Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Medicinal Chemistry Enabling Novel Strategies for Intracellular and Targeted Delivery
7:40 pm - 8:10 pm
"Development of Novel Insulins Capable of Glucose-Regulated Delivery to Mitigate Hypoglycemia Risk"
8:10 pm - 8:15 pm
Discussion
8:15 pm - 8:45 pm
"Optimization of Lipid Nanoparticles for mRNA-Based Therapeutics"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
"Discovery of Potent BRD4 Degraders and Their Delivery as Antibody Conjugates"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Recent Developments of Immune Modulators
9:00 am - 9:30 am
"Discovery and Evolution of Potent and Selective Heme-Displacing IDO1 Inhibitors"
9:30 am - 9:45 am
Discussion
9:45 am - 10:15 am
"Discovery of STING Agonist with Systemic Anti-Tumor Response"
10:15 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:30 am
"Target Based Identification and Optimization of Toll-Like Receptor 7/8 Antagonists"
11:30 am - 11:45 am
Discussion
11:45 am - 12:15 pm
"Discovery of GS-9688, a Selective Toll-Like Receptor 8 Agonist for Hepatitis B Cure"
12:15 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hourâ„¢
The GRC Power Hourâ„¢ is designed to address challenges women face in science and issues of diversity and inclusion. The program supports the professional growth of all members of our communities by providing an open forum for discussion and mentoring.
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
High Quality Leads from Encoded Screening Technologies
7:30 pm - 8:00 pm
"DNA-Encoded Libraries: Hit Generation from Vast Chemical Spaces"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
"Hit-to-Lead with DNA-Encoded Libraries: Autotaxin and DDR1"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
"From Haystack to Needle: Clinical Candidate Using Encoded Libraries at GSK"
9:20 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Recent Advances in Neuroscience
9:00 am - 9:30 am
"Discovery of CoREST Complex-Selective HDAC Inhibitors with Pro-Synaptic Effects for the Treatment of Synaptopathies"
9:30 am - 9:45 am
Discussion
9:45 am - 10:15 am
"Optimization and Identification of Brain Penetrant, M4 Subtype-Selective Muscarinic Receptor Positive Allosteric Modulator (M4 PAM) Clinical Candidate"
10:15 am - 10:30 am
Discussion
10:30 am - 11:00 am
Group Photo / Coffee Break
11:00 am - 11:30 am
"Discovery of LY3154207, a Potent, Selective and Orally Available Positive Allosteric Modulator of the Dopamine D1 Receptor"
11:30 am - 11:45 am
Discussion
11:45 am - 12:15 pm
"TRPA1 as a Neuronal Regulator of Inflammation in the Lung: Discovery of a Clinical Candidate for the Treatment of Asthma"
12:15 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Expanded Modalities in Targeting Cancer
7:30 pm - 8:00 pm
"Allosteric Covalent Inhibitors of the Mutant GTPase KRASG12C "
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
"ARV-110, an Orally Bioavailable PROTACâ„¢ Protein Degrader Molecule for the Treatment of Men with Metastatic Castration Resistant Prostate Cancer"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
"Development of Selective Estrogen Receptor Covalent Antagonists (SERCA) for the Treatment of ERαWT and ERαMUT Breast Cancer"
9:20 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Enabling and Inspiring Drug Discovery via Innovations in Synthesis
9:00 am - 9:30 am
"Synthesis Inspired Design: Benzocyclobutyl Amines as Aniline Surrogates Within the IDO Program"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
"Optimization of the Arylomycins Results in a New Class of Gram-Negative Antibiotics"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:20 am
"Design and Synthesis of Carbonucleoside Inhibitors of PRMT5 for the Treatment of Cancer: A Desymmetrization Approach"
11:20 am - 11:30 am
Discussion
11:30 am - 12:00 pm
"Impacting the Pipeline Through Discovery Synthesis Groups: Cystic Fibrosis, HCV and Immunology"
12:00 pm - 12:10 pm
Discussion
12:10 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
New Approaches for the Treatment of Heart Failure
7:30 pm - 8:00 pm
"Learning from Recent Efforts in Heart Failure Drug Discovery"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
"The Journey of Neprilysin Inhibitors"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
"Identification of an APJ Receptor Agonist Clinical Candidate for Heart Failure"
9:20 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
9:00 am - 12:30 pm
Late-Breaking Topics: First Disclosures of Clinical Candidates
9:00 am - 9:30 am
"Discovery of CAD-1883, a Clinical-Stage Positive Allosteric Modulator of the SK Channel for the Treatment of Essential Tremor and Spinocerebellar Ataxia"
9:30 am - 9:45 am
Discussion
9:45 am - 10:15 am
"Discovery of LNP023, a First-in-Class, Oral Factor B Inhibitor for Treatment of Rare Alternative Complement Pathway Driven Diseases"
10:15 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:30 am
"Discovery of CC-90009, a CRBN E3 Ligase Modulating Drug (CELMoD) with Selective GSPT1 Degradation for the Treatment of Acute Myeloid Leukemia"
11:30 am - 11:45 am
Discussion
11:45 am - 12:15 pm
"Discovery of JNJ-61393215, a Selective Orexin-1 Receptor Antagonist"
12:15 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Keynote Session: Hunting the Future of Drug Discovery
7:30 pm - 8:30 pm
"Hunting the Future of Drug Discovery"
8:30 pm - 8:55 pm
Discussion
8:55 pm - 9:15 pm
General Discussion
9:15 pm - 9:30 pm
Closing Remarks
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure