| SUNDAY PM |
Regulation of gene expression |
- 7:15pm - Introduction/Welcome
- 7:30pm - Victor DiRita Ph.D. (University of Michigan, Ann Arbor) Discussion Leader - Overview of Session
- 7:40pm - Michele Swanson Ph.D. (University of Michigan, Ann Arbor)
"Expression of Legionella pneumophila virulence traits in response to amino acid deprivation".
- 8:15pm - Discussion
- 8:25pm - Guangyong Ji, Ph.D. (Uniformed Services University of the Health Sciences, Bethesda)
"Regulation of staphylococcal virulence by autoinducing peptides"
- 9:00pm - Discussion
- 9:10pm - Scott Stibitz Ph.D. (Center for Biologics Evaluation and Research/FDA, Bethesda)
"Differential transcriptional activation of virulence genes in Bordetella pertussis by the response regulator BvgA".
- 9:45pm - Discussion
- 9:00am - John Mekalanos, Ph.D. (Harvard Medical School, Boston) Discussion Leader - Overview of Session
- 9:10am - David Relman, M.D., Ph.D. (Stanford University School of Medicine, Stanford)
"Emerging infections: Identification of new or previously undetected pathogens".
- 9:40am - Discussion
- 9:50am - James Musser, M.D., Ph.D. (Baylor College of Medicine, Houston
"Lessons learned from analysis of allelic variation in virulence genes of emerged bacterial pathogens".
- 10:20am - Discussion
- 10:30am - Coffee Break
- 10:45am - Doug Brutlag (Stanford University School of Medicine, Stanford)
"EMOTIF: Using highly specific sequence motifs to identify bacterial genes".
- 11:15am - Discussion
- 11:25am - John Mekalanos, Ph.D. (Harvard Medical School, Boston)
"Functional genomics: A GAMBIT on the edge of the abbis"
- 11:55am - Discussion
- 12:15pm - Photograph
- 12:30pm - Lunch
| MONDAY PM |
In vivo apoptosis |
- 7:15pm - Alison O'Brien, Ph.D. (Uniformed Services University of Health Sciences, Bethesda) Discussion Leader - Overview of Session
- 7:25pm - Arturo Zychlinsky, Ph.D. (New York University School of Medicine, New York)
"Apoptosis in dysentery".
- 8:00pm - Discussion
- 8:10pm - Denise M. Monack, Ph.D. (Stanford University School of Medicine, Stanford)
"Yersinia-induced apoptosis in macrophages: the role in pathogenesis.
- 8:45pm - Discussion
- 8:55pm - Lee Ann Sporn, Ph.D. (University of Rochester School of Medicine, Rochester)
"NF-kappa B activation and host cell survival during infection with Rickettsia rickettsii"
- 9:30pm - Discussion
| TUESDAY AM |
Secretion of toxins/virulence factors |
- 9:00am - Drusilla Burns, Ph.D. (Center for Biologics Evaluation and Research/FDA, Bethesda) Discussion Leader - Overview of Session
- 9:10am - Peter Christie, Ph.D. (University of Texas Health Sciences Center, Houston)
"The agrobacterium T-complex transporter: a paradigm for understanding assembly pathways for toxin secretion systems".
- 9:40am - Discussion
- 9:50am - Dara Frank, Ph.D. (Medical College of Wisconsin, Milwaukee)
"Role of protein secretion in the action of exoenzymes S from Pseudomonas aeruginosa".
- 10:20am - Discussion
- 10:30am - Coffee Break
- 10:45am - Olaf Schneewind, Ph.D. (University of California, Los Angeles)
"Secretion and Targeting of Yop Proteins by the Type III pathway of Yersinia Enterocolitica"
- 11:15am - Discussion
- 11:25am - Camille Locht, Ph.D. (Institut Pasteur, Lille)
"Secretion of the Bordetella pertussis filamentous hemagglutinin and its use for the presentation of foreign antigens".
- 11:55am - Discussion
- 12:30pm - Lunch
| TUESDAY PM |
Microbe-host signaling |
- 7:15pm - Guy Cornelis, Ph.D. (Catholic University of Louvain, Brussells) Discussion Leader - Overview of Session
- 7:25pm - Vernon Carruthers, Ph.D. (Johns Hopkins University School of Hygiene and Public Health, Baltimore)
"Polarized secretion of Toxoplasma gondii" adhesins is triggered by a calcium-dependent signaling pathway in the parasite
- 8:00pm - Discussion
- 8:10pm - Gail Hecht, M.D. (University of Illinois, Chicago)
"Enteropathogenic E. coli-induced signaling pathways: Functional consequences in host intestinal epithelial cells".
- 8:45pm - Discussion
- 8:55pm - Brett Finlay, Ph.D. (University of British Columbia, Vancouver)
"Enteropathogenic and enterohemorrhagic E. coli interactions with host cells".
- 9:30pm - Discussion
| WEDNESDAY AM |
Recent advances in technology applicable to toxin/pathogenesis research |
- 9:00am - Joseph Barbieri, Ph.D. (Medical College of Wisconsin, Milwaukee) Discussion Leader - Overview of Session
- 9:10am - Murray Hackett, Ph.D. (University of Washington, Seattle)
"Mass spectrometry and microbial pathogenesis".
- 9:40am - Discussion
- 9:50am - Wayne Hubbell, Ph.D. (University of California, Los Angeles)
"Site-directed spin labeling studies of membrane protein structure".
- 10:20am - Discussion
- 10:30am - Coffee Break
- 10:45am - Haian Fu, Ph.D. (Emory University, Atlanta)
"Direct interaction of exoenzyme S of Pseudomonas aeruginosa with 14-3-3 proteins determined by surface plasmon resonance".
- 11:15am - DIscussion
- 11:25am - Harry Mobley, Ph.D. (University of Maryland School of Medicine, Baltimore)
"Analysis of the in vivo expression of bacterial virulence factors, utilizing green fluorescence protein reporters".
- 11:55am - Discussion
- 12:30pm - Lunch
| WEDNESDAY PM |
New Toxins/Mechanisms |
- 7:15pm - Jim Kaper, Ph.D. (University of Maryland School of Medicine, Baltimore) Discussion Leader - Overview of Session
- 7:25pm - William Goldman, Ph.D. (Washington University School of Medicine, St. Louis)
"How peptidoglycan became an exotoxin"
- 8:00pm - Discussion
- 8:10pm - James P. Nataro, M.D., Ph.D. (University of Maryland School of Medicine, Baltimore)
"Autotransporter toxins in EAEC pathogenesis".
- 8:45pm - Discussion
- 8:55pm - Pamela Small, Ph.D. (Rocky Mountain Lab, Hamilton)
"Structure and biological activity of a polyketide cytotoxin from Mycobacteria ulcerans"
- 9:30pm - Discussion
| THURSDAY AM |
Structural biology of toxins/virulence factors |
- 9:00am - R. John Collier, Ph.D. (Harvard Medical School, Boston) Discussion Leader - Overview of Session
- 9:10am - Borden Lacy (University of California, Berkeley)
"Structures of the 150 kDa botulinum neurotoxin and the 900 kDa botulinum neurotoxin complex".
- 9:40am - Discussion
- 9:50am - Rodney K. Tweten Ph.D. (University of Oklahoma Health Sciences Center, Oklahoma City)
"Chaperone function of the propeptide of Clostridium septicum alpha toxin".
- 10:20am - Discussion
- 10:30am - Coffee Break
- 10:45am - F.G. Van der Goot, Ph.D. (University of Geneva, Geneva)
"Structure and function of aerolysin"
- 11:15am - Discussion
- 12:30pm - Lunch
| THURSDAY PM |
Plant pathogens and shared virulence factors |
- 7:15pm - Erik L. Hewlett, M.D. (University of Virginia School of Medicine, Charlottesville) Discussion Leader - Overview of Session
- 7:20pm - Frederick M. Ausubel Ph.D. (Harvard Medical School, Boston)
"Use of model plant, nematode, and insect hosts to identify Pseudomonas aeruginosa virulence factors".
- 8:00pm - Discussion
- 8:10pm - Brian Staskawicz, Ph.D. (University of California, Berkeley)
"Signalling in bacteria-plant interactions".
- 8:50pm - Discussion
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