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Inhibition in the CNS

Gordon Research Conference

Assembly and Function of Inhibitory Neurons in Health and Disease

July 16 - 21, 2023

Chairs

and

Vice Chairs

and

Les Diablerets Conference Center

Eurotel Victoria

Les Diablerets, Vaud (fr), Switzerland

Venue and Travel Information

Conference Description

The Inhibition in the CNS GRC is a premier, international scientific conference focused on advancing the frontiers of science through the presentation of cutting-edge and unpublished research, prioritizing time for discussion after each talk and fostering informal interactions among scientists of all career stages. The conference program includes a diverse range of speakers and discussion leaders from institutions and organizations worldwide, concentrating on the latest developments in the field. The conference is five days long and held in a remote location to increase the sense of camaraderie and create scientific communities, with lasting collaborations and friendships. In addition to premier talks, the conference has designated time for poster sessions from individuals of all career stages, and afternoon free time and communal meals allow for informal networking opportunities with leaders in the field.

Current knowledge in the field provides strong evidence that inhibition is fundamental to fine-tune the activity of neural circuitries in healthy brains and that unbalance between inhibition and excitation underlies some of the most devastating neurodevelopmental and neurological disorders including autism and schizophrenia. Therefore, it will be a special emphasis on linking cutting-edge fundamental and translation science, including research in humans. The spectacular location of Les Diablerets at the heart of the Alps will provide a unique and secluded environment to discuss science with top leaders in the field.

Related Meeting

This GRC will be held in conjunction with the "Inhibition in the CNS" Gordon Research Seminar (GRS). Those interested in attending both meetings must submit an application for the GRS in addition to an application for the GRC. Refer to the associated GRS program page for more information.

Conference Program

Sunday
2:00 pm - 9:00 pm	Arrival and Check-in
6:00 pm - 7:00 pm	Dinner
7:30 pm - 7:40 pm	Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm	Keynote Session: Organization and Function of Hippocampal and Neocortical Circuitries Discussion Leader:
7:40 pm - 8:25 pm	"Reconfiguration of Visual Cortical Circuits during Prey Capture Learning"
8:25 pm - 8:35 pm	Discussion
8:35 pm - 9:20 pm	"Organization and Control of Hippocampal Circuits"
9:20 pm - 9:30 pm	Discussion
Monday
7:30 am - 8:30 am	Breakfast
9:00 am - 12:30 pm	Excitation Inhibition Balance In Developing and Mature Circuits Discussion Leader:
9:00 am - 9:20 am	"Transient Neurons and Immune Cells in the Early Development of Cortical Interneurons"
9:20 am - 9:30 am	Discussion
9:30 am - 9:50 am	"Shedding Light on Chandelier Cell Development and Connectivity"
9:50 am - 10:00 am	Discussion
10:00 am - 10:30 am	Coffee Break
10:30 am - 10:50 am	"Mechanisms of GABAergic Circuit Assembly in the Somatosensory Cortex"
10:50 am - 11:00 am	Discussion
11:00 am - 11:20 am	"Long-range Inhibitory Neurons Coordinate State-Dependent Cortical Network Synchronization"
11:20 am - 11:30 am	Discussion
11:30 am - 11:40 am	"Cortical Inhibitory Neurons Exhibit Cell-Type Specific Maturation Programmes"
11:40 am - 11:45 am	Discussion
11:45 am - 11:55 am	"Beyond Transcription - miRNA Mechanisms of Interneuron Development"
11:55 am - 12:00 pm	Discussion
12:00 pm - 12:10 pm	"Cadherins Instruct Cell- and Input-Specific Inhibition Patterns onto L5 Pyramidal Neuron Subpopulations"
12:10 pm - 12:15 pm	Discussion
12:15 pm - 12:25 pm	"Development of Cortical Disinhibitory Circuits"
12:25 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Group Photo / Lunch
1:30 pm - 4:30 pm	Free Time
3:00 pm - 4:00 pm	The GRC Power Hour™ The GRC Power Hour™ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring. Organizer:
4:30 pm - 6:00 pm	Poster Session
6:00 pm - 8:00 pm	Functional and Structural Plasticity of GABAergic Cells Discussion Leader:
6:00 pm - 6:20 pm	"Heterogeneity of Inhibitory Dendritic Innervation"
6:20 pm - 6:30 pm	Discussion
6:30 pm - 6:50 pm	"The Emergence and Plasticity of Axo-axonic Synapses at the Axon Initial Segment"
6:50 pm - 7:00 pm	Discussion
7:00 pm - 7:20 pm	"Functionally Distinct NPAS4-expressing Somatostatin Interneuron Ensembles Critical for Motor Learning"
7:20 pm - 7:30 pm	Discussion
7:30 pm - 7:50 pm	"Precise Synaptic Architecture in Cortical Inhibitory Circuits Mediates Image Segmentation"
7:50 pm - 8:00 pm	Discussion
8:00 pm - 9:00 pm	Dinner
Tuesday
7:30 am - 8:30 am	Breakfast
9:00 am - 12:30 pm	Inhibition and Sensory Information Processing Discussion Leader:
9:00 am - 9:20 am	"Sensory-Induced Genomic Mechanism that Maintain Visual Processing by Normalizing E/I-Ratio"
9:20 am - 9:30 am	Discussion
9:30 am - 9:50 am	"Contributions of Cortical GABAergic Neurons for Whisker Sensorimotor Processing"
9:50 am - 10:00 am	Discussion
10:00 am - 10:30 am	Coffee Break
10:30 am - 10:50 am	"Do VIP Interneurons Signal Reward to Sensory Cortex?"
10:50 am - 11:00 am	Discussion
11:00 am - 11:20 am	"Cortical Encoding of Temperature"
11:20 am - 11:30 am	Discussion
11:30 am - 11:40 am	"Population Level Analysis of Cortical Interneuron Synapses Through Spatial Statistical Analysis"
11:40 am - 11:45 am	Discussion
11:45 am - 11:55 am	"Activity-dependent Regulation of Synaptic Integration in Parvalbumin-Positive Interneurons"
11:55 am - 12:00 pm	Discussion
12:00 pm - 12:10 pm	"Attentional Modulation of Activity in V1: Insights from All-Optical Inhibitory Circuit Manipulations"
12:10 pm - 12:15 pm	Discussion
12:15 pm - 12:25 pm	"Experience-dependent Plasticity of GABAergic Circuits in Visual Cortex"
12:25 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:30 pm	Free Time
4:30 pm - 6:00 pm	Poster Session
6:00 pm - 8:00 pm	Inhibition and Network Dynamics in Prefrontal Cortex: Decision-Making, Enhanced Attention and Gambling Discussion Leader:
6:00 pm - 6:20 pm	"Cortical Inhibition for Cognitive Flexibility and Decision Making"
6:20 pm - 6:30 pm	Discussion
6:30 pm - 6:50 pm	"VIP access: How Cortex's Very Important Players Control Reinforcement Learning"
6:50 pm - 7:00 pm	Discussion
7:00 pm - 7:20 pm	"Functional Maps of the Mouse Prefrontal Cortex, with a Focus on Inhibition"
7:20 pm - 7:30 pm	Discussion
7:30 pm - 7:50 pm	"The Role of Prefrontal PV Neuron-generated Gamma Synchrony in Cognitive Flexibility"
7:50 pm - 8:00 pm	Discussion
8:00 pm - 9:00 pm	Dinner
Wednesday
7:30 am - 8:30 am	Breakfast
9:00 am - 12:30 pm	Inhibitory Subnetworks During Learning Discussion Leader:
9:00 am - 9:20 am	"The Long and the Short of Inhibition"
9:20 am - 9:30 am	Discussion
9:30 am - 9:50 am	"Neuronal Firing Dynamics in CA1 Superficial Layers."
9:50 am - 10:00 am	Discussion
10:00 am - 10:30 am	Coffee Break
10:30 am - 10:50 am	"Inhibitory Top-down Control of Neocortical Threat Memory"
10:50 am - 11:00 am	Discussion
11:00 am - 11:20 am	"Hippocampal VIP Interneurons Detect Novelty in the Environment and Regulate Encoding of Recognition Memory"
11:20 am - 11:30 am	Discussion
11:30 am - 11:40 am	"Somatostatin-Expressing Interneurons of the Dentate Gyrus Support Goal-Oriented Reward Learning"
11:40 am - 11:45 am	Discussion
11:45 am - 11:55 am	"Dynamics of Entorhinal Reactivations over Learning"
11:55 am - 12:00 pm	Discussion
12:00 pm - 12:10 pm	"Parvalbumin-positive Neurons Mediate Contingency- Dependent Inhibition in the Mouse Parietal Cortex"
12:10 pm - 12:15 pm	Discussion
12:15 pm - 12:25 pm	"Functional Dissociation of Ventral Hippocampal Inhibitory Circuits during Anxiety and Fear Behaviors"
12:25 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:30 pm	Free Time
4:30 pm - 6:00 pm	Poster Session
6:00 pm - 8:00 pm	Modulation of Inhibition, Metabolic States, Memory and Sleep Discussion Leader:
6:00 pm - 6:20 pm	"The ‘Low-Power Mode’ of Neocortex: Energy Use and Coding Precision during Food Scarcity"
6:20 pm - 6:30 pm	Discussion
6:30 pm - 6:50 pm	"Modulation of Fear and Sleep"
6:50 pm - 7:00 pm	Discussion
7:00 pm - 7:20 pm	"Brainstem Control of the Memory of Negative Experience"
7:20 pm - 7:30 pm	Discussion
7:30 pm - 7:50 pm	"Inhibitory Synapse Diversity in the Modulation of Defensive Behaviors"
7:50 pm - 8:00 pm	Discussion
8:00 pm - 9:00 pm	Dinner
Thursday
7:30 am - 8:30 am	Breakfast
8:30 am - 9:00 am	Business Meeting Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Discuss Future Dates and Venue; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm	Influence of Inhibition on Network Activity and Behavior in Diseases Discussion Leader:
9:00 am - 9:20 am	"Cortical Inhibitory Interneurons and Sensory Processing in Fragile X Syndrome."
9:20 am - 9:30 am	Discussion
9:30 am - 9:50 am	"Mechanisms Underlying Behavioural Inflexibility in FXS"
9:50 am - 10:00 am	Discussion
10:00 am - 10:30 am	Coffee Break
10:30 am - 10:50 am	"Voltage Imaging Reveals Cell-specific Interneuron Dynamics during Working Memory"
10:50 am - 11:00 am	Discussion
11:00 am - 11:20 am	"Network Abnormalities and Interneuron Dysfunction in Alzheimer’s Disease"
11:20 am - 11:30 am	Discussion
11:30 am - 11:40 am	"Higher Hyperpolarization Activated Current (Ih) in a Subpopulation of Hippocampal Stratum Oriens CA1 Interneurons in Fragile X Mice."
11:40 am - 11:45 am	Discussion
11:45 am - 11:55 am	"Simultaneous 3D Imaging of Interneuron Subtypes in CA1 depicts Deficits in Interneuron Activity Resulting in Microcircuit Disruption in a Mouse Model for the 22q11.2 Deletion Syndrome"
11:55 am - 12:00 pm	Discussion
12:00 pm - 12:10 pm	"Dysfunctional Mitochondria of Parvalbumin Positive Interneurons Impairs Hippocampal CA1 Function"
12:10 pm - 12:15 pm	Discussion
12:15 pm - 12:25 pm	"hPSC-derived Inhibitory Interneuron Cell Therapy, NRTX-1001, for Drug-Refractory Focal Epilepsy: from Preclinical Characterization to first Clinical Trial Results"
12:25 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:30 pm	Free Time
4:30 pm - 6:00 pm	Poster Session
6:00 pm - 8:00 pm	Inhibition in Human: Molecular Programs, Circuitries and Networks Discussion Leader:
6:00 pm - 6:20 pm	"Development and Evolution of Human Neural Circuits"
6:20 pm - 6:30 pm	Discussion
6:30 pm - 6:50 pm	"A Retinotopic Push-pull Dynamic Structures Perceptual-mnemonic Interactions in the Human Brain"
6:50 pm - 7:00 pm	Discussion
7:00 pm - 7:20 pm	"When Inhibition Fails: Circuits, Synaptopathies and Seizures"
7:20 pm - 7:30 pm	Discussion
7:30 pm - 7:50 pm	"GABAergic Cell type, Region, and Layer Specific Alterations in Schizophrenia"
7:50 pm - 8:00 pm	Discussion
8:00 pm - 9:00 pm	Dinner
Friday
7:30 am - 8:30 am	Breakfast
9:00 am	Departure

Contributors

Funding for this conference was made possible (in part) by the National Institutes of Health Award Number R13NS132568. from the National Institute of Neurological Disorders and Stroke. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of NIH; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.

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Conference History Inhibition in the CNS (GRS)

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