SUNDAY |
2:00 pm - 9:00 pm | Arrival and Check-in (Office Closed 6:00 pm - 7:00 pm) |
6:00 pm | Dinner |
7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
7:40 pm - 9:30 pm | Chemical Synthesis of Complex Natural Products |
| Discussion Leader: Richard Taylor (University of Notre Dame) |
7:40 pm - 8:15 pm | David Williams (Indiana University)
"The Evolution of Strategies for Natural Product Synthesis: A Wellspring for Inspiration, Innovation, and Discovery in Organic Chemistry" |
8:15 pm - 8:20 pm | Discussion |
8:20 pm - 8:40 pm | Frank Fang (Eisai Research Institute)
"Process Research on Natural Product-Based Drug Candidates" |
8:40 pm - 8:45 pm | Discussion |
8:45 pm - 9:25 pm | John Wood (Colorado State University)
"Recent Progress in the Synthesis of Oxindole-Containing Natural Products"
|
9:25 pm - 9:30 pm | Discussion |
MONDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Natural Product Biosynthesis, Isolation, and Structure Determination |
| Discussion Leader: Amber Onorato (College of St. Benedict/St.John's University) |
9:00 am - 9:40 am | Amy Wright (FAU/Harbor Branch)
"Investigation of Marine Natural Products as Potential Therapeutic Agents" |
9:40 am - 9:50 am | Discussion |
9:50 am - 10:10 am | Erin Carlson (Indiana University)
"Chemoselective Enrichment for Natural Products Discovery"
|
10:10 am - 10:20 am | Discussion |
10:20 am - 10:50 am | Coffee Break |
10:50 am - 11:30 am | William Gerwick (UCSD/Scripps)
"Discovery and Synthesis of Anticancer and Antiinflammatory Lead Molecules from Marine Cyanobacteria"
|
11:30 am - 11:40 am | Discussion |
11:40 am - 12:20 pm | Jon Clardy (Harvard Medical School)
"Bacterial Signals that Affect Eukaryotic Development"
|
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Natural Products Synthesis and Applications to Chemical Biology |
| Discussion Leader: Brandon Ashfeld (University of Notre Dame) |
7:30 pm - 8:10 pm | Sergey Kozmin (University of Chicago)
"Chemistry and Biology of Streptolydigin Antibiotics"
|
8:10 pm - 8:15 pm | Discussion |
8:15 pm - 8:40 pm | Carmela Molinaro (Merck)
"CRTH2 Antagonist MK-7248: A Synthetic Evolution from Discovery through Development"
|
8:40 pm - 8:45 pm | Discussion |
8:45 pm - 9:25 pm | Andrew Phillips (Yale University)
"Natural Products: Discovery and Synthesis"
|
9:25 pm - 9:30 pm | Discussion |
TUESDAY |
7:30 am - 8:30 am | Breakfast |
8:30 am | Group Photo |
9:00 am - 12:30 pm | Use of Metal-Mediated Methods in Natural Products Synthesis |
| Discussion Leader: Silas Cook (Indiana University) |
9:00 am - 9:30 am | Vy Dong (University of California/Irvine)
"Catalysis Inspired by Macrocyclic Natural Products"
|
9:30 am - 9:35 am | Discussion |
9:35 am - 9:55 am | Erik Alexanian (University of North Carolina/Chapel Hill)
"Transition Metal Catalyzed Cycloadditions for Complex Molecule Synthesis" |
9:55 am - 10:00 am | Discussion |
10:00 am - 10:30 am | Coffee Break |
10:30 am - 11:00 am | John Wolfe (University of Michigan)
"New Palladium-Catalyzed Alkene Carboamination Reactions for the Stereoselective Synthesis of Nitrogen Heterocycles"
|
11:00 am - 11:10 am | Discussion |
11:10 am - 11:40 am | Neil Garg (UCLA)
"Total Synthesis of Heterocyclic Natural Products"
|
11:40 am - 11:50 am | Discussion |
11:50 am - 12:20 pm | Huw Davies (Emory University)
"Natural Product Synthesis Using C-H Functionalization Methodologies"
|
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Biogenetic Inspired Synthesis of Natural Products |
| Discussion Leader: Michael Luzzio (Novartis Institutes for Biomedical Research) |
7:30 pm - 8:05 pm | Erik Sorensen (Princeton University)
"Taking Risks in Complex Synthesis Design"
|
8:05 pm - 8:10 pm | Discussion |
8:10 pm - 8:45 pm | Robert Williams (Colorado State University)
"Enantiomeric Natural Products: Biosynthetic, Synthetic and Genetic Revelations"
|
8:45 pm - 8:50 pm | Discussion |
8:50 pm - 9:25 pm | Mohammad Movassaghi (MIT)
"Complex Alkaloid Total Synthesis"
|
9:25 pm - 9:30 pm | Discussion |
WEDNESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Discovery and Elucidation of Natural Product Biosynthetic Pathways |
| Discussion Leader: William Wuest (Temple University) |
9:00 am - 9:40 am | Rebecca Goss (University of East Anglia)
"Elucidating and Harnessing Pacidamycin Biosynthesis"
|
9:40 am - 9:50 am | Discussion |
9:50 am - 10:10 am | Doug Mitchell (University of Illinois)
"Structure and Functional Studies of Emerging Polyheterocyclic Antibiotics"
|
10:10 am - 10:20 am | Discussion |
10:20 am - 10:50 am | Coffee Break |
10:50 am - 11:30 am | Dean Tantillo (Universtiy of California/Davis)
"Formation Mechanisms and Structural Assignments for Complex Terpenes from Quantum Chemical Calculations"
|
11:30 am - 11:40 am | Discussion |
11:40 am - 12:20 pm | Ben Shen (The Scripps Research Institute/Florida)
"Impact of Genomics on Discovery and Elucidation of Natural Product Biosynthetic Pathways"
|
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Novel Synthetic Methods for Natural Products Synthesis |
| Discussion Leader: Jennifer Stockdill (Wayne State University) |
7:30 pm - 8:05 pm | Tarek Sammakia (University of Colorado)
"New Methods for the Synthesis of Natural Products Bearing Hindered Quaternary Carbons"
|
8:05 pm - 8:10 pm | Discussion |
8:10 pm - 8:45 pm | Matthias Christmann (Technische Universitat Dortmund)
"Enabling Methods for the Step-Efficient Synthesis of Biologically Active Natural Products"
|
8:45 pm - 8:50 pm | Discussion |
8:50 pm - 9:25 pm | Chris Vanderwal (University of California/Irvine)
"Strategies for Complex Molecule Synthesis"
|
9:25 pm - 9:30 pm | Discussion |
THURSDAY |
7:30 am - 8:30 am | Breakfast |
8:30 am - 9:00 am | Business Meeting |
| Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair |
9:00 am - 12:30 pm | Development and Application of Novel Synthetic Methods for Natural Product Synthesis |
| Discussion Leader: Zachary Aron (Indiana University) |
9:00 am - 9:40 am | Dan Romo (Texas A&M)
"Tandem, Organocatalyzed Reactions Leading to β-Lactones and Natural Products"
|
9:40 am - 9:50 am | Discussion |
9:50 am - 10:10 am | Seth Herzon (Yale University)
"Target-Driven Total Synthesis"
|
10:10 am - 10:20 am | Discussion |
10:20 am - 10:50 am | Coffee Break |
10:50 am - 11:30 am | Richmond Sarpong (University of California/Berkeley)
"Strategies and Tactics Inspired by Complex Alkaloids" |
11:30 am - 11:40 am | Discussion |
11:40 am - 12:20 pm | Glenn Micalizio (The Scripps Research Institute/Florida)
"Metallacycle-Mediated Cross Coupling: Reaction Development and Application in Stereoselective Synthesis"
|
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 6:00 pm | Free Time |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Biosynthesis/Total Synthesis of Antibiotic Natural Products |
| Discussion Leader: Katherine Lee (Pfizer) |
7:30 pm - 7:55 pm | Amy DeBaillie (Eli Lilly and Company)
"An Efficient Synthesis of a Chiral Sulfone-Acid to Enable a Multi-Kilogram Preparation of a Glucokinase Activator" |
7:55 pm - 8:00 pm | Discussion |
8:00 pm - 8:40 pm | Wilfred van der Donk (University of Illinois)
"Combining Synthetic and Biosynthetic Chemistry to Prepare Natural Product Analogs"
|
8:40 pm - 8:45 pm | Discussion |
8:45 pm - 9:25 pm | Dale Boger (The Scripps Research Institute/La Jolla)
"Vancomycin Redesigned"
|
9:25 pm - 9:30 pm | Discussion |
FRIDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am | Departure |