SUNDAY |
2:00 pm - 11:00 pm | Arrival and Check-in |
6:00 pm | Dinner |
7:30 pm - 7:35 pm | Welcome / Introductory Comments by GRC Site Staff |
7:35 pm - 7:45 pm | Chair's Welcome by Scott Gilbertson (University of Texas Medical Branch) |
7:45 pm - 9:30 pm | Catalysis and Synthetic Methodology I |
| Discussion Leader: Dee Ann Casteel (Bucknell University) |
7:45 pm - 8:20 pm | M. Christina White (University of Illinois at Urbana-Champaign)
"Streamlining Synthesis via C-H Oxidation" |
8:20 pm - 8:25 pm | Discussion |
8:25 pm - 9:15 pm | David W.C. MacMillan (Princeton University)
"Enantioselective Organo-SOMO Catalysis" |
9:15 pm - 9:30 pm | Discussion |
9:30 pm | Chair's Reception |
MONDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 10:25 am | Catalysis and Synthetic Methodology II |
| Discussion Leader: Fred Luzzio (University of Louisville) |
9:00 am - 9:35 am | Ohyun Kwon (University of California, Los Angeles)
"Phosphine-Catalyzed Annulations" |
9:35 am - 9:40 am | Discussion |
9:40 am - 10:20 am | Matthew Gaunt (University of Cambridge)
"New Catalytic Strategies for the Chemical Synthesis of Natural Products" |
10:20 am - 10:25 am | Discussion |
10:25 am - 10:50 am | Coffee Break / Group Photo |
10:50 am - 12:30 pm | Catalysis and Synthetic Methodology III |
| Discussion Leader: Cynthia McClure (Montana State University) |
10:50 am - 11:30 am | Tamio Hayashi (Kyoto University)
"Recent Advances in the Rhodium-Catalyzed Asymmetric Carbon-Carbon Bond Formation" |
11:30 am - 11:35 am | Discussion |
11:35 am - 12:00 pm | Timothy Towne (Abbott Laboratories)
"Process development of (1S,5S)-3-(5,6-dichloro-3-pyridinyl)-3,6-diazabicyclo[3.2.0]heptane" |
12:00 pm - 12:05 pm | Discussion |
12:05 pm - 12:25 pm | Tehshik P. Yoon (University of Wisconsin)
"New Reactions of Oxaziridines" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session I |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Novel Synthetic Methods |
| Discussion Leader: Paul Blakemore (Oregon State University) |
7:30 pm - 8:10 pm | Jeffrey Bode (University of Pennsylvania)
"Catalytic, Enantioselective Annulation Reactions" |
8:10 pm - 8:15 pm | Discussion |
8:15 pm - 8:40 pm | Marlys Hammond (GlaxoSmithKline)
"Design and Synthesis of Orally Active Selective Progesterone Receptor Ligands" |
8:40 pm - 8:45 pm | Discussion |
8:45 pm - 9:25 pm | Kevin Moeller (Washington University)
"You Want to Build it Where? New Umpolung Chemistry for the Construction of Addressable Molecular Libraries" |
9:25 pm - 9:30 pm | Discussion |
TUESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 10:10 am | Synthesis of Biologically Active Molecules I |
| Discussion Leader: Sylvie Asselin (Amgen) |
9:00 am - 9:30 am | Chen Cheng (Merck Research Laboratories)
"Practical asymmetric syntheses of complex drug targets" |
9:30 am - 9:35 am | Discussion |
9:35 am - 10:05 am | Melvin Yu (Eisai)
"Natural Product Optimization Strategies" |
10:05 am - 10:10 am | Discussion |
10:10 am - 10:30 am | Coffee Break |
10:30 am - 12:30 pm | Natural Products Isolation and Biosynthesis |
| Discussion Leader: Amarnath Natarajan (UTMB) |
10:30 am - 11:05 am | Jeffrey L.C. Wright (University of North Carolina Wilmington)
"Poisons, peptides, and polyethers: building a diverse chemical library" |
11:05 am - 11:10 am | Discussion |
11:10 am - 11:45 am | Sarah O'Connor (Massachusetts Institute of Technology)
"Alkaloid Biosynthesis in Madagascar Periwinkle" |
11:45 am - 11:50 am | Discussion |
11:50 am - 12:25 pm | Kirk R. Gustafson (National Cancer Institute)
"New Natural Product Inhibitors of Cancerous Processes and Phenotypes" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session II |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Natural Products Synthesis |
| Discussion Leader: David Uehling (GlaxoSmithKline) |
7:30 pm - 8:05 pm | Craig J. Forsyth (The Ohio State University)
"Total Synthesis of Complex Marine Natural Products" |
8:05 pm - 8:10 pm | Discussion |
8:10 pm - 8:45 pm | Erik J. Sorensen (Princeton University)
"Rapid formation of molecular complexity in natural product synthesis" |
8:45 pm - 8:50 pm | Discussion |
8:50 pm - 9:25 pm | Deukjoon Kim (Seoul National University)
"Substrate-Controlled Asymmetric Total Synthesis of Medium-Sized Oxacyclic Marine Natural Products" |
9:25 pm - 9:30 pm | Discussion |
WEDNESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 10:20 am | Synthesis of Biologically Active Molecules II |
| Discussion Leader: Grace Arhancet (Pfizer) |
9:00 am - 9:35 am | Jeffrey Aube (University of Kansas)
"Natural Products from Azides" |
9:35 pm - 9:40 am | Discussion |
9:40 am - 10:15 am | Frederick G. West (University of Alberta)
"Recent Progress in the Chemical Synthesis of Cyclooctane-Containing Natural Products" |
10:15 am - 10:20 am | Discussion |
10:20 am - 10:40 am | Coffee Break |
10:40 am - 12:30 pm | Synthesis of Biologically Active Molecules III |
| Discussion Leader: Nancy Totah (Syracuse University) |
10:40 am - 11:00 am | Scott A. Snyder (Columbia University)
"Achieving Synthetic Control When Nature Abandons Selectivity" |
11:00 am - 11:05 am | Discussion |
11:05 am - 11:40 am | John A. Porco (Boston University)
"New Synthetic Methods Inspired by Complex Natural Products" |
11:40 am - 11:45 am | Discussion |
11:45 am - 12:20 pm | Jef K. De Brabander (UT Southwestern Medical Center)
"Natural Product Synthesis - A Platform for Discovery" |
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session III |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Transition Metal Catalysis |
| Discussion Leader: Cheng-Wei Tom Chang (Utah State University) |
7:30 pm - 8:05 pm | Vladimir Gevorgyan (University of Illinois at Chicago)
"New Transition Metal-Catalyzed Synthetic Methodologies" |
8:05 pm - 8:10 pm | Discussion |
8:10 pm - 8:45 pm | Robert Singer (Pfizer)
"Development of Nonproprietary Pd-Catalyzed Processes for Industry" |
8:45 pm - 8:50 pm | Discussion |
8:50 pm - 9:25 pm | F. Dean Toste (University of California, Berkeley)
"Development and Applications of Gold-Catalyzed Reaction for Organic Synthesis" |
9:25 pm - 9:30 pm | Discussion |
THURSDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 10:25 am | Synthesis of Active Molecules and Natural Products I |
| Discussion Leader: Rima S. Al-Awar (Ontario Institute for Cancer Research) |
9:00 am - 9:20 am | Michael Burkart (University of California, San Diego)
"Investigations on medium ring polyketides" |
9:20 am - 9:25 am | Discussion |
9:25 am - 9:45 am | Louis Barriault (University of Ottawa)
"Recent progress toward the total synthesis of a compact diterpene: vinigrol" |
9:45 am - 9:50 am | Discussion |
9:50 am - 10:20 am | Eric Bercot (Amgen)
"Discovery and Development of a Scaleable Route to an 11b-HSD1 Inhibitor" |
10:20 am - 10:25 am | Discussion |
10:25 am - 10:40 am | Coffee Break |
10:40 am - 12:30 pm | Synthesis of Active Molecules and Natural Products II |
| Discussion Leader: Michael Calter (Wesleyan University) |
10:40 am - 11:15 am | Gary A. Sulikowski (Vanderbilt University)
"Natural Products as Targets of Opportunity in Synthetic and Bioorganic Chemistry" |
11:15 am - 11:20 am | Discussion |
11:20 am - 11:50 am | Brian S.J. Blagg (University of Kansas)
"Redesigning Old Drugs for the Inhibition of New Targets, a Case Study with Novobiocin" |
11:50 am - 11:55 am | Discussion |
11:55 am - 12:25 pm | Katherine Seley-Radtke (University of Maryland Baltimore County)
"Exploring Structural Diversity in Nucleoside Drug Design" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 6:00 pm | Free Time |
2:00 pm - 4:00 pm | Annual Academic vs. Industrial All-Stars Softball Game |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:00 pm - 7:30 pm | Business Meeting |
| (Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair) |
7:30 pm - 9:30 pm | Perspectives and Studies in Synthesis and Med Chem |
| Discussion Leader: Richard Taylor (Notre Dame University) |
7:30 pm - 8:05 pm | Christopher A. Lipinski (Melior Discovery)
"Natural products, hype and hope: straight talk from a medicinal chemistry veteran" |
8:05 pm - 8:10 pm | Discussion |
8:10 pm - 8:35 pm | Thomas Engler (Eli Lilly and Company)
"Phenotypic Drug Discovery: New Tricks For an Old Dog" |
8:35 pm - 8:40 pm | Discussion |
8:40 pm - 9:25 pm | Andrew G. Myers (Harvard University)
"Addressing Problems in Human Health with Complex Synthesis" |
9:25 pm - 9:30 pm | Discussion |
FRIDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am | Depart |