SESSION ONE, Sunday P. M.
Pathogenicity Islands and genetic differences between pathogens and nonpathogens
- Fred Quinn, Ph.D., (Chief, Pathogenesis Laboratory, Division of AIDs, STD, and TB Laboratory Research, Centers for Disease Control, Atlanta )Discussion leader
- Jörg Hacker, Ph.D., (Professor, Intitut für Molekulare Infektionsbiologie, Würzburg, Germany) "Pathogenicity Islands in uropathogenic E. coli"
- James Kaper, Ph.D. (Professor, Center for Vaccine Development, University of Maryland, Baltimore) "The locus of enterocyte effacement (LEE) locus in enteropathogenic E. coli"
- Robert Perry, Ph.D., (Associate Professor Albert Chandler Medical Center, Lexington, Kentucky) "Virulence-associated region in Yersinia pestis"
SESSION TWO, Monday A.M.
Antigenic variation
- June R. Scott, Ph.D. (Professor, Emory University) Discussion Leader
- Janne G. Cannon, Ph.D. (Professor, University of North Carolina School of Medicine, Chapel Hill) "Importance of the variation of gonococcal opacity proteins (opas) in a human model of Neisseria gonorrhoeae infection"
- Alan G. Barbour, M.D. (Professor, University of Texas Health Sciences Center, San Antonio) "Genetic basis for antigenic variation of outer surface proteins (osps) in Borrelia burgdorferi"
- Mumtaz Virji, Ph.D. (Senior Research Fellow, Oxford University, U.K.) "Interactions of variable Neisseria meningitidis surface components with the host cell"
- Martin J. Blaser, M.D. (Professor, Vanderbilt University School of Medicine, Nashville, Tennessee) "Variability of the S layer of Campylobacter"
SESSION THREE, Monday P.M.
Chaperones and escorts
- Susan Straley, Ph.D. (Professor, Albert Chandler Medical Center, Lexington, Kentucky) Discussion Leader
- Guy Cornelis, Ph.D. (Professor, Université catholique Louvain, Brussels, Belgium)"Secretion of Yersinia outer proteins (YOPs)"
- Claude Parsot, Ph.D. (Research Assistant Professor equivalent, Institut Pasteur, Paris, France "Molecular basis for export of Shigella invasin protein antigens (ipas)"
- Scott Hultgren, Ph.D. (Associate Professor, Washington University, Saint Louis, Missouri) "Synthesis and assembly of uropathogenic Escherichia coli P fimbriae"
SESSION FOUR. Tuesday A.M.
Activation, modification, and trafficking of toxins and toxin receptors
- Drusilla Burns, Ph.D., (Chief, Pertussis Laboratory, Center for Biologics Evaluation and Research, FDA) Discussion Leader
- Angela Melton-Celsa, Ph.D., (Research Associate, Uniformed Services University of the Health Sciences, Bethesda, Maryland "Activation of Shiga-like toxins of E. coli by intestinal mucus"
- Erik Hewlett, M.D., (Professor, University of Virginia Health Sciences Center, Charlottesville, Virginia) "Biochemical modification of adenylate cyclase of Bordetella pertussis and a-hemolysin of E. coli"
- June Almenoff, M.D., Ph.D., (Assistant Professor, Duke University Medical Center, Durham, North Carolina) "Mechanism of activation of E. coli heat stable toxin (STa) intestinal receptor guanylyl cyclase C"
- Wayne Lencer, M.D., (Assistant Professor, Harvard Medical School, Boston, Massachusetts) "Targeting of cholera toxin and E. coli heat-labile toxin in polarized epithelia"
SESSION FIVE. Tuesday P.M.
Salmonella- a tool and what's new
- Eduardo Groisman, Ph.D., (Assistant Professor, Washington University, Saint Louis, Missouri) Discussion Leader
- David Holden, Ph.D.,(Assistant Professor equivalent, Royal Postgraduate Medical College, London, U.K.) "Signature tagged mutagenesis of Salmonella"
- Sam Miller, M.D. (Associate Professor, Washington University, Seattle) "Secreted proteins of Salmonella"
- Catherine Lee, Ph.D. (Assistant Professor, Harvard Medical School, Boston Massachusetts "A new regulator of Salmonella virulence"
SESSION SIX. Wednesday A.M.
Cytoskelatal rearrangements and cell signalling mediated by toxins
- Henry Wu, M.D., Ph.D., (Professor, Uniformed Services University of the Health Sciences, Bethesda, Maryland) Discussion Leader
- Allen Aderem, Ph.D., (Professor, Rockefellar University, New York) Signal transduction in macrophages mediated by lipopolysaccharide"
- Cynthia Sears, M.D., (Associate Professor, Johns Hopkins University School of Medicine) "Effects of Bacteroides fragilis toxin on the actin skeleton of the target host cell"
- Klaus Aktories, M.D., Ph.D.(Professor Pharmakologisches Institut, Freiburg, Germany) "Modification of Rho by Clostridium difficile cytotoxin"
- Motoyuki Sugai, D.D.S., Ph.D., (Associate Professor equivalent, Hiroshima University School of Dentistry, Hiroshima, Japan) "Intracellular trafficking of Staphylococcus aureus epidermal cell differentiation inhibitor (EDIN)"
SESSION SEVEN. Wednesday P.M.
Structure-function analyses of virulence determinants and regulators
- Randall K. Holmes, M.D., Ph.D., (Professor and Chair, University of Colorado Health Sciences Center, Denver) Discussion Leader
- Carlos Petosa, (currently graduate student Harvard Medical School, will be post-doctoral fellow, University of Leicester, Leicester, U.K.) "X-ray crystallographic structure of anthrax protective antigen"
- Vim Hol, Ph.D., (Professor, University of Washington, Seattle), "Structure of the diphtheria toxin repressor"
- Ralph Isberg, Ph.D., (Associate Professor, Tufts University) "Yersinia invasin-receptor interaction"
SESSION EIGHT Thursday A.M.
Immunization: immune modulation, vectors, and new approaches
- Eleanor Metcalf, Ph.D., (Professor Uniformed Services University of the Health Sciences), Discussion Leader
- Charles Elson, M.D., (Professor, University of Alabama Medical Center, Birmingham) "E. coli heat labile toxin and cholera toxin as adjuvants"
- May Jo Wick, Ph. D., (Research Associate, University of Lund, Sweden) "Epitope expression in E. coli"
- Robert Munford, M.D., (Professor, University of Texas Southwestern Medical School, Dallas) "Viral vectors with inducible acute-phase protein promoters"
- Stephen Johnson, Ph.D., Ph.D.,(Assistant Professor University of Texas Southwestern Medical School, Dallas) "Expression library immunization"
SESSION NINE. Thursday P.M.
Plants, antibodies, and vaccines
- Myrone Levine, M.D., (Center for Vaccine Development, University of Maryland, Baltimore) Discussion Leader
- Charles Arntzen, Ph.D, (now Professor, University of Texas Medical Center, Houston; will be President and Chief Executive Officer, Boyce Thompson Institute for Plant Research, Ithaca, New York) "Transgenic plants as vaccine vectors-the technology"
- John Clements, Ph.D., (Professor, Tulane Medical Center, New Orleans, Louisiana)"Transgenic plants as vaccine vectors-the biology"
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