Sunday, August 5th
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2:00 PM - 8 PM | Arrival & Registration |
4:30 PM - 6 PM | Welcoming Mixer |
6:00 PM - 7:00 PM | Dinner |
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Sunday Evening Session | Topics in Drug Safety |
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Discussion Leader: Joel Barrish (BMS) |
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7:15 PM - 7:30 PM | Introduction and Conference Welcome |
7:30 PM - 8:00 PM | Kathleen Uhl (FDA) Drug Safety in the 21st Century: An FDA Perspective |
8:00 PM - 8:10 PM | Discussion |
8:10 PM - 8:40 PM | Kenneth Thummel (U. Washington) Drug-Drug Interactions: Quantitative Predictions and Clinical Significance |
8:40 PM - 8:50 PM | Discussion |
8:50 PM - 9:20 PM | Robert Gerwien (Curagen) Strategies of Toxicogenomic Data Analysis |
9:20 PM - 9:30 PM | Discussion |
9:30 PM - 10:00 PM | Stephen Durham (BMS) Predictive Toxicology: The Early Identification of Drug Safety Liabilities |
10:05 PM - 10:10 PM | Discussion |
10:10 PM | Continuation of Welcoming Mixer |
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Monday, August 6th
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7:00 AM - 8:30 AM | Breakfast |
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Monday Morning Session | Quality of Life Drugs |
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Discussion Leader: Steve Street (Pfizer) |
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8:45 AM - 9:00 AM | Greeting and Meeting Business |
9:00 AM - 9:30 AM | Don Middleton (Pfizer) The Design and Profile of Peripherally Restricted Delta Opioid Agonists for the Treatment of Irritable Bowel Syndrome |
9:30 AM - 9:40 AM | Discussion |
9:40 AM - 10:10 AM | Guixue Yu (BMS) Novel PDE5 Inhibitors with Greater Potency and Selectivity than Sildenafil, for treatment of Male Erectile Dysfunction |
10:10 AM - 10:20 AM | Discussion |
10:20 AM - 10:50 AM | Photograph and Break |
10:50 AM -11:20 AM | Bob Mook (Glaxo Smith-Kline) Discovery of GG745, a 5-a Reductase Inhibitor for Treatment of BPH |
11:20 AM - 11:30 AM | Discussion |
11:30 AM - 12:00 PM | Kristof Van Emelen (Janssen) Design of Fundus-Relaxing Compounds for Treatment of Functional Dyspepsia |
12:00 PM - 12:10 PM | Discussion |
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12:30 PM - 1:30 PM | Lunch |
12:10 PM - 6:00 PM | FREE TIME (organized Mt. Kearsearge hike available) |
6:00 PM - 7:00 PM | Dinner |
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Monday Evening Session | New Approaches to Treating Obesity |
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Discussion Leader: Karin Briner (Lilly) |
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7:30 PM - 8:00 PM | Atonio Tataranni (NIDDK Laboratories) New Targets for Obesity Research |
8:00 PM - 8:10 PM | Discussion |
8:10 PM - 8:40 PM | Dennis Heyer (Glaxo Smith-Kline) NPY5 Antagonists for Obesity |
8:40 PM - 8:50 PM | Discussion |
8:50 PM - 9:20 PM | Al Robichaud (Dupont) A Novel Approach to the Treatment of Obesity. The Design and Synthesis of Orally Bioavailable, Selective 5-HT2C Agonists |
9:20 PM - 9:30 PM | Discussion |
9:30 PM - 10:00 PM | Brad Morgan (Pfizer) Selective Glucocorticoid Receptor Modulators |
10:00 PM - 10:10 PM | Discussion |
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Tuesday, August 7th
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7:00 AM - 8:30 AM | Breakfast |
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Tuesday Morning Session | New Approaches to Treating Atherosclerosis |
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Discussion Leader: Christine Tarby (DuPont) |
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9:00 AM - 9:30 AM | Mark Kowala (BMS) Beyond Traditional Cardiovascular Risk Factors - Treating Atherosclerosis as a Chronic Inflammatory Disease |
9:30 AM - 9:40 AM | Discussion |
9:40 AM - 10:10 AM | Colin Leach (Glaxo Smith-Kline) Lp-PLA2 inhibitors - Novel, non lipid lowering drugs for atherosclerosis |
10:10 AM - 10:20 AM | Discussion |
10:20 AM - 10:50 AM | Break |
10:50 AM -11:20 AM | Huw Davies (AstraZeneca) Identification of novel CCR2b antagonists for the treatment of inflammatory conditions including atherosclerosis |
11:20 AM - 11:30 AM | Discussion |
11:30 AM - 12:00 PM | Jon L. Collins
(Glaxo Smith-Kline) LXR Agonists and Atherosclerosis |
12:00 PM - 12:10 PM | Discussion |
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12:30 PM - 1:30 PM | Lunch |
12:10 PM - 5:00 PM | FREE TIME (organized annual East/West Softball game) |
5:00 PM - 6:00 PM | POSTER SESSION #1 (Discussion Leader: John Mallamo [Cephalon]) |
6:00 PM - 7:00 PM | Dinner |
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Tuesday Evening Session | New Approaches for the Prevention/ Treatment of Osteoporosis |
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Discussion Leader: Mark Duggan (Merck) |
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7:30 PM - 8:00 PM | Sevgi Rodan (Merck) New Molecular Targets for Inhibition of Bone Resorption |
8:00 PM - 8:10 PM | Discussion |
8:10 PM - 8:40 PM | Robert Marquis (Glaxo Smith-Kline) Inhibition of the Cysteine Protease Cathepsin K |
8:40 PM - 8:50 PM | Discussion |
8:50 PM - 9:20 PM | Eva Altmann (Novartis) N-Acyl-a-amino acid-(arylaminoethyl)amides Represent a New Class of Selective Non-covalent Inhibitors of Cathepsin K |
9:20 PM - 9:30 PM | Discussion |
9:30 PM - 10:00 PM | Robert Meissner (Merck) Tetrahydronaphthyridine-Containing Antagonists of the Integrin avb3 |
10:00 PM - 10:10 PM | Discussion |
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Wednesday, August 8th
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7:00 AM - 8:30 AM | Breakfast |
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Wednesday Morning Session | New Approaches to Treating Microbial Infections |
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Discussion Leader: Joanne Bronson (BMS) |
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9:00 AM - 9:30 AM | David Payne (Glaxo Smith-Kline) The Impact of Genomics on Antibacterial Discovery |
9:30 AM - 9:40 AM | Discussion |
9:40 AM - 10:10 AM | Michael Barbachyn (Pharmacia Upjohn) Recent Developments with Oxazolidinone Antibacterial Agents |
10:10 AM - 10:20 AM | Discussion |
10:20 AM - 10:50 AM | Election of Vice-Chair Elect and Break |
10:50 AM - 11:20 AM | Thomas Renau (Microcide Pharmaceuticals) Developing Inhibitors of Efflux Pumps in Pseudomonas aeruginosa: Program Challenges and SAR |
11:20 AM - 11:30 AM | Discussion |
11:30 AM - 12:00 PM | Marvin Miller (University of Notre Dame) Design, Synthesis, and Study of New Antimicrobial Agents and Drug Delivery Systems |
12:00 PM - 12:10 PM | Discussion |
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12:30 PM - 1:30 PM | Lunch |
12:10 PM - 5:00 PM | FREE TIME (organized annual Vice-Chair Elect Golf Tournament) |
5:00 PM - 6:00 PM | POSTER SESSION #2 (Discussion Leader: John Mallamo [Cephalon]) |
6:00 PM - 7:00 PM | Dinner |
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Wednesday Evening Session | Drugs Modulating Kinases and Phosphatase |
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Discussion Leader: Celia Dominguez (Amgen) |
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7:30 PM - 8:00 PM | Rick Kendall (Amgen): Biological Overview of Kinases and Phosphatases |
8:00 PM - 8:10 PM | Discussion |
8:10 PM - 8:40 PM | Henrik Sune Andersen (Novo Nordisk) PTP1B (diabetes, inflammation) |
8:40 PM - 8:50 PM | Discussion |
8:50 PM - 9:20 PM | Paul Manley (Novartis) GLIVEC (STI571): A tyrosine kinase inhibitor tailored for leukemia therapy |
9:20 PM - 9:30 PM | Discussion |
9:30 PM - 10:00 PM | Allan Wagman (Chiron) GSK3 |
10:00 PM - 10:10 PM | Discussion |
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Thursday, August 9th
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7:00 AM - 8:30 AM | Breakfast |
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Thursday Morning Session | Special Topics |
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Discussion Leader: John Lowe (Pfizer) |
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9:00 AM - 9:30 AM | George Chang (Pfizer) Discovery of a potent, orally active and clinically efficacious MTP inhibitor via a high-speed synthesis paradigm |
9:30 AM - 9:40 AM | Discussion |
9:40 AM - 10:10 AM | Paul Ornstein (Lilly) The discovery of potent, selective mGluR5 antagonists and their activity as anti-migraine agents |
10:10 AM - 10:20 AM | Discussion |
10:20 AM - 10:50 AM | Break |
10:50 AM -11:20 AM | George Muller (Celgene) Clinical activity of novel PDE4 inhibitors |
11:20 AM - 11:30 AM | Discussion |
11:30 AM - 12:00 PM | Iyassu Sebhat (Merck) The erectogenic activity of small molecule MC4-R agonists |
12:00 PM - 12:10 PM | Discussion |
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12:30 PM - 1:30 PM | Lunch |
5:00 PM - 6:00 PM | Chairman's Social/Mixer |
6:00 PM - 7:00 PM | Dinner |
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Thursday Evening Session | New Drugs for Treating Alzheimer's Disease |
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Discussion Leader: Donna Huyrn (Wyeth-Ayerst) |
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7:30 PM - 8:00 PM | Steve Jacobsen (Wyeth-Ayerst) Approaches to Alzheimer's Disease |
8:00 PM - 8:10 PM | Discussion |
8:10 PM - 8:40 PM | James Audia (Lilly) Inhibitors of APP Processing |
8:40 PM - 8:50 PM | Discussion |
8:50 PM - 9:20 PM | Mark Findeis (Praecis Pharmaceuticals) Inhibitors of b-amyloid Aggregation |
9:20 PM - 9:30 PM | Discussion |
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END OF SCIENTIFIC SESSION |
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Friday, August 10th
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7:00 AM - 8:30 AM | Breakfast |
9:00 AM | Bus Departs for Logan Airport |