Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Chromosome Synapsis: Organization, Regulation and Functions
Discussion Leader: Jinmin Gao (Shandong Normal University, China)
7:40 pm - 7:55 pm
Scott Hawley (Stowers Institute for Medical Research, USA)
"Fine Structure Analysis of the Synaptonemal Complex and Recombination Nodule in Drosophila "
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:20 pm
Abby Dernburg (University of California, Berkeley, USA)
"Patterning of Meiotic Crossovers by a Reaction-Diffusion Mechanism"
8:20 pm - 8:25 pm
Discussion
8:25 pm - 8:40 pm
Amy MacQueen (Wesleyan University, USA)
"SC Assembly and Recombination Unite at Zip1's N Terminal Tip"
8:40 pm - 8:45 pm
Discussion
8:45 pm - 9:00 pm
Ricardo Benavente (University of Würzburg, Germany)
"Electron Tomography of Meiotic Telomere Tethering to the Nuclear Envelope"
9:00 pm - 9:05 pm
Discussion
9:05 pm - 9:20 pm
Sarit Smolikove (The University of Iowa, USA)
"The CUL-4 E3 Ligase Complex Controls SC Assembly, Recombination and Transposition in the C. elegans Germline"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Meiotic Recombination: Regulation of Initiation and Progression of Recombination
Discussion Leader: Luke Berchowitz (Columbia University Medical Center, USA)
9:00 am - 9:15 am
Scott Keeney (Memorial Sloan Kettering Cancer Center, USA)
"Breaking PAR: Promoting Sex Chromosome Recombination in Male Meiosis"
9:15 am - 9:25 am
Discussion
9:25 am - 9:40 am
Douglas Bishop (The University of Chicago, USA)
"Interactions of Dmc1, Rad51 and Mei5-Sae3"
9:40 am - 9:50 am
Discussion
9:50 am - 10:05 am
Maria Jasin (Memorial Sloan Kettering Cancer Center, USA)
"Consequences of ATM Deficiency on Meiotic DSB Repair in Mouse Spermatocytes"
10:05 am - 10:15 am
Discussion
10:15 am - 10:50 am
Coffee Break
10:50 am - 11:05 am
Bernard de Massy (Institute of Human Genetics, France)
"Meiotic DNA Double Strand Formation: The Essential Role of Mouse REC114"
11:05 am - 11:15 am
Discussion
11:15 am - 11:30 am
Rafael Camerini-Otero (National Institute of Diabetes and Digestive and Kidney Diseases, NIH, USA)
"Linking Meiotic Replication and Recombination in Mice and Men"
11:30 am - 11:40 am
Discussion
11:40 am - 11:55 am
Attila Toth (Technische Universität Dresden, Germany)
"Pairing PARs in Male Meiosis"
11:55 am - 12:05 pm
Discussion
12:05 pm - 12:20 pm
Franz K. Klein (Max F. Perutz Laboratories, University of Vienna, Austria)
"Spatial Coordination Between Spo11-Dependent DSBs"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
Power Hour
The GRC Power Hour is an optional informal gathering open to all meeting participants. It is designed to help address the challenges women face in science and support the professional growth of women in our communities by providing an open forum for discussion and mentoring.
Organizers: Needhi Bhalla (University of California, Santa Cruz, USA) and Andreas Hochwagen (New York University, USA)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Aneuploidy: New Emerging Technologies and Health Implications
Discussion Leader: Ewelina Bolcun-Filas (The Jackson Laboratory, USA)
7:30 pm - 7:45 pm
Eva Hoffmann (University of Copenhagen, Denmark)
"Cellular Heterogeneity and Reproductive Aging in Human Oocytes"
7:45 pm - 7:55 pm
Discussion
7:55 pm - 8:10 pm
Melina Schuh (Max Planck Institute for Biophysical Chemistry, Germany)
"New Insights into Causes of Aneuploidy in Mammalian Eggs"
8:10 pm - 8:20 pm
Discussion
8:20 pm - 8:35 pm
David Page (Whitehead Institute, Massachusetts Institute of Technology / Howard Hughes Medical Institute, USA)
"STRA8 Directly Activates a Broad Transcriptional Program for Meiotic Initiation in Mice"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 9:00 pm
Michael Klutstein (Hebrew University of Jerusalem, Israel)
"Intellectual Property Theft! Or: Cancer Hitchhikes on Meiosis"
9:00 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
Kei-ichiro Ishiguro (Institute of Molecular Embryology and Genetics, Kumamoto University, Japan)
"A Novel Nuclear Factor, MEIOSIN, Recruits STRA8 to Direct Initiation of Meiosis in Mammals"
9:25 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Chromosome Segregation: Spindle Assembly and Cohesion
Discussion Leader: Karen Schindler (Rutgers, The State University of New Jersey, USA)
9:00 am - 9:15 am
Adele Marston (University of Edinburgh, United Kingdom)
"Reductional Meiosis I Chromosome Segregation Is Established by Coordination of Key Meiotic Kinases"
9:15 am - 9:25 am
Discussion
9:25 am - 9:40 am
Tomoya Kitajima (RIKEN Center for Developmental Biology, Japan)
"A Unique Role of Kinetochores in Mammalian Oocytes"
9:40 am - 9:50 am
Discussion
9:50 am - 10:05 am
Iva Tolic (Ruder Boskovic Institute (RBI), Croatia)
"Forces, Torques and Architecture of the Spindle"
10:05 am - 10:15 am
Discussion
10:15 am - 10:50 am
Group Photo / Coffee Break
10:50 am - 11:05 am
JoAnne Engebrecht (University of California, Davis, USA)
"The BRCA1/BARD1 Tumor Suppressor Complex and the Spindle Assembly Checkpoint Mediate Accurate Chromosome Segregation During Male Meiosis"
11:05 am - 11:15 am
Discussion
11:15 am - 11:30 am
Akira Shinohara (Institute for Protein Research, Osaka University, Japan)
"Local Chromosome Context Is a Major Determinant of Crossover Pathway Biochemistry During Yeast Meiosis"
11:30 am - 11:40 am
Discussion
11:40 am - 11:55 am
Raphael Mercier (Institut National de la Recherche Agronomique (INRA), France)
"PATRONUS Regulates Chromosome Separation by Antagonizing SEPARASE I"
11:55 am - 12:05 pm
Discussion
12:05 pm - 12:20 pm
Sadie Wignall (Northwestern University, USA)
"Dynamic SUMO Remodeling Drives a Series of Critical Events During the Meiotic Divisions"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Epigenetics, Expression and Germ Cells
Discussion Leader: Yonatan Tzur (Hebrew University of Jerusalem, Israel)
7:30 pm - 7:45 pm
Barbara Meyer (Howard Hughes Medical Institute / University of California, Berkeley, USA)
"Precise and Imprecise Repair Outcomes Following DNA Cleavage by CRISPR/Cas9"
7:45 pm - 7:55 pm
Discussion
7:55 pm - 8:10 pm
Satoshi Namekawa (Cincinnati Children's Hospital Medical Center, USA)
"Dynamic Epigenetic Regulation for Gene Activation During Meiosis"
8:10 pm - 8:20 pm
Discussion
8:20 pm - 8:35 pm
Andreas Hochwagen (New York University, USA)
"SNP-ChIP: A Versatile and Tag-Free Method to Quantify Changes in Protein Binding Across the Genome"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 9:00 pm
Gloria Brar (University of California, Berkeley, USA)
"Global Meiotic Gene Expression Measurements Reveal Regulated Protein Degradation and Imprecise Synthesis Matching for Protein Complex Members"
9:00 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
Christine Mezard (Institut National de Recherche Agronomique (INRA), France)
"The Neddylation Pathway Regulates the Localization of Meiotic CO, the Pairing of Homologous Chromosomes and the Level of DNA Methylation in Arabidopsis thaliana "
9:25 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Meiotic Recombination: Regulation of Frequency and Distribution
Discussion Leader: Philip Jordan (Johns Hopkins University Bloomberg School of Public Health, USA)
9:00 am - 9:15 am
Michael Lichten (National Cancer Institute, NIH, USA)
"Fine Structure Analysis Reveals Distinct Mechanisms for Noncrossover and Crossover Formation in Budding Yeast"
9:15 am - 9:25 am
Discussion
9:25 am - 9:40 am
Francesca Cole (University of Texas MD Anderson Cancer Center, USA)
"Timing Is Everything: Meiotic Recombination in Mouse Spermatocytes"
9:40 am - 9:50 am
Discussion
9:50 am - 10:05 am
Jeff Sekelsky (University of North Carolina at Chapel Hill, USA)
"Synapsis and DSB Repair in the Absence of Homologous Chromosome Pairing"
10:05 am - 10:15 am
Discussion
10:15 am - 10:50 am
Coffee Break
10:50 am - 11:05 am
Nancy Kleckner (Harvard University, USA)
"The Nature of the Meiotic Chromosomal Program and Its Implications for Evolution"
11:05 am - 11:15 am
Discussion
11:15 am - 11:30 am
Paula Cohen (Cornell University, USA)
"CNTD1: This Is Not the Mouse Cyclin You're Looking For"
11:30 am - 11:40 am
Discussion
11:40 am - 11:55 am
Gerald Smith (Fred Hutchinson Cancer Research Center, USA)
"Long- and Short-Range Control of Meiotic DSB and Crossover Formation"
11:55 am - 12:05 pm
Discussion
12:05 pm - 12:20 pm
Valerie Borde (Institut Curie / UMR3244, CNRS, France)
"Control of the Extent of DNA Synthesis During Meiotic Recombination"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Checkpoints and Regulation of Cell Cycle Progression
Discussion Leader: Yumi Kim (Johns Hopkins University, USA)
7:30 pm - 7:45 pm
James Turner (The Francis Crick Institute, United Kingdom)
"Linking Prophase I Chromosome Defects to Germ Cell Elimination in Mammals"
7:45 pm - 7:55 pm
Discussion
7:55 pm - 8:10 pm
Neil Hunter (University of California, Davis, USA)
"Regulation of Meiosis by Ubiquitin-Like Molecules"
8:10 pm - 8:20 pm
Discussion
8:20 pm - 8:35 pm
Roberto Pezza (Oklahoma Medical Research Foundation, USA)
"Mechanisms and Regulation of Telomere-Led Chromosome Movements in Yeast and Mouse"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 9:00 pm
Ignasi Roig (Universitat Autònoma de Barcelona, Spain)
"CHK2 Regulates Oocyte Pool in Mammals"
9:00 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
Needhi Bhalla (University of California, Santa Cruz, USA)
"PCH-2 Proofreads Meiotic Homolog Interactions"
9:25 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
9:00 am - 12:30 pm
Chromosome Dynamics and Chromatin Organization
Discussion Leader: Aimee Jaramillo-Lambert (University of Delaware, USA)
9:00 am - 9:15 am
Matthew Neale (University of Sussex, United Kingdom)
"A Hi-C View of Meiotic Chromosomes"
9:15 am - 9:25 am
Discussion
9:25 am - 9:40 am
Enrique Martinez-Perez (MRC London Institute of Medical Sciences, Imperial College London, United Kingdom)
"Surveillance of Cohesin-Mediated Chromosome Structure Regulates Meiotic Progression"
9:40 am - 9:50 am
Discussion
9:50 am - 10:05 am
Denise Zickler ( I2BC, Université Paris-Sud, France)
"The Sordaria Zip2/Zip4 Duo"
10:05 am - 10:15 am
Discussion
10:15 am - 10:50 am
Coffee Break
10:50 am - 11:05 am
Anne Villeneuve (Stanford University, USA)
"Coordinating, Constraining and Counterbalancing Enzyme Activities During Meiotic Prophase"
11:05 am - 11:15 am
Discussion
11:15 am - 11:30 am
Monica Pradillo (Universidad Complutense de Madrid, Spain)
"Nuclear Pore Complexes and Meiosis: A New Face of Arabidopsis Nucleoporins"
11:30 am - 11:40 am
Discussion
11:40 am - 11:55 am
Sean Burgess (University of California, Davis, USA)
"Progressive Homolog Pairing Starts at the Ends of Chromosomes in Zebrafish, Danio rerio "
11:55 am - 12:05 pm
Discussion
12:05 pm - 12:20 pm
Owen Davies (University of Newcastle, United Kingdom)
"The Molecular Architecture of the Meiotic Telomere Complex"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Evolution: Diversity and Conservation of Meiosis
Discussion Leader: Sarah Zanders (Stowers Institute for Medical Research, USA)
7:30 pm - 7:45 pm
Hiro Ohkura (The University of Edinburgh, United Kingdom)
"A Novel Microtubule Nucleation Pathway for Meiotic Spindle Assembly in Oocytes"
7:45 pm - 7:55 pm
Discussion
7:55 pm - 8:10 pm
Jesus Page (Universidad Autonoma de Madrid, Spain)
"Meiotic Factors in the Transmission and Evolution of Sex Chromosomes in Non-Model Mammals"
8:10 pm - 8:20 pm
Discussion
8:20 pm - 8:35 pm
Kevin Corbett (University of California, San Diego / Ludwig Institute for Cancer Research, USA)
"Molecular Architecture and Evolutionary Conservation of the Meiotic Chromosome Axis"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 9:00 pm
Elcin Unal (University of California, Berkeley, USA)
"Mitochondrial Dynamics During Meiotic Differentiation"
9:00 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
Soni Lacefield (Indiana University, USA)
"Autophagy Is Essential for Meiotic Exit"
9:25 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure