| SUNDAY |
| 2:00 pm - 11:00 pm | Arrival and Check-in |
| 4:00 pm - 6:00 pm | Reception |
| 6:00 pm | Dinner |
| 7:30 pm - 7:40 pm | Welcome and introductory comments |
| 7:40 pm - 9:30 pm | Host-Pathogen Interactions |
| 7:40 pm - 7:50 pm | Discussion Leader: Virginia Miller (Washington University School of Medicine) |
| 7:50 pm - 8:15 pm | William Goldman (Washington University School of Medicine)
"An inside look at primary pneumonic plague" |
| 8:15 pm - 8:25 pm | Discussion |
| 8:25 pm - 8:45 pm | Hattie Gresham (University of New Mexico)
"Innate immunity and control of bacterial quorum sensing" |
| 8:45 pm - 8:55 pm | Discussion |
| 8:55 pm - 9:20 pm | Manuel Amieva (Stanford University)
"Breaching and reaching the junctions: how bacterial pathogens unlock the epithelium" |
| 9:20 pm - 9:30 pm | Discussion |
| MONDAY |
| 7:30 am - 8:30 am | Breakfast |
| 8:30 am | Group Photo |
| 9:00 am - 12:30 pm | Genomics and Gene Regulation |
| 9:00 am - 9:15 am | Discussion Leader: Peggy Cotter (University of California, Santa Barbara) |
| 9:15 am - 9:35 am | Andrew Camilli (Tufts University School of Medicine)
"Cyclic diguanylate signaling in Vibrio cholerae during infection" |
| 9:35 am - 9:50 am | Discussion |
| 9:50 am - 10:10 am | David Relman (Stanford University)
"Genomics, diversity, and human indigenous microbial communities" |
| 10:10 am - 10:25 am | Discussion |
| 10:25 am - 10:55 am | Coffee Break |
| 10:55 am - 11:15 am | Eduardo Groisman (Washington University School of Medicine)
"Signal transduction by the PhoP/PhoQ regulatory system" |
| 11:15 am - 11:30 am | Discussion |
| 11:30 am - 11:50 am | Christopher Sassetti (University of Massachusetts)
"Connecting the dots: mapping functional interactions in Mycobacterium tuberculosis" |
| 11:50 am - 12:10 pm | Michael Gilmore (Harvard Medical School)
"Regulation of virulence traits, including cytolysin, within the pathogenicity island of Enterococcus faecalis" |
| 12:10 pm - 12:25 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Intracellular Pathogens |
| 7:30 pm - 7:45 pm | Discussion Leader: Michele Swanson (University of Michigan Medical School) |
| 7:45 pm - 8:10 pm | John Brumell (Hospital for Sick Children)
"A screen for Rab GTPases associated with the Salmonella-containing vacuole" |
| 8:10 pm - 8:20 pm | Discussion |
| 8:20 pm - 8:45 pm | Barbara Burleigh (Harvard School of Public Health)
"Type I interferon response in Trypanosoma cruzi-infected fibroblasts is triggered by vacuole egress" |
| 8:45 pm - 8:55 pm | Discussion |
| 8:55 pm - 9:20 pm | Mary O'Riordan (University of Michigan Medical School)
"Role of TBK1 in innate immunity to intracellular bacterial pathogens" |
| 9:20 pm - 9:30 pm | Discussion |
| TUESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Toxins and Effectors: Structure, Function, and Mechanism of Action |
| 9:00 am - 9:15 am | Discussion Leader: Joseph Barbieri (Medical College of Wisconsin) |
| 9:15 am - 9:35 am | Roman Melnyk (Harvard Medical School)
"The molecular basis of protein translocation through the anthrax toxin pore" |
| 9:35 am - 9:50 am | Discussion |
| 9:50 am - 10:10 am | Karla Satchell (Northwestern University Medical School)
"Cell rounding by the multifunctional RTX toxin of Vibrio cholerae" |
| 10:10 am - 10:25 am | Discussion |
| 10:25 am - 10:55 am | Coffee Break |
| 10:55 am - 11:15 am | Giampietro Schiavo (London Research Institute)
"Neuronal endocytic trafficking of tetanus toxin" |
| 11:15 am - 11:30 am | Discussion |
| 11:30 am - 11:50 am | Neal Alto (University of California, San Diego)
"GTPase mimicry and subcellular targeting domains of the WxxxE type III effector family" |
| 11:50 am - 12:10 pm | Gudula Schmidt (Universitat Freiberg)
"CNFs: an overview" |
| 12:10 pm - 12:25 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Advancing Technologies and Approaches |
| 7:30 pm - 7:45 pm | Discussion Leader: Erik Hewlett (University of Virginia School of Medicine) |
| 7:45 pm - 8:10 pm | Julian Parkhill (The Sanger Institute)
"Comparative genomic analysis of bacterial pathogens" |
| 8:10 pm - 8:20 pm | Discussion |
| 8:20 pm - 8:45 pm | Darren Higgins (Harvard Medical School)
"Genome-wide approaches to identify host determinants of virulence and antigenic determinants of immunity to intracellular pathogens" |
| 8:45 pm - 8:55 pm | Discussion |
| 8:55 pm - 9:20 pm | Adam Hoppe (University of Michigan)
"FRET microscopy: Imaging the molecular mechanisms of bacterial invasion and innate immune response" |
| 9:20 pm - 9:30 pm | Discussion |
| WEDNESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Toxins, Effectors, and the Cell |
| 9:00 am - 9:15 am | Discussion Leader: James Bliska (SUNY Stony Brook) |
| 9:15 am - 9:35 am | Craig Roy (Yale University School of Medicine)
"Targeting of vesicular transport proteins by Legionella effectors" |
| 9:35 am - 9:50 am | Discussion |
| 9:50 am - 10:10 am | Christoph Dehio (University of Basel)
"Role of type IV secretion in Bartonella pathogenesis" |
| 10:10 am - 10:25 am | Discussion |
| 10:25 am - 10:55 am | Coffee Break |
| 10:55 am - 11:15 am | Daniel Kalman (Emory University School of Medicine)
"How do poxviruses and enteropathogenic E. coli utilize host tyrosine kinases?" |
| 11:15 am - 11:30 am | Discussion |
| 11:30 am - 11:50 am | Steven Blanke (University of Illinois)
"Micromanaging the executioner: Targeting mitochondria within host cells" |
| 11:50 am - 12:10 pm | Wolf-Dietrich Hardt (Eidgenossische Technische Hochschule)
"Salmonella type III secretion: from real time imaging to function" |
| 12:10 pm - 12:25 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:00 pm - 7:30 pm | Business Meeting |
| (Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair) |
| 7:30 pm - 9:30 pm | Pathogenic Strategies |
| 7:30 pm - 7:45 pm | Discussion Leader: Joanne Engel (University of California, San Francisco) |
| 7:45 pm - 8:10 pm | John Mekalanos (Harvard Medical School)
"Functional, structural, and regulatory analysis of the Type VI secretion systems of Vibrio and Pseudomonas" |
| 8:10 pm - 8:20 pm | Discussion |
| 8:20 pm - 8:45 pm | Olaf Schneewind (University of Chicago)
"Sortases and surface proteins - Tool boxes of Staphylococcal pathogenesis" |
| 8:45 pm - 8:55 pm | Discussion |
| 8:55 pm - 9:20 pm | Brett Finlay (University of British Columbia)
"The role of normal flora in diarrhea" |
| 9:20 pm - 9:30 pm | Discussion |
| THURSDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Host Response to Infection |
| 9:00 am - 9:15 am | Discussion Leader: Michael Starnbach (Harvard Medical School) |
| 9:15 am - 9:35 am | Karen Elkins (CBER, FDA)
"Chemokine and cytokine responses to Francisella infection: The host fights back early and often" |
| 9:35 am - 9:50 am | Discussion |
| 9:50 am - 10:10 am | Patrick O'Farrell (University of California, San Francisco)
"A new immunological role for nitric oxide: It acts as a signal stimulating innate immune responses" |
| 10:10 am - 10:25 am | Discussion |
| 10:25 am - 10:55 am | Coffee Break |
| 10:55 am - 11:15 am | JoAnne Flynn (University of Pittsburgh School of Medicine)
"The dynamic nature of T cell responses in the lungs during tuberculosis" |
| 11:15 am - 11:30 am | Discussion |
| 11:30 am - 11:50 am | Jonathan Kagan (Yale University School of Medicine)
"Sorting and signaling adaptor proteins in TLR signal transduction" |
| 11:50 am - 12:10 pm | Andreas Baumler (University of California, Davis)
"Evasion of innate immune surveillance by Salmonella typhi" |
| 12:10 pm - 12:25 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 6:00 pm | Free Time |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Cellular Microbiology |
| 7:30 pm - 7:35 pm | Discussion Leader: Drusilla Burns (CBER, FDA) |
| 7:35 pm - 8:10 pm | Philippe Sansonetti (Institut Pasteur)
"Carving of the host cell transcriptome by Shigella: hobby or necessity?" |
| 8:10 pm - 8:25 pm | Discussion |
| 8:25 pm - 9:00 pm | Ralph Isberg (Tufts University School of Medicine)
"Enteropathogenic Yersinia: Trojan horse at the molecular and cellular level" |
| 9:00 pm - 9:15 pm | Discussion |
| 9:15 pm - 9:30 pm | Closing Discussion |
| FRIDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am | Depart |
