- 6:00 PM - 50th Anniversary Celebration - Bill Greenlee / Allen Krantz
New And Old Targets in Oncology:
Balu Balasubramanian, Discussion Leader
- 8:30 AM - Greetings / Announcements
- 8:45 AM - Introduction - Balu Balasubramanian (Chair), Bristol-Myers Squibb
- 9:00 AM - Robert Kramer, Bristol-Myers Squibb - "Overview: cytotoxic agents and other targets"
- 9:35 AM - Discussion
- 9:45 AM - Judah Folkman, Harvard University - "Angiogenesis as a future target"
- 10:20 AM - Discussion
- 10:30 AM - Coffee break and picture
- 10:50 AM - Laurent Meijer, CNRS, Paris - CDK and related kinases"
- 11:25 AM - Discussion
- 11:35 AM - Sam Graham, Merck - "Ras farnesyl transferase"
- 12:10 PM - Discussion
- 12:20 PM - CLOSE - LUNCH
Special Topics
Jim McCarthy, Discussion Leader
- 7:00 PM - Neil Upton - "Discovery and Pharmacology of SB-204269, A Mechanistically Novel Anticonvulsant Drug"
- 7:25 PM - Discussion
- 7:35 PM - Ellen Dobrusin - "Affinity Induced Irreversible Inhibitors (AI3) of the Epidermal Growth Factor Receptor Tyrosine Kinase (EGFrTD)"
- 8:00 PM - Discussion
- 8:10 PM - John W. Ellingboe - "The Discovery and Development of Verdia, a Novel Long Acting AT1 Specific Angiotensin II Receptor Blocker"
- 8:35 PM - Discussion
- 8:45 PM - Sander G. Mills - "Discovery of Long-Acting, Orally Active Non-Peptide Substance P (NK1) Receptor Antagonists"
- 9:10 PM - Discussion
- 9:20 PM - Thomas W. von Geldern - "ABT-627 and Beyond: The Discovery of Highly ETA-selective, ETB-selective, and ETA/ETB Mixed Endothelin Antagonists"
- 9:45 PM - Discussion
- 10:00 PM - CLOSE
Nuclear Hormone Receptors
Alex Nadzan, Discussion Leader
- 9:00 AM - Introduction - Alex Nadzan (Chair), Ligand
- 9:15 AM - John Katzenellenbogen, University of Illinois - "Molecular probes and structure-function studies on the estrogen receptor"
- 9:45 AM - Discussion
- 9:55 AM - Rosh Chandraratna, Allergan - "Receptor and Function Selective Retinoids"
- 10:25 AM - Discussion
- 10:35 AM - Coffee Break
- 10:55 AM - Marcus Boehm, Ligand - "RXR selective ligands as modulators of intracellular receptor function"
- 11:25 AM - Discussion
- 11:35 AM - Tim Wilson, Glaxo Wellcome - "The chemistry of nuclear orphan receptors"
- 12:05 PM - Discussion
- 12:15 PM - CLOSE - LUNCH
NPY
Don Gehlert, Discussion Leader
- 7:30 PM - Introduction - Donald Gehlert (Chair) - "Biology and receptors for the NPY family of peptides"
- 7:45 PM - Annette Beck-Sickinger, Dept. Pharmazie, ETH - "Neuropeptide Y and its receptors: characterization of the interactions on molecular level"
- 8:20 PM - Discussion
- 8:30 PM - Hamideh Zarrinmeyeh, Lilly Reseaerch Laboratories - "Structure-activity relationships of a novel series of neuropeptide Y Y-1 Receptor antagonists"
- 9:05 PM - Discussion
- 9:15 PM - John Finn, Synaptic - "The Discovery of Potent and Selective small molecule NPY Y5 antagonists"
- 9:50 PM - Discussion
- 10:00 PM - CLOSE
|
Wednesday, August 3, 1997 |
Combinatorial Chemistry as Applied to Drug Discovery
John Kiely, Discussion Leader
- 9:00 AM - Introduction - John Kiely (Chair), Houghton
- 9:10 AM - Robert Root-Bernstein, Michigan State - "Combinatorial chemistry in perspective"
- 9:35 AM - Discussion
- 9:40 AM - Bernard King, Houghton - "Combinatorial biology: the past as prologues to the future"
- 10:05 AM - Discussion
- 10:15 AM - Coffee Break
- 10:30 AM - Dan Flynn, Searle - "Solution Phase Chemical Library Synthesis Strategies Based on the Principles of Molecular Recognition"
- 11:00 AM - Discussion
- 11:10 AM - Philip A. Hipskind - "CombiChem in Lead Optimization for NK1 Antagonists"
- 11:40 AM - Discussion
- 11:50 AM - Roland Dolle - "Metalloprotease Leads from a Solid Phase Library"
- 12:20 PM - Discussion
- 12:30 PM - CLOSE - LUNCH
- 5:00 PM - Poster Session - Boyd Harrison, Leader
Neurotrophic Small Molecules
John Mallamo, Discussion Leader
- 7:30 PM - Introduction - David Kaplan, Montreal Neurological Institute - "The biology and biochemistry of neurotrophins"
- 8:00 PM - Discussion
- 8:05 PM - Uri Saragovi, McGill University - "Design, development and uses of NGF receptor (trk A and P75) small molecule ligands"
- 8:35 PM - Discussion
- 8:45 PM - Gregory Hamilton, Guilford - "Design and synthesis of neuroimmunophillin small molecule neurotrophic agents"
- 9:15 PM - Discussion
- 9:25 PM - John Mallamo, Cephalon - "Small molecules Neurotrophic Agents: SAR of Neurotrophic analogs of K252a"
- 9:55 PM - Discussion
- 10:00 PM - CLOSE
New Developments Respiratory Diseases
Kelvin Cooper, Discussion Leader
- 9:00 AM - Introduction - Kelvin Cooper (Chair), Pfizer
- 9:15 AM - Victoria L. Cohan, Pfizer - "Mechanisms of Eosinophil Trafficking in Allergy and Asthma"
- 9:45 AM - Discussion
- 9:55 AM - Steven Adams, Biogen - "VLA4 Inhibitors: A Novel Therapy for Airways Inflammation"
- 10:25 AM - Discussion
- 10:35 AM - Coffee Break
- 10:55 AM - Paul Rothman, Columbia - "IL-4 : From receptor to recombination"
- 11:25 AM - Discussion
- 11:35 AM - Ashak Shenvi, Zeneca - "ZD-7944 : A Selective and Orally Active NK2-Receptor Antagonist for the Treatment of Asthma"
- 12:10 PM - Discussion
- 12:20 PM - CLOSE - LUNCH
- 5:00 PM - Poster Session - Boyd Harrison, Leader
Sleep Disorders
Graham Johnson, Discussion Leader
- 7:15 PM - Introduction - Graham Johnson (Chair), Bristol-Myers Squibb
- 7:25 PM - Allan Pack, Center for Sleep Neurobiology, UPenn - "Potential new pharmacotherapeutic approaches to sleep and its disorders"
- 7:55 PM - Discussion
- 8:05 PM - Katherine S. Takaki, Bristol-Myers Squibb - "The design and biological evaluation of novel ligands of melatonin binding sites"
- 8:35 PM - Discussion
- 8:45 PM - Daniel Caignard - "Structure-activity relationships of novel naphtalenic and bioisosteric related amidic derivatives as melatonin receptor ligands"
- 9:15 PM - Discussion
- 9:25 PM - Dale Boger, The Scripps Research Institute - "Discovery and investigation of oleamide: an endogenous lipid with sleep-inducing properties"
- 9:55 PM - Discussion
- 10:05 PM - CLOSE
|
