SUNDAY |
2:00 pm - 9:00 pm | Arrival and Check-in |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Total Synthesis |
| Discussion Leader: Jim Heck (Merck Research Laboratories) |
7:30 pm - 7:40 pm | Opening Remarks: Joseph D. Armstrong, III |
7:40 pm - 8:20 pm | Mark Rizzacasa (Melbourne Univ., Australia)
Structure Determination and Total Synthesis of Bioactive Natural Products |
8:20 pm - 8:50 pm | Short Talk: Alison Frontier (Univ. of Rochester)
Progress toward the Synthesis of Merrilactone A |
8:50 pm - 9:30 pm | Sam Danishefsky (Columbia Univ.)
Recent Findings in a Venerable Science |
9:30 pm | Chair's Reception |
MONDAY |
7:30 am - 8:30 am | Breakfast |
8:30 am | Group Photo |
9:00 am - 10:30 am | Catalytic Methodology I |
| Discussion Leader: Janis Louie (Univ. of Utah) |
9:00 am - 9:40 am | Tim Jamison (Massachusetts Institute of Technology)
Catalytic Stereoselective Fragment Coupling Reactions in Total Synthesis |
9:40 am - 10:00 am | Helene Lebel (Univ. of Montreal, Canada)
Cascade Multicatalytic Strategies: Toward the Synthesis of Natural Products |
10:00 am - 10:30 am | BREAK |
10:30 am - 12:30 pm | Catalytic Methodology II |
| Discussion Leader: Michael Lusch (Minnesota State Univ.) |
10:30 am - 11:10 am | Dan Yang (Univ. of Hong Kong, China)
Catalytic Asymmetric Cyclization Reactions for Natural Product Synthesis |
11:10 am - 11:50 am | Huw Davies (State University of New York at Buffalo)
Catalytic Enantioselective C-H Activation as a Strategic Reaction for Natural Product Synthesis |
11:50 am - 12:30 pm | Mikiko Sodeoka (Tohuku Univ., Japan)
Catalytic Enantioselective Reactions Useful for the Synthesis of Bioactive Molecules |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session 1 |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Methodology & Total Synthesis I |
| Discussion Leader: Steve Wittenberger (Abbott Laboratories) |
7:30 pm - 8:15 pm | Jim Leighton (Columbia Univ.)
Silane Lewis Acids for the Practical Asymmetric Synthesis of Chiral Carbinols and Carbinamines |
8:15 pm - 8:45 pm | Brian Stoltz (California Institute of Technology)
Complex Natural Products as a Driving Force for Discovery in Organic Chemistry |
8:45 pm - 9:30 pm | Erick Carreira (ETH, Switzerland)
Studies in Asymmetric Synthesis |
TUESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 10:45 am | Methodology & Total Synthesis II |
| Discussion Leader: Martin Lear (Univ. of Singapore) |
9:00 am - 9:45 am | Gary Molander (Univ. of Pennsylvania)
Methods Development and Applications to Natural Product Synthesis |
9:45 am - 10:15 am | Corrine Aubert (Universite Pierre et Marie Curie, Paris)
Cobalt-Mediated Cyclizations as Efficient Tools for Synthesis |
10:15 am - 10:45 am | BREAK |
10:45 am - 12:30 pm | Chemical Ecology/Biology |
| Discussion Leader: Bradley Moore (Univ. of Arizona) |
10:45 am - 11:15 am | Joern Piel (Max Planck Inst. for Chemical Ecology, Germany)
Exploring natural product pathways from uncultivated bacterial symbionts |
11:15 am - 11:45 am | Nicola Pohl (Iowa State Univ.)
Microwaves and Microarrays |
11:45 am - 12:30 pm | Jerrold Meinwald (Cornell Univ.)
Exploring the Chemistry of Biotic Interactions |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session 2 |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Protein Chemical Biology |
| Discussion Leader: Marcey Waters (Univ of N. Carolina) |
7:30 pm - 8:15 pm | Suzanne Walker (Harvard Univ.)
Assembly of the Peptidoglycan Shell: When and Where Does Peptidoglycan Synthesis Take Place? |
8:15 pm - 8:45 pm | Ben Davis (Oxford Univ.)
Sugars and Enzymes |
8:45 pm - 9:30 pm | Herbert Waldmann (Max Planck Institut)
Charting Biologically Relevant Chemistry Space |
WEDNESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 10:40 am | Medicinal & Process Chemistry I |
| Discussion Leader: Vincent Sandanayaka (deCode) |
9:00 am - 9:35 am | Milton Brown (Univ. of Virginia, Charlottesville)
Chemical Evolution of Small Molecule Imposters of Natural Product Tubulin Inhibitors |
9:35 am - 10:10 am | Chris Senanayake (Boehringer Ingelheim)
Practical Synthetic Methodologies for Efficient Drug Development |
10:10 am - 10:40 am | BREAK |
10:40 am - 12:30 pm | Nutraceuticals & Medical Plants |
| Discussion Leader: Phil Crews (Univ of California - Santa Barbara) |
10:40 am - 11:20 am | Uwe Koetter
Pharmacology and Clinical Efficacy of Medicinal Plants |
11:20 am - 11:55 am | Qun Yi Zheng (Pure World Botanicals, Inc.)
MacaPure® - From an Andean Natural Remedy to a Standardized Nutraceutical Product |
11:55 am - 12:30 pm | Bruce Lipshutz (Univ. of California, Santa Barbara)
The Miracle Nutrient Coenzyme Q10: We Make it & We Take It! |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session 3 |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Medicinal & Process Chemistry II |
| Discussion Leader: Mike Martinelli (Amgen) |
7:30 pm - 8:05 pm | Musical Interlude (Jerrold Meinwald & Eiichi Nakamura) |
8:05 pm - 8:45 pm | Ann Weber (Merck & Co., Inc.)
Discovery of MK-0431, a Selective DPP-IV Inhibitor for the Treatment of Type 2 Diabetes |
8:45 pm - 9:30 pm | Karl Hansen (Merck & Co., Inc.)
Synthesis of the DPP-IV Inhibitor MK-0431 |
THURSDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 10:30 am | Methodology & Total Synthesis III |
| Discussion Leader: Spencer Knapp (Rutgers Univ.) |
9:00 am - 9:30 am | Short Talk: Gregory Dudley (Florida State Univ.)
CC Bond Cleavage Strategies for Natural Product Synthesis |
9:20 am - 9:40 am | Short Talk: Sherry Chemley (SUNY Buffalo)
Copper(II) Promoted Intramolecular Diamination and Aminocarbonation of Unactivated Olefins for the Synthesis of Nitrogen-Containing Heterocyclic Small Molecules |
9:40 am - 10:00 am | Short Talk: Chulbom Lee (Princeton Univ.)
Chemical Synthesis of Kendomycin |
10:00 am - 10:30 am | BREAK |
10:30 am - 12:30 pm | Methodology & Total Synthesis IV |
| Discussion Leader: David Carini (BMS) |
10:30 am - 11:15 am | Peter Wipf (Univ. of Pittsburgh)
Chemistry & Biology of Disorazole |
11:15 am - 11:45 am | Short Talk: Tony Haight (Abbott)
Synthesis of quinolone antibiotic ABT-492 |
11:45 am - 12:30 pm | Eiichi Nakamura (Univ. of Tokyo, Japan)
New Metallo Enamine Chemistry |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session 4 |
6:00 pm | Dinner |
7:15 pm - 7:30 pm | Softball Awards & Announcements |
7:30 pm - 9:30 pm | Methodology & Total Synthesis V |
| Discussion Leader: Suzy Shuker (Georgia Tech) |
7:30 pm - 8:15 pm | Andy Evans (Indiana University)
Enantioselective Total Synthesis of Batzelladine A and D using Novel Reductive and Oxidative Free Radical Cyclization Reactions |
8:15 pm - 8:45 pm | Short Talk: Andrew Phillips (Univ. of Colorado)
Tandem Reaction Strategies for Synthesis: Cylindramide A and Aburatubolactam A |
8:45 pm - 9:30 pm | Paul Wender (Stanford Univ.)
Speed and Leads: Step Economy, New Reactions, New Natural and Designed
Products, and New Drug Delivery Systems |
FRIDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am | Depart |