Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: From Genes to Drugs in Neurodevelopmental Disorders
Session in memory of Stephen T. Warren.
Discussion Leader: Kimberly Huber (University of Texas Southwestern Medical Center, United States)
7:40 pm - 7:45 pm
Opening Remarks
7:45 pm - 8:10 pm
David Nelson (Baylor College of Medicine, United States)
"Finding Fragile X: A Tribute to Steve Warren"
8:10 pm - 8:20 pm
Discussion
8:20 pm - 8:45 pm
Evdokia Anagnostou (Holland Bloorview Kids Rehab Hospital / University of Toronto, Canada)
"Therapeutic Studies in Autism Spectrum Disorder"
8:45 pm - 8:55 pm
Discussion
8:55 pm - 9:20 pm
Tracy King (National Institutes of Health, United States)
"How Diversity and Inclusion Influence Our Understanding of Mechanisms Underlying Fragile X and Autism-Related Disorders"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Genetic Heterogeneity
Discussion Leader: Eric Klann (New York University, United States)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:30 am
Catalina Betancur (INSERM / CNRS / Sorbonne University, France)
"Genetic Architecture of Autism"
9:30 am - 9:40 am
Discussion
9:40 am - 10:05 am
Sebastian Jacquemont (University of Montréal, Sainte Justine Hospital, Canada)
"Estimating the Effect Sizes of Undocumented CNVs on Cognition, Autism Risk and Brain Connectivity"
10:05 am - 10:15 am
Discussion
10:15 am - 10:45 am
Coffee Break
10:45 am - 11:10 am
Peter Kind (University of Edinburgh, United Kingdom)
"Convergent and Divergent Pathophysiology in Neurodevelopmental Disorders"
11:10 am - 11:20 am
Discussion
11:20 am - 11:30 am
Sameer Bajikar (Baylor College of Medicine, United States)
"GDF11 Expression Level Modulates Neurological Behavior and is Regulated by MeCP2"
11:30 am - 11:35 am
Discussion
11:35 am - 11:45 am
Haitham Amal (Hebrew University of Jerusalem, Israel)
"Autism Spectrum Disorder: from Systems Biology to Diagnostic Models and Drug Targets"
11:45 am - 11:50 am
Discussion
11:50 am - 12:00 pm
General Discussion
12:00 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hour™
The GRC Power Hour™ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
Organizers: Elizabeth Berry-Kravis (Rush University Medical Center, United States) and Liz McCullagh (Oklahoma State University, United States)
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Convergence of Molecular Mechanisms
Discussion Leader: Eric Klann (New York University, United States)
6:00 pm - 6:05 pm
Introduction by Discussion Leader
6:05 pm - 6:30 pm
Barbara Bardoni (INSERM, France)
"Perturbed Signaling in Fmr1-Null Neurons: A Starting Point to Search for Therapies for FXS"
6:30 pm - 6:40 pm
Discussion
6:40 pm - 7:05 pm
Helen Bateup (University of California, Berkeley, United States)
"Synaptic Changes in the Striatum Drive Autism-Related Behaviors in Mice"
7:05 pm - 7:15 pm
Discussion
7:15 pm - 7:25 pm
Devin Wehle (University of Washington, United States)
"The Response of the mTOR Protein Interaction Network During Homeostatic Scaling is Disrupted in Shank3 Knockout Mice"
7:25 pm - 7:30 pm
Discussion
7:30 pm - 7:40 pm
Gemma Molinaro (UT Southwestestern Medical Center, United States)
"Sex-Specific, mGlu5 Receptor-Dependent Dysfunction of Sensory Neocortical Circuits in a Mouse Model of Autism-Spectrum Disorder, Caused by Deletion of PTEN"
7:40 pm - 7:45 pm
Discussion
7:45 pm - 7:55 pm
Vitaly Klyachko (Washington University School of Medicine, United States)
"FMRP Regulates GABAA Receptor Channel Activity to Control Signal Integration in the Hippocampus"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Human Cellular Models
Discussion Leader: Julia Sommer (Simons Foundation, United States)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:30 am
Xinyu Zhao (University of Wisconsin-Madison, United States)
"Interrogating FMRP Function Using Stem Cells"
9:30 am - 9:40 am
Discussion
9:40 am - 10:05 am
Marija Mihailovic (European Institute of Oncology (IEO), Human Technopole (HT), Italy)
"iPSC Modelling of Altered Translation in Autism and Intellectual Disability"
10:05 am - 10:15 am
Discussion
10:15 am - 10:45 am
Coffee Break
10:45 am - 11:10 am
Nael Nadif Kasri (Radboudumc, Donders Institue for Brain, Cognition and Behaviour, The Netherlands)
"Neurons-on-a-Chip to Model ASD"
11:10 am - 11:20 am
Discussion
11:20 am - 11:45 am
Anita Bhattacharyya (University of Wisconsin-Madison, United States)
"Altered Patterning of Interneuron Progenitors in Down Syndrome"
11:45 am - 11:55 am
Discussion
11:55 am - 12:00 pm
General Discussion
12:00 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Translational Biomarkers and Human Physiology
Discussion Leader: Alice Luo Clayton (Simons Foundation, United States)
6:00 pm - 6:05 pm
Introduction by Discussion Leader
6:05 pm - 6:30 pm
Charlotte DiStefano (University of Southern California & Children's Hospital Los Angeles, United States)
"Electrophysiological Biomarkers of SyndromicNeurodevelopment Disorders: Implications for RiskPrediction and Clinical Trials"
6:30 pm - 6:40 pm
Discussion
6:40 pm - 7:05 pm
Lauren Ethridge (University of Oklahoma, United States)
"The Role of EEG and Sensory Systems in Bench toBiomarker Translation in Fragile X Syndrome"
7:05 pm - 7:15 pm
Discussion
7:15 pm - 7:40 pm
Devin Binder (University of California, Riverside, United States)
"Translational EEG Biomarkers Derived Using Multielectrode Array EEG in Mice"
7:40 pm - 7:50 pm
Discussion
7:50 pm - 8:00 pm
General Discussion
8:00 pm - 9:00 pm
Dinner
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Circuit Biology in Animal Models
Discussion Leader: Laura Mamounas (National Institutes of Health, United States)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:30 am
Andreas Frick (INSERM U1215, Neurocentre Magendie, France)
"Mechanistic Understanding of Neocortical Circuit Alterations Underlying Atypical Sensory Information Processing in Genetic ASD Mice"
9:30 am - 9:40 am
Discussion
9:40 am - 10:05 am
Zhaolan (Joe) Zhou (University of Pennsylvania, United States)
"Genetic Dissection of the Pathogenic Mechanisms Underlying Autism Spectrum Disorders"
10:05 am - 10:15 am
Discussion
10:15 am - 10:45 am
Coffee Break
10:45 am - 11:10 am
Brielle Ferguson (Stanford University, United States)
"Exploring Mechanisms of Attention Impairments in Absence Epilepsy and ASD"
11:10 am - 11:20 am
Discussion
11:20 am - 11:45 am
Peter Tsai (University of Texas Southwestern Medical Center, United States)
"Cerebellar-Cerebro Cortical Circuits in ASD"
11:45 am - 11:55 am
Discussion
11:55 am - 12:05 pm
Catharine Rankin (University of British Columbia, Canada)
"Investigating the Relationship between Sensory Over-responsivity and Habituation Impairments in Autism Spectrum Disorder using C. Elegans"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:20 pm
Carol Wilkinson (Boston Children's Hospital, United States)
"Neural Markers of Cognitive and Language Development in Young Children with FXS and Down Syndrome"
12:20 pm - 12:25 pm
Discussion
12:25 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Mechanisms and Therapies for Syndromic Autism
Discussion Leader: Michael Tranfaglia (FRAXA Research Foundation, United States)
6:00 pm - 6:05 pm
Introduction by Discussion Leader
6:05 pm - 6:30 pm
Michela Fagiolini (Boston Children's Hospital, United States)
"Arousal, Sensory Processing and Biomarkers in Rett Syndrome"
6:30 pm - 6:40 pm
Discussion
6:40 pm - 7:05 pm
Mark Zylka (University of North Carolina at Chapel Hill, United States)
"Advancing a CRISPR/Cas-Based Gene Therapy for Angelman Syndrome"
7:05 pm - 7:15 pm
Discussion
7:15 pm - 7:40 pm
David Hampson (University of Toronto, Canada)
"The Successes and the Challenges of Developing Viral Vector-Mediated Gene Therapy for Fragile X Syndrome and Dravet Syndrome"
7:40 pm - 7:50 pm
Discussion
7:50 pm - 8:00 pm
General Discussion
8:00 pm - 9:00 pm
Dinner
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
9:00 am - 12:30 pm
Novel Model Systems and Platforms
Discussion Leader: Claudia Bagni (University of Lausanne, Switzerland)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:30 am
Nicola Allen (Salk Institute for Biological Studies, United States)
"Astrocyte-Neuron Interactions in Neurodevelopmental Disorders"
9:30 am - 9:40 am
Discussion
9:40 am - 10:05 am
Mauro Costa-Mattioli (Baylor College of Medicine, United States)
"mTOR Complexes in Neurological Disorders"
10:05 am - 10:15 am
Discussion
10:15 am - 10:45 am
Coffee Break
10:45 am - 10:55 am
Dilek Colak (Weill Cornell Medical College, United States)
"Astrocyte Pathology in ASD"
10:55 am - 11:00 am
Discussion
11:00 am - 11:10 am
Anna Dunaevsky (University of Nebraska Medical Center, United States)
"Astrocytic Contribution to Sensory Hypersensitivity in Fragile X Syndrome"
11:10 am - 11:15 am
Discussion
11:15 am - 11:25 am
Yang Yang (Purdue University, United States)
"Reversible Social Deficits in Mice with Autism-Associated Scn2a-Deficiency"
11:25 am - 11:30 am
Discussion
11:30 am - 11:40 am
Annette Schenck (Radboud University Medical Center, The Netherlands)
"Studying Sleep Disturbances in Autism and Intellectual Disability Disorders Using Drosophila – of Mechanisms and Treatment Strategies"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
Peng Jin (Emory University, United States)
"Genetic Modifiers of the Seizure Associated with Fragile X syndrome"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Innovative Approaches to Clinical Outcome Measures and Trial Design
Discussion Leader: Elizabeth Berry-Kravis (Rush University Medical Center, United States)
6:00 pm - 6:05 pm
Introduction by Discussion Leader
6:05 pm - 6:30 pm
Flora Tassone (University of California, Davis, United States)
"Metformin: Targeted Treatment for Fragile X Syndrome"
6:30 pm - 6:40 pm
Discussion
6:40 pm - 7:05 pm
Michelle Krishnan (Novartis Institutes for Biomedical Research, Switzerland)
"Translational Medicine in Gene Therapy for Rare Neurodevelopmental Diseases"
7:05 pm - 7:15 pm
Discussion
7:15 pm - 7:40 pm
Xavier Liogier (Loulou Foundation, United Kingdom)
"Clinical Trial Design and Methodology for Genetic Neurodevelopmental Disorders"
7:40 pm - 7:50 pm
Discussion
7:50 pm - 8:00 pm
Closing Remarks
8:00 pm - 9:00 pm
Dinner
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure