Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Methodological Breakthroughs with Heterocyclic Compounds
7:40 pm - 7:45 pm
Opening Remarks
7:45 pm - 8:15 pm
"Catalytic Alkene Functionalization for Heterocycle Synthesis and Derivatization"
8:15 pm - 8:25 pm
Discussion
8:25 pm - 8:40 pm
"Calcium Catalysed Generation and Utilization of Reactive Intermediates"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
"C-H Functionalization of Heterocycles by Cooperative Catalysis"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Heterocycles in Complex Molecule Synthesis
9:00 am - 9:35 am
"Synthesis of Bioactive Heterocyclic Natural Products"
9:35 am - 9:45 am
Discussion
9:45 am - 10:20 am
"Regiospecific Syntheses and Reactions of Aromatic Molecules"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:15 am
"3D Hetero-Spirocycles: Synthesis and Application"
11:15 am - 11:25 am
Discussion
11:25 am - 12:00 pm
"Total Synthesis of Polycyclic Indole Alkaloids Enabled by Skeletal Reorganization"
12:00 pm - 12:10 pm
Discussion
12:10 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hourâ„¢
The GRC Power Hourâ„¢ is designed to address challenges women face in science and issues of diversity and inclusion. The program supports the professional growth of all members of our communities by providing an open forum for discussion and mentoring.
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Catalysis in Heterocyclic Contexts
7:30 pm - 8:00 pm
"Harnessing Non-Covalent Interactions to Address Selectivity Challenges in Catalysis"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
"Stereoselective Alkene Functionalization via Radical Pathways"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
"Organophosphorus-Catalyzed Methods Based on P(III)/P(V) Redox Cycling"
9:20 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 12:30 pm
Free Time
12:30 pm - 1:30 pm
Lunch
1:30 pm - 5:00 pm
Heterocycles as a Platform for Advances in Synthesis
1:30 pm - 2:00 pm
"Stereoselective Functionalization of Unsaturated Hydrocarbons"
2:00 pm - 2:10 pm
Discussion
2:10 pm - 2:35 pm
"Isotope and Medicinal Chemistry Late Stage Functionalizations in Drug Discovery"
2:35 pm - 2:45 pm
Discussion
2:45 pm - 3:15 pm
Coffee Break
3:15 pm - 3:30 pm
"Biomimetic Synthesis of Hitorins A and B"
3:30 pm - 3:40 pm
Discussion
3:40 pm - 4:05 pm
"Mechanistic Studies on the Unexpected Racemization of Cyclopropyl Isoxazolines"
4:05 pm - 4:15 pm
Discussion
4:15 pm - 4:50 pm
"New Strategies for the C-H Functionalization of Amines"
4:50 pm - 5:00 pm
Discussion
5:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Inventions in Heterocycle-Based Functionalization
7:30 pm - 8:05 pm
"Engaging Challenging Substrates in Cross-Electrophile Coupling"
8:05 pm - 8:15 pm
Discussion
8:15 pm - 8:30 pm
"Atropisomerism as a Tool in Drug Discovery and an Inspiration for New Chemistry"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:20 pm
"Asymmetric C-H Oxidations"
9:20 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Route Development and Optimization to Bioactive Heterocycles
9:00 am - 9:30 am
"Synthetic Route Development Utilizing a C-N Cross-Coupling Approach for a Drug Candidate"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
"Diastereoselective Pictet-Spengler Based Synthesis of a D1 Potentiator"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:20 am
"Commercial Route Development of Daurismo (Glasdegib), a SMO Inhibitor"
11:20 am - 11:30 am
Discussion
11:30 am - 12:00 pm
"Process Development Enables the Synthesis of a Complex Macrocyclic Peptide Antibiotic"
12:00 pm - 12:10 pm
Discussion
12:10 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
New Methods Toward Heterocyclic Compounds
7:30 pm - 8:00 pm
"Allylic Azides: Harnessing the Winstein Rearrangement Through DKR"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
"Beyond Cp*: Mechanism Driven Development of a New Rhodium Complex for Enantioselective C-H Functionalization"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
"Donor-Acceptor Cyclopropanes as Masked 1,3-Dipoles for the Synthesis of Heterocyclic Compounds"
9:20 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
The Interplay of Heterocyclic Compounds and Biological Inquiries
9:00 am - 9:30 am
"Biocatalysis and Complex Molecule Synthesis"
9:30 am - 9:40 am
Discussion
9:40 am - 10:05 am
"Discovery and Synthesis of AZD4573, a Potent and Selective CDK9 Inhibitor"
10:05 am - 10:15 am
Discussion
10:15 am - 10:45 am
Coffee Break
10:45 am - 11:10 am
"Rapid Discovery of Selective and Potent G-Protein-Coupled Receptor Kinase 2 (GRK2) Inhibitors"
11:10 am - 11:20 am
Discussion
11:20 am - 11:45 am
"Discovery of Tetflupyrolimet: A New Mode-of-Action Herbicide Interfering with De Novo Pyrimidine Biosynthesis"
11:45 am - 11:55 am
Discussion
11:55 am - 12:20 pm
"Synthetic Transformations via C-H Bond Functionalization"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Prospects in Heterocyclic Chemistry: Synthesis and Related Studies
7:30 pm - 8:10 pm
"Recent Efforts in the Synthesis of Complex Natural Products"
8:10 pm - 8:20 pm
Discussion
8:20 pm - 9:05 pm
"Synthetic, Bioorganic and Medicinal Chemistry in the Smith Group"
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:30 pm
Closing Remarks
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure