Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Keynote Session: The Chemistry Biology Interface
7:40 pm - 8:20 pm
"Chemical Probes Uncover a New Anti-Bacterial Strategy"
8:20 pm - 8:35 pm
Discussion
8:35 pm - 9:15 pm
"Hijacking Molecular Machines to Reveal New Chemistry and New Biology"
9:15 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Early Career Investigator Presentations
9:00 am - 9:20 am
"New Avenues in Cyclase Phase Total Synthesis"
9:20 am - 9:25 am
Discussion
9:25 am - 9:45 am
"Biosynthesis of Natural and New-to-Nature Glycosides in Engineered Yeast"
9:45 am - 9:50 am
Discussion
9:50 am - 10:10 am
"Novel Strategies for Complex Bioactive Molecule Synthesis"
10:10 am - 10:15 am
Discussion
10:15 am - 10:45 am
Coffee Break
10:45 am - 11:05 am
"Synthesis of Amino Acid-Derived Natural Products"
11:05 am - 11:10 am
Discussion
11:10 am - 11:30 am
"Total Synthesis of Sulfur-Containing Sesquiterpenoid Natural Products"
11:30 am - 11:35 am
Discussion
11:35 am - 11:55 am
"Efficient Natural Product Synthesis via a Common Polyfunctional Building Block Approach"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Medicinal Chemistry of Natural Products and Bioactive Compounds
7:30 pm - 8:00 pm
"Adventures in Chemistry: Drugging KRAS Past and Present"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
"Prodrugs to the Rescue: The Discovery of a Potent eIF2B Activator Clinical Candidate"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
"Synthesis of Novel Bicyclic Azetidine Antimalarials"
9:20 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Biosynthesis and Biotechnology Related to Natural Products
9:00 am - 9:30 am
"Biosynthesis of Unusual Molecules by Opportunistic Pathogens"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
"Discovery of New Natural Product from Fungi using Genome-Based Approaches"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:20 am
"Discovery and Engineering of Plant Natural Product Pathways"
11:20 am - 11:30 am
Discussion
11:30 am - 12:00 pm
"Stereoselective Pyridoxal Radical Biocatalysis for Diversity-Oriented Synthesis"
12:00 pm - 12:10 pm
Discussion
12:10 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Process Chemistry Toward Complex Bioactive Compounds
7:30 pm - 8:00 pm
"Development of a Commercial Manufacturing Process for Vepdegestrant, an Orally Bioavailable PROTAC Estrogen Receptor Degrader"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
"Pivoting to Catalysis for Kilo Scale API Deliveries"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
"Process Chemistry Toward Complex Bioactive Compounds"
9:20 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Total Synthesis of Complex Natural Products
9:00 am - 9:30 am
"Synthetic Studies Toward Complex Natural Products"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
"Tactic Combinations for the Synthesis of Complex Natural Products with Important Biological Activities"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:20 am
"Computationally Augmented Total Synthesis"
11:20 am - 11:30 am
Discussion
11:30 am - 12:00 pm
"Primary and Secondary Metabolites as Inspiration for Synthesis"
12:00 pm - 12:10 pm
Discussion
12:10 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Synthetic Methods for Construction and Modification of Biologically Important Molecules
7:30 pm - 8:00 pm
"New Concepts for Atom and Functional Group Transfer"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
"Chemical Synthesis as a Tool for Discovery: Targeting Bioactivity Through Natural Product Design"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
"New Synthetic Methods Using Photochemistry"
9:20 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Strategies and Tactics for Rapid Construction of Chemical Complexity
9:00 am - 9:30 am
"Exploring Ring Transformations: Opening, Formation, and Swapping of Cyclic Structures"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
"Creating Confined Spaces: Supramolecular Lewis Acid-Base Catalysis for Unlocking New Reactivities in Terpene Cyclizations"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:20 am
"Simplicity and Complexity: Photochemistry as an Enabling Tool"
11:20 am - 11:30 am
Discussion
11:30 am - 12:00 pm
"Natural Product Synthesis With Designed Hydrocarbons"
12:00 pm - 12:10 pm
Discussion
12:10 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Keynote Session: Synthesis and Biosynthesis of Complex Natural Products
7:30 pm - 8:15 pm
"Genome Mining for New Chemistry"
8:15 pm - 8:30 pm
Discussion
8:30 pm - 9:15 pm
"Discovery and Surprises with Natural Products"
9:15 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure