Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Keynote Session: Chemical Biology of Natural Products and Bioactive Compounds
7:40 pm - 8:20 pm
"Activity-Based Proteomics – Protein and Ligand Discovery on A Global Scale"
8:20 pm - 8:35 pm
Discussion
8:35 pm - 9:15 pm
"The Rise of Molecular Glues and Bifunctional Compounds"
9:15 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Target Oriented Synthesis of Bioactive Compounds
9:00 am - 9:30 am
"Process Development of a Suzuki Reaction Used in the Manufacture of Lenacapavir"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
"COVID Therapies: Process Development and Sustainability"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:20 am
"Biocatalysis and Complex Molecule Synthesis"
11:20 am - 11:30 am
Discussion
11:30 am - 12:00 pm
"Manipulating Macrocycles: The Total Synthesis of Darobactin A"
12:00 pm - 12:10 pm
Discussion
12:10 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hour™
The GRC Power Hour™ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Strategies and Tactics for Complex Natural Product Total Synthesis
7:30 pm - 8:00 pm
"Empowering Organic Synthesis: From Unique Methods to Complex Natural Products"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
"Lessons From Total Synthesis of Hybrid Natural Products"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
"Choose Your Own Adventure in Metal-Hydride Catalysis"
9:20 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Synthetic Biology and Biosynthesis of Natural Products
9:00 am - 9:30 am
"Development of an Alternative Bacterial Host For Natural Product Discovery"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
"Discovery of New Biocatalysts for Selective C-F Bond Formation and Application Toward The Synthesis of Halogenated Natural Products"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:20 am
"Harnessing Natural Product Pathways"
11:20 am - 11:30 am
Discussion
11:30 am - 12:00 pm
"A Naturally Occurring LyTAC"
12:00 pm - 12:10 pm
Discussion
12:10 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Paradigm Shifting Technology
7:30 pm - 8:00 pm
"Unlocking Natural Product-Based Drug Discovery with Metabolomics and Machine Learning: Natural Intelligence Meets It's Artificial Counterpart."
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
"Correlative Metabologenomics of 110 Fungi Reveals Metabolite/Gene Cluster Pairs"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
"Sustainable Synthesis Using Only Sunlight, Air and Water"
9:20 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Discovery of Natural Products and Their Signaling Pathways
9:00 am - 9:30 am
"Natural Products as Signaling Molecules in Complex Microbiome Systems"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
"Natural Products Inhibit and Promote Bacteriophage Infectivity"
10:10 am - 10:20 am
Discussion
10:20 am - 10:45 am
Coffee Break
10:45 am - 11:15 am
"Bioactive Natural Products From High Desert Bacteria and Termite Associated Fungi"
11:15 am - 11:25 am
Discussion
11:25 am - 11:55 am
"Metals, Secondary Metabolites, and The Variable Host Environment"
11:55 am - 12:05 pm
Discussion
12:05 pm - 12:25 pm
"Steroids to Natural Products to Bioactive Materials: 1951 - 2023"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Medicinal Chemistry of Natural Products and Bioactive Compounds
7:30 pm - 8:00 pm
"Discovery of Glucocorticoid Receptor Modulator Payloads for Immunology Antibody-Drug Conjugates"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
"Exploring Biological Systems with a Collection of Complex and Diverse Small Molecules"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
"Bridging Unknown Unknowns. An Unpredicted Journey From Natural Products to Unmet Needs in Neuroscience"
9:20 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Discuss Future Dates and Venue; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Novel Synthetic Strategies and Methodologies
9:00 am - 9:30 am
"Utilizing Biocatalysis and Synthetic Chemistry to Access New Natural Products"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
"Opportunities in Stereocontrolled Syntheses of Complex Amines"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:20 am
"Harnessing Radicals and Carbenes To Enable Unconventional Reactivity"
11:20 am - 11:30 am
Discussion
11:30 am - 12:00 pm
"Natural Products: Opportunities to Develop Synthetic Methods"
12:00 pm - 12:10 pm
Discussion
12:10 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Keynote Session: Total Synthesis of Complex Natural Products
7:30 pm - 8:15 pm
"The Molecular Mystique of Nature's Poisons"
8:15 pm - 8:25 pm
Discussion
8:25 pm - 8:35 pm
Introduction by Discussion Leader
8:35 pm - 9:20 pm
"Necessity is the Mother of Invention: Natural Products and The Chemistry They Inspire"
9:20 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure