SUNDAY |
2:00 pm - 9:00 pm | Arrival and Check-in (Office Closed 6:00 pm - 7:00 pm) |
6:00 pm | Dinner |
7:30 pm - 7:40 pm | Welcome Comments by GRC Site Staff / Chair's Welcome by Karl Hansen (Amgen) |
7:40 pm - 9:30 pm | Stereoselective Synthesis |
| Discussion Leader: Raj Singh (Rigel) |
7:40 pm - 8:15 pm | Tim Jamison (Massachusetts Institute of Technology) "Epoxide-Opening Cascades: Development, Mechanism, Application " |
8:15 pm - 8:20 pm | Discussion |
8:20 pm - 8:40 pm | Corey Stephenson (Boston University) "Total Synthesis of Gliocladin C Enabled by Visible Light Photoredox Catalysis" |
8:40 pm - 8:45 pm | Discussion |
8:45 pm - 9:25 pm | Jim Leighton (Columbia University) "Doing more with Less: In Pursuit of the Ideal in Chemical Synthesis" |
9:25 pm - 9:30 pm | Discussion |
9:30 pm | Chair's Reception |
MONDAY |
7:30 am - 8:30 am | Breakfast |
8:30 am | Group Photo |
9:00 am - 10:20 am | Process Chemistry 1 |
| Discussion Leader: Hao Xu (Georgia State University) |
9:00 am - 9:25 am | Debra Wallace (Merck Process Research) "Development of the manufacturing route for Suvorexant, a Dual Orexin Antagonist for Sleep Disorder" |
9:25 am - 9:30 am | Discussion |
9:30 am - 9:55 am | Oliver Thiel (Amgen, Chemical Process R&D) "Practical Synthesis of Heterocyclic Cores for p38-Inhibitors" |
9:55 am - 10:00 am | Discussion |
10:00 am - 10:40 am | Coffee Break / Group Photo |
10:40 am - 12:30 pm | Radical Chemistry and Natural Products |
| Discussion Leader: Lisa Marcaurelle (H3 Biomedicine) |
10:40 am - 11:15 am | Masayuki Inoue (University of Tokyo) "Radical-Based Approach for Synthesis of Complex Natural Products" |
11:15 am - 11:20 am | Discussion |
11:20 am - 11:40 am | William Chain (UIniversity of Hawaii) "A Brief Synthesis of Englerin A" |
11:40 am - 11:45 am | Discussion |
11:45 am - 12:25 pm | Samir Zard (Ecole Polytechnique) "Fun with Radicals. Some New Perspectives for Organic Synthesis" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session I |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Synthesis of Biologically Useful Natural Products |
| Discussion Leader: Mary Watson (University of Delaware) |
7:30 pm - 8:00 pm | Douglass F. Taber (University of Delaware) "Polycarbocyclic Construction: Synthesis of (-)-Veratramine |
8:00 pm - 8:05 pm | Discussion |
8:05 pm - 8:40 pm | Karl Scheidt (Northwestern University) "92 Years Old and Still Kicking: Prins-based Strategies for the Synthesis of Pyran Natural Products" |
8:40 pm - 8:45 pm | Discussion |
8:45 pm - 9:25 pm | Larry Overman (University of California, Irvine) "Enantioselective Total Synthesis of Polycyclic Natural Products" |
9:25 pm - 9:30 pm | Discussion |
TUESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 10:10 am | Medicinal Chemistry and Drug Discovery |
| Discussion Leader: Brian Albrecht (Constellation Pharmaceuticals) |
9:00 am - 9:30 am | Jotham Coe (Pfizer) "The Natural Product Road to Chantix" |
9:30 am - 9:35 am | Discussion |
9:35 am - 10:05 am | C. Eric Anderson (Reata Pharmaceuticals) "Discovery of Bardoxolone" |
10:05 am - 10:10 am | Discussion |
10:10 am - 10:40 am | Coffee Break |
10:40 am - 12:30 pm | Isolation, Chemistry, and Biology of Natural Products 1 |
| Discussion Leader: Xinyu Liu (University of Pittsburg) |
10:40 am - 11:15 am | Eric Schmidt (University of Utah) "Direct Genomic Approaches to Marine Natural Product Discovery and Analoging" |
11:15 am - 11:20 am | Discussion |
11:20 am - 11:40 am | Don Coltart (Duke University) "Leveraging the Reactivity of Activated Hydrazones in the Development of New Synthetic Methods: Applications to Natural Product Synthesis" |
11:40 am - 11:45 am | Discussion |
11:45 am - 12:25 pm | Brad Moore (University of California, San Diego) "Probing a Favorskii-Like Rearrangement in Enterocin Biosynthesis" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session II |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Enabling Methodology and Total Synthesis of Natural Products |
| Discussion Leader: Steve Olson (Amgen) |
7:30 pm - 8:10 pm | Christina White (University of Illinois, Urbana Champagne) |
8:10 pm - 8:15 pm | Discussion |
8:15 pm - 8:35 pm | Brandon Ashfeld (University of Notre Dame) "Harnessing Masked Electrophilicity: Alternative Strategies for Selective Carbonyl Functionalization" |
8:35 pm - 8:40 pm | Discussion |
8:40 pm - 9:25 pm | Scott Miller (Yale University) "Natural Products, Synthetic Catalysts, Unnatural Products" |
9:25 pm - 9:30 pm | Discussion |
WEDNESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 10:20 am | Pharmaceutical Process Chemistry II |
| Discussion Leader: Amber Onorato (Saint John's University) |
9:00 am - 9:30 am | Scott Frank (Eli Lilly) "Applications of the DARA (Direct Asymmetric Reductive Amination) Reaction in Large Scale Drug Candidate Manufacture" |
9:30 am - 9:35 am | Discussion |
9:35 am - 10:05 am | Dave Barnes (Abbott) "A Scaleable Asymmetric Synthesis of a PARP Inhibitor, Employing a Memory of Chirality Cyclization" |
10:05 am - 10:10 am | Discussion |
10:10 am - 10:40 am | Coffee Break |
10:40 am - 12:30 pm | Isolation, Chemistry, and Biology of Natural Products 2 |
| Discussion Leader: Silas Cook (Indiana University) |
10:40 am - 11:00 am | Uttam Tambar (University of Texas Southwestern Medical Center) "Stereoselective Catalysis of [2,3]-Rearrangements" |
11:00 am - 11:05 am | Discussion |
11:05 am - 11:40 am | Mark Hamann (University of Mississippi) "New natural products from remote marine and terrestrial communities with activity against cancer and infectious diseases" |
11:40 am - 11:45 am | Discussion |
11:45 am - 12:25 pm | Rob Capon (University of Queensland) |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session III |
6:00 pm | Dinner |
7:00 pm - 7:30 pm | Business Meeting |
| Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair |
7:30 pm - 9:30 pm | Transition Metals in Synthetic Methodology and Natural Product Synthesis |
| Discussion Leader: Noah Burns (Harvard University) |
7:30 pm - 8:10 pm | Ilan Marek (Israel Institute of Technology) "Recent Advances in Stereoselective Synthesis" |
8:10 pm - 8:15 pm | Discussion |
8:15 pm - 8:35 pm | Abigail Doyle (Princeton University) "Nickel-Catalyzed Cross Coupling with N,O-Acetals and Acetals" |
8:35 pm - 8:40 pm | Discussion |
8:40 pm - 9:25 pm | Brian Stoltz (California Institute of Technology) "Complex Natural Products as a Driving Force for Discovery in Organic Chemistry" |
9:25 pm - 9:30 pm | Discussion |
THURSDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 10:20 am | Synthetic Methods for Oxidation |
| Discussion Leader: Vinod Patel (SANOFI) |
9:00 am - 9:30 am | Tehshik Yoon (University of Wisconsin, Madison) "Oxidative Photocatalysis: Synthetic Chemistry of Radical Ions." |
9:30 am - 9:35 am | Discussion |
9:35 am - 10:05 am | Tobias Ritter (Harvard University) "Late-Stage Fluorination" |
10:05 am - 10:10 am | Discussion |
10:10 am - 10:35 am | Coffee Break |
10:30 am - 12:30 pm | Methods and Synthesis |
| Discussion Leader: Jef Marcoux (Group Novasep) |
10:35 am - 11:10 am | Jerry Tanoury (Vertex) "Development of a Manufacturing Process for Telaprevir" |
11:10 am - 11:15 am | Discussion |
11:15 am - 11:40 am | Sarah Riesman (California Institute of Technology) "New Methods and Strategies for the Synthesis of Polycyclic Natural Products" |
11:40 am - 11:45 am | Discussion |
11:45 am - 12:25 pm | Andre Charette (University of Montreal) "Fine-tuning of rhodium based catalysts and their use in stereoselective reactions and in natural product synthesis" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 6:00 pm | Free Time / Annual Academic vs Industrial All-Stars Softball Game (2:00 pm - 4:00 pm) |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Asymmetric Catalysis and Natural Product Synthesis |
| Discussion Leader: Petr Vachal (Merck & Co.) |
7:30 pm - 8:10 pm | Matt Sigman (University of Utah) "New Approaches to Asymmetric Catalyst Design and Development" |
8:10 pm - 8:15 pm | Discussion |
8:15 pm - 9:25 pm | Eric Jacobsen (Harvard University) "Dual Catalysis in Enantioselective Oxidopyrylium-Based [5+2] Cycloadditions" |
9:25 pm - 9:30 pm | Discussion |
FRIDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am | Departure |