Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Stress of Being in a Host
Discussion Leader: Jan-Ulrik Dahl (Illinois State University, United States)
7:40 pm - 7:45 pm
Introduction by Discussion Leader
7:45 pm - 8:05 pm
Sophie Helaine (Harvard Medical School, United States)
"Persisting in Macrophages"
8:05 pm - 8:10 pm
Discussion
8:10 pm - 8:30 pm
William Navarre (University of Toronto, Canada)
"How H-NS and the Core Transcriptional Machinery Collaborate to Regulate Foreign Genes"
8:30 pm - 8:35 pm
Discussion
8:35 pm - 8:45 pm
Mariya Lobanovska (University of California Berkeley, United States)
"Role of Stressosomes in the Regulation of Listeria Monocytogenes Virulence"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:10 pm
Jan-Willem Veening (University of Lausanne, Switzerland)
"The Transcriptional and Phenotypic Landscape of Streptococcus Pneumoniae During Infection"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:30 pm
General Discussion
Monday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Replication and Nutrient Stress
Discussion Leader: Amy Schmid (Duke University, United States)
9:00 am - 9:20 am
Peter Freddolino (University of Michigan, United States)
"The E. coli “Leucine-responsive Regulatory Protein” Integrates Host and Microbial Stress Signals to Reshape DNA and Gene Expression"
9:20 am - 9:25 am
Discussion
9:25 am - 9:35 am
Thalia Sass (Brandeis University, United States)
"Replication Stalling and Transcription Termination Conflicts Induce the RpoS General Stress Response through the Regulation of iraD by DnaA and SspA"
9:35 am - 9:40 am
Discussion
9:40 am - 9:50 am
Ryan Otto (The University of Texas Southwestern Medical Center, United States)
"Predicting the Effect of Gene Expression and Environmental Variation on E. coli Growth Rate"
9:50 am - 9:55 am
Discussion
9:55 am - 10:15 am
Carol Gross (University of California, San Francisco, United States)
"Expression-Fitness Relationships in Essential Genes"
10:15 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:10 am
Lyle Simmons (University of Michigan, United States)
"Regulation of the DNA Damage Checkpoint"
11:10 am - 11:15 am
Discussion
11:15 am - 11:25 am
Erika Smith (Johns Hopkins University School of Medicine, United States)
"Sound the Alarmone: The role of CdnL in the Caulobacter Stringent Response"
11:25 am - 11:30 am
Discussion
11:30 am - 11:50 am
Anjana Badrinarayanan (National Centre for Biological Sciences (TIFR), India)
"Searching for Homology"
11:50 am - 11:55 am
Discussion
11:55 am - 12:05 pm
Irina Artsimovitch (Ohio State University, United States)
"Restraining Rho Termination During Stress"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hour™
The GRC Power Hour™ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
Organizers: Petra Levin (Washington University in St. Louis, United States) and Allison Williams (University of California San Francisco , United States)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Stress of Other Cells
Discussion Leader: Petra Levin (Washington University in St. Louis, United States)
7:30 pm - 7:50 pm
Marie Elliot (McMaster University, Canada)
"Exploring Uncharted Territory in Streptomyces Growth and Development"
7:50 pm - 7:55 pm
Discussion
7:55 pm - 8:05 pm
Anthony Martini (National Cancer Institute, United States)
"Development and Mechanisms of Pyocyanin Resistance in Staphylococcus aureus"
8:05 pm - 8:10 pm
Discussion
8:10 pm - 8:30 pm
Daniel Wall (University of Wyoming, United States)
"Adapting to Cell Envelope Stress as a Cooperative Microbial Community"
8:30 pm - 8:35 pm
Discussion
8:35 pm - 8:45 pm
Maria Hadjifrangiskou (Vanderbilt University Medical Center, United States)
"Subversion of Mitochondrial Metabolism Supports Intracellular Bacterial Expansion Inside the Host Cell"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:10 pm
Chris Waters (Michigan State University, United States)
"Cyclic Di-Nucleotide Signaling and Adaptation in Microorganisms"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Jiqiang Ling (University of Maryland, College Park, United States)
"Role of Translational Fidelity in Bacteria-Host Interactions"
9:25 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Oxidative, Metal and Antibiotic Stress
Discussion Leader: Joan Slonczewski (Kenyon College, United States)
9:00 am - 9:20 am
Christina Stallings (Washington University School of Medicine, United States)
"Metabolic Remodeling in Response to Antibiotic Stress in Mycobacteria"
9:20 am - 9:25 am
Discussion
9:25 am - 9:35 am
Amir Mitchell (University of Massachusetts Medical School, United States)
"Bacterial Response and Adaptation to Host-Targeting Chemotherapies Alters Drug Metabolism"
9:35 am - 9:40 am
Discussion
9:40 am - 9:50 am
Jason Peters (University of Wisconsin-Madison, United States)
"The Genetics of Antibiotic Function in Acinetobacter baumannii"
9:50 am - 9:55 am
Discussion
9:55 am - 10:15 am
Frederic Barras (Institut Pasteur, France)
"Fe-S Cluster-Based Biology and Redox Adaptation"
10:15 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:05 am
John Helmann (Cornell University, United States)
"Bacillus Subtilis Stress Responses"
11:05 am - 11:10 am
Discussion
11:10 am - 11:20 am
Susan Rosenberg (Baylor College of Medicine, United States)
"How Drugs and Gambling Promote Antibiotic Resistance Evolution and Drugs to Stop Them"
11:20 am - 11:25 am
Discussion
11:25 am - 11:35 am
Carissa Chan (Yale School of Medicine, United States)
"Universal Protein Chaperone Hsp70 Advances Bacterial Survival During Magnesium Starvation by Inhibiting Protein Synthesis"
11:35 am - 11:40 am
Discussion
11:40 am - 11:50 am
Hualiang Pi (Vanderbilt University Medical Center, United States)
"Clostridioides difficile Adapts to Iron Stress Through Intracellular Iron Biomineralization"
11:50 am - 11:55 am
Discussion
11:55 am - 12:05 pm
William Beavers (Louisiana State University School of Veterinary Medicine, United States)
"Polyunsaturated Fatty Acids Potentiate Aminoglycoside Killing of S. Aureus Small Colony Variants"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Energy and Metabolic Stress
Discussion Leader: Daniel Stoebel (Harvey Mudd College, United States)
7:30 pm - 7:50 pm
Lars Dietrich (Columbia University, United States)
"The Effect of Light on Biofilm Metabolism in Pseudomonas Aeruginosa"
7:50 pm - 7:55 pm
Discussion
7:55 pm - 8:15 pm
N. Cecilia Martinez-Gomez (University of California, Berkeley, United States)
"Unraveling Lanthanide Transport, Storage, and Usage in Methylorubrum Extorquens"
8:15 pm - 8:20 pm
Discussion
8:20 pm - 8:30 pm
Rylee Hackley (Duke University, United States)
"TrmB Targets Anaplerotic Enzymes from Diverse Evolutionary Lineages to Regulate Gluconeogenesis in Halophilic Archaea"
8:30 pm - 8:35 pm
Discussion
8:35 pm - 8:55 pm
Caroline Harwood (University of Washington, United States)
"Bacterial Longevity"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
Thomas Kehl-Fie (University of Illinois at Urbana-Champaign, United States)
"Alternative Glycolytic Isozymes Facilitate Glucose Consumption by Pathogens When Metal-starved by the Host"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:30 pm
General Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Regulatory Systems for Stress
Discussion Leader: Amy Gehring (Williams College, United States)
9:00 am - 9:20 am
Mark Buttner (John Innes Centre, United Kingdom)
"How C-Di-GMP Controls Progression Through the Streptomyces Life Cycle"
9:20 am - 9:25 am
Discussion
9:25 am - 9:35 am
Christina Savage (NIH, United States)
"Morphological Coupling Between Coat Assembly and Transcription During Sporulation"
9:35 am - 9:40 am
Discussion
9:40 am - 9:50 am
Wade Winkler (University of Maryland, United States)
"Microcompartment-Related Structures Exhibit Dynamic Behavior"
9:50 am - 9:55 am
Discussion
9:55 am - 10:15 am
Sean Crosson (Michigan State University, United States)
"Coordinate Regulation of Stress Response and Surface Adhesion"
10:15 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:10 am
Susan Gottesman (National Cancer Institute, NIH, United States)
"Novel Regulatory Loops for Turning On and Off the RpoS Response"
11:10 am - 11:15 am
Discussion
11:15 am - 11:25 am
Philip Adams (National Institutes of Health, United States)
"Characterization of B. burgdorferi Regulatory RNAs Detected by Transcriptome Mapping"
11:25 am - 11:30 am
Discussion
11:30 am - 11:40 am
Danny Fung (University of Wisconsin-Madison, United States)
"Spontaneous and Triggered Antibiotic Persistence by (p)ppGpp-GTP Antagonism in Bacillus Subtilis"
11:40 am - 11:45 am
Discussion
11:45 am - 12:05 pm
Gisela Storz (National Institute of Child Health and Human Development, NIH, United States)
"Regulating Stress Responses From Inside Genes"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Discuss Future Dates and Venue; Election of the Next Vice Chair(s)
7:30 pm - 9:30 pm
Stress of Phage and Mobile Genetic Elements
Discussion Leader: Mona Orr (Amherst College (Mona Wu Orr), United States)
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:00 pm
Alan Grossman (Massachusetts Institute of Technology, United States)
"Bacterial Sex is Stressful"
8:00 pm - 8:05 pm
Discussion
8:05 pm - 8:15 pm
Charlie Mo (Rockefeller University, United States)
"Exploring the Impact of Type III CRISPR-Cas Immunity on Bacterial Variation"
8:15 pm - 8:20 pm
Discussion
8:20 pm - 8:30 pm
Tong Zhang (Massachusetts Institute of Technology, Department of Biology, United States)
"Direct Activation of a Fused Toxin-Antitoxin System by the Major Capsid Protein of Bacteriophages"
8:30 pm - 8:35 pm
Discussion
8:35 pm - 8:45 pm
Amar Deep (University of California, San Diego, United States)
"The Condensin-like Wadjet Defense System Impairs Bacterial Plasmid Transformation by Recognition and Cleavage of Closed-Circular DNA"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:00 pm
Amelia McKitterick (Harvard Medical School, United States)
"Bursting at the Seams: Characterization of a Novel Phage Lysis Gene in Actinophages"
9:00 pm - 9:05 pm
Discussion
9:05 pm - 9:15 pm
Late-Breaking Topic
9:15 pm - 9:20 pm
Discussion
9:20 pm - 9:30 pm
General Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Proteotoxic and Translational Stress
Discussion Leader: Eduardo Groisman (Yale School of Medicine, United States)
9:00 am - 9:20 am
Jean-Francois Collet (UCLouvain, Belgium)
"Protecting Nascent Polypeptides from Premature Aging"
9:20 am - 9:25 am
Discussion
9:25 am - 9:35 am
Andrew Savinov (Massachusetts Institute of Technology, United States)
"Mapping Functional Regions of Essential Bacterial Proteins with Dominant-negative Protein Fragments"
9:35 am - 9:40 am
Discussion
9:40 am - 9:50 am
Jonathan Dworkin (Columbia University, United States)
"Making and Breaking Ribosome Dimers"
9:50 am - 9:55 am
Discussion
9:55 am - 10:15 am
Stefan Katharios-Lanwermeyer (National Institutes of Health (NIH), United States)
"Pseudomonas aeruginosa Induces Aggregation in the Co-Infecting Pathogen Stenotrophomonas maltophilia"
10:15 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:00 am
Short Talk Selected from Poster Abstracts
11:00 am - 11:05 am
Discussion
11:05 am - 11:25 am
Gert Bange (Philipps University Marburg, Germany)
"Are You Stressed? Functional Roles of Di-Adenosine Nucleotides"
11:25 am - 11:30 am
Discussion
11:30 am - 11:40 am
David Ranava (Northwestern University, United States)
"Extraribosomal Role of Hibernation Promoting Factor in Staphylococcus Aureus"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
Srujana Samhita Yadavalli (Rutgers University, United States)
"Dual Functions of a Biosynthetic Enzyme (QueE) in tRNA Modification and Bacterial Stress Response"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
Daniel Kearns (Indiana University Bloomington, United States)
"Adaptor-Mediated Lon Proteolysis in Bacillus Subtilis"
12:20 pm - 12:25 pm
Discussion
12:25 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Cell Envelope Stress
Discussion Leader: William Navarre (University of Toronto, Canada)
7:30 pm - 7:50 pm
Allison Williams (University of California San Francisco , United States)
"Visualizing the Bacterial Stress Sensing Machinery in Action"
7:50 pm - 7:55 pm
Discussion
7:55 pm - 8:05 pm
Rachna Chaba (Indian Institute of Science Education and Research (IISER) Mohali, India)
"Long-Chain Fatty Acid Metabolism is Intricately Interconnected to the Cpx Envelope Stress Response"
8:05 pm - 8:10 pm
Discussion
8:10 pm - 8:30 pm
Natividad Ruiz (Ohio State University, United States)
"Building an Outer Membrane – How Stressful!"
8:30 pm - 8:35 pm
Discussion
8:35 pm - 8:45 pm
Angela Mitchell (Texas A&M University, United States)
"Cold Stress as an Instrument to Elucidate the Unique Role of YhdP in E. coli Cell Envelope Biogenesis"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:10 pm
Petra Levin (Washington University in St. Louis, United States)
"How the Environment Shapes E. coli"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:30 pm
General Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure