SUNDAY |
2:00 pm - 11:00 pm | Arrival and Check-in |
5:00 pm - 6:00 pm | Welcome Mixer (Dining Center) |
6:00 pm | Dinner |
7:15 pm - 7:30 pm | Conference Chair: John Lowe (Pfizer) & Colby-Sawyer Site Manager: Adam Zuber
Opening Remarks |
7:30 pm - 9:30 pm | Fragment-Based Drug Design |
| Discussion Leader: Alan Stobie (Pfizer) |
7:30 pm - 8:00 pm | Ben Davis (Vernalis)
"The SeeDs Approach - Integrating Fragment Screening into Drug Discovery" |
8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:40 pm | Wolfgang Jahnke (Novartis)
"Recent Progress in Fragment-Based Ligand Design: When structure meets screening" |
8:40 pm - 8:50 pm | Discussion |
8:50 pm - 9:20 pm | Miles Congreves (Astex)
"From Fragment Hits to Clinical Candidate" |
9:20 pm - 9:30 pm | Discussion |
9:45 pm - 10:45 pm | Poster Session / Social Hour |
| Discussion Leader: Dmitry Zuev (BMS) |
MONDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Novel mGluR Targets |
| Discussion Leader: Jeff Schkeryantz (Lilly) |
9:00 am - 9:30 am | Jeff Conn (Vanderbilt)
"Physiologic Roles and Therapeutic Potential of Metabotropic Glutamate Receptors" |
9:30 am - 9:40 am | Discussion |
9:40 am - 10:10 am | Mike Johnson (Lilly)
"Selective Allosteric Potentiators of the Metabotropic Glutamate 2 Receptor" |
10:10 am - 10:20 am | Discussion |
10:20 am - 10:40 am | Group Photo |
10:40 am - 11:15 am | Coffee Break |
11:15 am - 11:45 am | Craig Lindsley (Merck)
"Discovery and development of the first centrally active mGluR5 positive allosteric modulators" |
11:45 am - 11:55 am | Discussion |
11:55 am - 12:25 pm | Fabrizio Gasoparini (Novartis)
"mGluR5 Antagonists: Discovery, characterization and drug development" |
12:25 pm - 12:35 pm | Discussion |
12:45 pm | Lunch |
1:30 pm - 6:00 pm | Free Time (organized Mt. Kearsarge hike available) |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Selective Androgen Receptor Modulators (SARMS) |
| Discussion Leader: Rob Meissner (Merck) |
7:30 pm - 8:00 pm | Duane Miller (U. Tennessee)
"Search for reversible and irreversible selective androgen receptor modulators (SARMs)" |
8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:40 pm | Lin Zhi (Ligand)
"Improving the selectivity of androgen modulators" |
8:40 pm - 8:50 pm | Discussion |
8:50 pm - 9:20 pm | James Li (BMS)
"The Discovery of Tissue-Selective Androgen Receptor Modulators" |
9:20 pm - 9:30 pm | Discussion |
9:45 pm - 10:45 pm | Poster Session / Social Hour |
| Discussion Leader: Dmitry Zuev (BMS) |
TUESDAY |
7:30 am - 8:30 am | Breakfast |
8:45 am | Nominations for Chair of the 2009 Meeting Nominating Committee |
9:00 am - 12:30 pm | Alzheimer's Disease |
| Discussion Leader: Jim McCarthy (Lilly) |
9:00 am - 9:30 am | Steve Paul (Lilly)
"Alzheimer's disease: From genes to drug" |
9:30 am - 9:40 am | Discussion |
9:40 am - 10:10 am | Boyd Harrison (Wyeth)
"Design and synthesis of potent gamma-secretase inhibitors for the disease-modifying treatment of Alzheimer's disease" |
10:10 am - 10:20 am | Discussion |
10:20 am - 11:00 am | Coffee Break |
11:00 am - 11:30 am | Tim Durham (Lilly)
"The design and synthesis of efficacious BACE inhibitors" |
11:30 am - 11:40 am | Discussion |
11:40 am - 12:10 pm | Philippe Nantermet (Merck)
"Discovery and Evolution of Tertiary Carbinamine Inhibitors of BACE" |
12:10 pm - 12:20 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 5:00 pm | Free Time (organized annual East/West Softball game) |
5:00 pm - 6:00 pm | Poster Session |
| Discussion Leader: Dmitry Zuev (BMS) |
6:00 pm | Dinner |
7:15 pm | Speeches by the Candidates for Chair of the 2009 Meeting Nominating Committee |
7:30 pm - 9:30 pm | Potential New Drugs for the Treatment of Cancer |
| Discussion Leader: Jon Wright (Celgene) |
7:30 pm - 8:00 pm | Marcus F. Boehm (Conforma Therapeutics)
"Inhibitors of the HSP90 chaperone complex as novel cancer chemotherapeutic agents: Medicinal Chemistry Studies towards CNF2024" |
8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:40 pm | Michael Wendt (Abbott)
"Discovery of ABT-737, an inhibitor of Bcl-2 family proteins that promotes apoptosis" |
8:40 pm - 8:50 pm | Discussion |
8:50 pm - 9:20 pm | Jeffrey Besterman (Methylgene)
"MGCD0103, A Novel HDAC Inhibitor: From Bench to Clinic" |
9:20 pm - 9:30 pm | Discussion |
9:30 pm - 10:30 pm | Presentation of Poster Awards / Presentations by Poster Awardees (Ware Center) |
| Discussion Leader: Dmitry Zuev (BMS) |
WEDNESDAY |
7:30 am - 8:30 am | Breakfast |
8:30 am - 9:00 am | Business Meeting |
| (Election of Chair of the 2009 Meeting; Discussion of Site Preference; Fill out Evaluation Forms) |
9:00 am - 12:30 pm | Novel GPCR Targets |
| Discussion Leader: Ginny Ho (Schering-Plough) |
9:00 am - 9:30 am | Graeme Semple (Arena)
"Discovery of selective agonists for GPR109A and GPR109B, the high and low affinity receptors for Niacin" |
9:30 am - 9:40 am | Discussion |
9:40 am - 10:10 am | Michael Neeb (GSK)
"Urotensin Receptor Antagonists as Novel Mediators of Cardiovascular Disease" |
10:10 am - 10:20 am | Discussion |
10:20 am - 11:00 am | Coffee Break |
11:00 am - 11:30 am | Carolyn Dzierba (BMS)
"Recent Advances with Corticotropin-Releasing Factor-1 Receptor Antagonists" |
11:30 am - 11:40 am | Discussion |
11:40 am - 12:10 pm | Scott Kuduk (Merck)
"Bradykinin B1 Receptor Antagonists: A New Approach for the Management of Chronic Pain" |
12:10 pm - 12:20 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 5:00 pm | Free Time (organized annual Vice-Chair elect Golf Tournament) |
5:00 pm - 6:00 pm | Poster Session |
| Discussion Leader: Dmitry Zuev (BMS) |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Monoamine Transporters |
| Discussion Leader: Al Robichaud (Wyeth) |
7:30 pm - 8:00 pm | Lori Krim Gavrin (Wyeth)
"Design and synthesis of novel norepinephrine reuptake inhibitors" |
8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:40 pm | Magnus Walter (Lilly)
"From discovery to clinical candidate: novel selective norepinephrine reuptake inhibitors" |
8:40 pm - 8:50 pm | Discussion |
8:50 pm - 9:20 pm | Derek Denhart (BMS)
"Conformationally-restricted homotryptamines as a treatment for sexual dysfunction" |
9:20 pm - 9:30 pm | Discussion |
THURSDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Late Breaking Topics |
| Discussion Leader: Suzanne Stokes (Astra-Zeneca) |
9:00 am - 9:30 am | Michael Rowley (Istituto di Ricerche di Biologia Molecolare, Rome, Italy)
"Inhibitors of HIV Integrase for the Treatment of HIV/AIDS" |
9:30 am - 9:40 am | Discussion |
9:40 am - 10:10 am | James Jaquith (Aegera Therapeutics)
"The Development of AEG33783, a Novel JNK Pathway Inhibitor, to Treat Neuropathy Induced by Chemotherapeutic Agents" |
10:10 am - 10:20 am | Discussion |
10:20 am - 11:00 am | Coffee Break |
11:00 am - 11:30 am | Juan Luengo (GlaxoSmithKline)
"Discovery and Development of Eltrombopag, a Novel Small-Molecule, Orally Active Thrombopoietin Receptor Agonist for the Treatment of Thrombocytopenia" |
11:30 am - 11:40 am | Discussion |
11:40 am - 12:10 pm | Bradley Morgan (Cytokinetics)
"Discovery of the First Small Molecule Activators of Cardiac Myosin for the Treatment of Congestive Heart Failure" |
12:10 pm - 12:20 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 5:00 pm | Free Time |
5:00 pm - 6:00 pm | Chair's Reception |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Chair's Talk |
| Discussion Leader: John Lowe (Pfizer) |
7:30 pm - 8:30 pm | John Talley (Microbia)
"The Discovery of COX-2 Inhibitors" |
8:30 pm - 9:30 pm | Discussion |
FRIDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am | Depart |