SUNDAY |
2:00 pm - 9:00 pm | Arrival and Check-in (Office Closed 6:00 pm - 7:00 pm) |
6:00 pm | Dinner |
7:30 pm - 7:40 pm | Chair's Welcome by Marv Hansen (Eli Lilly and Company); Opening Remarks by GRC Site Staff |
7:40 pm - 9:30 pm | Synthesis and Synthetic Methodology |
| Discussion Leader: Jon Njardarson (Cornell University) |
7:40 pm - 8:10 pm | Kay Brummond (University of Pittsburgh)
"Exploiting Allenes in the Synthesis of Natural Product-like Compounds" |
8:10 pm - 8:15 pm | Discussion |
8:15 pm - 8:35 pm | Ryan Looper (University of Utah)
"Propargyl Guanidine Cyclizations and Their Application to Natural Product Targets" |
8:35 pm - 8:40 pm | Discussion |
8:40 pm - 9:25 pm | Barry Trost (Stanford University)
"On the Impact of New Synthetic Methods for the Synthesis of Bioactive Targets" |
9:25 pm - 9:30 pm | Discussion |
9:30 pm | Chair's Reception |
MONDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 10:45 am | Catalysis and Synthetic Methodology |
| Discussion Leader: Kathy Lee (Wyeth Pharmaceuticals) |
9:00 am - 9:35 am | Greg Dudley (Florida State University)
"A New Fragmentation Reaction for the Synthesis of Functionalized Alkynes" |
9:35 am - 9:40 am | Discussion |
9:40 am - 10:15 am | Veronique Gouverneur (University of Oxford)
"New Methods for the Construction and Deconstruction of C-F Bonds" |
10:15 am - 10:20 am | Discussion |
10:20 am - 10:45 am | Coffee Break / Group Photo |
10:45 am - 12:30 pm | Catalysis and Synthesis |
| Discussion Leader: Matthew Bourbeau (Amgen) |
10:45 am - 11:25 am | John Hartwig (University of Illinois)
"Discovery and Understanding of Transition Metal-Catalyzed Reactions for Organic Synthesis" |
11:25 am - 11:30 am | Discussion |
11:30 am - 11:55 am | Jason Tedrow (Amgen)
"A Templated Strategy for the Assembly of Hydroxyethylamine-Based Protease Inhibitors for the Synthesis of a BACE Clinical Candidate" |
11:55 am - 12:00 pm | Discussion |
12:00 pm - 12:25 pm | Alfredo Castro (Infinity Pharmaceuticals)
"Role of the Hedgehog Pathway in Cancer: Harnessing Nature's Antagonist, Cyclopamine, To Make a Drug - IPI-926" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session I |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Chemical Biology |
| Discussion Leader: Angela Koehler (Broad Institute of Harvard and MIT) |
7:30 pm - 7:55 pm | Jennifer Kohler (UT Southwestern Medical Center at Dallas)
"Capturing Glycoconjugate Interactions With Photoactivatable Crosslinking Sugars" |
7:55 pm - 8:00 pm | Discussion |
8:00 pm - 8:35 pm | Laura Kiessling (University of Wisconsin-Madison)
"Chemical Probes of Carbohydrate Biosynthesis in Mycobacteria" |
8:35 pm - 8:40 pm | Discussion |
8:40 pm - 9:25 pm | Stuart Schreiber (Broad Institute of Harvard and MIT)
"The Gap Between Scientists' Aspirations and Society's Expectations" |
9:25 pm - 9:30 pm | Discussion |
TUESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 10:30 am | Medicinal Chemistry |
| Discussion Leader: John Duncia (Bristol-Myers Squibb) |
9:00 am - 9:30 am | Milan Bruncko (Abbott Laboratories)
"N-Aryl-benzimidazolones as Novel Small Molecule HSP-90 Inhibitors" |
9:30 am - 9:35 am | Discussion |
9:35 am - 10:05 am | Thomas Magee (Pfizer)
"Erythromycin Semisynthesis Leading to Next Generation Macrolide Antibiotics: The Discovery of Clinical Candidate PF-04287881" |
10:05 am - 10:10 am | Discussion |
10:10 am - 10:30 am | Coffee Break |
10:30 am - 12:30 pm | Chemistry and Biology of Natural Products |
| Discussion Leader: Jon Rainier (University of Utah) |
10:30 am - 11:05 am | David Sherman (University of Michigan)
"Chemical Diversity and Metabolic Versatility in Microbial Natural Product Biosynthesis" |
11:05 am - 11:10 am | Discussion |
11:10 am - 11:45 am | Rolf Müller (Universität des Saarlandes)
"Chemistry and Biotechnology of Myxobacteria - Promising Resources for Novel Bioactive Natural Products" |
11:45 am - 11:50 am | Discussion |
11:50 am - 12:25 pm | Carole Bewley (National Institutes of Health)
"Targeting Sponge-microbe Symbioses: An Unconventional Approach for Natural Products Discovery" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session II |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Natural Products Synthesis |
| Discussion Leader: John D'Angelo (Alfred University) |
7:30 pm - 8:10 pm | Raymond Funk (Penn State University)
"Total Synthesis of Structurally Challenging Heterocyclic Natural Products" |
8:10 pm - 8:15 pm | Discussion |
8:15 pm - 8:35 pm | Chuo Chen (UT Southwestern Medical Center)
"Synthesis of Marine Natural Products" |
8:35 pm - 8:40 pm | Discussion |
8:40 pm - 9:25 pm | Amos Smith (University of Pennsylvania)
"Recent Advances in Complex Natural and Unnatural Products" |
9:25 pm - 9:30 pm | Discussion |
WEDNESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 10:40 am | Asymmetric and Organic Synthesis |
| Discussion Leader: Rebecca Hoye (Macalester College) |
9:00 am - 9:35 am | Michael Krische (University of Texas at Austin)
"Asymmetric Synthesis via C-C Bond Forming Hydrogenation and Transfer-Hydrogenation" |
9:35 am - 9:40 am | Discussion |
9:40 am - 10:15 am | Kyoko Nozaki (University of Tokyo)
"Carbon Monoxide and Carbon Dioxide as a C1 Synthon in Organic Synthesis" |
10:15 am - 10:20 am | Discussion |
10:20 am - 10:40 am | Coffee Break |
10:40 am - 12:30 pm | Synthesis, Chemistry and Natural Products |
| Discussion Leader: Jennifer Riggs (Celgene) |
10:40 am - 11:05 am | Artis Klapars (Merck and Company)
"Catalytic Asymmetric Reactions in the Synthesis of Complex Drug Targets" |
11:05 am - 11:10 am | Discussion |
11:10 am - 11:45 am | Richard Taylor (Notre Dame University)
"New Sources of Chemical Diversity Inspired by Polyketide Biosynthesis" |
11:45 am - 11:50 am | Discussion |
11:50 am - 12:25 pm | Markus Kalesse (Universität Hannover)
"Leads From Natural Products - From Proteasom Inhibitors to Antiinfectives" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session III |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Methodology and Synthesis |
| Discussion Leader: Debbie Mohler (James Madison University) |
7:30 pm - 8:05 pm | Zhu-Jun Yao (Shanghai Institute of Organic Chemistry)
"Comprehension and Application of the Chemical Intelligence From Bioactive Natural Products" |
8:05 pm - 8:10 pm | Discussion |
8:10 pm - 8:35 pm | Scott Frank (Eli Lilly and Company)
"Practical Approaches to the Assembly of Aminotetrazole Containing Drug Candidates" |
8:35 pm - 8:40 pm | Discussion |
8:40 pm - 9:25 pm | William Roush (The Scripps Research Institute, Florida)
"New Methodology for the Stereocontrolled Synthesis of Natural Products" |
9:25 pm - 9:30 pm | Discussion |
THURSDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 10:45 am | Synthesis, Chemistry and Biology of Natural Products I |
| Discussion Leader: Steve Castle (Brigham Young University) |
9:00 am - 9:20 am | Paul Floreancig (University of Pittsburgh)
"Applications of Oxidative Carbon-Hydrogen Bond Activation Reactions to Natural Product Synthesis" |
9:20 am - 9:25 am | Discussion |
9:25 am - 9:45 am | Chris Vanderwal (University of California-Irvine)
"Complex Molecule Synthesis Inspired by the Zincke Ring-Opening of Pyridines" |
9:45 am - 9:50 am | Discussion |
9:50 am - 10:20 am | Michael VanNieuwenhze (Indiana University)
"Combating Bacterial Resistance with Peptide Antibiotics that Inhibit Bacterial Cell Wall Biosynthesis" |
10:20 am - 10:25 am | Discussion |
10:25 am - 10:45 am | Coffee Break |
10:45 am - 12:30 pm | Synthesis, Chemistry and Biology of Natural Products II |
| Discussion Leader: Marianne Carlsen (Lexicon Pharmaceuticals) |
10:45 am - 11:15 am | Martin Banwell (Australian National University)
"Chemoenzymatic Methods for the Assembly of Biologically Active Natural Products and Related Compounds" |
11:15 am - 11:20 am | Discussion |
11:20 am - 11:50 am | Paul Hergenrother (University of Illinois)
"Direct Procaspase Activation as an Anti-cancer Strategy: Compound Identification, Mechanism of Action, and a Phase I Clinical Trial" |
11:50 am - 11:55 am | Discussion |
11:55 am - 12:25 pm | Peter Seeberger (Swiss Federal Institute of Technology - ETH)
"Chemistry and Biology of Carbohydrates" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 6:00 pm | Free Time |
2:00 pm - 4:00 pm | Annual Academic vs Industrial All-Stars Softball Game |
6:00 pm | Dinner |
7:00 pm - 7:30 pm | Business Meeting |
| (Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair) |
7:30 pm - 9:30 pm | Natural Product Synthesis and Medicinal Chemistry |
| Discussion Leader: Chris Vanderwal (University of California-Irvine) |
7:30 pm - 8:10 pm | Dirk Trauner (Ludwig-Maximilians-Universität, Munich)
"Building Molecules to Tackle Cancer and Blindness" |
8:10 pm - 8:15 pm | Discussion |
8:15 pm - 8:35 pm | Rob Webb (RW Consulting)
"Neurotrophin-Drug Conjugates For the Treatment of Pain" |
8:35 pm - 8:40 pm | Discussion |
8:40 pm - 9:25 pm | Peter Wipf (University of Pittsburgh)
"Natural Products and Beyond" |
9:25 pm - 9:30 pm | Discussion |
FRIDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am | Depart |