Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
The Connectivity Between Methodology Development and Total Synthesis
Discussion Leader: Christa Chrovian (Janssen R&D, USA)
7:40 pm - 7:50 pm
Opening Remarks
7:50 pm - 8:30 pm
Doug Frantz (University of Texas at San Antonio, USA)
"From Synthesis to Therapeutic Application: Making Heterocycles Great Again"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:20 pm
Tehshik Yoon (University of Wisconsin-Madison, USA)
"Photocatalytic Oxidation Reactions"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Improvements to the Synthesis of Heterocyclic Compounds
Discussion Leader: Sarah Wengryniuk (Temple University, USA)
9:00 am - 9:35 am
Jennifer Roizen (Duke University, USA)
"Sulfamate Esters Guide Atom-Transfer Processes"
9:35 am - 9:45 am
Discussion
9:45 am - 10:00 am
Selected from Poster Abstracts: Tomohiro Yasukawa (The University of Tokyo, Japan)
"N-Doped Carbon-Supported Cobalt Nanoparticle Catalysis for Oxidation Reactions Based on Polymer Incarceration Methods"
10:00 am - 10:10 am
Discussion
10:10 am - 10:40 am
Coffee Break
10:40 am - 11:10 am
Chong Han (Genentech, Inc., USA)
"Chemoselective, Stereocontrolled Cu-Catalyzed C-N Couplings Towards a Highly Potent mPI3Ka Inhibitor"
11:10 am - 11:20 am
Discussion
11:20 am - 12:00 pm
Jeffrey Johnson (University of North Carolina at Chapel Hill, USA)
"Bioactive Natural Products and New Reactions to Prepare Them: The Symbiotic Loop"
12:00 pm - 12:10 pm
Discussion
12:10 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Unique Applications of Heterocycles to Broad Biology Challenges
Discussion Leader: Daniel Elbaum (QurAlis Corporation, USA)
7:30 pm - 8:05 pm
Cynthia Jesudason (Independent Consultant, USA)
"Discovery and Development of PET Tracers for Neuroscience"
8:05 pm - 8:15 pm
Discussion
8:15 pm - 8:35 pm
Selected from Poster Abstracts: Ryan Altman (The University of Kansas, USA)
"Tryptophan-Derived Probes for Studying the Kynurenine Pathway"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 9:20 pm
Matthew Shair (Harvard University, USA)
"Roles of CDK8/19 in Oncology"
9:20 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Development of Methodology for Improved Heterocyclic Synthesis
Discussion Leader: Jason Herr (Albany Molecular Research, Inc (AMRI), USA)
9:00 am - 9:30 am
David Nagib (The Ohio State University, USA)
"C-H and C-O Functionalization via Radical Chaperones"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
Brian Laforteza (Janssen Pharmaceuticals, Johnson & Johnson, USA)
"Discovery and Synthesis of Triazolopyridines as Potent and Selective AMPAR γ8-TARP Negative Modulators"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:20 am
Song Lin (Cornell University, USA)
"An Electrocatalytic Approach to New Reaction Discovery"
11:20 am - 11:30 am
Discussion
11:30 am - 12:00 pm
Carolyn Anderson (Calvin College, USA)
"Synthesis of Highly Functionalized N-Alkyl 2-Pyridones and Indolizines"
12:00 pm - 12:10 pm
Discussion
12:10 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
The Use of Novel Approaches to the Synthesis of Biologically Active Compounds
Discussion Leader: Corinna Schindler (University of Michigan, USA)
7:30 pm - 8:05 pm
Amelie Dion (Pfizer Inc, USA)
"Exploratory Process Development of a Second Generation Beta-Amyloid Cleaving Enzyme (BACE1) Inhibitor"
8:05 pm - 8:15 pm
Discussion
8:15 pm - 8:35 pm
Selected from Poster Abstracts: Kevin Frankowski (University of North Carolina at Chapel Hill, USA)
"Discovery and Optimization of Novel Dopamine Receptor Modulators for the Treatment of CNS Disorders"
8:35 pm - 8:40 pm
Discussion
8:40 pm - 9:20 pm
Jeff Kuethe (Merck & Co., Inc., USA)
"Synthesis of a Highly Functionalized Octahydro-Isoindole-Based NK1 Receptor Antagonist"
9:20 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Heterocycles and Their Use as Biological Probes
Discussion Leader: George Sheppard (AbbVie, Inc., USA)
9:00 am - 9:30 am
Jimmy Wu (Dartmouth College, USA)
"New Reactions of Indole for Enabling Synthesis and Biology"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
Alison Frontier (University of Rochester, USA)
"Reaction Cascades for Heterocycle Synthesis"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:20 am
Thomas Hoye (University of Minnesota, USA)
"Natural Product Synthesis"
11:20 am - 11:30 am
Discussion
11:30 am - 12:05 pm
Sarah Reisman (California Institute of Technology, USA)
"Total Synthesis of Complex Natural Products"
12:05 pm - 12:15 pm
Discussion
12:15 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
The Use of Heterocycles in Catalysis
Discussion Leader: Jennifer Howell (Eli Lilly and Company, USA)
7:30 pm - 8:05 pm
Eric Voight (AbbVie, USA)
"Heterocycle Synthesis for the Treatment of Pain, Cystic Fibrosis and Hepatitis C"
8:05 pm - 8:15 pm
Discussion
8:15 pm - 8:35 pm
Selected from Poster Abstracts: Indrajeet Sharma (University of Oklahoma, USA)
"Leveraging Metal Carbenes for Assembling Complexity"
8:35 pm - 8:40 pm
Discussion
8:40 pm - 9:20 pm
Corey Stephenson (University of Michigan, USA)
"Redox Catalysis Strategies for Complex Molecules"
9:20 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
New Strategies for the Synthesis of Heterocycles
Discussion Leader: Paul Ornstein (Medical College of Wisconsin, USA)
9:00 am - 9:35 am
Ryan Moslin (Bristol-Myers Squibb, USA)
"TYK2"
9:35 am - 9:45 am
Discussion
9:45 am - 10:20 am
Emily Balskus (Harvard University, USA)
"Deciphering the Gut Microbiota with Chemistry"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:35 am
Scott Sutton (Pfizer, USA)
"Discovery and Synthesis of PF-6821497, a Potent EZH2 Inhibitor"
11:35 am - 11:45 am
Discussion
11:45 am - 12:20 pm
Laura Anderson (University of Illinois at Chicago, USA)
"New Synthetic Opportunities with Alkenyl Nitrones and Hydroxylamines"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Keynote Session: Nature Inspired Synthesis of Heterocyclic Natural Products
Discussion Leader: Justin Lopchuk (Moffitt Cancer Center, USA)
7:30 pm - 8:15 pm
Phil Baran (The Scripps Research Institute, USA)
"Translational Chemistry"
8:15 pm - 8:25 pm
Discussion
8:25 pm - 9:10 pm
Erik Sorensen (Princeton University, USA)
"Inspired by Molecular Structure and the Challenge of Doing Chemistry on Strong C-H Bonds"
9:10 pm - 9:20 pm
Discussion
9:20 pm - 9:30 pm
Closing Remarks
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure