SUNDAY |
4:00 pm - 8:00 pm | Arrival and Check-in |
6:00 pm | Dinner |
7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
7:40 pm - 9:30 pm | Heterocyclic Compounds in Natural Products Synthesis I |
| Discussion Leader: R. Nancy Tao (Yale University) |
7:40 pm - 8:25 pm | Glenn C. Micalizio (Scripps Research Institute)
"Metallacycle-Mediated Alkene-Imine Cross-Coupling in Heterocycle Synthesis"
|
8:25 pm - 8:35 pm | Discussion |
8:35 pm - 9:20 pm | Amos B. Smith, III (The University of Pennsylvania)
"Evolution of Anion Relay Chemistry (ARC) Leading to Siloxane-Based Transfer Agents for Palladuim Cross-Coupling Reactions" |
9:20 pm - 9:30 pm | Discussion |
MONDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Heterocyclic Compounds of Pharmaceutical Relevance |
| Discussion Leader: Tatsuya Shirahata (Kitasato University) |
9:00 am - 9:35 am | Brian Lucas (Amgen)
"A Facile Approach to the Piperidinone Class of MDM2/p53 Inhibitors"
|
9:35 am - 9:45 am | Discussion |
9:45 am - 10:20 am | Prabhakar Jadhav (Eli Lilly)
"Discovery of Potent, Orally Bioavailable, Nonpetide Cathepsin S Inhibitor Lacking Interactions with Catalytic Cysteine"
|
10:20 am - 10:30 am | Discussion |
10:30 am | Group Photo / Coffee Break |
11:00 am - 11:35 am | Don Pinto (Bristol-Myers Squibb)
"Next Generation Antithrombotics; Lessons Learned in Discovering a Drug" |
11:35 am - 11:45 am | Discussion |
11:45 am - 12:20 pm | John Maxwell (Vertex)
"Use of Heterocycles in Drug Discovery"
|
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session I |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Methods for the Synthesis of Heterocyclic Compounds I |
| Discussion Leader: Graham C. Murphy (University of Waterloo) |
7:30 pm - 8:10 pm | Victor Snieckus (Queen's University)
"Progress in Aromatic Metalation with a Tribute to Ted Taylor"
|
8:10 pm - 8:20 pm | Discussion |
8:20 pm - 8:35 pm | Anita Mattson (The Ohio State University) |
8:35 pm - 8:40 pm | Discussion |
8:40 pm - 9:20 pm | Karl Hale (Queen's University, Belfast)
"Total Synthesis Studies on Pyran-Containing Antitumor Natural Products"
|
9:20 pm - 9:30 pm | Discussion |
TUESDAY |
Important Note: Please be aware that the order of events on Tuesday, June 18 deviates from the standard schedule that is used on all other days of the meeting. The revised schedule is displayed below.
|
7:30 am - 8:30 am | Breakfast |
8:30 am - 10:30 am | Free Time |
10:30 am - 12:30 pm | Poster Session I |
12:30 pm | Lunch |
1:30 pm - 5:00 pm | Methods for the Synthesis of Heterocyclic Compounds II |
| Discussion Leader: Jenny L. Roizen (Duke University) |
1:30 pm - 2:05 pm | Javier Read de Alaniz (University of California, Santa Barbara)
"Methods for Carbon-Nitrogen Bond Formation"
|
2:05 pm - 2:15 pm | Discussion |
2:15 pm - 2:55 pm | Ryan Looper (University of Utah)
"Propargylguanidine hydroaminations and their applications to important heterocyclic systems"
|
2:55 pm - 3:05 pm | Discussion |
3:05 pm | Coffee Break |
3:20 pm - 4:00 pm | Jón Njardarson (University of Arizona)
"New Heterocyclic Sagas from the Sonoran Desert"
|
4:00 pm - 4:10 pm | Discussion |
4:10 pm - 4:50 pm | Seth Herzon (Yale University)
"Target-Driven Total Synthesis"
|
4:50 pm - 5:00 pm | Discussion |
5:00 pm - 6:00 pm | Free Time |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Catalytic Methods for the Synthesis of Heterocyclic Compounds |
| Discussion Leader: Neil Garg (University of California, Los Angeles) |
7:30 pm - 8:10 pm | Liz Jarvo (University of California, Irvine)
"Mechanism-Based Design and Development of Nickel-Catalyzed Stereospecific Cross-Coupling Reactions" |
8:10 pm - 8:20 pm | Discussion |
8:20 pm - 8:35 pm | David Lupton (Monash University) |
8:35 pm - 8:40 pm | Discussion |
8:40 pm - 9:20 pm | Joe Ready (University of Texas, Southwest Medical Center)
"Synthesis of small molecules with anti-cancer properties"
|
9:20 pm - 9:30 pm | Discussion |
WEDNESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Heterocyclic Compounds in Natural Products Synthesis II |
| Discussion Leader: Frances R. Blase (Haverford University) |
9:00 am - 9:45 am | Toshiaki Sunazuka (Kitastato Institute)
"Total synthesis of novel polycyclic bioactive indole alkaloids"
|
9:45 am - 9:55 am | Discussion |
9:55 am - 10:10 am | Guangbin Dong (University of Texas, Austin)
|
10:10 am - 10:15 am | Discussion |
10:15 am | Coffee Break |
10:40 am - 11:25 am | Carol Taylor (Louisiana State University)
"Running Rings Around Peptides"
|
11:25 am - 11:35 am | Discussion |
11:35 am - 12:20 pm | Gary Sulikowski (Vanderbilt Universiyt)
"Synthesis and Study of Heterocyclic Natural Products"
|
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session II |
7:30 pm - 9:30 pm | Biological Applications of Heterocyclic Compounds |
| Discussion Leader: Eric M. Ferreira (Colorado State University) |
7:30 pm - 8:10 pm | George Moniz (Eisai)
"Process Research and Development Towards Medicinally Relevant Heterocyclic Compounds"
|
8:10 pm - 8:20 pm | Discussion |
8:20 pm - 8:35 pm | Daniel Fandrick (Boehringer-Ingelheim) |
8:35 pm - 8:40 pm | Discussion |
8:40 pm - 9:20 pm | David Spiegel (Yale University)
"Synthetic and Biological Studies of Advanced Glycation End-Products"
|
9:20 pm - 9:30 pm | Discussion |
THURSDAY |
7:30 am - 8:30 am | Breakfast |
8:30 am - 9:00 am | Business Meeting |
| Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair |
9:00 am - 12:30 pm | The Evolution of a Research Program in Heterocyclic Chemistry |
| Discussion Leader: Brian E. Love (East Carolina University) |
9:00 am - 9:35 am | John Macor (Bristol-Myers Squibb)
"Heterocycles as Bioisosteres in the Discovery of Orally Active CGRP Receptor Antagonists for the Treatment of Migraine"
|
9:35 am - 9:45 am | Discussion |
9:45 am - 10:20 am | Huw M. L. Davies (Emory University)
"Unusual Reactions Between Rhodium Carbenes and Heterocycles"
|
10:20 am - 10:30 am | Discussion |
10:30 am | Coffee Break |
11:00 am - 11:35 am | John Warner (Warner-Babcock Institute)
"Heterocycles in Materials Science" |
11:35 am - 11:45 am | Discussion |
11:45 am - 12:20 pm | Stephen F. Martin (University of Texas, Austin)
"Total Synthesis of Heterocyclic Natural Products"
|
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session II |
7:30 pm - 9:30 pm | A Perspective on Heterocyclic Compounds in Academics and Industry |
| Discussion Leader: John LaMattina (PureTech Ventures) |
7:30 pm - 7:50 pm | Louis Jungheim (Roosevelt University and LNJ Consulting)
"Pyrazolidinones and oxazoles, two of my favorite heterocycles"
|
7:50 pm - 8:00 pm | Discussion |
8:00 pm - 8:20 pm | Paul Reider (Princeton University)
"The Synthesis of Heterocycles as Novel Agents in the Fight Against TB, Malaria and Other Neglected Diseases"
|
8:20 pm - 8:30 pm | Discussion |
8:30 pm - 9:20 pm | E. C. Taylor (Princeton University)
"Reflections on 67 Years of Heterocyclic Chemistry"
|
9:20 pm - 9:30 pm | Discussion |
FRIDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am | Departure |