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Inhibition in the CNS

Gordon Research Conference

Assembly and Function of Inhibitory Neurons in Health and Disease

July 16 - 21, 2023

Chairs Beatriz Rico and Marlene Bartos

Vice Chairs Gordon Fishell and Attila Losonczy

Les Diablerets Conference Center

Eurotel Victoria

Les Diablerets, Vaud (fr), Switzerland

Venue and Travel Information

Conference Description

The Inhibition in the CNS GRC is a premier, international scientific conference focused on advancing the frontiers of science through the presentation of cutting-edge and unpublished research, prioritizing time for discussion after each talk and fostering informal interactions among scientists of all career stages. The conference program includes a diverse range of speakers and discussion leaders from institutions and organizations worldwide, concentrating on the latest developments in the field. The conference is five days long and held in a remote location to increase the sense of camaraderie and create scientific communities, with lasting collaborations and friendships. In addition to premier talks, the conference has designated time for poster sessions from individuals of all career stages, and afternoon free time and communal meals allow for informal networking opportunities with leaders in the field.

Current knowledge in the field provides strong evidence that inhibition is fundamental to fine-tune the activity of neural circuitries in healthy brains and that unbalance between inhibition and excitation underlies some of the most devastating neurodevelopmental and neurological disorders including autism and schizophrenia. Therefore, it will be a special emphasis on linking cutting-edge fundamental and translation science, including research in humans. The spectacular location of Les Diablerets at the heart of the Alps will provide a unique and secluded environment to discuss science with top leaders in the field.

Related Meeting

This GRC will be held in conjunction with the "Inhibition in the CNS" Gordon Research Seminar (GRS). Those interested in attending both meetings must submit an application for the GRS in addition to an application for the GRC. Refer to the associated GRS program page for more information.

Conference Program

Sunday
2:00 pm - 9:00 pm	Arrival and Check-in
6:00 pm - 7:00 pm	Dinner
7:30 pm - 7:40 pm	Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm	Keynote Session: Organization and Function of Hippocampal and Neocortical Circuitries Discussion Leader: Gordon Fishell (Harvard Medical School, United States)
7:40 pm - 8:25 pm	Gina Turrigiano (brandeis university, United States) "Reconfiguration of Visual Cortical Circuits during Prey Capture Learning"
8:25 pm - 8:35 pm	Discussion
8:35 pm - 9:20 pm	Ivan Soltesz (Stanford University, United States) "Organization and Control of Hippocampal Circuits"
9:20 pm - 9:30 pm	Discussion
Monday
7:30 am - 8:30 am	Breakfast
9:00 am - 12:30 pm	Excitation Inhibition Balance In Developing and Mature Circuits Discussion Leader: Rosa Cossart (INMED Inserm u1249, France)
9:00 am - 9:20 am	Sonia Garel (Ecole Normale Superieure / College de France, France) "Transient Neurons and Immune Cells in the Early Development of Cortical Interneurons"
9:20 am - 9:30 am	Discussion
9:30 am - 9:50 am	Linda Van Aelst (Cold Spring Harbor Laboratory, United States) "Shedding Light on Chandelier Cell Development and Connectivity"
9:50 am - 10:00 am	Discussion
10:00 am - 10:30 am	Coffee Break
10:30 am - 10:50 am	Natalia De Marco Garcia (Weill Cornell Medical College, United States) "Mechanisms of GABAergic Circuit Assembly in the Somatosensory Cortex"
10:50 am - 11:00 am	Discussion
11:00 am - 11:20 am	Renata Batista-Brito (Albert Einstein College of Medicine, United States) "Long-range Inhibitory Neurons Coordinate State-Dependent Cortical Network Synchronization"
11:20 am - 11:30 am	Discussion
11:30 am - 11:40 am	Lynette Lim (KU Leuven / VIB Center for Brain & Diseases, Belgium) "Cortical Inhibitory Neurons Exhibit Cell-Type Specific Maturation Programmes"
11:40 am - 11:45 am	Discussion
11:45 am - 11:55 am	Giordano Lippi (The Scripps Research Institute, United States) "Beyond Transcription - miRNA Mechanisms of Interneuron Development"
11:55 am - 12:00 pm	Discussion
12:00 pm - 12:10 pm	Julie JEZEQUEL (Centre for Developmental Neurobiology, King's College London, United Kingdom) "Cadherins Instruct Cell- and Input-Specific Inhibition Patterns onto L5 Pyramidal Neuron Subpopulations"
12:10 pm - 12:15 pm	Discussion
12:15 pm - 12:25 pm	Soohyun Lee (National Institutes of Health, National Institute of Mental Health, United States) "Development of Cortical Disinhibitory Circuits"
12:25 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Group Photo / Lunch
1:30 pm - 4:30 pm	Free Time
3:00 pm - 4:00 pm	The GRC Power Hour™ The GRC Power Hour™ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring. Organizer: Rosa Cossart (INMED Inserm u1249, France)
4:30 pm - 6:00 pm	Poster Session
6:00 pm - 8:00 pm	Functional and Structural Plasticity of GABAergic Cells Discussion Leader: Alberto Bacci (ICM - Paris Brain Institute, France)
6:00 pm - 6:20 pm	Elly Nedivi (Massachusetts Institute of Technology, United States) "Heterogeneity of Inhibitory Dendritic Innervation"
6:20 pm - 6:30 pm	Discussion
6:30 pm - 6:50 pm	Juan Burrone (King's College London, United Kingdom) "The Emergence and Plasticity of Axo-axonic Synapses at the Axon Initial Segment"
6:50 pm - 7:00 pm	Discussion
7:00 pm - 7:20 pm	Simon Chen (University of Ottawa, Canada) "Functionally Distinct NPAS4-expressing Somatostatin Interneuron Ensembles Critical for Motor Learning"
7:20 pm - 7:30 pm	Discussion
7:30 pm - 7:50 pm	Hillel Adesnik (UC Berkeley, United States) "Precise Synaptic Architecture in Cortical Inhibitory Circuits Mediates Image Segmentation"
7:50 pm - 8:00 pm	Discussion
8:00 pm - 9:00 pm	Dinner
Tuesday
7:30 am - 8:30 am	Breakfast
9:00 am - 12:30 pm	Inhibition and Sensory Information Processing Discussion Leader: Alison Barth (Carnegie Mellon University, United States)
9:00 am - 9:20 am	Ivo Spiegel (Weizmann Institute of Science, Israel) "Sensory-Induced Genomic Mechanism that Maintain Visual Processing by Normalizing E/I-Ratio"
9:20 am - 9:30 am	Discussion
9:30 am - 9:50 am	Carl Petersen (Ecole Polytechnique Federale de Lausanne (EPFL), Switzerland) "Contributions of Cortical GABAergic Neurons for Whisker Sensorimotor Processing"
9:50 am - 10:00 am	Discussion
10:00 am - 10:30 am	Coffee Break
10:30 am - 10:50 am	Daniel Feldman (University of California, Berkeley, United States) "Do VIP Interneurons Signal Reward to Sensory Cortex?"
10:50 am - 11:00 am	Discussion
11:00 am - 11:20 am	James Poulet (Max Delbrück Center, Germany) "Cortical Encoding of Temperature"
11:20 am - 11:30 am	Discussion
11:30 am - 11:40 am	Edmund Au (Columbia University Irving Medical Center, United States) "Population Level Analysis of Cortical Interneuron Synapses Through Spatial Statistical Analysis"
11:40 am - 11:45 am	Discussion
11:45 am - 11:55 am	Martijn Selten (King's College London, United Kingdom) "Activity-dependent Regulation of Synaptic Integration in Parvalbumin-Positive Interneurons"
11:55 am - 12:00 pm	Discussion
12:00 pm - 12:10 pm	Adil Khan (King's College London, United Kingdom) "Attentional Modulation of Activity in V1: Insights from All-Optical Inhibitory Circuit Manipulations"
12:10 pm - 12:15 pm	Discussion
12:15 pm - 12:25 pm	Stefan Sun (Yale University, United States) "Experience-dependent Plasticity of GABAergic Circuits in Visual Cortex"
12:25 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:30 pm	Free Time
4:30 pm - 6:00 pm	Poster Session
6:00 pm - 8:00 pm	Inhibition and Network Dynamics in Prefrontal Cortex: Decision-Making, Enhanced Attention and Gambling Discussion Leader: Attila Losonczy (Columbia University, United States)
6:00 pm - 6:20 pm	Thomas Klausberger (Center for Brain Research, Medical University Vienna, Austria, Austria) "Cortical Inhibition for Cognitive Flexibility and Decision Making"
6:20 pm - 6:30 pm	Discussion
6:30 pm - 6:50 pm	Adam Kepecs (Washington University in St Louis, MO, USA, United States) "VIP access: How Cortex's Very Important Players Control Reinforcement Learning"
6:50 pm - 7:00 pm	Discussion
7:00 pm - 7:20 pm	Marie Carlen (Karolinska Institutet, Sweden) "Functional Maps of the Mouse Prefrontal Cortex, with a Focus on Inhibition"
7:20 pm - 7:30 pm	Discussion
7:30 pm - 7:50 pm	Vikaas Sohal (University of California, San Francisco, United States) "The Role of Prefrontal PV Neuron-generated Gamma Synchrony in Cognitive Flexibility"
7:50 pm - 8:00 pm	Discussion
8:00 pm - 9:00 pm	Dinner
Wednesday
7:30 am - 8:30 am	Breakfast
9:00 am - 12:30 pm	Inhibitory Subnetworks During Learning Discussion Leader: Liset Menendez de la Prida (ES-Q-2818002D, Instituto Cajal, Spanish National Research Council (CSIC), Spain)
9:00 am - 9:20 am	Hannah Monyer (Heidelberg University, Germany) "The Long and the Short of Inhibition"
9:20 am - 9:30 am	Discussion
9:30 am - 9:50 am	David Dupret (University of Oxford, United Kingdom) "Neuronal Firing Dynamics in CA1 Superficial Layers."
9:50 am - 10:00 am	Discussion
10:00 am - 10:30 am	Coffee Break
10:30 am - 10:50 am	Johannes Letzkus (University of Freiburg, Germany) "Inhibitory Top-down Control of Neocortical Threat Memory"
10:50 am - 11:00 am	Discussion
11:00 am - 11:20 am	Lisa Topolnik (Laval University, Canada) "Hippocampal VIP Interneurons Detect Novelty in the Environment and Regulate Encoding of Recognition Memory"
11:20 am - 11:30 am	Discussion
11:30 am - 11:40 am	Mei Yuan (University of Freiburg, Germany) "Somatostatin-Expressing Interneurons of the Dentate Gyrus Support Goal-Oriented Reward Learning"
11:40 am - 11:45 am	Discussion
11:45 am - 11:55 am	Emily Aery Jones (Stanford University, United States) "Dynamics of Entorhinal Reactivations over Learning"
11:55 am - 12:00 pm	Discussion
12:00 pm - 12:10 pm	Ilsong Choi (Institute for Basic Science, South Korea) "Parvalbumin-positive Neurons Mediate Contingency- Dependent Inhibition in the Mouse Parietal Cortex"
12:10 pm - 12:15 pm	Discussion
12:15 pm - 12:25 pm	Kaizhen Li (University of Bern, Switzerland) "Functional Dissociation of Ventral Hippocampal Inhibitory Circuits during Anxiety and Fear Behaviors"
12:25 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:30 pm	Free Time
4:30 pm - 6:00 pm	Poster Session
6:00 pm - 8:00 pm	Modulation of Inhibition, Metabolic States, Memory and Sleep Discussion Leader: Imre Vida (Charite - Universitaetsmedizin Berlin, Germany)
6:00 pm - 6:20 pm	Nathalie Rochefort (University of Edinburgh, United Kingdom) "The ‘Low-Power Mode’ of Neocortex: Energy Use and Coding Precision during Food Scarcity"
6:20 pm - 6:30 pm	Discussion
6:30 pm - 6:50 pm	Liping Wang (Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences (CAS), China) "Modulation of Fear and Sleep"
6:50 pm - 7:00 pm	Discussion
7:00 pm - 7:20 pm	Gábor Nyiri (Institute of Experimental Medicine, Hungary) "Brainstem Control of the Memory of Negative Experience"
7:20 pm - 7:30 pm	Discussion
7:30 pm - 7:50 pm	Dilja Krueger-Burg (Mainz University Medical Center, Germany) "Inhibitory Synapse Diversity in the Modulation of Defensive Behaviors"
7:50 pm - 8:00 pm	Discussion
8:00 pm - 9:00 pm	Dinner
Thursday
7:30 am - 8:30 am	Breakfast
8:30 am - 9:00 am	Business Meeting Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Discuss Future Dates and Venue; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm	Influence of Inhibition on Network Activity and Behavior in Diseases Discussion Leader: Chris McBain (National Institute of Child Health and Human Development, NIH, United States)
9:00 am - 9:20 am	Carlos Portera-Cailliau (David Geffen School of Medicine at UCLA, United States) "Cortical Inhibitory Interneurons and Sensory Processing in Fragile X Syndrome."
9:20 am - 9:30 am	Discussion
9:30 am - 9:50 am	Claudia Bagni (University of Lausanne, Switzerland) "Mechanisms Underlying Behavioural Inflexibility in FXS"
9:50 am - 10:00 am	Discussion
10:00 am - 10:30 am	Coffee Break
10:30 am - 10:50 am	Peyman Golshani (University of California, Los Angeles, United States) "Voltage Imaging Reveals Cell-specific Interneuron Dynamics during Working Memory"
10:50 am - 11:00 am	Discussion
11:00 am - 11:20 am	Jorge Palop (Gladstone Institutes / University of California, San Francisco, United States) "Network Abnormalities and Interneuron Dysfunction in Alzheimer’s Disease"
11:20 am - 11:30 am	Discussion
11:30 am - 11:40 am	Lauren Hewitt (The University of Texas at Austin, United States) "Higher Hyperpolarization Activated Current (Ih) in a Subpopulation of Hippocampal Stratum Oriens CA1 Interneurons in Fragile X Mice."
11:40 am - 11:45 am	Discussion
11:45 am - 11:55 am	Stephanie Herrlinger (Columbia University, United States) "Simultaneous 3D Imaging of Interneuron Subtypes in CA1 depicts Deficits in Interneuron Activity Resulting in Microcircuit Disruption in a Mouse Model for the 22q11.2 Deletion Syndrome"
11:55 am - 12:00 pm	Discussion
12:00 pm - 12:10 pm	Silvia Viana da Silva (DZNE-Berlin, Germany) "Dysfunctional Mitochondria of Parvalbumin Positive Interneurons Impairs Hippocampal CA1 Function"
12:10 pm - 12:15 pm	Discussion
12:15 pm - 12:25 pm	Luis Fuentealba (Neurona Therapeutics, United States) "hPSC-derived Inhibitory Interneuron Cell Therapy, NRTX-1001, for Drug-Refractory Focal Epilepsy: from Preclinical Characterization to first Clinical Trial Results"
12:25 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:30 pm	Free Time
4:30 pm - 6:00 pm	Poster Session
6:00 pm - 8:00 pm	Inhibition in Human: Molecular Programs, Circuitries and Networks Discussion Leader: Zoltan Nusser (Institute of Experimental Medicine, Hungary)
6:00 pm - 6:20 pm	Nenad Sestan (Yale University, United States) "Development and Evolution of Human Neural Circuits"
6:20 pm - 6:30 pm	Discussion
6:30 pm - 6:50 pm	Caroline Robertson (Dartmouth, United States) "A Retinotopic Push-pull Dynamic Structures Perceptual-mnemonic Interactions in the Human Brain"
6:50 pm - 7:00 pm	Discussion
7:00 pm - 7:20 pm	Dimitri Kullmann (University College London, United Kingdom) "When Inhibition Fails: Circuits, Synaptopathies and Seizures"
7:20 pm - 7:30 pm	Discussion
7:30 pm - 7:50 pm	Kenneth Fish (University of Pittsburgh, United States) "GABAergic Cell type, Region, and Layer Specific Alterations in Schizophrenia"
7:50 pm - 8:00 pm	Discussion
8:00 pm - 9:00 pm	Dinner
Friday
7:30 am - 8:30 am	Breakfast
9:00 am	Departure

Contributors

Funding for this conference was made possible (in part) by the National Institutes of Health Award Number R13NS132568. from the National Institute of Neurological Disorders and Stroke. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of NIH; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.

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Conference History Inhibition in the CNS (GRS)

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