United States)
"NMDA Receptor Signaling Mechanisms in Structural Plasticity of Dendrite Spines"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Discuss Future Dates and Venue; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Synapse Specification and Transsynaptic Signaling
Discussion Leader: Peter Scheiffele (Biozentrum, University of Basel, Switzerland)
9:00 am - 9:20 am
Eunjoon Kim (Institute for Basic Science, South Korea)
"Transsynaptic Organization by LAR Family Receptor Tyrosine Phosphatases"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Scott Soderling (Duke University, United States)
"In Vivo Proximity Proteomics to Uncover New Synaptic Mechanisms"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
Joris de Wit (VIB-KU Leuven Center for Brain and Disease Research, Belgium)
"Cell Adhesion-Mediated Regulation of Synaptic Organelle Distribution Controls Dendritic Spine Maturation"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Thomas Blanpied (University of Maryland School of Medicine, United States)
"Making and Breaking Transsynaptic Nanoalignment"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
Susanne Falkner (University of Basel, Biozentrum, Switzerland)
"Patterned Activity-driven Molecular Diversification During Neonatal Cortical Circuit Formation"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
Joongkyu Park (Wayne State University School of Medicine, United States)
"Dendritic Translation in Learning and Memory"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Anna Antoniou (University of Bonn Medical Center, Germany)
"Extracellular Vesicles as Mediators of Trans-Synaptic Signaling and Circuit Connectivity"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Wen-Chieh Hsieh (National Institutes of Health, HHS, United States)
"Multilayered Control for Subcellular Distribution and functional properties of KaiR1D Autoreceptor"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Gene Transcription in Neural Circuit Function
Discussion Leader: Karen Zito (University of California, Davis, United States)
6:00 pm - 6:20 pm
Denis Jabaudon (University of Geneva, Switzerland)
"Cell Intrinsic and Extrinsic Controls of Circuit Assembly in The Neocortex"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:50 pm
Elizabeth Pollina (Washington University St. Louis, United States)
"Neuronal Activity-Dependent DNA Repair in Plasticity and Disease"
6:50 pm - 7:00 pm
Discussion
7:00 pm - 7:20 pm
Hongkui Zeng (Allen Institute for Brain Science, United States)
"Organization of Cell Types Across The Mouse Brain"
7:20 pm - 7:30 pm
Discussion
7:30 pm - 7:50 pm
Sacha Nelson (Dept of Biology and Program in Neuroscience, Brandeis University, United States)
"Clock Genes and the Transcriptional Control of Homeostatic Plasticity in Mammalian Neocortex"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure