SUNDAY |
2:00 pm - 9:00 pm | Arrival and Check-in (Office Closed 6:00 pm - 7:00 pm) |
6:00 pm | Dinner |
7:30 pm - 7:40 pm | Welcome Comments by GRC Site Staff / Chair’s Welcome by Jef De Brabander (UT Southwestern Medical Center) |
7:40 pm - 9:30 pm | Synthesis and Function of Natural Products |
| Discussion Leader: Sarah Reisman (California Institute of Technology) |
7:40 pm - 8:10 pm | Martin Burke (University of Illinois) "The prospect of molecular prosthetics: small molecules with protein-like functions" |
8:10 pm - 8:15 pm | Discussion |
8:15 pm - 8:35 pm | Paul Blakemore (Oregon State University) "Functionalized Carbenoids in the Stereospecific Reagent Controlled Homologation of Boronic Esters Toward Polycyclic Targets" |
8:35 pm - 8:40 pm | Discussion |
8:40 pm - 9:25 pm | Justin Dubois (Stanford University) "Chemical Synthesis: An Engine for Discovery" |
9:25 pm - 9:30 pm | Discussion |
9:30 pm | Chair’s Reception |
MONDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 10:20 am | Catalysis and Reaction Discovery |
| Discussion Leader: Mimi Hii (Imperial College London) |
9:00 am - 9:35 am | Tomislav Rovis (Colorado State University) "Asymmetric Catalysis in the Service on Natural Product Synthesis" |
9:35 am - 9:40 am | Discussion |
9:40 am - 10:15 am | Jeffrey Johnson (University of North Carolina) "Complexity-Building Reactions: Recent Case Studies" |
10:15 am - 10:20 am | Discussion |
10:20 am - 10:45 am | Coffee Break / Group Photo |
10:20 am - 12:30 pm | Bioorganic, Process, and Medicinal Chemistry |
| Discussion Leader: Lisbet Kvaernø (Lundbeck) |
10:45 am - 11:25 am | Erick Carreira (Swiss federal Institute of Technology - ETH) "Discovery and Surprises with Natural Products" |
11:25 am - 11:30 am | Discussion |
11:30 am - 11:55 am | Johann Chan (Amgen) "Process Development of a Selective Agonist of the S1P1 Receptor" |
11:55 am - 12:00 pm | Discussion |
12:00 pm - 12:25 pm | David Barda (Eli Lilly) "Discovery of a Selective Chk1 Inhibitor for the Treatment of Cancer" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session I |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Discovery Biology and Natural Product Synthesis |
| Discussion Leader: Scott Gilbertson (University of Houston) |
7:30 pm - 7:55 pm | Matthew Lamarche (Novartis Institute for Biomedical Research) "Big Drugs for Very Bad Bugs" |
7:55 pm - 8:00 pm | Discussion |
8:00 pm - 8:40 pm | Patrick Harran (University of California - Los Angeles) "Synthetic Means to Reach Natural Ends" |
8:40 pm - 8:45 pm | Discussion |
8:45 pm - 9:25 pm | P. Andrew Evans (University of Liverpool) "New Metal-Catalyzed Reactions as Enabling Tools for the Expeditious Synthesis of Complex Natural Products" |
9:25 pm - 9:30 pm | Discussion |
TUESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 10:10 am | Medicinal Chemistry |
| Discussion Leader: Rajinder Singh (Rigel) |
9:00 am - 9:30 am | Bart DeCorte (Jonson & Johnson Pharmaceutical Research & Development) "The Discovery of Intelence, a Next-Generation NNRTI for the Treatment of HIV" |
9:30 am - 9:35 am | Discussion |
9:35 am - 10:05 am | Graciela Arhancet (Pfizer) "Discovery of Clinical Candidate PF-3882845, a Mineralocorticoid Receptor (MR) Antagonist for Hypertension and Nephropathy" |
10:05 am - 10:10 am | Discussion |
10:10 am - 10:30 am | Coffee Break |
10:30 am - 12:30 pm | Isolation, Chemistry, and Biology of Marine Natural Products |
| Discussion Leader: Yali Fu (National Cancer Institute / National Institutes of Health) |
10:30 am - 11:05 am | John MacMillan (UT Southwestern Medical Center) "Integration of a Marine Microbial Natural Products Library with High
Throughput Screening" |
11:05 am - 11:10 am | Discussion |
11:10 am - 11:45 am | Tadeusz Molinski (University of California - San Diego) "Marine Natural Products: From the Extreme to the Enigmatic" |
11:45 am - 11:50 am | Discussion |
11:50 am - 12:25 pm | Raymond Andersen (University of British Columbia) "Bioactivity Driven Discovery of New Marine Natural Products" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session II |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Enabling Methodology and Total Synthesis of Natural Products |
| Discussion Leader: Martin Lear (National University Singapore) |
7:30 pm - 8:10 pm | Jin-Quan Yu (The Scripps Research Institute - La Jolla) "From Accelerated C-H Activation Reactions to Polyketide Synthesis" |
8:10 pm - 8:15 pm | Discussion |
8:15 pm - 8:35 pm | Regan Thomson (Northwestern University) "Development and Application of Oxidative Carbon-Carbon Bond Construction to Natural Product Synthesis" |
8:35 pm - 8:40 pm | Discussion |
8:40 pm - 9:25 pm | Keisuke Suzuki (Tokyo Institute of Technology) "Total Synthesis of Poly-oxygenated Natural Products" |
9:25 pm - 9:30 pm | Discussion |
WEDNESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 10:20 am | Natural Product Synthesis and Bioorganic Chemistry |
| Discussion Leader: Emily Balskus (Harvard Medical School) |
9:00 am - 9:35 am | Joseph Ready (UT Southwestern Medical Center) "Total synthesis of biologically active natural products" |
9:35 am - 9:40 am | Discussion |
9:40 am - 10:15 am | Matthew Francis (University of California - Berkeley) "New Chemical Strategies for the Modification of Complex Biomolecules" |
10:15 am - 10:20 am | Discussion |
10:20 am - 10:40 am | Coffee Break |
10:40 am - 12:30 pm | Natural Product Synthesis and Bioorganic Chemistry |
| Discussion Leader: Xin Jiang (Reata Pharmaceuticals) |
10:40 am - 11:05 am | Yiyin Ku (Abbott Laboratories) "Process Research and Development of a Potent and Selective HCV Polymerase Inhibitor" |
11:05 am - 11:10 am | Discussion |
11:10 am - 11:45 am | Scott Denmark (University of Illinois) "Understanding Asymmetric Phase Transfer Catalysis through Chemoinformatics" |
11:45 am - 11:50 am | Discussion |
11:50 am - 12:25 pm | Jonathan Ellman (Yale University) "Applications of New C-C Bond-Forming Reactions in Natural Product Synthesis" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session III |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Synthesis of Complex Natural Products |
| Discussion Leader: Mark Rizzacasa (University of Melbourne) |
7:30 pm - 8:10 pm | Eun Lee (Seoul National University) "Bioactive Oxacyclic Natural Products: New Strategies" |
8:10 pm - 8:15 pm | Discussion |
8:15 pm - 8:35 pm | Neil Garg (UCLA) "Studies toward the Total Synthesis of Heterocyclic Natural Products" |
8:35 pm - 8:40 pm | Discussion |
8:40 pm - 9:25 pm | Ian Paterson (Cambridge University) "Synthesis of Polyketide Natural Products as Promising Anticancer Agents" |
9:25 pm - 9:30 pm | Discussion |
THURSDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 10:20 am | Synthesis Heterocyclic Natural Products |
| Discussion Leader: Uttam Tambar (UT Southwestern Medical Center) |
9:00 am - 9:35 am | Jon Rainier (University of Utah) "Targeting Heterocyclic Natural Products at 4700 Feet" |
9:35 am - 9:40 am | Discussion |
9:40 am - 10:15 am | Emmanuel Theodorakis (University of California - San Diego) "Strategies and Methods in Natural Products Synthesis" |
10:15 am - 10:20 am | Discussion |
10:20 am - 10:40 am | Coffee Break |
10:40 am - 12:30 pm | Isolation of Natural Products |
| Discussion Leader: Chris Beaudry (Oregon State University) |
10:40 am - 11:00 am | Martin Lear (National University of Singapore) "One Small Step for Synthesis; One Giant Leap for Total Synthesis" |
11:00 am - 11:05 am | Discussion |
11:05 am - 11:45 am | Phil Crews (University of California - Santa Cruz) "Milestone Discoveries & Lessons Learned Based on UCSC Marine-Derived
Small Molecules" |
11:45 am - 11:50 am | Discussion |
11:50 am - 12:25 pm | Peter Northcote (Victoria University of Wellington) "NMR Guided Isolation of Marine Natural Products: Teaching an Old Dog New Tricks?" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 6:00 pm | Free Time / Annual Academic vs Industrial All-Stars Softball Game (2:00 pm - 4:00 pm) |
6:00 pm | Dinner |
7:00 pm - 7:30 pm | Business Meeting |
| (Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair) |
7:30 pm - 9:30 pm | Natural Product Synthesis, Biology, and Structure-Function Studies |
| Discussion Leader: Michael Luzzio (Novartis) |
7:30 pm - 8:10 pm | Tomas Hudlicky (Brock University) "Chemoenzymatic Total Synthesis of Natural Products and Pursuit of New
Medicinal Agents in the Areas of Cancer, Pain Control, and Viral Infections" |
8:10 pm - 8:15 pm | Discussion |
8:15 pm - 9:25 pm | Paul Wender (Stanford University) "Channeling the Power of New Reactions, Step Economy and Function Oriented Synthesis into Transformative Strategies for Eradicating HIV/
AIDS, Overcoming Resistant Cancer and Treating Alzheimer's Disease" |
9:25 pm - 9:30 pm | Discussion |
FRIDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am | Departure |