SUNDAY |
2:00 pm - 9:00 pm | Arrival and Check-in |
6:00 pm | Dinner |
7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
7:40 pm - 9:30 pm | Methodology for Natural Product Synthesis |
| Discussion Leader: David Myles (Olema Pharmaceuticals) |
7:40 pm - 7:55 pm | Guangbin Dong (University of Texas at Austin)
"Catalytic C-C Activation: A 'Cut and Sew' Approach to Bridged and Fused Rings"
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7:55 pm - 8:00 pm | Discussion |
8:00 pm - 8:35 pm | Jared Shaw (University of California, Davis)
"Enantioselective Intramolecular C-H Insertion Reactions of 'Donor-Donor' Carbenoids"
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8:35 pm - 8:40 pm | Discussion |
8:40 pm - 9:25 pm | Robert Grubbs (California Institute of Technology)
"Design and Applications of Selective Olefin Metathesis Catalysts"
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9:25 pm - 9:30 pm | Discussion |
MONDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Biologically Active Molecules Through Synthesis and Isolation |
| Discussion Leader: Lisa Marcaurelle (H3 Biomedicine) |
9:00 am - 9:15 am | Jennifer Stockdill (Wayne State University)
"Enabling Reactivity of Neutral Aminyl Radicals in Polycyclic Heterocycle Synthesis"
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9:15 am - 9:20 am | Discussion |
9:20 am - 9:55 am | Tomislav Rovis (Colorado State University)
"Rh(III) Catalyzed C-H Activation for N-Heterocycle Synthesis"
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9:55 am - 10:00 am | Discussion |
10:00 am | Coffee Break |
10:40 am - 10:55 am | Silas Cook (Indiana University)
"A Unified Strategy for Iron-Catalyzed C-H Alkylations" |
10:55 am - 11:00 am | Discussion |
11:00 am - 11:40 am | Marvin Hansen (Eli Lilly and Company)
"Synthesis of BACE Inhibitor LY2886721 via an Asymmetric Nitrone Cycloaddition"
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11:40 am - 11:45 am | Discussion |
11:45 am - 12:25 pm | Tadeusz Molinski (University of California, San Diego)
"Marine Natural Products. Chemical Tales from the Wine Dark Sea"
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12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Methods and Strategy for the Synthesis of Natural Products |
| Discussion Leader: Amber Onorato (Northern Kentucky University) |
7:30 pm - 8:05 pm | Jonathan Ellman (Yale University)
"Rapid Assembly of Heterocycles by C-H Bond Functionalization" |
8:05 pm - 8:10 pm | Discussion |
8:10 pm - 8:45 pm | Sherry Chemler (SUNY at Buffalo)
"Asymmetric Synthesis of Saturated Nitrogen and Oxygen Heterocycles"
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8:45 pm - 8:50 pm | Discussion |
8:50 pm - 9:25 pm | Peter Wipf (University of Pittsburgh)
"Total Synthesis of Strained Ring Alkaloids"
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9:25 pm - 9:30 pm | Discussion |
TUESDAY |
7:30 am - 8:30 am | Breakfast |
8:30 am | Group Photo |
9:00 am - 12:30 pm | Clinical and Public Health Applications of Natural Products and Their Analogs |
| Discussion Leader: Joie Garfunkle (Merck) |
9:00 am - 9:35 am | Steven Castle (Brigham Young University)
"New Strategies for the Synthesis of Unusual Peptides |
9:35 am - 9:40 am | Discussion |
9:40 am - 10:15 am | Bruce Littlefield (Eisai)
"Discovery and Development of Eribulin, a Macrocyclic Ketone Analog of Halichondrin B, for Advanced Breast Cancer"
|
10:15 am - 10:20 am | Discussion |
10:20 am | Coffee Break |
11:00 am - 11:40 am | Craig Crews (Yale University)
"Carfilzomib/KyprolisTM: The Next Generation Proteasome Inhibitor Inspired by Nature"
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11:40 am - 11:45 am | Discussion |
11:45 am - 12:25 pm | Peter Seeberger (Max Planck Institute for Colloids and Interfaces)
"Preventing and Fighting Infectious Disease: Continuous Flow Synthesis of Malaria Drugs and Carbohydrate Vaccines"
|
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Synthesis and Biological Activity of Natural Products |
| Discussion Leader: Robert Orr (Merck) |
7:30 pm - 8:05 pm | Gregory Dudley (Florida State University)
"Innovations in Alkyne Chemistry"
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8:05 pm - 8:10 pm | Discussion |
8:10 pm - 8:45 pm | Jason Sello (Brown University)
"Structure-Guided Optimization of Microbial Natural Products for Use as Anti-Infective Agents" |
8:45 pm - 8:50 pm | Discussion |
8:50 pm - 9:25 pm | Richard Taylor (University of Notre Dame)
"Chemical and Biological Synthesis of Polyketide Natural Products"
|
9:25 pm - 9:30 pm | Discussion |
WEDNESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Synthesis of Natural Products and Other Biologically Active Molecules |
| Discussion Leader: Eric Bercot (Suterra) |
9:00 am - 9:15 am | Christopher Beaudry (Oregon State University)
"Synthesis of Natural Products with Conformational Chirality"
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9:15 am - 9:20 am | Discussion |
9:20 am - 9:55 am | Annaliese Franz (University of California, Davis)
"Asymmetric Catalysis and Mechanistic Insight for the Synthesis of Spirocyclic Heterocycles"
|
9:55 am - 10:00 am | Discussion |
10:00 am | Coffee Break |
10:40 am - 10:55 am | Ke Chen (Bristol Myers Squibb)
"Overcoming Electronics with Strategy: Approaches Towards Introduction of 3-Methyl-1,2,4-Triazole in the Synthesis of a Novel Antiretroviral"
|
10:55 am - 11:00 am | Discussion |
11:00 am - 11:40 am | Donald Gauthier (Merck)
"Manufacturing Route Development for Doravirine" |
11:40 am - 11:45 am | Discussion |
11:45 am - 12:25 pm | Christopher Senanayake (Boehringer Ingelheim Pharmaceuticals)
"Practical Catalytic and Asymmetric Transformations for Drug Development"
|
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:00 pm - 7:30 pm | Business Meeting |
| Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair |
7:30 pm - 9:30 pm | Methodology for Natural Product Synthesis |
| Discussion Leader: Steve Mennen (Amgen) |
7:30 pm - 8:05 pm | John Montgomery (University of Michigan)
"Development and Application of Regioselective Catalytic Processes" |
8:05 pm - 8:10 pm | Discussion |
8:10 pm - 8:45 pm | Janis Louie (University of Utah)
"Insights into Cycloaddition Chemistry"
|
8:45 pm - 8:50 pm | Discussion |
8:50 pm - 9:25 pm | Marisa Kozlowski (University of Pennsylvania)
"Development of Oxidative Bond Forming Reactions and Applications in Natural Product Synthesis"
|
9:25 pm - 9:30 pm | Discussion |
THURSDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Biosynthesis and Isolation of Natural Products |
| Discussion Leader: Jonathan Scheerer (William and Mary) |
9:00 am - 9:25 am | James La Clair (Xenobe Research Institute)
"Unveiling New Modes of Action"
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9:25 am - 9:30 am | Discussion |
9:30 am - 10:10 am | Yi Tang (University of California, Los Angeles)
"Exciting New Enzymes from Fungal Biosynthetic Pathways"
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10:10 am - 10:15 am | Discussion |
10:15 am | Coffee Break |
10:55 am - 11:35 am | Gerhard Bringmann (University of Wurtzburg)
"Absolute Stereostructures of Novel Mono- and Dimeric Naphthylisoquinoline Alkaloids from Tropical Plants" |
11:35 am - 11:40 am | Discussion |
11:40 am - 12:25 pm | Sarah O'Connor (The John Innes Center)
"Chemistry and Biology of Plant Alkaloid Biosynthesis"
|
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Methods and Strategy for the Synthesis of Natural Products and Analogs |
| Discussion Leader: Hahdi Perfect (Pfizer) |
7:30 pm - 7:45 pm | Pavel Nagorny (University of Michigan)
"The Development of Catalyst-Controlled Acetalization Reactions" |
7:45 pm - 7:50 pm | Discussion |
7:50 pm - 8:25 pm | Craig Hutton (University of Melbourne)
"Synthesis of Cyclized Peptide Natural Products" |
8:25 pm - 8:30 pm | Discussion |
8:30 pm - 9:25 pm | Paul Wender (Stanford University)
"Translating Nature's Library: Toward the Ideal Synthesis and Transformative Therapies"
|
9:25 pm - 9:30 pm | Discussion |
FRIDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am | Departure |