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Inhibition in the CNS

Gordon Research Conference

July 22 - 27, 2007
Chair
Vice Chair

Conference Description

The general topic of the conference is inhibitory control of circuits in the central nervous system. Sessions will be devoted to the structure and function of ion channels gated by the inhibitory neurotransmitters GABA and glycine, the anatomy, physiology and pathophysiology of the numerous subsets of neurons in the brain containing these inhibitory transmitters, the function and regulation of inhibitory synapses, and the role these specific interneurons play in regulating and synchronizing the activity of defined neuronal networks.

Conference Program

SUNDAY
2:00 pm - 11:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:00 pmKeynote Lecture I
7:40 pm - 7:45 pmIntroductory Remarks: Chris J. McBain (NICHD, Bethesda, USA)
7:45 pm - 8:45 pmRichard Miles (INSERM, Paris, France)
"Inhibitory cells and circuits: a personal view"
8:45 pm - 9:00 pmDiscussion
9:00 pmReception
MONDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmDevelopment of Inhibitory Circuits
Discussion Leader: Hannah Monyer (U. Heidelberg, Germany)
9:00 am - 9:30 amGordon Fishell (NYU School Medicine, New York, USA)
"The contribution of developmental gene expression in the ventral telencephalon to cortical interneuron diversity"
9:30 am - 9:35 amDiscussion
9:35 am - 10:05 amJosh Huang (Cold Spring Harbor Labs, New York, USA)
"Development of GABAergic innervation patterns in neocortex and cerebellum"
10:05 am - 10:10 amDiscussion
10:10 amCoffee Break
10:40 am - 11:10 amAngelique Bordey (Yale Univ., New Haven, USA)
"Non-synaptic GABAergic inhibition of neuroblast production in the postnatal forebrain"
11:10 am - 11:15 amDiscussion
11:15 am - 11:45 amRosa Cossart (Inmed, Marseilles, France)
"A new step in the maturation of hippocampal GABAergic microcircuits: Synchronous calcium plateaus in oscillating neuronal assemblies"
11:45 am - 11:50 amDiscussion
11:50 am - 12:00 pmShort Talk #1: Tija Jacob (Univ. Pennsylvania, Philadelphia, USA)
"GABAA receptor cell surface number modulates spinogenesis"
12:00 pm - 12:05 pmDiscussion
12:05 pm - 12:15 pmShort Talk #2: Wolfgang Kelsch (Picower, MIT, Massachusetts, USA)
"Asynchrony of synaptic development and diversity of lamina-specific dendritic targeting of interneurons during adult neurogenesis"
12:15 pm - 12:20 pmDiscussion
12:30 pmGroup Photo / Lunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session I (Family Names A-L)
6:00 pmDinner
7:30 pm - 9:30 pmStructure and Function of GABAA and GABAB Receptors
Discussion Leader: Istvan Mody (UCLA, Los Angeles, USA)
7:30 pm - 7:55 pmRobert Macdonald (Vanderbilt Univ., Nashville, USA)
"Assembly of αβγ and αβδ GABAA receptor channels"
7:55 pm - 8:00 pmDiscussion
8:00 pm - 8:25 pmCynthia Czajkowski (Univ. Wisconsin, Madison, USA)
"Linking Structure to Function in GABAA Receptors"
8:25 pm - 8:30 pmDiscussion
8:30 pm - 8:55 pmNeil Harrison (Cornell Univ., New York, USA)
"Biology of the GABAA Receptor Alpha-4 Subunit"
8:55 pm - 9:00 pmDiscussion
9:00 pm - 9:25 pmBernard Bettler (Univ. Basel, Basel, Switzerland)
"Genetic dissociation of native GABAB functions"
9:25 pm - 9:30 pmDiscussion
TUESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmInhibition in CNS Circuits I
Discussion Leader: Gianmaria Maccaferri (Northwestern Univ., Chicago, USA)
9:00 am - 9:30 amMassimo Scanziani (UCSD, San Diego, USA)
"The relative contribution of excitation and inhibition in shaping pyramidal cell activity"
9:30 am - 9:35 amDiscussion
9:35 am - 10:05 amPablo Castillo (Einstein Univ., New York, USA)
"Inhibitory synaptic plasticity mediated by endocannabinoids"
10:05 am - 10:10 amDiscussion
10:10 amCoffee Break
10:40 am - 11:10 amPeter Jonas (Univ. Freiburg, Freiburg, Germany)
"Molecular mechanisms of fast inhibitory synaptic transmission at hippocampal basket cell-granule cell synapses"
11:10 am - 11:15 amDiscussion
11:15 am - 11:45 amThomas Klausberger (MRC, Oxford, United Kingdom)
"GABAergic interneurons and hippocampal network oscillations in vivo"
11:45 am - 11:50 amDiscussion
11:50 am - 12:00 pmShort Talk #1: Richard Pressler (Case Western Univ., Ohio, USA)
"Activation of cholinergic M1 receptors modulates olfactory bulb granule cell excitability and potentiates inhibition onto mitral cells"
12:00 pm - 12:05 pmDiscussion
12:05 pm - 12:15 pmShort Talk #2: Alexey Ponomarenko (Univ. Heidelburg, Germany)
"Network synchronization in the intact hippocampus with abolished inhibition onto basket cells"
12:15 pm - 12:20 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session II (Family names M-Z)
6:00 pmDinner
7:30 pm - 9:00 pmGABA Receptor Modulation
Discussion Leader: Tim Hales (George Washington Univ., Washington DC, USA)
7:30 pm - 7:55 pmJamie Maguire (UCLA, Los Angeles, USA)
"Steroid Hormones and Changes in GABAA Receptors"
7:55 pm - 8:00 pmDiscussion
8:00 pm - 8:25 pmBryndis Birnir (Univ. Lund, Lund, Sweden)
"GABA-activated channels"
8:25 pm - 8:30 pmDiscussion
8:30 pm - 8:55 pmDavid Weiss (UTSA, San Antonio, USA)
"New Insights into the Antagonism of the GABA Receptor by Picrotoxin"
8:55 pm - 9:00 pmDiscussion
9:00 pm - 9:30 pmData Blitz
Chair: Hannah Monyer (Univ. Heidelberg, Germany)
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmGABA and Glycine Receptors
Discussion Leader: Stefano Vicini (Georgetown Univ., Washington DC, USA)
9:00 am - 9:30 amAmy MacDermott (Columbia Univ., New York, USA)
"Inhibitory regulation of pain signaling in the dorsal horn"
9:30 am - 9:35 amDiscussion
9:35 am - 10:05 amJohn Huguenard (Stanford Univ., Palo Alto, USA)
"Molecular determinants of fast and slow GABA receptor gating in thalamus: Circuit implications"
10:05 am - 10:10 amDiscussion
10:10 amCoffee Break
10:40 am - 11:10 amGabor Tamas (Univ. Szeged, Szeged, Hungary)
"Feed-forward circuits in the human cerebral cortex"
11:10 am - 11:15 amDiscussion
11:15 am - 11:45 amLori McMahon (Univ. Alabama, Birmingham, USA)
"Glycine-gated chloride channels and inhibition in hippocampus"
11:45 am - 11:50 amDiscussion
11:50 am - 12:00 pmShort Talk #1: Kristen Ade (Georgetown Univ., Washington DC, USA)
"Tonic GABAergic Inhibition Differs Between Dopamine Receptor D1 and D2 Expressing Medium Spiny Neurons in the Dorsal Striatum"
12:00 pm - 12:05 pmDiscussion
12:05 pm - 12:15 pmShort Talk #2: Marcel Goldschen (Univ. Wisconsin-Madison, USA)
"Diazepam dissociation kinetics with the GABAA receptor"
12:15 pm - 12:20 pmDiscussion
12:30 pmLunch
1:30 pm - 6:00 pmFree Time
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
(Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair)
7:30 pm - 9:00 pmInhibition in CNS Circuits II
Discussion Leader: Gyorgy Buzsaki (Rutgers Univ., Newark, USA)
7:30 pm - 7:55 pmNorbert Hajos (Inst. Exp Med. Budapest, Hungary)
"Cooperation of NO and endocannabinoids in retrograde signaling at GABAergic synapses"
7:55 pm - 8:00 pmDiscussion
8:00 pm - 8:25 pmAlex Thomson (London Univ., London, United Kingdom)
"Selectivity in the expression of pre- and post-synaptic mechanisms"
8:25 pm - 8:30 pmDiscussion
8:30 pm - 8:55 pmIvan Soltesz (Univ. California, Irvine, USA)
"Control of GABA-release at CCK-positive basket cell terminals"
8:55 pm - 9:00 pmDiscussion
THURSDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmPlasticity and Pathology of Inhibition
Discussion Leader: Richard Miles (INSERM, Paris, France)
9:00 am - 9:30 amDimitri Kullmann (Univ. College London, London, United Kingdom)
"Plasticity of feed-forward and feed-back inhibition in the hippocampus"
9:30 am - 9:35 amDiscussion
9:35 am - 10:05 amJulie Kauer (Brown Univ., Providence, USA)
"LTP at GABAergic synapses"
10:05 am - 10:10 amDiscussion
10:10 amCoffee Break
10:40 am - 11:10 amJean Claude Lacaille (Univ. Montreal, Montreal, Canada)
"mGluR5 mediated plasticity in hippocampal interneurons"
11:10 am - 11:15 amDiscussion
11:15 am - 11:45 amDavid Lewis (Univ. Pittsburgh, Pittsburgh, USA)
"GABA Neurons and Cortical Dysfunction in Schizophrenia"
11:45 am - 11:50 amDiscussion
11:50 am - 12:00 pmShort Talk #1: Melanie Woodin (Univ. Toronto, Canada)
"Spike-timing dependent plasticity of GABAergic synapses in the hippocampus"
12:00 pm - 12:05 pmDiscussion
12:05 pm - 12:15 pmShort Talk #2: Miho Teranuma (Univ. Pennsylvania, USA)
"Modified GABAA receptor phospho-dependent endocytosis underlies compromised synaptic inhibition in Status epilepticus"
12:15 pm - 12:20 pmDiscussion
12:30 pmLunch
1:30 pm - 6:00 pmFree Time
6:00 pmDinner
7:30 pm - 9:30 pmKeynote Lecture II
7:30 pm - 8:30 pmGyorgy Buzsaki (Univ. Rutgers, Newark, USA)
"Interneuron hierarchies and oscillatory organization of cell assemblies"
8:30 pm - 8:45 pmDiscussion
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDepart

Contributors

Conference Links

Conference History
Additional Fee Info

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