Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Novel Catalytic Strategies
Discussion Leader: Elaine Lee (Vertex Pharmaceuticals, USA)
7:40 pm - 8:05 pm
Nick Desrosiers (Boehringer-Ingelheim, USA)
"Development of Novel Non-Precious Metal Catalyzed Methodologies for the Synthesis of Biologically Active Heterocyclic Compounds"
8:05 pm - 8:15 pm
Discussion
8:15 pm - 8:40 pm
Kami Hull (University of Illinois at Urbana-Champaign, USA)
"Transition Metal-Catalyzed Amination and Amidation Reactions"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
Eric Jacobsen (Harvard University, USA)
"Stereoselective Catalysis of Nucleophilic Substitution Reactions"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Discovery of Novel Natural Products
Discussion Leader: Mariya Kozytska (Mersana Therapeutics, USA)
9:00 am - 9:30 am
Mohammad Seyedsayamdost (Princeton University, USA)
"New Approaches for the Discovery of Microbial Natural Products"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
Wenjun Zhang (University of California, Berkeley, USA)
"Discovery of Novel Bioactive Polyketides/Non-Ribosomal Peptides from Microbes"
10:10 am - 10:20 am
Discussion
10:20 am - 10:40 am
Coffee Break
10:40 am - 11:10 am
Daniel Gray (Warp Drive Bio, Inc., USA)
"Harnessing Genomic Information to Engineer the Biosynthesis of Natural Products"
11:10 am - 11:20 am
Discussion
11:20 am - 11:50 am
Sean Brady (Rockefeller University, USA)
"Culture Independent Approaches for the Discovery of New Bacterial Metabolites"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
Power Hour
The GRC Power Hour is an optional informal gathering open to all meeting participants. It is designed to help address the challenges women face in science and support the professional growth of women in our communities by providing an open forum for discussion and mentoring.
Organizers: Elizabeth Swift (AbbVie, USA) and Sarah Reisman (California Institute of Technology, USA)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Innovations in Drug Discovery
Discussion Leader: Matthew Lamarche (Novartis, USA)
7:30 pm - 8:00 pm
Siegfried Reich (eFFECTOR Therapeutics, USA)
"Correcting Disregulated Translation: Disciplined Structure-Based Inhibitor Design of eFT508 for the Treatment of Cancer"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
Cheryl Hayward (Pfizer, USA)
"Scaling Highly Potent Bifunctional Duocarmycin Derivatives for Treatment of Cancer"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
Samarjit Patnaik (National Center for Advancing Translational Sciences, NIH, USA)
"Bioactivity and Mechanism of Action of N-Docosahexaenoylethanolamine Derivatives in Neuronal Development"
9:20 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Natural Products Biosynthesis
Discussion Leader: Ryan Phelan (AbbVie, USA)
9:00 am - 9:30 am
Elizabeth Sattley (Stanford University, USA)
"Discovery and Engineering of Plant Chemistry"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
Amy Lane (University of North Florida, USA)
"Harnessing the Biosynthetic Capabilities of Marine Actinomycetes"
10:10 am - 10:20 am
Discussion
10:20 am - 10:40 am
Coffee Break
10:40 am - 11:10 am
Anne Osbourn (John Innes Centre, United Kingdom)
"Harnessing Plant Metabolic Diversity"
11:10 am - 11:20 am
Discussion
11:20 am - 11:50 am
Jay Keasling (Lawrence Berkeley National Laboratory, USA)
"Engineered Polyketide Synthases for Production of Commodity and Specialty Chemicals"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
The Chemistry, Structure and Function of Complex Glycosides
Discussion Leader: Katie Garber (St. Norbert College, USA)
7:30 pm - 8:00 pm
Jennifer Kohler (University of Texas Southwestern Medical Center, USA)
"New Chemical Biology Methods to Uncover the Functional Roles of Glycosylation"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
Lai-Xi Wang (University of Maryland, College Park, USA)
"Chemoenzymatic Synthesis of Glycoproteins for Probing Functions"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
Laura Kiessling (University of Wisconsin-Madison, USA)
"Chemistry to Explore and Exploit Microbial Carbohydrates for Health and Disease"
9:20 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Structurally Complex Natural Products Synthesis
Discussion Leader: Cedric Hugelshofer (University of California, Berkeley, USA)
9:00 am - 9:30 am
Thomas Maimone (University of California, Berkeley, USA)
"Synthesis of Complex Terpenes from Simple Precursors"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
Ryan Shenvi (Scripps Research Institute, USA)
"Chemical Synthesis of Secondary Metabolites"
10:10 am - 10:20 am
Discussion
10:20 am - 10:40 am
Coffee Break
10:40 am - 11:10 am
Ang Li (Chinese Academy of Sciences, China)
"Total Synthesis of Polycyclic Natural Products"
11:10 am - 11:20 am
Discussion
11:20 am - 11:50 am
Sarah Reisman (California Institute of Technology, USA)
"Building Bridges: Strategies for the Synthesis of Complex Polycyclic Natural Products"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
Rare and Neglected Disease Research
Discussion Leader: Thomas Von Geldern (Embedded Consulting, USA)
7:30 pm - 8:00 pm
Benjamin Perry (Drugs for Neglected Diseases Initiative, Switzerland)
"Collaborative Virtual Screening to Boost Neglected Tropical Disease Drug Discovery"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
Jidong Zhang (Sanofi, France)
"Discovery of Sequanamycin Derivatives as Potent Oral Anti-Tuberculosis Agents"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
Clifton Barry (National Institute of Allergy and Infectious Diseases, NIH, USA)
"Bogged Down: An Ecology-Inspired Search for Novel Antituberculars"
9:20 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
New Approaches to the Study of Bioactive Natural Products
Discussion Leader: Michael Luzzio (Organic Chemist, USA)
9:00 am - 9:30 am
Erin Carlson (University of Minnesota, USA)
"Exploring the Master Regulators of Microbial Behavior"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
Joshua Pierce (North Carolina State University, USA)
"Marine Natural Products Synthesis: A Driving Force for Chemical and Biological Discovery"
10:10 am - 10:20 am
Discussion
10:20 am - 10:40 am
Coffee Break
10:40 am - 11:00 am
Timothy Newhouse (Yale University, USA)
"Total Synthesis of Neurologically Active Terpenoid Natural Products"
11:00 am - 11:10 am
Discussion
11:10 am - 11:40 am
Guangxin Liang (Nankai University, China)
"Syntheses Through 'Seeding and Growing' Strategy Inspired by Molecular Pattern Recognition"
11:40 am - 11:50 am
Discussion
11:50 am - 12:20 pm
Karl Scheidt (Northwestern University, USA)
"Leveraging Carbene Catalysis for Complex Synthesis"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Strategies and Tactics for Chemical Synthesis
Discussion Leader: Elizabeth Swift (AbbVie, USA)
7:30 pm - 7:50 pm
Todd Hyster (Princeton University, USA)
"Unlocking Catalytic Promiscuity with Light: Non-Natural Free Radical Chemistry Within a Protein Active Site"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:30 pm
Kevin Moeller (Washington University, USA)
"From Radical Cations to Microelectrode Arrays to the Valorization of Lignin: Using Principles in Physical Organic Chemistry to Guide Electrochemical Solutions to Modern Synthetic Challenges"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:20 pm
Alexander M. Cruickshank Lecture: David MacMillan (Princeton University, USA)
"New Photoredox Reactions"
9:20 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure
