SUNDAY |
2:00 pm - 11:00 pm | Arrival and Check-in |
5:00 pm - 6:00 pm | Welcome Mixer (Dining Center) |
6:00 pm | Dinner |
7:30 pm - 7:45 pm | Introductory Comments by GRC Site Staff / Welcome by Les McQuire, Conference Chair |
7:45 pm - 9:30 pm | Novel Approaches to Neurodegenerative Diseases |
| Discussion Leader: Stephen Hitchcock (Amgen) |
7:45 pm - 8:10 pm | Peter Lansbury (Harvard)
"Approaches to a Disease-Modifying Drug for Parkinson's Disease" |
8:10 pm - 8:20 pm | Discussion |
8:20 pm - 8:45 pm | Ellen Baxter (Johnson & Johnson)
"Aminoheterocycles as BACE-1 Inhibitors for the Potential Treatment of Alzheimer's Disease" |
8:45 pm - 8:55 pm | Discussion |
8:55 pm - 9:20 pm | Mark Layton (Merck)
"NR2B Selective NMDA Receptor Antagonists" |
9:20 pm - 9:30 pm | Discussion |
9:45 pm - 10:45 pm | Poster Session / Social Hour |
| Discussion Leader: Young Shin Cho (Novartis) |
MONDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Approaches to Treating Cognition and Schizophrenia |
| Discussion Leader: Robert Hudkins (Cephalon) |
9:00 am - 9:30 am | Joseph T. Coyle (Harvard Medical School)
"Glutamate and the Emerging Pathologic Circuit in Schizophrenia" |
9:30 am - 9:40 am | Discussion |
9:40 am - 10:10 am | Jonathan Gross (Wyeth)
"The Design and Synthesis of Novel, Potent and Selective H3 Antagonists for use in CNS Disorders" |
10:10 am - 10:20 am | Discussion |
10:20 am | Coffee Break / Group Photo |
11:00 am - 11:30 am | Klaus Bæk Simonsen (H. Lundbeck A/S)
"Novel NK3 Receptor Antagonists for the Treatment of Schizophrenia. Lead Optimization and Preclinical Pharmacology" |
11:30 am - 11:40 am | Discussion |
11:40 am - 12:10 pm | Neil D. Miller (GlaxoSmithKline)
"5-HT6 Receptor Antagonists for Symptomatic Treatment of Alzheimers Disease, from Discovery to Clinic" |
12:10 pm - 12:20 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 6:00 pm | Free Time (Organized Mt. Kearsarge Hike available) |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Allosteric Modulation of G-Protein Coupled Receptors |
| Discussion Leader: Scott Kuduk (Merck) |
7:30 pm - 8:00 pm | Craig W. Lindsley (Vanderbilt University)
"In Vitro and In Vivo Characterization of Highly Subtype-Selective Allosteric Modulators of the M1 and M4 Muscarinic Receptors" |
8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:40 pm | Jesper Lau (Novo Nordisk A/S)
"Discovery of Peptide and Non-peptide GLP-1 Agonists" |
8:40 pm - 8:50 pm | Discussion |
8:50 pm - 9:20 pm | Jean-Phillipe Rocher (Addex Pharma SA)
"Discovery and Structure Activity Relationships of a New Series of mGluR5 Negative Allosteric Modulators" |
9:20 pm - 9:30 pm | Discussion |
9:45 pm - 10:45 pm | Poster Session / Social Hour |
| Discussion Leader: Young Shin Cho (Novartis) |
TUESDAY |
7:30 am - 8:30 am | Breakfast |
8:45 am - 9:00 am | Nominations for Chair of the 2011 meeting |
| Nominating Committee |
9:00 am - 12:30 pm | Foundation Funded Drug Discovery and Development |
| Discussion Leader: Celia Dominguez (CHDI) |
9:00 am - 9:30 am | Robert Pacific (CHDI)
"Disease Foundation Driven Research: A New Paradigm for Translational Drug Discovery" |
9:20 am - 9:40 am | Discussion |
9:40 am - 10:10 am | Alex Kiselyov (Decode)
"Novel Small Molecule SMN2 Promoter Activators for the Potential Treatment of Spinal Muscular Atrophy" |
10:10 am - 10:20 am | Discussion |
10:20 am | Coffee Break |
11:00 am - 11:30 am | Steve Courtney (Evotec)
"Optimization of Novel, Potent Inhibitors of Kynurenine Mono-oxygenase (KMO) for the Treatment of Huntington's Disease" |
11:30 am - 11:40 am | Discussion |
11:40 am - 12:10 pm | Keith Barnes (AMRI/NINDS)
"Optimization of Indoprofen for the Treatment of Spinal Muscular Atrophy: A New NIH Driven Translational Research Model for Therapy Development" |
12:10 pm - 12:20 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 5:00 pm | Free Time (Organized Annual East-West Softball Game) |
5:00 pm - 6:00 pm | Poster Session |
| Discussion Leader: Young Shin Cho (Novartis) |
6:00 pm | Dinner |
7:15 pm - 7:30 pm | Speeches by the candidates for Chair of the 2011 meeting |
| Nominating Committee |
7:30 pm - 9:30 pm | New Advances in Inflammation Therapy |
| Discussion Leader: Francesco Salituro (Wyeth) |
7:30 pm - 8:00 pm | Liping Pettus (Amgen)
"The Discovery of Potent, Selective and Orally Efficacious p38 MAP Kinase Inhibitors Based on a Phthalazine Scaffold" |
8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:40 pm | Wei Li (Wyeth)
"Selective MMP-12 Inhibitors as Potential Treatment for Respiratory Inflammatory Diseases" |
8:40 pm - 8:50 pm | Discussion |
8:50 pm - 9:20 pm | David Goldstein (Roche)
"The Discovery of Pamapimod, a Potent and Selective Inhibitor of P38 MAP Kinase" |
9:20 pm - 9:30 pm | Discussion |
9:45 pm - 10:45 pm | Social Hour |
WEDNESDAY |
7:30 am - 8:30 am | Breakfast |
8:30 am - 9:00 am | Business Meeting |
| (Election of Chair for the 2011 meeting; Discussion of 2011 meeting site; Fill out Conference Evaluation Forms) |
9:00 am - 12:30 pm | Applications of New Technologies |
| Discussion Leader: Bradley Morgan (Cytokinetics) |
9:00 am - 9:30 am | William Goddard III (California Institute of Technology)
"Methods for Predicting Structures of and Ligand Bonding to Membrane Proteins: Application to Receptors for Epinephrine, Dopamine, Serotonin, GLP1, Urotensin, and Tastants" |
9:30 am - 9:40 am | Discussion |
9:40 am - 10:10 am | Nicholas Cosford (Burnham Institute for Medical Research)
"Chemical Genomics: A New Wave of HTS and Medicinal Chemistry in Academia" |
10:10 am - 10:20 am | Discussion |
10:20 am | Coffee Break |
11:00 am - 11:30 am | X. Shawn Qian (Cytokinetics)
"Application of Electrostatic Potential Maps in the Discovery of Novel Inhibitors of Kinesin Spindle Protein" |
11:30 am - 11:40 am | Discussion |
11:40 am - 12:10 pm | Roger Ruggeri (Pfizer)
"Integration of Statistical Models in Drug Discovery and Design" |
12:10 pm - 12:20 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 5:00 pm | Free Time (Organized Annual Vice-Chair Elect Golf Tournament) |
5:00 pm - 6:00 pm | Poster Session |
| Discussion Leader: Young Shin Cho (Novartis) |
6:00 pm | Dinner |
7:45 pm - 9:30 pm | From A Natural Product To A Clinical Candidate |
| Discussion Leader: Michael Luzzio (Novartis) |
7:30 pm - 8:00 pm | Kun Liu (Merck)
"Synthesis and Antibacterial Activity of Thiazomycin Analogs" |
8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:40 pm | Soong-Hoon (Andres) Kim (BMS)
"Synthesis and Biological Effects of BMS-753493: an Epothilone-folate Conjugate Designed to Selectively Target FR-α Expressing Tumor Cells" |
8:40 pm - 8:50 pm | Discussion |
8:50 pm - 9:20 pm | Frank Fang (Eisai Research)
"Chemical Evolution of Natural Products in Drug Discovery and Development" |
9:20 pm - 9:25 pm | Discussion |
9:25 pm - 9:30 pm | Presentation of Poster Awards |
| Presenter: Young Shin Cho (Novartis) |
9:45 pm - 10:45 pm | Social Hour |
THURSDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:00 pm | Late Breaking Topics |
| Discussion Leader: Lori Krim Gavrin (Wyeth) |
9:00 am - 9:30 am | Lihu Yang (Merck)
"Discovery of GPR40 Agonists for the Treatment of Diabetes" |
9:30 am - 9:40 am | Discussion |
9:40 am - 10:10 am | Robert Marquis (GlaxoSmithKline)
"Discovery of Ronacaleret an Orally Bioavailable PTH Secretagogue for the Treatment of Osteoporosis" |
10:10 am - 10:20 am | Discussion |
10:20 am | Coffee Break |
10:40 am - 11:10 am | Graham Johnson (Rib-X Pharmaceuticals)
"Discovery and Clinical Development of RX-1741, a Designer Oxazolidinon" |
11:10 am - 11:20 am | Discussion |
11:20 am - 11:50 am | Heather Finlay (BMS)
"The discovery of Pyrazolodihydropyrimidine KV1.5 Blockers" |
11:50 am - 12:00 pm | Discussion |
12:00 pm - 12:30 pm | Poster Award Winner Talks |
| Discussion Leader: Young Shin Cho (Novartis) |
12:30 pm | Lunch |
1:30 pm - 5:00 pm | Free Time |
5:00 pm - 6:00 pm | Chair's Reception |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Chair's Talk |
7:30 pm - 8:30 pm | Paul J. Reider (Princeton University) |
8:30 pm - 9:30 pm | General Discussion |
9:45 pm - 10:45 pm | Social Hour |
FRIDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am | Depart |