Sunday |
2:00 pm - 9:00 pm | Arrival and Check-in |
6:00 pm | Dinner |
7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
7:40 pm - 9:30 pm | Synthesis
Enabled Biological Studies |
| Discussion Leader: Joanne Harvey (Victoria University of Wellington, New Zealand) |
7:40 pm - 8:10 pm | Emmanuel Theodorakis (University of California, San Diego, USA) "Natural Products: From Flask to Cell" |
8:10 pm - 8:20 pm | Discussion |
8:20 pm - 8:40 pm | Corinna Schindler (University of Michigan, USA) "New Carbocyclization Reactions for the Synthesis of Complex Molecules" |
8:40 pm - 8:50 pm | Discussion |
8:50 pm - 9:20 pm | Armen Zakarian (University of California, Santa Barbara, USA) "Recent Advances in Natural Products Synthesis and Biological Studies" |
9:20 pm - 9:30 pm | Discussion |
Monday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Technology
Driven Chemical Synthesis |
| Discussion Leader: Arun Thottumkara (Revolution Medicines, USA) |
9:00 am - 9:30 am | Timothy Jamison (Massachusetts Institute of Technology, USA) "Continuous Flow Multistep Synthesis" |
9:30 am - 9:40 am | Discussion |
9:40 am - 10:00 am | Alexander Godfrey (Eli Lilly & Co., USA) "Automated Synthesis: An Invitation to the Lab of the Future" |
10:00 am - 10:10 am | Discussion |
10:10 am - 10:40 am | Coffee Break |
10:40 am - 11:10 am | Peter Seeberger (Max Planck Institute of Colloids and Interfaces, Germany) "From Automated Glycan Assembly to Synthetic Vaccines Against Infectious Diseases" |
11:10 am - 11:20 am | Discussion |
11:20 am - 11:50 am | Ian Davies (Merck Research Laboratories, USA) "Big Data and Its Impact on the Synthetic Chemistry Skillset" |
11:50 am - 12:00 pm | Discussion |
12:00 pm - 12:30 pm | Poster Previews |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
3:00 pm - 4:00 pm | Power Hour |
| The GRC Power Hour is an optional informal gathering open to all meeting participants. It is designed to help address the challenges women face in science and support the professional growth of women in our communities by providing an open forum for discussion and mentoring. |
| Organizer: Michelle Garnsey (Pfizer, Inc., USA) |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Antibiotic Discovery |
| Discussion Leader: Marcy Balunas (University of Connecticut, USA) |
7:30 pm - 8:00 pm | Christian Melander (North Carolina State University, USA) "Adjunctive Approaches to Break Antibiotic Resistance" |
8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:40 pm | Stefan Koenig (Genentech, Inc., USA) "Arming S. aureus-Targeting Antibody-Antibiotic Conjugates (AACs) Through Process Chemistry" |
8:40 pm - 8:50 pm | Discussion |
8:50 pm - 9:20 pm | Elizabeth Nolan (Massachusetts Institute of Technology, USA) "Siderophores, Antibiotics and the Microbiota" |
9:20 pm - 9:30 pm | Discussion |
Tuesday |
7:30 am - 8:30 am | Breakfast |
8:30 am | Group Photo |
9:00 am - 12:30 pm | Next Generation Drug Discovery |
| Discussion Leader: Leslie Aldrich (University of Illinois at Chicago, USA) |
9:00 am - 9:25 am | Paul Fatheree (Theravance, USA) "The Chemistry and Preclinical Biology of Novel Polymyxin Antibacterials for the Treatment of Gram Negative Infections" |
9:25 am - 9:35 am | Discussion |
9:35 am - 10:00 am | Denise Barrault (National Phenotypic Screening Centre, United Kingdom) "Public-Private Partnerships that Drive Innovation in Drug Discovery" |
10:00 am - 10:10 am | Discussion |
10:10 am - 10:40 am | Coffee Break |
10:40 am - 11:10 am | Stephen Frye (University of North Carolina at Chapel Hill, USA) "Chemical Biology of Methyl Lysine" |
11:10 am - 11:20 am | Discussion |
11:20 am - 11:50 am | Hendrik Luesch (University of Florida, USA) "Multilevel Characterization of Natural Products from Marine Cyanobacteria" |
11:50 am - 12:00 pm | Discussion |
12:00 pm - 12:30 pm | Poster Previews |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Chemistry of the Human Microbiome |
| Discussion Leader: Sean Davies (Vanderbilt University, USA) |
7:30 pm - 8:00 pm | Michael Fischbach (University of California, San Francisco, USA) "Small Molecules from the Human Microbiota" |
8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:40 pm | Emily Balskus (Harvard University, USA) "Gut Reactions: Chemical Discovery and the Human Microbiota" |
8:40 pm - 8:50 pm | Discussion |
8:50 pm - 9:20 pm | Pieter Dorrestein (University of California, San Diego, USA) "Global Natural Products Social Molecular Networking in Space and Time" |
9:20 pm - 9:30 pm | Discussion |
Wednesday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Strategies and Tactics for Chemical Synthesis |
| Discussion Leader: Joshua Pierce (North Carolina State University, USA) |
9:00 am - 9:30 am | Patrick Harran (University of California, Los Angeles, USA) "Crafting Macrocycles with Designed Scaffolding" |
9:30 am - 9:40 am | Discussion |
9:40 am - 10:00 am | Rendy Kartika (Louisiana State University, USA) "New Chemistries with Oxyallyl Cations" |
10:00 am - 10:10 am | Discussion |
10:10 am - 10:40 am | Coffee Break |
10:40 am - 11:10 am | Paul Floreancig (University of Pittsburgh, USA) "Transposition Reactions for Increasing Molecular Complexity" |
11:10 am - 11:20 am | Discussion |
11:20 am - 11:50 am | Toshiaki Sunazuka (The Kitasato Institute, Kitasato University, Japan) "Synthetic Strategy for Construction of Unique Polycyclic Natural Products" |
11:50 am - 12:00 pm | Discussion |
12:00 pm - 12:30 pm | Poster Previews |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:00 pm - 7:30 pm | Business Meeting |
| Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair |
7:30 pm - 9:30 pm | Biosynthesis-Inspired Technologies |
| Discussion Leader: Wendy Kelly (Georgia Institute of Technology, USA) |
7:30 pm - 8:00 pm | Adrian Keatinge-Clay (University of Texas at Austin, USA) "Visualizing and Harnessing Polyketide Assembly Lines" |
8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:40 pm | Michael Burkart (University of California, San Diego, USA) "Directing Natural Product Biosynthesis in the Acetate Pathway" |
8:40 pm - 8:50 pm | Discussion |
8:50 pm - 9:20 pm | Michelle Chang (University of California, Berkeley, USA) "Synthetic Biology Approaches to New Fluorine Chemistry" |
9:20 pm - 9:30 pm | Discussion |
Thursday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Drug Discovery Platforms for Cancer and Rare Diseases |
| Discussion Leader: Michelle Garnsey (Pfizer, Inc., USA) |
9:00 am - 9:30 am | Andres Francesch (Pharmamar, Spain) "Discovery and Development of Marine Anticancer Drugs" |
9:30 am - 9:40 am | Discussion |
9:40 am - 10:10 am | Roger Linington (Simon Fraser University, Canada) "Towards Universal Compound Discovery: Applications of the Natural Products Atlas" |
10:10 am - 10:20 am | Discussion |
10:20 am - 10:50 am | Coffee Break |
10:50 am - 11:05 am | Selected from Poster Abstracts: Alexander Grenning (University of Florida, USA) "A Tunable Terpenoid Synthesis Strategy" |
11:05 am - 11:10 am | Discussion |
11:10 am - 11:40 am | Qiu Wang (Duke University, USA) "Leveraging Chemistry for Biology and Therapy: New Amination Strategies to Access Biologically Important Molecules" |
11:40 am - 11:50 am | Discussion |
11:50 am - 12:20 pm | Mark O'Neil-Johnson (Sequoia Sciences, Inc., USA) "Has Combinatorial Chemistry Hurt Us All?" |
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Keynote Session: State-of-the-Art Chemistry and Biology |
| Discussion Leader: Jon Rainier (University of Utah, USA) |
7:30 pm - 8:00 pm | Gabriela Chiosis (Memorial Sloan Kettering Cancer Center, USA) "The Chaperome as a Target in Cancer" |
8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:40 pm | Stephen Moss (Isomerase Therapeutics, United Kingdom) "Natural Product Drug Discovery Through Biosynthetic Engineering" |
8:40 pm - 8:50 pm | Discussion |
8:50 pm - 9:20 pm | Thomas Hoye (University of Minnesota, USA) "Natural Product vis-à-vis Benzyne Chemistry" |
9:20 pm - 9:30 pm | Discussion |
Friday |
7:30 am - 8:30 am | Breakfast |
9:00 am | Departure |