SUNDAY |
2:00 pm - 9:00 pm | Arrival and Check-in |
6:00 pm | Dinner |
7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
7:40 pm - 9:30 pm | Catalysis |
| Discussion Leader: Cynthia Shafer (Novartis) |
7:40 pm - 7:45 pm | Chair's Opening Remarks |
7:45 pm - 8:15 pm | Silas Cook (Indiana University)
"The Complementary Reactivity of Base Metal Catalysis" |
8:15 pm - 8:25 pm | Discussion |
8:25 pm - 8:40 pm | Jennifer Schomaker (University of Wisconsin-Madison)
"Synthetic Applications of Oxidative Allene Amination"
|
8:40 pm - 8:45 pm | Discussion |
8:45 pm - 9:20 pm | Dean Toste (Univ. of California, Berkeley)
"Concepts and Catalysts for Enantioselective Synthesis of Heterocycles" |
9:20 pm - 9:30 pm | Discussion |
MONDAY |
7:30 am - 8:30 am | Breakfast |
8:30 am | Group Photo |
9:00 am - 12:30 pm | Synthesis of Heterocyclic Compounds |
| Discussion Leader: Sebastien Caille (Amgen) |
9:00 am - 9:40 am | Steven Miller (Merck)
"Development of a Robust Commercial Route to a β-Lactamase Inhibitor" |
9:40 am - 9:50 am | Discussion |
9:50 am - 10:05 am | Laura Anderson (University of Illinois at Chicago)
"Synthetic Versatility of N-O Bond Rearrangements"
|
10:05 am - 10:10 am | Discussion |
10:10 am | Coffee Break |
10:40 am - 11:20 am | Eric Fang (Amgen)
"Design of a Scalable Process for Complex Heterocyclic API Synthesis" |
11:20 am - 11:30 am | Discussion |
11:30 am - 12:15 pm | Tohru Fukuyama (Nagoya University)
"Synthetic Studies on Heterocyclic Natural Products" |
12:15 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Synthetic Methods |
| Discussion Leader: Donna Huryn (University of Pennsylvania) |
7:30 pm - 8:10 pm | Andre Beauchemin (University of Ottawa)
"Heterocyclic Synthesis Using Alkenes, Alkynes and Bifunctional Reagents" |
8:10 pm - 8:20 pm | Discussion |
8:20 pm - 8:35 pm | Eric Ferreira (University of Georgia)
"Total Synthesis of Gelsemium Alkaloids via Platinum-Catalyzed Cycloisomerization"
|
8:35 pm - 8:40 pm | Discussion |
8:40 pm - 9:20 pm | Karl Scheidt (Northwestern University)
"Bioactive Oxacycles as Inspirations for New Catalytic Reactions" |
9:20 pm - 9:30 pm | Discussion |
TUESDAY |
Important Note: Please be aware that the order of events on Tuesday, June 17 deviates from the standard schedule that is used on all other days of the meeting. The revised schedule is displayed below.
|
7:30 am - 8:30 am | Breakfast |
9:00 am - 10:30 am | Free Time |
10:30 am - 12:30 pm | Poster Session |
12:30 pm | Lunch |
1:30 pm - 5:00 pm | Contemporary Problems |
| Discussion Leader: Tom von Geldern (Embedded Consulting) |
1:30 pm - 2:05 pm | Martin Burke (University of Illinois)
"Making Molecular Prosthetics with a Small Molecule Synthesizer" |
2:05 pm - 2:15 pm | Discussion |
2:15 pm - 2:50 pm | Martine Keenan (Epichem)
"New Treatments for Chagas Disease" |
2:50 pm - 3:00 pm | Discussion |
3:00 pm | Coffee Break |
3:30 pm - 4:05 pm | James Mack (University of Cincinnati)
"Developing Greener Reactions Through Mechanochemistry" |
4:05 pm - 4:15 pm | Discussion |
4:15 pm - 4:50 pm | Brandon Ashfeld (University of Notre Dame)
"Unconventional Chemoselective Nucleophilic Substitutions in Heterocyclic Natural Products and Designed Materials Synthesis"
|
4:50 pm - 5:00 pm | Discussion |
5:00 pm - 6:00 pm | Free Time |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Target Directed Synthesis |
| Discussion Leader: Eric Voight (AbbVie) |
7:30 pm - 8:00 pm | Joseph Harrity (University of Sheffield)
"'New Strategies for the Synthesis of Boronic Acid Derivatives" |
8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:40 pm | Jeff Kallemeyn (AbbVie)
"The Synthesis of Ilorasertib: Approaches to the Heterocyclic Core" |
8:40 pm - 8:50 pm | Discussion |
8:50 pm - 9:20 pm | Alison Frontier (University of Rochester)
"Cascade Cyclizations for Natural Product Synthesis" |
9:20 pm - 9:30 pm | Discussion |
WEDNESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Heterocyclic Compounds in Cancer Research |
| Discussion Leader: Chudi Ndubaku (Genentech) |
9:00 am - 9:35 am | Katherine Seley-Radtke (Univ. of Maryland, Baltimore County)
"Exploiting the Nucleobase Scaffold for Drug Design and Diversity" |
9:35 am - 9:45 am | Discussion |
9:45 am - 10:20 am | Michael Collins (Pfizer)
"The Discovery and Synthesis of PF-06463922, a Novel Small Molecule Inhibitor of ALK/ROS1 with Pre-Clinical Brain Availability and Broad Spectrum Potency Against ALK-Resistant Mutations" |
10:20 am - 10:30 am | Discussion |
10:30 am | Coffee Break |
11:00 am - 11:35 am | Jennifer Prescher (Univ. of California, Irvine)
"Expanding the Imaging Toolbox" |
11:35 am - 11:45 am | Discussion |
11:45 am - 12:20 pm | Jeff Johnston (Vanderbilt University)
"Brønsted Acid Organocatalysis in New Reaction and Therapeutic Development" |
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | New Approaches to Heterocyclic Compounds |
| Discussion Leader: Michael Nee (Oberlin College) |
7:30 pm - 8:00 pm | Anita Mattson (The Ohio State University)
"Catalysis with Chiral Silanediols" |
8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:40 pm | R. Jason Herr (Albany Molecular Research, Inc.)
"Skunk Works Short Stories: Small, Unpublished Synthesis Projects" |
8:40 pm - 8:50 pm | Discussion |
8:50 pm - 9:20 pm | Dawei Ma (Shanghai Institute of Organic Chemistry)
"Total Synthesis of Bioactive Alkaloids" |
9:20 pm - 9:30 pm | Discussion |
THURSDAY |
7:30 am - 8:30 am | Breakfast |
8:30 am - 9:00 am | Business Meeting |
| Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair |
9:00 am - 12:30 pm | Biologically Active Heterocyclic Compounds |
| Discussion Leader: Stefan France (Georgia Institute of Technology) |
9:00 am - 9:35 am | Travis Remarchuk (Genentech)
"Process Route Development of the PI3k B-Sparing Inhibitor GDC-0032 (Taselisib®)" |
9:35 am - 9:40 am | Discussion |
9:40 am - 10:10 am | Ivar McDonald (Bristol-Myers Squibb)
"Compact Tricyclic Diamines as Novel Scaffolds for α7 Nicotinic Acetylcholine Receptor Agonists" |
10:10 am - 10:15 am | Discussion |
10:15 am | Coffee Break |
10:35 am - 11:05 am | Christopher Grote (Mallinckrodt Pharmaceuticals)
"Regioselective Synthesis of Protoberbine Isoquinoline Alkaloids" |
11:05 am - 11:10 am | Discussion |
11:10 am - 11:40 am | Greg Basarab (AstraZeneca)
"Spirocyclic Pyrimidinetrione DNA Gyrase Inhibiting Antibacterials: Novel Class, Novel Mode-of-Action" |
11:40 am - 11:45 am | Discussion |
11:45 am - 12:20 pm | Xiaoguang Lei (National Institute of Biological Sciences, Beijing)
"Diversity Oriented Synthesis of Bioactive Lycopodium Alkaloids"
|
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Synthesis of Heterocyclic Natural Products |
| Discussion Leader: J. Ramon Vargas (Albany Molecular Research, Inc.) |
7:30 pm - 8:10 pm | Ryan Shenvi (Scripps Research Institute)
"Chemical Synthesis of Secondary Metabolites" |
8:10 pm - 8:30 pm | Discussion |
8:30 pm - 9:05 pm | Dirk Trauner (Ludwig-Maximilians-Universität München)
"Two and a Half Molecules: The Synthesis of Sesterterpenoids and Other Heterocyclic Natural Products"
|
9:05 pm - 9:20 pm | Discussion |
9:20 pm - 9:30 pm | Vice-Chair's Closing Remarks |
FRIDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am | Departure |