Targeted Bioavailability

• 7:30 PM - Introduction and Overview
  Christopher Lipinski
• 7:40 PM - Oral Absorption and Solubility Screening in Early Drug Discovery
  Christopher Lipinski
• 8:15 PM - Interfacing Drug Discovery and Preclinical Pharmacokinetics - Scientific Limitations and Current Bottlenecks
  Patrick Sinko
• 8:50 PM - The Future of Pharmacokinetics in Drug Discovery
  George Grass
• 9:25 PM - Identification of Orally Bioavailable Compounds: Predictions and Measurements
  Chao-Pin Lee

New Methods in Pain Control

• 9:00 AM - Introduction and Overview
  Edward Roberts
• 9:10AM - Chronic Pain: Unique Pharmacology for New Therapies
  Andre Dray
• 9:50 AM - Pharmacology and Medicinal Chemistry of Gabapentin and Related Compounds
  Michael Rafferty
• 10:50 AM - Nicotinic Acetylcholine Receptor Modulators as Novel Analgesic Agents
  Mark Holladay
• 11:30 AM - Discovery and Investigation of Muscarinic Agonists with Potent Antinociceptive Activity
  Charles Mitch

Gender Based Drug Discovery

• 7:30 PM - Introduction and Over-view
  Jill Panetta
• 7:40 PM - Autoimmunity: The Forgotten Gender
  Denise Faustman
• 8:15 PM - Gender Specific Recovery in Experimental Stroke
  Patricia Hurn
• 8:50 PM - Consequences of Gender-related Differences in Drug Metabolism
  Stephen Hall
• 9:25 PM - Depression in Women
  Freda Lewis-Hall

Screening Technologies for the 21" Century

• 9:00 AM - Introduction and Overview
  Charles Gluchowski
• 9:10AM - Drug Discovery and Metabolic Screening Using, Pulsed Ultrafiltration Mass Spectrometry
  Richard van Breemen
• 9:50 AM - The Implications of High-throughput Microchip Based Experimentation for Fundamental Changes in the Drug Discovery Process
  Nick Hodge
• 10:50 AM - Yeast as a Platform for the Discovery of Surrogate Ligands for Orphan G-Protein Coupled Receptors
  David Webb
• 11:30 AM - Fluorescent Sensors of Intracellular Signal Transduction Applications to Pharmaceutical Screening
  Roger Tsien

Advances in Membrane and Ion Channel Protein Structure

• 7:30 PM - Introduction and Overview
  J. Ernest Villafranca
• 7:40 PM - Structural Models of Potassium Channels
  H. Robert Guy
• 8:15 PM - The Biofunctional Nature of Cytochrome Reductase as Revealed Through Its Complete Structure
  Bing Jap
• 8:50 PM - Structure of Membrane Protein Complexes: The Respiratory Chain
  Hartmut Michel
• 9:25 PM - The High Resolution Structure of Bacteriorhodopsin, a Seven-Pass Transmembrane Protein
  Eva Pebay-Peyroula

Recent Therapeutic Advances in Serotonergics

• 9:OOAM - Introduction and Overview
  John Macor
• 9:10 AM - Overview of Recent Therapeutic Advances in Serotonergics
  Frank Yocca
• 9:50 AM - New Insights from the Discovery of Silent 5-HT_IA Antagonists
  Michael Kelly
• 10:50 AM - Therapeutic Uses of 5-HT_1F Agonists and 5-HT_2B Antagonists
  James Audia
• 11:30 AM - Recent Advances in the Understanding of the Function of the 5-HT₆ Receptor
  Andrew Sleight

Poster Session

Purinocepters as Targets for Novel Therapeutics

• 7:30 PM - Introduction and Overview
  Michael Williams
• 7:40 PM - Advances in PI and P2 Receptor Chemistry
  Kenneth Jacobson
• 8:15 I'M - Purines and Nociception
  Jana Swaynok
• 8:50 PM - P_2T - Receptor Antagonists - A Novel Class of Anti-Thrombotic Agents
  Paul Willis
• 9:25 PM - Receptors for ATP and Other Nucleotides as Therapeutic Targets
  George Dubyak

Special Topics in Medicinal Chemistry

• 9:00 AM - Design and SAR of Novel Potassium Channel Openers: Selective Agents Targeted for Urge Urinary Incontinence
  John Butera
• 9:35 AM - Farnesyl Transferase Inhibitors - A Novel Class of Antitumor Agents
  Viyyoor Girijavallablian
• 10:30 AM - Development of Neuroactive Steroids (Epalons) as Anticonvulsants and Anxiolytics
  Derk Hogenkamp
• 11:05 AM - The Design, Synthesis and Anti-Diabetic Activity of PPAR-Gamrna Agonists
  Brad Henke
• 11:40 AM - Discovery of L-791, 456: A Selective and Orally Active Cyclooxygenase-2 Inhibitor
  Rick Friesen

Poster Session

Special Topic Lecture

• 8:00 PM - Implications of Cloning to the Future of Medicine
  M. Westhusin