Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: Host-Pathogen-Microbiota Interactions
Discussion Leader: Heran Darwin (New York University School of Medicine, USA)
7:40 pm - 7:45 pm
Introduction by Discussion Leader
7:45 pm - 7:55 pm
Walter Adams (Tufts University, USA)
"Getting Your Neutrophil: Hepoxilin A3 (HXA3)-Dependent Neutrophil Migration During Streptococcus pneumoniae Infection"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 8:10 pm
Jeannette Tenthorey (Fred Hutchinson Cancer Research Center, USA)
"A Multi-Surface Recognition Strategy Constrains Bacterial Immune Evasion"
8:10 pm - 8:15 pm
Discussion
8:15 pm - 8:40 pm
Erin Gaynor (University of British Columbia, Canada)
"Campylobacter jejuni , Fecal Metabolites and a Novel Iron Uptake System"
8:40 pm - 8:45 pm
Discussion
8:45 pm - 9:20 pm
Andreas Baumler (University of California, Davis, USA)
"Salmonella , the Host and Its Gut Microbiota"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
The Dynamics of Pathogens
Discussion Leader: Sarah D'Orazio (University of Kentucky, USA)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:30 am
Robert Abramovitch (Michigan State University, USA)
"Chemical Biology of Mycobacterium tuberculosis Pathogenesis"
9:30 am - 9:35 am
Discussion
9:35 am - 10:00 am
Alan Hauser (Northwestern University, USA)
"The Bacterial Accessory Genome: Concealed Carry"
10:00 am - 10:05 am
Discussion
10:05 am - 10:30 am
Group Photo / Coffee Break
10:30 am - 10:55 am
John Brumell (Hospital for Sick Children, Canada)
"Dissemination of Listeria monocytogenes Within Its Host"
10:55 am - 11:00 am
Discussion
11:00 am - 11:25 am
Stephen Trent (University of Georgia, USA)
"Modifications to Lipid A Are Dynamic in Response to Host Environmental Conditions"
11:25 am - 11:30 am
Discussion
11:30 am - 11:55 am
Stefan Schild (University of Graz, Austria)
"Friend or Foe: Membrane Vesicles of Bacterial Pathogens"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:25 pm
Sam Light (University of California, Berkeley, USA)
"A Conserved Flavin-Mediated Mechanism of Extracellular Electron Transfer"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
Power Hour
The GRC Power Hour is an optional informal gathering open to all meeting participants. It is designed to help address the challenges women face in science and support the professional growth of women in our communities by providing an open forum for discussion and mentoring.
Organizer: Mary O'Riordan (University of Michigan Medical School, USA)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Aspects of the Microbiota and Pathogen Virulence in Disease
Discussion Leader: Jeremiah Johnson (University of Tennessee, USA)
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 8:00 pm
Jenifer Coburn (Medical College of Wisconsin, USA)
"Dissection of the Roles of Multifunctional Borrelia burgdorferi Adhesins In Vivo "
8:00 pm - 8:05 pm
Discussion
8:05 pm - 8:30 pm
James Slauch (University of Illinois at Urbana-Champaign, USA)
"Sensing Spatial Location in the Intestine"
8:30 pm - 8:35 pm
Discussion
8:35 pm - 9:10 pm
Samuel Miller (University of Washington, USA)
"Adaptation of the Microbiota in Cystic Fibrosis"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:30 pm
General Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Toxins and Effector Proteins Pave the Way
Discussion Leader: Wilmara Salgado-Pabón (University of Iowa, USA)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:30 am
James Bliska (Geisel School of Medicine at Dartmouth, USA)
"How Pathogens Coerce Pyrin to Drop Its Guard in Lymphoid and Mucosal Tissues"
9:30 am - 9:35 am
Discussion
9:35 am - 10:00 am
Juliane Bubeck Wardenburg (Washington University in St. Louis, USA)
"Staphylococcus aureus Toxin: Patterning the Host-Bacterial Interaction"
10:00 am - 10:05 am
Discussion
10:05 am - 10:30 am
Victor Torres (New York University School of Medicine, USA)
"Staphylococcus aureus Follows a 'DARC' Path to Lethal Infections"
10:30 am - 10:35 am
Discussion
10:35 am - 11:05 am
Coffee Break
11:05 am - 11:30 am
Alex Ensminger (University of Toronto, Canada)
"Effect the Unexpected: Metaeffectors in Legionella and Beyond"
11:30 am - 11:35 am
Discussion
11:35 am - 12:00 pm
Joseph Vogel (Washington University in St. Louis, USA)
"Structural Analysis of the Legionella Dot/Icm T4SS"
12:00 pm - 12:05 pm
Discussion
12:05 pm - 12:25 pm
Katharina Kubatzky (University Hospital Heidelberg, Germany)
"Pasteurella multocida Toxin Hijacks the Host Cell Metabolism"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Toxins: Action, Targeting and Structure
Discussion Leader: Stephanie Shames (Kansas State Univerisity, USA)
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 8:00 pm
Joseph Barbieri (Medical College of Wisconsin, USA)
"Entry Pathways of the Clostridial Neurotoxins"
8:00 pm - 8:05 pm
Discussion
8:05 pm - 8:30 pm
Peter Sebo (Institute of Microbiology of the Czech Academy of Sciences, v.v.i., Czech Republic)
"The How and Why of Bordetella Adenylate Cyclase Toxin"
8:30 pm - 8:35 pm
Discussion
8:35 pm - 9:00 pm
Steven Blanke (University of Illinois at Urbana-Champaign, USA)
"Unexpected Convergence Between Bacterial Development and Intracellular Egress"
9:00 pm - 9:05 pm
Discussion
9:05 pm - 9:25 pm
Kimberly Kline (Nanyang Technological University, Singapore)
"Mechanisms of Enterococcus faecalis Persistence During Chronic Wound Infections"
9:25 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Pathogenesis and New Approaches
Discussion Leader: Rebecca Lamason (Massachusetts Institute of Technology, USA)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:30 am
Timothy Cover (Vanderbilt University School of Medicine, USA)
"Helicobacter pylori Diversity and Gastric Cancer Risk"
9:30 am - 9:35 am
Discussion
9:35 am - 10:00 am
Deborah Hung (Broad Institute / Harvard Medical School / Massachusetts General Hospital, USA)
"Single Cell Behavior During Infection and Antibiotic Resistance"
10:00 am - 10:05 am
Discussion
10:05 am - 10:30 am
Christopher Sassetti (University of Massachusetts, USA)
"Systems Genetic Analysis of Tuberculosis Susceptibility"
10:30 am - 10:35 am
Discussion
10:35 am - 11:05 am
Coffee Break
11:05 am - 11:30 am
Hank Seifert (Northwestern University, USA)
"Mechanisms of Gene Diversification in the Pathogenic Neisseria "
11:30 am - 11:35 am
Discussion
11:35 am - 12:00 pm
Marvin Whiteley (Georgia Institute of Technology, USA)
"The Impact of Biogeography on Pathogenesis During Polymicrobial Infection"
12:00 pm - 12:05 pm
Discussion
12:05 pm - 12:25 pm
Neal Hammer (Michigan State University, USA)
"Persistence, Metabolic Flexibility and Antibiotic Resistance in Staphylococcus aureus "
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
Close Encounters with the Host Cell
Discussion Leader: Michelle Reniere (University of Washington, USA)
7:30 pm - 7:55 pm
Peggy Cotter (University of North Carolina at Chapel Hill, USA)
"Integration of Signal Transduction Pathways for Survival of Bordetella in both Mammalian and Non-Mammalian Eukaryotic Hosts"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 8:25 pm
Kelly Doran (University of Colorado School of Medicine, USA)
"Modulation of Blood Brain Barrier Permeability During Group B Streptococcal Meningitis"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:55 pm
Vanessa Sperandio (University of Texas Southwestern Medical Center, USA)
"You're Hot and You're Cold: Neurotransmitters Modulation of Bacterial Virulence Gene Expression"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:25 pm
Jay Zhu (University of Pennsylvania, USA)
"S-Nitrosylation of a Virulence Regulator Shapes Vibrio cholerae Intestinal Infection Landscapes"
9:25 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Immune Responses and Pathogenesis
Discussion Leader: Daniel Portnoy (University of California, Berkeley, USA)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:30 am
Lee-Ann Allen (University of Iowa, USA)
"Neutrophil Plasticity and Helicobacter pylori Pathogenesis"
9:30 am - 9:35 am
Discussion
9:35 am - 10:00 am
Russell Vance (University of California, Berkeley, USA)
"A Unified Mechanism for Innate Detection of Diverse Bacterial Toxins"
10:00 am - 10:05 am
Discussion
10:05 am - 10:30 am
Igor Brodsky (University of Pennsylvania, USA)
"Regulation of Inflammatory Cell Death During Bacterial Infection"
10:30 am - 10:35 am
Discussion
10:35 am - 11:05 am
Coffee Break
11:05 am - 11:30 am
Mary O'Riordan (University of Michigan Medical School, USA)
"Cells on Fire: Control of Inflammation and Host Defense by Cellular Stress Responses"
11:30 am - 11:35 am
Discussion
11:35 am - 12:00 pm
Christina Stallings (Washington University in St. Louis School of Medicine, USA)
"Outcomes of the Interactions Between Neutrophils and Mycobacterium tuberculosis "
12:00 pm - 12:05 pm
Discussion
12:05 pm - 12:25 pm
Francis Alonzo (Loyola University Chicago, USA)
"Control of Innate Immune Cell Activation by Staphylococcus aureus "
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 5:30 pm
Poster Session
5:30 pm - 7:30 pm
Keynote Session: Host-Pathogen Biochemistry
Discussion Leaders: Walter Adams (Tufts University, USA) and Jeannette Tenthorey (Fred Hutchinson Cancer Research Center, USA)
5:30 pm - 5:40 pm
Aaron Whiteley (Harvard Medical School, USA)
"Bacterial cGAS-Like Enzymes at the Host-Pathogen Interface"
5:40 pm - 5:45 pm
Discussion
5:45 pm - 5:55 pm
Elisabet Bjanes (University of Pennsylvania, USA)
"The Mitochondrial Protein CARD19 Regulates a Cell Death Checkpoint Downstream of Caspase Activation and Gasdermin D Cleavage"
5:55 pm - 6:00 pm
Discussion
6:00 pm - 6:35 pm
Matthias Machner (National Institutes of Health, USA)
"Molecular Mechanisms of Host Cell Manipulation by Legionella "
6:35 pm - 6:45 pm
Discussion
6:45 pm - 7:20 pm
Kim Orth (Howard Hughes Medical Institute / University of Texas Southwestern Medical Center, USA)
"Black Spot, Black Death, Black Pearl: The Tales of Bacterial Effectors"
7:20 pm - 7:30 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure