| Sunday, July 16 PM |
Session 1: New Toxins/New Insights |
Discussion leader: Erik Hewlett (University of Virginia)
- Michael Gilmore (Oklahoma University Health Services Center)
Expression and maturation of a novel three-component modified protein toxin that contributes to the pathogenesis of enterococcal infection
- David Acheson (Tufts University/New England Medical Center)
Shiga toxins effect on chemokine expression in intestinal epithelial cells
- Timothy Hirst (University of Bristol)
Cholera toxin's Achilles' heel
- Partho Ghosh (University of California, San Diego)
Molecular recognition and catalysis by cytotoxic necrotizing factor 1
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| Monday, July 17 AM |
Session 2: DNA Arrays & Genomics |
Discussion leader: John Mekalanos (Harvard University)
- Steve Lory (University of Washington)
Use of microarrays to monitor evolution and global gene expression in Pseudomonas aeruginosa
- Karen Guillemin (Stanford University)
Microanalysis of Helicobacter pylori - host interactions
- Xavier Nassif (INSERM, Paris)
Comparative genomics of the neisseria using microarrays
- Fred Blattner (University of Wisconsin)
The "pathosphere" of enteric genomic sequences
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| Monday, July 17 PM |
Session 3: Interaction with host cell receptors & cytoskeleton |
Discussion leader: Dan Portnoy (University of California, Berkeley)
- Maggie So (Oregon Health Sciences University)
Type IV pilus retraction drives bacterial motility
- Gail Hecht (University of Illinois, Chicago)
Enteric pathogen-induced upregulation of galanin receptor expression in intestinal epithelia: A novel mechanism of enhanced chloride secretion
- Matthew Welch (University of California, Berkeley)
Interaction of the host Arp2/3 complex and the Listeria monocytogenes ActA protein in actin polymerization and bacterial motility
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| Tuesday, July 18 AM |
Session 4: Regulation of virulence gene expression |
Discussion leader: Ron Taylor (Dartmouth Medical School)
- Virginia Miller (Washington University)
A chromosomal regulator of invasion and virulence of Yersinia enterocolitica
- Ambrose Cheung (Dartmouth Medical School)
Regulation of α-hemolysin in Staphylococcus aureus
- Bonnie Bassler (Princeton University)
The luxS quorum sensing system
- Andrew Camilli (Tufts University)
Investigation of V. cholerae gene expression during infection
- Vanessa Sperandio (University of Maryland)
Quorum sensing: a key player in regulation of virulence and non-virulence factors in enterohemorrhagic E. coli O157:H7
- June Scott (Emory University)
Rns, the prototype for a new class of activators that use upstream and downstream binding sites
|
| Tuesday, July 18 PM |
Session 5: Novel animal/cell models of infection |
Discussion leader: Alison O'Brien (Uniformed Services University)
- Ann Jerse (Uniformed Services University)
Estradiol-treated mice for studying Neisseria gonorrhoeae infections
- Michele Trucksis (University of Maryland)
Signature-tagged mutagenesis using a goldfish model of mycobacterial pathogenesis
- Cammie Lesser (University of Washington)
Development of Saccharomyces cerevisiae as a model system to study pathogenic bacterial proteins
- Short talk:
Gee Lau (Massachusetts General Hospital)
Development of Drosophila melanogaster as a model system to study bacterial pathogenesis
|
| Wednesday, July 19 AM |
Session 6: Innate Immunity |
Discussion leader: Sam Miller (University of Washington)
- Ruslan Medzhitov (Yale University)
The Toll receptor family and control of immunity
- Doug Golenbock (Boston University)
Toll-like receptor 4 and MD-2: specific components of the LPS recognition system and targets for anti-sepsis therapy
- Jerry Weiss (University of Iowa)
Molecular and physical determinants of interactions of endotoxin with specific host targets
- Agneta Richter Dahlfors (Karolinska Institute)
Innate immune responses upon host-pathogen interactions at epithelial linings
- Ferric Fang (University of Colorado)
Salmonella interactions with mononuclear phagocytes
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| Wednesday, July 19 PM |
Session 7: Intracellular pathogens |
Discussion leader: Ralph Isberg (Tufts University)
- Hélène Bierne (Institut Pasteur)
InlB, the broad host range invasion protein of Listeria monocytogenes
- Philippe Sansonetti (Institut Pasteur)
Shigella invasion of epithelial cells: molecular mechanisms and consequences
- Richard Stephens (UC Berkeley)
Processes of Chlamydia Infection of Eukaryotic Cells
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| Thursday, July 20 AM |
Session 8: Host - Pathogen Interactions |
Discussion leader: Bill Goldman (Washington University)
- Joanne Engel (University of California, San Francisco)
Inhibition of internalization by Pseudomonas aeruginosa
- Christoph Dehio (University of Basel)
Bartonella interaction with erythrocytes and endothelial cells
- Gerry Byrne (University of Wisconsin)
Chlamydia pneumoniae and the pathogenesis of atherosclerosis
- Mike Vasil (University of Colorado)
Eucaryotic and prokaryotic phospholipases C and D in host-microbe interactions
- Rino Rappuoli (IRIS/Chiron, Siena)
Translocation of CagA into host cells via a type IV secretion pathway
- Jorge Giron (University of Maryland)
Cell contact stimulates induction of flagella with adhesive properties in Enteropathogenic E. Coli (EPEC)
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| Thursday, July 20 PM |
Session 9: Translocation of virulence factors |
Discussion leader: Jim Kaper (University of Maryland)
- Kelly Hughes (Univ. of Washington)
Say goodbye to Type III secretion chaperones and hello to Type III translation/secretion couplers
- Dr. Vassilis Koronakis (Cambridge University)
Type I toxin export and multidrug efflux via the TolC channel-tunnel
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