SUNDAY |
2:00 pm - 11:00 pm | Arrival and Check-in |
6:00 pm | Dinner |
7:15 pm - 7:30 pm | Welcome by Conference Chair, David E. Uehling |
7:30 pm - 7:40 pm | Introductory Comments by GRC Site Staff |
7:40 pm - 9:30 pm | Total Synthesis of Natural Products |
| Discussion Leader: Tony Shuker (Metastatix) |
7:40 pm - 8:10 pm | Phil Baran (Scripps Research Institute) "The Catalytic Cycle of Discovery in Total Synthesis" |
8:10 pm - 8:15 pm | Discussion |
8:15 pm - 8:45 pm | Richmond Sarpong (University of California, Berkeley) "Synthetic Strategies Inspired by Seven-Membered Ring Containing Natural Products" |
8:45 pm - 8:50 pm | Discussion |
8:50 pm - 9:25 pm | Steve Martin (University of Texas) "Recent Progress in the Synthesis of Heterocyclic Natural Products" |
9:25 pm - 9:30 pm | Discussion |
MONDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 10:20 am | Catalytic Methodology |
| Discussion Leader: Sarah Reisman (Harvard University) |
9:00 am - 9:35 am | Greg Fu (Massachusetts Institute of Technology) "Palladium- and Nickel-Catalyzed Coupling Reactions" |
9:35 am - 9:40 am | Discussion |
9:40 am - 10:15 am | Andreas Pfaltz (University of Basel) "Recent Progress in Asymmetric Hydrogenation" |
10:15 am - 10:20 am | Discussion |
10:20 am - 10:45 am | Coffee Break |
10:45 am - 12:30 pm | Synthesis of Medicinal and Biologically Active Agents |
| Discussion Leader: Kirk Stevens (GlaxoSmithKline) |
10:45 am - 11:15 am | Steve Davidsen (Abbott Laboratories) "ABT-869: A Selectively Promiscuous Kinase Inhibitor" |
11:15 am - 11:20 am | Discussion |
11:20 am - 11:45 am | Mui Cheung (GlaxoSmithKline) "Discovery of Novel Polo-like Kinase 1 (PLK1) Inhibitors" |
11:45 am - 11:50 am | Discussion |
11:50 am - 12:25 pm | Marvin Miller (University of Notre Dame) "Modular Enhancement of Nature's Diversity (MEND): Nitroso Diels-Alder Reactions in Syntheses and for facile Derivatization and Functionalization of Complex Diene-containing Natural Products" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Group Photo |
12:45 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session I |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | New Synthetic Methods |
| Discussion Leader: Chris Pigge (University of Iowa) |
7:30 pm - 8:10 pm | Mark Lautens (University of Toronto) "Natural Products Synthesis via Ring Forming and Ring Closing Reactions" |
8:10 pm - 8:15 pm | Discussion |
8:15 pm - 8:35 pm | Jon Tryggvi Njardarson (Cornell University) Short Talk: "Development of New Catalytic Ring Expansion Methods" |
8:35 pm - 8:40 pm | Discussion |
8:40 pm - 9:20 pm | Robert Grubbs (California Institute of Technology) "The Design of Olefin Metathesis Catalysts for the Synthesis of Complex Molecules" |
9:20 pm - 9:30 pm | Discussion |
TUESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 10:20 am | Natural Product Synthesis |
| Discussion Leader: Deborah Mohler (James Madison University) |
9:00 am - 9:35 am | Richard Taylor (University of York) "Novel Cyclisation Processes to Prepare Bioactive Marine Natural Products" |
9:35 am - 9:40 am | Discussion |
9:40 am - 10:15 am | Janine Cossy (ESPCI) "Complexity and Chemoselectivity. Synthesis of Biologically Active Natural Products" |
10:15 am - 10:20 am | Discussion |
10:20 am - 10:40 am | Coffee Break |
10:40 am - 12:30 pm | Biorganic Chemistry and Chemical Genetics |
| Discussion Leader: Victoria Lombardo (Lexicon Pharmaceuticals) |
10:40 am - 11:10 am | Helen Blackwell (University of Wisconsin-Madison) "Synthetic Ligands that Attenuate Bacterial Quorum Sensing and Its Outcomes" |
11:10 am - 11:15 am | Discussion |
11:15 am - 11:45 am | Anna Mapp (University of Michigan) "Transcriptional Upregulation Stimulated by Natural and Unnatural Products" |
11:45 am - 11:50 am | Discussion |
11:50 am - 12:25 pm | David Liu (Harvard University) "Synthesis and Discovery Enabled by DNA-Templated Chemistry" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session II |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Chemistry and Biology of Natural Products |
| Discussion Leader: Jef De Brabender (University of Texas Southwestern Medical Center) |
7:30 pm - 8:05 pm | Peter Jacobi (Dartmouth College) "Studies on the Synthesis of Furanosteroid PI3-Kinase Inhibitors" |
8:05 pm - 8:10 pm | Discussion |
8:10 pm - 8:45 pm | Sergey Kozmin (University of Chicago) "Bioactive Natural Products: From Synthesis to Function" |
8:45 pm - 8:50 pm | Discussion |
8:50 pm - 9:25 pm | John Wood (Colorado State University) "Bridged Polycyclic Natural Products: Inspirational Targets for Total Synthesis" |
9:25 pm - 9:30 pm | Discussion |
WEDNESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 10:15 am | New Developments in Natural Products Synthesis |
| Discussion Leader: Greg Dudley (Florida State University) |
9:00 am - 9:30 am | Murat Acemoglu (Novartis Pharma AG) "Process R&D on Radical Based Derivatizations of Natural Products: Applications in Drug Substance Syntheses" |
9:30 am - 9:35 am | Discussion |
9:35 am - 10:10 am | Jay Keasling (University of California, Berkeley) "Synthesis of Plant-derived Terpenoids in Microorganisms" |
10:10 am - 10:15 am | Discussion |
10:15 am - 10:35 am | Coffee Break |
10:35 am - 12:30 pm | Natural Products and Chemical Communication |
| Discussion Leader: Cynthia McClure (National Science Foundation) |
10:35 am - 11:10 am | Walter Leal (University of California, Davis) "Looking into Mosquito’s Nose with an Eye on West Nile Virus Surveillance" |
11:10 am - 11:15 am | Discussion |
11:15 am - 11:45 am | Julia Kubanek (Georgia Institute of Technology) "Natural Products as Chemical Cues in Marine Environments" |
11:45 am - 11:50 am | Discussion |
11:50 am - 12:25 pm | William Fenical (Scripps Institute of Oceanography) "Molecules in the Mud: The Natural Products Chemistry of the Deep Oceans" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session III |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Methodology and Synthesis of Natural and Unnatural Products |
| Discussion Leader: Marvin Hansen (Eli Lilly and Company) |
7:30 pm - 8:05 pm | Justin Du Bois (Stanford University) "The Allure of the Guanidinium Toxins for Target-Directed Synthesis" |
8:05 pm - 8:10 pm | Discussion |
8:10 pm - 8:40 pm | Eric Moher (Eli Lilly and Company) "Process Development for the Preparation of a Conformationally Restricted Glutamic Acid Analog" |
8:40 pm - 8:45 pm | Discussion |
8:45 pm - 9:20 pm | Richard Larock (Iowa State University) "Synthesis of Carbocycles and Heterocycles via Iodine- and Palladium-Promoted Cyclization and Annulation" |
9:20 pm - 9:30 pm | Discussion |
THURSDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 10:20 am | Synthesis of Biologically Active Compounds |
| Discussion Leader: Regan Thomson (Northwestern University) |
9:00 am - 9:35 am | Jan Van Maarseveen (University of Amsterdam) "Tackling Difficult Small Cyclic Peptide Cyclizations" |
9:35 am - 9:40 am | Discussion |
9:40 am - 9:55 am | Vladimir Birman (Washington University) Short Talk: "Synthetic Studies Towards Diazobenzo[b]fluorene Antibiotics" |
9:55 am - 10:00 am | Discussion |
10:00 am - 10:15 am | Martin Burke (University of Illinois) Short Talk: "Towards the Total Synthesis of the Channel-forming Natural Product Amphotericin B" |
10:15 am - 10:20 am | Discussion |
10:20 am - 10:45 am | Coffee Break |
9:00 am - 12:30 pm | Drug Discovery |
| Discussion Leader: Robert Hubbard (Abbott Laboratories) |
10:45 am - 11:15 am | Emma Parmee (Merck & Company) "Development of Glucagon Receptor Antagonists for the Treatment of Type 2 Diabetes" |
11:15 am - 11:20 am | Discussion |
11:20 am - 11:50 am | Raj Singh (Rigel, Incorporated) "Application of Functional Cell Based Screens for Optimization of Kinase Inhibitors Targeting Inflammatory and Oncology Diseases" |
11:50 am - 11:55 am | Discussion |
11:55 am - 12:25 pm | Michael Luzzio (Pfizer) "Design, Synthesis, Activity and Properties of Selective Focal Adhesion Kinase Inhibitors Suitable for Advanced Preclinical Evaluation. The Discovery of PF-562271 and Related Analogs" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
2:00 pm - 4:00 pm | Annual Academic Versus Industrial All-Stars Softball Game |
6:00 pm | Dinner |
7:00 pm - 7:30 pm | Business Meeting |
| (Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair) |
7:30 pm - 9:30 pm | Synthesis and Methodology |
| Discussion Leader: Karl Hansen (Amgen Chemical Process R&D) |
7:30 pm - 8:05 pm | Tohru Fukuyama (University of Tokyo) "Synthetic Studies on Bioactive Molecules" |
8:05 pm - 8:10 pm | Discussion |
8:10 pm - 8:35 pm | Jeremy Scott (Merck Sharp & Dohme LTD) "Practical Syntheses of Gamma-Secretase Inhibitors" |
8:35 pm - 8:40 pm | Discussion |
8:40 pm - 9:25 pm | Eric Jacobsen (Harvard University) "New Enantioselective Heterocycle-Forming Reactions" |
9:25 pm - 9:30 pm | Discussion |
FRIDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am | Departure |