Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: Virulence Regulation During Infections
Discussion Leader: Andrew Darwin (New York University School of Medicine, United States)
7:40 pm - 7:50 pm
Introduction by Discussion Leader
7:50 pm - 8:05 pm
Andrew Perault (New York University Grossman School of Medicine, United States)
"Comparative Genomics-Driven Investigation of Enterobacter Pathogenesis"
8:05 pm - 8:15 pm
Discussion
8:15 pm - 8:30 pm
Britney Hardy (National Cancer Institute, United States)
"Lung Commensal Bacterium Arrests Growth of the Pathogen Pseudomonas aeruginosa via Reactive Nitrogen Species"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:20 pm
Virginia Miller (University of North Carolina at Chapel Hill, United States)
"The Long and Sticky Road to RmpD and Wzc"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Bacterial Toxins: Structure, Function and Outcome
Discussion Leader: Victor Torres (New York University Grossman School of Medicine, United States)
9:00 am - 9:15 am
Introduction by Discussion Leader
9:15 am - 9:35 am
Andreas Peschel (University of Tübingen, Germany)
"The Staphylococcus Peptide Armory - Toxins, Modulins, Antimicrobials"
9:35 am - 9:45 am
Discussion
9:45 am - 10:05 am
Christopher Hayes (University of California, Santa Barbara, United States)
"Licensed to Kill: Post-Translational Activation of a Phospholipase Toxin"
10:05 am - 10:15 am
Discussion
10:15 am - 10:45 am
Coffee Break
10:45 am - 11:05 am
Jeongmin Song (Cornell University, United States)
"Salmonella typhi 's Success: A Glycobiology Perspective"
11:05 am - 11:15 am
Discussion
11:15 am - 11:35 am
Borden Lacy (Vanderbilt University School of Medicine, United States)
"Molecular Mechanisms of Clostridioides difficile Toxin Action"
11:35 am - 11:45 am
Discussion
11:45 am - 11:55 am
Horst Posthaus (University of Bern, Switzerland)
"Functional Analyses of Clostridial Hemolysin Beta-Pore-Forming Toxins"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
Isaac Chiu (Harvard Medical School, United States)
"Bacterial Toxin Interactions with Neurons in Pain and Host Defense"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hourâ„¢
The GRC Power Hourâ„¢ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
Organizer: Sarah Stanley (University of California, Berkeley, United States)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Toxic Defense Mechanisms
Discussion Leader: Peggy Cotter (University of North Carolina at Chapel Hill, United States)
7:30 pm - 7:45 pm
Introduction by Discussion Leader
7:45 pm - 8:05 pm
Marek Basler (University of Basel, Switzerland)
"Spatial and Temporal Regulation of Type 6 Secretion System Dynamics During Interactions with Bacterial and Eukaryotic Cells"
8:05 pm - 8:15 pm
Discussion
8:15 pm - 8:25 pm
Nathan Bullen (McMaster University, Canada)
"A Bacterial Toxin Inhibits Translation in Competitor Cells"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
Anna Tischler (University of Minnesota, United States)
"New Tn-seq Approaches to Identify Mycobacterium tuberculosis Persistence Mechanisms"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
Sarah Stanley (University of California, Berkeley, United States)
"Weaponizing Metabolism for Control of TB Infection"
9:20 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Subverting Host Functions with Bacterial Toxins and Effectors
Discussion Leader: Eric Skaar (Vanderbilt University Medical Center, United States)
9:00 am - 9:20 am
Introduction by Discussion Leader
9:20 am - 9:40 am
Alecia Septer (University of North Carolina at Chapel Hill, United States)
"The T6SS as a Defensive Weapon During Host Colonization"
9:40 am - 9:50 am
Discussion
9:50 am - 10:10 am
ZhaoQing Luo (Purdue University, United States)
"The ADP-Ribosylation Arsenals of Legionella pneumophila "
10:10 am - 10:20 am
Discussion
10:20 am - 10:55 am
Group Photo / Coffee Break
10:55 am - 11:15 am
Ivan Dikic (Goethe University Frankfurt, Germany)
"Bacterial Virulence Effectors Impact ER and Mitochondria Remodeling in Host Cells"
11:15 am - 11:25 am
Discussion
11:25 am - 11:45 am
Tamara O'Connor (Johns Hopkins University School of Medicine, United States)
"Peroxisomes - A New Player in Bacterial Pathogenesis"
11:45 am - 11:55 am
Discussion
11:55 am - 12:15 pm
Wilmara Salgado Pabón (University of Wisconsin-Madison, United States)
"Staphylococcus aureus Infective Endocarditis: The Secret Life of Superantigens"
12:15 pm - 12:25 pm
Discussion
12:25 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Regulation of Genes and Proteins in Pathogens
Discussion Leader: Raphael Valdivia (Duke University, United States)
7:30 pm - 7:45 pm
Introduction by Discussion Leader
7:45 pm - 8:05 pm
Petra Dersch (University of Münster, Germany)
"Shaping Yersinia Type III Secretion Gene Expression Through Multiple Post-Transcriptional Control Mechanisms"
8:05 pm - 8:15 pm
Discussion
8:15 pm - 8:35 pm
Ankur Dalia (Indiana University, United States)
"Regulation and Mechanisms of Type IV Pilus Dynamic Activity"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 9:05 pm
Aimee Shen (Tufts University School of Medicine, United States)
"Pseudoprotease-mediated Regulation of Clostridioides difficile Spore Germination"
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Jessica Kelliher (University of Wisconsin-Madison, United States)
"PASTA Kinase-Dependent Control of Peptidoglycan Synthesis is Required for Adaptation of Listeria monocytogenes to Cell Wall Stress in the Cytosol"
9:25 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Intracellular Problems and Solutions
Discussion Leader: Joanne Engel (University of California, San Francisco, United States)
9:00 am - 9:20 am
Introduction by Discussion Leader
9:20 am - 9:40 am
Sophie Helaine (Harvard Medical School, United States)
"Unlocking Persister Regrowth During Infection"
9:40 am - 9:50 am
Discussion
9:50 am - 10:10 am
Marcia Goldberg (Massachusetts General Hospital / Harvard Medical School, United States)
"Macrophage Recognition of Shigella "
10:10 am - 10:20 am
Discussion
10:20 am - 10:55 am
Coffee Break
10:55 am - 11:15 am
Isabelle Derré (University of Virginia, United States)
"Chlamydia Intracellular Development"
11:15 am - 11:25 am
Discussion
11:25 am - 11:45 am
Rebecca Lamason (Massachusetts Institute of Technology, United States)
"Understanding the Identity and Functions of the Rickettsia parkeri Secretome"
11:45 am - 11:55 am
Discussion
11:55 am - 12:15 pm
Stephanie Shames (Kansas State University, United States)
"Effector-Mediated Restriction of Legionella pneumophila in Activated Macrophages"
12:15 pm - 12:25 pm
Discussion
12:25 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Discuss Future Dates and Venue; Election of the Next Vice Chair(s)
7:30 pm - 9:30 pm
Evolution of Virulence Factors
Discussion Leader: Manuela Raffatellu (University of California, San Diego, United States)
7:30 pm - 7:45 pm
Introduction by Discussion Leader
7:45 pm - 8:05 pm
Asaf Levy (The Hebrew University of Jerusalem, Israel)
"Systematic Discovery and Function Elucidation of Novel Microbial Toxins"
8:05 pm - 8:15 pm
Discussion
8:15 pm - 8:25 pm
Emily Kibby (University of Colorado Boulder, United States)
"Bacteria Encode NLRs That Protect Against Phage"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
Matthew Waldor (Brigham and Women's Hospital / Harvard University, United States)
"New Axes of Host Defense"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
John Mekalanos (Harvard Medical School, United States)
"Understanding the Emergence of Pandemic Pathogens"
9:20 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Detection and Response to Bacterial Infections
Discussion Leader: Russell Vance (University of California, Berkeley, United States)
9:00 am - 9:20 am
Introduction by Discussion Leader
9:20 am - 9:40 am
Kim Orth (Howard Hughes Medical Institute / University of Texas Southwestern Medical Center, United States)
"To Build or Not to Build: Case Study: Vibrio Parahaemolyticus T3SS2"
9:40 am - 9:50 am
Discussion
9:50 am - 10:10 am
Katrin Mayer-Barber (National Institutes of Health, United States)
"Inflammatory Cytokines and Innate Effector Cells During M. tuberculosis Infection"
10:10 am - 10:20 am
Discussion
10:20 am - 10:55 am
Coffee Break
10:55 am - 11:15 am
Jim Cassat (Vanderbilt University Medical Center, United States)
"The Impact of RANKL Signaling and Monocyte Cell Fate on Innate Immunity to Salmonella "
11:15 am - 11:25 am
Discussion
11:25 am - 11:45 am
Ralph Isberg (Tufts University School of Medicine, United States)
"Temporal Control of L. pneumophila Vacuole Guards and Protection from Host Cell Cytosolic Attack"
11:45 am - 11:55 am
Discussion
11:55 am - 12:15 pm
Mariana Byndloss (Vanderbilt University Medical Center, United States)
"How to Thrive in the Inflamed Gut: Lessons from Salmonella -induced Gastroenteritis"
12:15 pm - 12:25 pm
Discussion
12:25 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Keynote Session: Innate Sensing of Pathogens
Discussion Leader: Kim Orth (Howard Hughes Medical Institute / University of Texas Southwestern Medical Center, United States)
7:30 pm - 7:50 pm
Introduction by Discussion Leader
7:50 pm - 8:00 pm
Stephanie Ragland (Boston Children's Hospital, United States)
"Toll-like Receptors and STING Control Type I Interferon Responses to Diverse Bacteria in Macrophages "
8:00 pm - 8:05 pm
Discussion
8:05 pm - 8:20 pm
Volker Briken (University of Maryland, United States)
"Inhibition of the Host Cell Inflammasome by Mycobacterium tuberculosis "
8:20 pm - 8:25 pm
Discussion
8:25 pm - 9:05 pm
Feng Shao (National Institute of Biological Sciences, Beijing, China)
"Innate Immunity to Cytosolic Bacteria: Pyroptosis & Beyond"
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:30 pm
Closing Remarks
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure