Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: Biomimetic Inspired Synthesis of Natural Products
Discussion Leader: Jonathan Scheerer (William & Mary, United States)
7:40 pm - 8:25 pm
Richmond Sarpong (University of California, Berkeley, United States)
"Skeletal Remodeling and Editing in Natural Product Synthesis"
8:25 pm - 8:35 pm
Discussion
8:35 pm - 9:20 pm
Dirk Trauner (University of Pennsylvania, United States)
"Bioinspired and Bioignorant Synthesis"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Innovative Chemical and Biological Technology
Discussion Leader: Cheryl Hayward (Pfizer, United States)
9:00 am - 9:30 am
Francis Gosselin (Genentech, Inc., United States)
"Multipronged Process Chemistry Towards the Synthesis of Novel Gram-Negative Antibiotics"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
Lisa Marcaurelle (GlaxoSmithKline, United States)
"Identification of Molecular Glues by DNA-Encoded Library Technology"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:20 am
Myles Smith (UT Southwestern Medical Center, United States)
"Symmetry-Driven Total Synthesis of Complex Alkaloids"
11:20 am - 11:30 am
Discussion
11:30 am - 12:00 pm
Derek Tan (Memorial Sloan Kettering Cancer Center, United States)
"SEAKERs: Targeted Cellular Micropharmacies that Generate Small-Molecule Drugs in situ "
12:00 pm - 12:10 pm
Discussion
12:10 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hour™
The GRC Power Hour™ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
Organizer: Cheryl Hayward (Pfizer, United States)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Chemical Biology of Natural Products and Bioactive Compounds
Discussion Leader: Allyson Boyington (Corteva Agriscience, United States)
7:30 pm - 8:00 pm
Amanda Garner (University of Michigan, United States)
"Enabling Technologies for Targeting RNA-Protein Interactions"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
Gavin Williams (North Carolina State University, United States)
"Synthetic Biology Approach to Polyketides and Terpenes"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
Janet Smith (University of Michigan, United States)
"Enzyme Adaptation in Loading Modules of Assembly-Line Biosynthetic Pathways"
9:20 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Novel Synthetic Strategies and Methodology
Discussion Leader: Robert Gaston (West Virginia University, United States)
9:00 am - 9:30 am
Uttam Tambar (University of Texas Southwestern Medical Center, United States)
"Stereoselective Reactions with Feedstock Chemicals"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
Mark Rizzacasa (University of Melbourne, Australia)
"It’s Hip to be Square: Alkyl Citrates Made Easy!"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:20 am
Tehshik Yoon (University of Wisconsin-Madison, United States)
"Sterocontrolled Photochemical Synthesis"
11:20 am - 11:30 am
Discussion
11:30 am - 12:00 pm
Andrew Roberts (University of Utah, United States)
"The Stevens Rearrangement and Deaminative Contraction Cascade Reactions for the Synthesis of Biaryl-linked Natural Products"
12:00 pm - 12:10 pm
Discussion
12:10 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Unique Methods for the Discovery of Natural Products
Discussion Leader: Katie Garber (St. Norbert College, United States)
7:30 pm - 8:00 pm
Ikuro Abe (The University of Tokyo, Japan)
"Unusual Enzyme Reactions in Natural Product Biosynthesis"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
Neha Garg (Georgia Institute of Technology, United States)
"Untargeted Metabolomics in Natural Product Discovery"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
Chambers Hughes (University of Tuebingen, Germany)
"Chemical Labeling for Natural Product Detection and Structure Elucidation"
9:20 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Medicinal Chemistry of Natural Products and Bioactive Compounds
Discussion Leader: Carlos Zepeda Velazquez (Treventis corporation, Canada)
9:00 am - 9:30 am
David Limburg (Pfizer, Inc., United States)
"Discovery of PF-07038124, a Boron Containing Phosphodiesterase 4 inhibitor for the Treatment of Inflammatory Diseases"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
David Myles (Olema Oncology, United States)
"Discovery and Development of Complete Estrogen Receptor Antagonists"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:20 am
Aaron Sather (Merck & Co., Inc., United States)
"Sugammadex: Wake-up to Better Chemistry"
11:20 am - 11:30 am
Discussion
11:30 am - 12:00 pm
Kyle Hadden (University of Connecticut, United States)
"Identification and Early-Stage Development of 8-Hydroxyquinoline Derivatives That Suppress GLI1-Mediated Transcription Through Multiple Mechanisms"
12:00 pm - 12:10 pm
Discussion
12:10 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Discuss Future Dates and Venue; Election of the Next Vice Chair(s)
7:30 pm - 9:30 pm
Discovery and Biological Activity of Natural Products
Discussion Leaders: John D'Angelo (Alfred University, United States)
7:30 pm - 8:00 pm
Lukasz Ciesla (The University of Alabama, United States)
"Neuroprotective Phytochemicals: Pleiotropic Dietary Soft Electrophiles and Compounds Mimicking Neurotrophins"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
Cassandra Quave (Emory University, United States)
"Ethnobotany as a Tool for Targeted Natural Products Discovery"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
Tadeusz Molinski (University of California, San Diego, United States)
"Natural Products Chemistry, Adventure Chemical Surprises from the “Wine Dark Sea”"
9:20 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Chemical Modifications and Biological Activity of Natural Products
Discussion Leader: Jeremy Cody (Rochester Institute of Technology, United States)
9:00 am - 9:30 am
Gregory Dudley (West Virginia University, United States)
"Benzannulation Reactions for Synthesis of the Illudalanes and Related Bioactive Compounds"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
Daniel Appella (National Institute of Diabetes and Digestive and Kidney Diseases, NIH, United States)
"Thyclotides: Cell Permeable Peptide Nucleic Acids that Target microRNA-21"
10:10 am - 10:20 am
Discussion
10:20 am - 10:45 am
Coffee Break
10:45 am - 11:15 am
David Perrin (University of British Columbia, Canada)
"Alpha-Amanitin - from Curiosity-Driven Total Synthesis to the Generation of More Cytotoxic Compounds - Applications and Methods"
11:15 am - 11:25 am
Discussion
11:25 am - 11:55 am
James Leahy (University of South Florida, United States)
"Natural Products and Synthetic Analogs for the Treatment of Infectious Diseases"
11:55 am - 12:05 pm
Discussion
12:05 pm - 12:25 pm
Short Talk Selected from Poster Abstracts
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Keynote Session: Pioneering Synthetic Efforts
Discussion Leader: Ryan Rafferty (Kansas State University, United States)
7:30 pm - 7:40 pm
Opening Remarks
7:40 pm - 8:25 pm
David Williams (Indiana University, United States)
"Studies of Cyclization Strategies: Natural Products as a Source of Inspiration"
8:25 pm - 8:35 pm
Discussion
8:35 pm - 9:20 pm
Mohammad Movassaghi (Massachusetts Institute of Technology, United States)
"Complex Alkaloid Total Synthesis"
9:20 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure