Natural Products

Gordon Research Conference

July 24 - 29, 2011
Chair
Vice Chair
Bryant University
1150 Douglas Pike
Smithfield, Rhode Island, United States
 Venue and Travel Information

Conference Description

The 60th Natural Products Gordon research Conference will feature cutting edge developments in natural products isolation, structure elucidation, synthesis, methods development, and other areas enabled by organic chemistry. The complex structures and remarkable biological properties of natural products serve as inspiration to drive the art of organic chemistry and drug discovery. They provide a platform for developing new synthetic strategies and methodology for the synthesis of complex small molecules. This year’s speakers will present lectures on synthetic organic chemistry (total synthesis, medicinal chemistry, process chemistry, asymmetric catalysis and organometallic chemistry), natural product isolation, bio-synthesis, chemical biology and structure elucidation.

The meeting will be held in a new location, Bryant University in Smithfield, Rhode Island. The site offers comfortable accommodations as well as suitable facilities for the exchange of science. The robust, relaxed and cordial social climate of this conference will be well-served by the Bryant site as well.

Poster sessions are a critical part of the scientific and social exchange at the Natural Products GRC. All conferees are encouraged to present a poster. A small number of posters will be selected as short talks during the conference.

The Chair and Vice-Chair hope to welcome you to what is anticipated to be an exciting, memorable, and enjoyable conference.

Conference Program

SUNDAY
2:00 pm - 9:00 pmArrival and Check-in (Office Closed 6:00 pm - 7:00 pm)
6:00 pmDinner
7:30 pm - 7:40 pmWelcome Comments by GRC Site Staff / Chair's Welcome by Karl Hansen (Amgen)
7:40 pm - 9:30 pmStereoselective Synthesis
Discussion Leader: Raj Singh (Rigel)
7:40 pm - 8:15 pmTim Jamison (Massachusetts Institute of Technology)
"Epoxide-Opening Cascades: Development, Mechanism, Application "
8:15 pm - 8:20 pmDiscussion
8:20 pm - 8:40 pmCorey Stephenson (Boston University)
"Total Synthesis of Gliocladin C Enabled by Visible Light Photoredox Catalysis"
8:40 pm - 8:45 pmDiscussion
8:45 pm - 9:25 pmJim Leighton (Columbia University)
"Doing more with Less: In Pursuit of the Ideal in Chemical Synthesis"
9:25 pm - 9:30 pmDiscussion
9:30 pmChair's Reception
MONDAY
7:30 am - 8:30 amBreakfast
8:30 amGroup Photo
9:00 am - 10:20 amProcess Chemistry 1
Discussion Leader: Hao Xu (Georgia State University)
9:00 am - 9:25 amDebra Wallace (Merck Process Research)
"Development of the manufacturing route for Suvorexant, a Dual Orexin Antagonist for Sleep Disorder"
9:25 am - 9:30 amDiscussion
9:30 am - 9:55 amOliver Thiel (Amgen, Chemical Process R&D)
"Practical Synthesis of Heterocyclic Cores for p38-Inhibitors"
9:55 am - 10:00 amDiscussion
10:00 am - 10:40 amCoffee Break / Group Photo
10:40 am - 12:30 pmRadical Chemistry and Natural Products
Discussion Leader: Lisa Marcaurelle (H3 Biomedicine)
10:40 am - 11:15 amMasayuki Inoue (University of Tokyo)
"Radical-Based Approach for Synthesis of Complex Natural Products"
11:15 am - 11:20 amDiscussion
11:20 am - 11:40 amWilliam Chain (UIniversity of Hawaii)
"A Brief Synthesis of Englerin A"
11:40 am - 11:45 amDiscussion
11:45 am - 12:25 pmSamir Zard (Ecole Polytechnique)
"Fun with Radicals. Some New Perspectives for Organic Synthesis"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session I
6:00 pmDinner
7:30 pm - 9:30 pmSynthesis of Biologically Useful Natural Products
Discussion Leader: Mary Watson (University of Delaware)
7:30 pm - 8:00 pmDouglass F. Taber (University of Delaware)
"Polycarbocyclic Construction: Synthesis of (-)-Veratramine
8:00 pm - 8:05 pmDiscussion
8:05 pm - 8:40 pmKarl Scheidt (Northwestern University)
"92 Years Old and Still Kicking: Prins-based Strategies for the Synthesis of Pyran Natural Products"
8:40 pm - 8:45 pmDiscussion
8:45 pm - 9:25 pmLarry Overman (University of California, Irvine)
"Enantioselective Total Synthesis of Polycyclic Natural Products"
9:25 pm - 9:30 pmDiscussion
TUESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 10:10 amMedicinal Chemistry and Drug Discovery
Discussion Leader: Brian Albrecht (Constellation Pharmaceuticals)
9:00 am - 9:30 amJotham Coe (Pfizer)
"The Natural Product Road to Chantix"
9:30 am - 9:35 amDiscussion
9:35 am - 10:05 amC. Eric Anderson (Reata Pharmaceuticals)
"Discovery of Bardoxolone"
10:05 am - 10:10 amDiscussion
10:10 am - 10:40 amCoffee Break
10:40 am - 12:30 pmIsolation, Chemistry, and Biology of Natural Products 1
Discussion Leader: Xinyu Liu (University of Pittsburg)
10:40 am - 11:15 amEric Schmidt (University of Utah)
"Direct Genomic Approaches to Marine Natural Product Discovery and Analoging"
11:15 am - 11:20 amDiscussion
11:20 am - 11:40 amDon Coltart (Duke University)
"Leveraging the Reactivity of Activated Hydrazones in the Development of New Synthetic Methods: Applications to Natural Product Synthesis"
11:40 am - 11:45 amDiscussion
11:45 am - 12:25 pmBrad Moore (University of California, San Diego)
"Probing a Favorskii-Like Rearrangement in Enterocin Biosynthesis"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session II
6:00 pmDinner
7:30 pm - 9:30 pmEnabling Methodology and Total Synthesis of Natural Products
Discussion Leader: Steve Olson (Amgen)
7:30 pm - 8:10 pmChristina White (University of Illinois, Urbana Champagne)
8:10 pm - 8:15 pmDiscussion
8:15 pm - 8:35 pmBrandon Ashfeld (University of Notre Dame)
"Harnessing Masked Electrophilicity: Alternative Strategies for Selective Carbonyl Functionalization"
8:35 pm - 8:40 pmDiscussion
8:40 pm - 9:25 pmScott Miller (Yale University)
"Natural Products, Synthetic Catalysts, Unnatural Products"
9:25 pm - 9:30 pmDiscussion
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 10:20 amPharmaceutical Process Chemistry II
Discussion Leader: Amber Onorato (Saint John's University)
9:00 am - 9:30 amScott Frank (Eli Lilly)
"Applications of the DARA (Direct Asymmetric Reductive Amination) Reaction in Large Scale Drug Candidate Manufacture"
9:30 am - 9:35 amDiscussion
9:35 am - 10:05 amDave Barnes (Abbott)
"A Scaleable Asymmetric Synthesis of a PARP Inhibitor, Employing a Memory of Chirality Cyclization"
10:05 am - 10:10 amDiscussion
10:10 am - 10:40 amCoffee Break
10:40 am - 12:30 pmIsolation, Chemistry, and Biology of Natural Products 2
Discussion Leader: Silas Cook (Indiana University)
10:40 am - 11:00 amUttam Tambar (University of Texas Southwestern Medical Center)
"Stereoselective Catalysis of [2,3]-Rearrangements"
11:00 am - 11:05 amDiscussion
11:05 am - 11:40 amMark Hamann (University of Mississippi)
"New natural products from remote marine and terrestrial communities with activity against cancer and infectious diseases"
11:40 am - 11:45 amDiscussion
11:45 am - 12:25 pmRob Capon (University of Queensland)
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session III
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair
7:30 pm - 9:30 pmTransition Metals in Synthetic Methodology and Natural Product Synthesis
Discussion Leader: Noah Burns (Harvard University)
7:30 pm - 8:10 pmIlan Marek (Israel Institute of Technology)
"Recent Advances in Stereoselective Synthesis"
8:10 pm - 8:15 pm Discussion
8:15 pm - 8:35 pmAbigail Doyle (Princeton University)
"Nickel-Catalyzed Cross Coupling with N,O-Acetals and Acetals"
8:35 pm - 8:40 pmDiscussion
8:40 pm - 9:25 pmBrian Stoltz (California Institute of Technology)
"Complex Natural Products as a Driving Force for Discovery in Organic Chemistry"
9:25 pm - 9:30 pmDiscussion
THURSDAY
7:30 am - 8:30 amBreakfast
9:00 am - 10:20 amSynthetic Methods for Oxidation
Discussion Leader: Vinod Patel (SANOFI)
9:00 am - 9:30 amTehshik Yoon (University of Wisconsin, Madison)
"Oxidative Photocatalysis: Synthetic Chemistry of Radical Ions."
9:30 am - 9:35 amDiscussion
9:35 am - 10:05 amTobias Ritter (Harvard University)
"Late-Stage Fluorination"
10:05 am - 10:10 amDiscussion
10:10 am - 10:35 amCoffee Break
10:30 am - 12:30 pmMethods and Synthesis
Discussion Leader: Jef Marcoux (Group Novasep)
10:35 am - 11:10 amJerry Tanoury (Vertex)
"Development of a Manufacturing Process for Telaprevir"
11:10 am - 11:15 amDiscussion
11:15 am - 11:40 amSarah Riesman (California Institute of Technology)
"New Methods and Strategies for the Synthesis of Polycyclic Natural Products"
11:40 am - 11:45 amDiscussion
11:45 am - 12:25 pmAndre Charette (University of Montreal)
"Fine-tuning of rhodium based catalysts and their use in stereoselective reactions and in natural product synthesis"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 6:00 pmFree Time / Annual Academic vs Industrial All-Stars Softball Game (2:00 pm - 4:00 pm)
6:00 pmDinner
7:30 pm - 9:30 pmAsymmetric Catalysis and Natural Product Synthesis
Discussion Leader: Petr Vachal (Merck & Co.)
7:30 pm - 8:10 pmMatt Sigman (University of Utah)
"New Approaches to Asymmetric Catalyst Design and Development"
8:10 pm - 8:15 pmDiscussion
8:15 pm - 9:25 pmEric Jacobsen (Harvard University)
"Dual Catalysis in Enantioselective Oxidopyrylium-Based [5+2] Cycloadditions"
9:25 pm - 9:30 pmDiscussion
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDeparture

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