SUNDAY |
2:00 pm - 9:00 pm | Arrival and Check-in |
6:00 pm | Dinner |
7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
7:40 pm - 9:30 pm | Total Synthesis of Natural Products |
| Discussion Leader: Robert Williams (Colorado State University) |
7:40 pm - 8:15 pm | Stephen Martin (University of Texas, Austin)
"Recent Progress in the Total Synthesis of Heterocyclic Natural Products"
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8:15 pm - 8:20 pm | Discussion |
8:20 pm - 8:40 pm | Jeremy May (University of Houston)
"Synthetic Discoveries from Polycyclic Natural Products"
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8:40 pm - 8:45 pm | Discussion |
8:45 pm - 9:25 pm | Rick Danheiser (Massachusetts Institute of Technology)
"New Cycloaddition Strategies Based on Strained and Unusual Molecules"
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9:25 pm - 9:30 pm | Discussion |
MONDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 10:10 am | Novel Technologies in the Discovery of Natural Products from Marine Sources |
| Discussion Leader: Kerry McPhail (Oregon State University) |
9:00 am - 9:25 am | Roger Linington (University of California, Santa Cruz)
"Function-First Approaches to Natural Products Discovery Through Image-Based High Content Screening"
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9:25 am - 9:30 am | Discussion |
9:30 am - 10:05 am | Hendrik Luesch (University of Florida)
"Marine Cyanobacterial Natural Products as Starting Points for Drug Discovery"
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10:05 am - 10:10 am | Discussion |
10:10 am - 10:40 am | Coffee Break |
10:40 am - 12:30 pm | Catalysis and Synthetic Methodology |
| Discussion Leader: Uttam Tambar (UT Southwestern Medical) |
10:40 am - 11:10 am | Ohyn Kwon (University of California, Los Angeles)
"Phosphine Catalysis - Old and New"
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11:10 am - 11:15 am | Discussion |
11:15 am - 11:45 am | Alison Frontier (University of Rochester)
"Cyclization Strategies for the Synthesis of Natural Products"
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11:45 am - 11:50 am | Discussion |
11:50 am - 12:25 pm | F. Dean Toste (University of California, Berkeley)
"Asymmetric Catalysis with Cations and Anions"
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12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Synthesis of Heterocyclic Natural Products and Chemical Biology |
| Discussion Leader: Brian Albrecht (Constellation Pharmaceuticals) |
7:30 pm - 8:05 pm | Marco Ciufolini (University of British Columbia)
"Synthetic Studies on Heterocyclic Natural Products"
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8:05 pm - 8:10 pm | Discussion |
8:10 pm - 8:40 pm | Steven Olson (Amgen)
"Structure-Based Design of Novel Piperidinone Inhibitors of the MDM2-p53 Interaction"
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8:40 pm - 8:45 pm | Discussion |
8:45 pm - 9:25 pm | Dirk Trauner (Ludwig-Maximilians-Universität, Munich)
"The Fascinating Chemistry of Red Colorants"
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9:25 pm - 9:30 pm | Discussion |
TUESDAY |
7:30 am - 8:30 am | Breakfast |
8:30 am | Group Photo |
9:00 am - 10:10 am | New Methods and Biomimetic Synthesis of Biologically Active Natural Products |
| Discussion Leader: Cameron Smith (Merck) |
9:00 am - 9:25 am | Armen Zakarian (University of California, Santa Barbara)
"Enantioselective Synthesis and Glucokinase Activating Properties of Tatanans A-C" |
9:25 am - 9:30 am | Discussion |
9:30 am - 10:05 am | Jeremy Robertson (University of Oxford)
"One Thing Leads to Another... The Interplay of Heterocyclic Natural Product Synthesis and New Reaction Development"
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10:05 am - 10:10 am | Discussion |
10:10 am - 10:40 am | Coffee Break |
10:40 am - 12:30 pm | Process Development and Biomimetic Inspired Synthesis of Natural Products |
| Discussion Leader: Guangbin Dong (University of Texas, Austin) |
10:40 am - 11:10 am | Mark Kerr (Eli Lilly)
"Development of a Glucagon Receptor Antagonist"
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11:10 am - 11:15 am | Discussion |
11:15 am - 11:45 am | Jonathan Reeves (Boehringer Ingleheim)
"New Strategies for Chiral Amine Synthesis"
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11:45 am - 11:50 am | Discussion |
11:50 am - 12:25 pm | Matthew Shair (Harvard University)
"Assembling Highly Complex Organic Molecules Using Hints From Nature" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Strategies for Synthesis of Natural Products Leading to Probes to Investigate Biological Function |
| Discussion Leader: Eric Bercot (Suterra) |
7:30 pm - 8:05 pm | Scott Snyder (Columbia University)
"Exploring Chemoselectivity through Natural Product Total Synthesis"
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8:05 pm - 8:10 pm | Discussion |
8:10 pm - 8:40 pm | Martin Burke (University of Illinois, Urbana-Champaign)
"Making Molecular Prosthetics"
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8:40 pm - 8:45 pm | Discussion |
8:45 pm - 9:25 pm | Viresh Rawal (University of Chicago)
"Recent Developments in Alkaloids Total Synthesis"
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9:25 pm - 9:30 pm | Discussion |
WEDNESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 10:10 am | Synthetic Methods and Natural Products |
| Discussion Leader: Joie Garfunkle (Merck) |
9:00 am - 9:25 am | Eric Ferreira (Colorado State University)
"Platinum Catalysis toward the Synthesis of Natural Products"
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9:25 am - 9:30 am | Discussion |
9:30 am - 10:05 am | Richard Hsung (University of Wisconsin-Madison)
"Tandem Cascades for Natural Products Synthesis"
|
10:05 am - 10:10 am | Discussion |
10:10 am - 10:40 am | Coffee Break |
10:40 am - 12:30 pm | Innovations in Discovery and Investigation of Biologically Active Natural Products |
| Discussion Leader: John MacMillan (UT Southwestern Medical) |
10:40 am - 11:10 am | Kerry McPhail (Oregon State University)
"Structure and Function of Microbial Natural Products from 'Unique' Marine Environments"
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11:10 am - 11:15 am | Discussion |
11:15 am - 11:45 am | Mandë Holford (Hunter College, CUNY)
"Building a Better M.O.U.S.E. (Marine Organisms Used in Shuttle Encapsulation) Trap"
|
11:45 am - 11:50 am | Discussion |
11:50 am - 12:25 pm | William Fenical (Scripps Institution of Oceanography, UCSD)
"Marine Microbial Metabolites Provide Access to Mechanistically-novel Antitumor Drugs"
|
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:00 pm - 7:30 pm | Business Meeting |
| Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair |
7:30 pm - 9:30 pm | New Methods in Synthesis, Bioactive Natural Products, Drug Discovery and Function |
| Discussion Leader: Jennifer Stockdill (Wayne State University) |
7:30 pm - 8:05 pm | Gary Sulikowski (Vanderbilt University)
"Synthesis and Study of Bioactive Natural Products"
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8:05 pm - 8:10 pm | Discussion |
8:10 pm - 8:40 pm | José R. Tormo (Fundación MEDINA)
"Challenges in Drug Discovery from Natural Products Libraries"
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8:40 pm - 8:45 pm | Discussion |
8:45 pm - 9:25 pm | Amir H. Hoveyda (Boston College)
"New Catalytic Processes for Synthesis of Natural Products"
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9:25 pm - 9:30 pm | Discussion |
THURSDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 10:45 am | Diversity Oriented Synthesis in Medicinal Chemistry and Natural Products |
| Discussion Leader: Simon Shaw (Rigel) |
9:00 am - 9:30 am | Lisa Marcaurelle (H3 Biomedicine)
"Structural Complexity: Hype or Hope"
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9:30 am - 9:35 am | Discussion |
9:35 am - 10:10 am | Derek Tan (Sloan-Kettering Institute)
"Natural Product-based Strategies in Diversity-Oriented Synthesis"
|
10:10 am - 10:15 am | Discussion |
10:15 am - 10:45 am | Coffee Break |
10:45 am - 12:30 pm | Process Development, Biosynthesis, and New Reactions for Natural Product Synthesis |
| Discussion Leader: Steven Olson (Amgen) |
10:45 am - 11:15 am | Qinghao Chen (Merck)
"Chemical Process Development of Omarigliptin"
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11:15 am - 11:20 am | Discussion |
11:20 am - 11:40 am | Wendy Kelly (Georgia Institute of Technology)
"Biosynthetic Engineering to Access Thiostrepton Derivatives"
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11:40 am - 11:45 am | Discussion |
11:45 am - 12:25 pm | Jón Njarðarson (University of Arizona)
"Natural Products and New Synthetic Methods"
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12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Total Synthesis of Bioactive Natural Products |
| Discussion Leader: Michael Luzzio (Novartis) |
7:30 pm - 8:20 pm | Anthony Barrett (Imperial College London)
"Recent Advances in the Synthesis of Resorcylate Natural Products"
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8:20 pm - 8:30 pm | Discussion |
8:30 pm - 9:20 pm | Andrew Myers (Harvard University)
"Bringing the Full Power of Chemical Synthesis to Bear on the Discovery of New Antibiotics"
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9:20 pm - 9:30 pm | Discussion |
FRIDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am | Departure |