Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
7:40 pm - 8:00 pm
"Enantioselective Copper-Catalyzed Synthesis of Saturated Cyclic Ethers"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
"Shuttle Catalysis: A Conceptual Blueprint for Reversible Functional Group Transfer"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
"Redox Catalysis Strategies for the Synthesis of Complex Molecules"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Aggressive Bond Disconnections in Total Synthesis
9:00 am - 9:30 am
"New Methods and Strategies in the Synthesis of Natural Products"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
"Non-Aromatic Pi-Bond-Rich Systems as Vehicles for Efficient Total Synthesis"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:20 am
"Synthesis of Complex Anticancer Natural Products"
11:20 am - 11:30 am
Discussion
11:30 am - 12:00 pm
"Recent Progress in the Synthesis of Complex Natural Products"
12:00 pm - 12:10 pm
Discussion
12:10 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Synthetic Biology for Natural Products
7:30 pm - 8:00 pm
"Innovative Approaches for Rapid Scale-up of a Diverse Range of Bio-Products"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
"Heterologous Biosynthesis of Indole-Diterpenes Using New Synthetic Biology Tools"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
"Building a Sequence-to-Molecule Pipeline"
9:20 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Advances in Drug Discovery
9:00 am - 9:30 am
"Lead Optimization: Developing New Antiparasitic Agents from Repurposed Kinase Inhibitor Chemotypes"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
"Discovery and Optimization of Novel, Potent and Orally Bioavailable BCL6-BTB Inhibitors"
10:10 am - 10:20 am
Discussion
10:20 am - 10:40 am
Coffee Break
10:40 am - 11:10 am
"eFT226, a Flavagline Analogue: A Selective and Highly Potent Inhibitor of Eukaryotic Initiation Factor 4A (eIF4A), a Novel Approach for the Treatment of Cancer"
11:10 am - 11:20 am
Discussion
11:20 am - 11:50 am
"Discovery and Development of SJ733, a Novel Antimalarial"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Chemical Probes for Characterizing Biology
7:30 pm - 8:00 pm
"Covalent Targeting of Cancer Associated Proteins with Electrophilic Small Molecules"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
"Application of Clickable Chemical Biology Probes in Drug Discovery"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
"Examining the Virus-Host Interactome Using Activity-Based Probes"
9:20 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Natural Product Discovery and Biosynthesis
9:00 am - 9:30 am
"Gene Activation Strategies in Fungi: New Chemistries and Where to Find Them"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
"Dendral to Deep Learning in Natural Products Chemistry"
10:10 am - 10:20 am
Discussion
10:20 am - 10:40 am
Coffee Break
10:40 am - 11:10 am
"Understanding and Engineering Multifunctional Enzymes for Nonribosomal Peptide Synthesis"
11:10 am - 11:20 am
Discussion
11:20 am - 11:50 am
"New Insights into Dynemicin and Enediyne Antitumor Antibiotic Biosynthesis"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
Combining Synthesis and Biosynthesis to Construct Complex Molecules
7:30 pm - 8:00 pm
"Enzymatic Synthesis of Polycyclic Natural Products In Vivo and Ex Vivo "
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
"Blending Synthetic Chemistry with Synthetic Biology to Access Novel Natural Products"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
"Bio-Synthetic Chemistry and New Drugs from Diverse Microorganisms"
9:20 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
New Directions in Antibiotic Discovery and Development
9:00 am - 9:30 am
"Digging Through the Data: Computational Tools for Genome Mining and Cluster Prioritization"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
"Bioactive Compounds from Nature: Natural Product Research in an Industrial Setting"
10:10 am - 10:20 am
Discussion
10:20 am - 10:40 am
Coffee Break
10:40 am - 11:10 am
"Predicting Antibiotic Mechanism Using Genome-Wide Mutant Fitness Profiling"
11:10 am - 11:20 am
Discussion
11:20 am - 11:50 am
"Starving Bacteria to Find New Antibiotics"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
"Exploiting Natural Products to Design Protein-Protein Interaction Stabilizers"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
The State-of-the-Art in Accessing Complex Molecules
7:30 pm - 8:00 pm
"Pursuing the Ideal Synthesis Nature's Way"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
"Biocatalysis for Natural Products and Their Derivatives"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
"Redesigning Vancomycin for Resistant Bacteria"
9:20 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure