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Natural Products

Gordon Research Conference

The Wide-Ranging Influence of Natural Products Research on Medicine and the Physical Sciences

July 26 - 31, 2015
Chair Steven H. Olson
Vice Chair Richard E. Taylor
Proctor Academy
204 Main Street
Andover, New Hampshire, United States
 Venue and Travel Information

Conference Description

Throughout human history, natural products have been used as a means of improving human health. Scientific investigation of these molecules and the biological pathways with which they interact has had a far-reaching impact on fundamental chemistry and biology and has led to enormous advances in human health.

The 64th Gordon Research Conference on Natural Products will feature presentations of cutting-edge science from a diverse group of scientists in the fields of organic synthesis, chemical biology, natural product isolation, biosynthesis, medicinal chemistry, methodology development, and process chemistry. The meeting will provide opportunities for in depth scientific discussions and sharing unpublished results in both formal and informal settings.

The poster sessions are essential to the success of the Natural Products GRC. The innovative research, scientific discussions and social interactions surrounding these informal presentations are, in many ways, the heart of the conference. All conferees are encouraged to submit abstracts for poster presentation. Posters will be selected for short talks to be presented by their primary authors during the conference.

Like last year, the meeting will be held at the Proctor Academy in Andover, New Hampshire. The site offers outstanding staff and a relaxed setting that is ideally suited for dynamic scientific discussions and an abundant opportunity for recreation.

The Chair and Vice Chair welcome your participation at this scientifically stimulating conference.

Conference Program

Sunday
2:00 pm - 9:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmMethods and Strategies for Natural Products Synthesis
Discussion Leader: Sarah Wengryniuk (Temple University, USA)
7:40 pm - 8:20 pmYujiro Hayashi (Tohoku University, Japan)
"Pot Economy in Total Synthesis"
8:20 pm - 8:35 pmDiscussion
8:35 pm - 9:15 pmJames Leighton (Columbia University, USA)
"Chemical Synthesis as the Essential Enabler of Natural Product-Based Drug Development"
9:15 pm - 9:30 pmDiscussion
Monday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmPharmaceutical Process Chemistry
Discussion Leader: Eric Bercot (Suterra, LLC, USA)
9:00 am - 9:40 amSebastien Caille (Amgen, USA)
"AMG 232: Pre-Pivotal and Commercial Process Development"
9:40 am - 10:00 amDiscussion
10:00 am - 10:30 amCoffee Break
10:30 am - 11:10 amSteven Wittenberger (AbbVie, USA)
"Neglected Tropical Disease Research: Macrolides to Treat Infectious Pathogens for Chagas Disease"
11:10 am - 11:30 amDiscussion
11:30 am - 12:10 pmJohn Porco (Boston University, USA)
"Recent Studies Towards the Synthesis of Tetrahydroxanthone Natural Products"
12:10 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmCatalysis and Synthetic Methodology
Discussion Leader: Steven Mennen (Amgen, USA)
7:30 pm - 8:10 pmRobert Knowles (Princeton University, USA)
"Proton-Coupled Electron Transfer in Organic Synthesis and Asymmetric Catalysis"
8:10 pm - 8:30 pmDiscussion
8:30 pm - 9:10 pmVy Dong (University of California, Irvine, USA)
"Catalysis Inspired by Nature's Macrocycles"
9:10 pm - 9:30 pmDiscussion
Tuesday
7:30 am - 8:30 amBreakfast
8:30 amGroup Photo
9:00 am - 12:30 pmNatural Product Biosynthesis, Isolation, and Structure Determination
Discussion Leader: Michael Calter (Wesleyan University, USA)
9:00 am - 9:40 amSesselja Omarsdottir (University of Iceland, Iceland)
"'Biophilia', Biodiversity and Bioprospecting in Natural Product Drug Discovery in Iceland"
9:40 am - 10:00 amDiscussion
10:00 am - 10:30 amCoffee Break
10:30 am - 11:10 amChristopher Boddy (University of Ottawa, Canada)
"The Screening Hypothesis: A Tool for Understanding and Predicting Activity of Catalytic Domains from Polyketide Biosynthetic Pathways"
11:10 am - 11:30 amDiscussion
11:30 am - 12:10 pmPeter Karuso (Macquarie University, Australia)
"Rapid Identification of Natural Product Binding Proteins"
12:10 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmInnovations in Drug Discovery
Discussion Leader: David Uehling (Ontario Institute for Cancer Research, Canada)
7:30 pm - 8:10 pmEdmund Graziani (Pfizer, USA)
"Natural Product Splicing Inhibitors as Antibody Drug Conjugate (ADC) Payloads"
8:10 pm - 8:30 pmDiscussion
8:30 pm - 9:10 pmHarold Wood (Merck Research Laboratories, USA)
"Optimization of Novel FIXa Inhibitors and Differentiation from FXa Inhibitors"
9:10 pm - 9:30 pmDiscussion
Wednesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmNatural Products Synthesis and Its Application to Improving Human Health
Discussion Leader: John D'Angelo (Alfred University, USA)
9:00 am - 9:40 amMingji Dai (Purdue University, USA)
"New Strategies and Tactics for Efficient and Divergent Synthesis of Natural Products of Medicinal Importance"
9:40 am - 10:00 amDiscussion
10:00 am - 10:30 amCoffee Break
10:30 am - 11:10 amNoah Burns (Stanford University, USA)
"Fully Selective Syntheses of Polyhalogenated Natural Products"
11:10 am - 11:30 amDiscussion
11:30 am - 12:10 pmWilliam Wuest (Temple University, USA)
"Draining the Moat: A Natural Product-Inspired Approach to Combat Bacterial Biofilms"
12:10 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pmSynthesis of Natural Products and Other Complex Molecules
Discussion Leader: Sergey Pronin (University of California, Irvine, USA)
7:30 pm - 8:10 pmAndrew McClory (Genentech, Inc., USA)
"PIM Inhibitor GDC-0339: First Generation cGMP Process Chemistry Route"
8:10 pm - 8:30 pmDiscussion
8:30 pm - 9:10 pmScott Gilbertson (University of Houston, USA)
"Synthesis of CNS Active Compounds"
9:10 pm - 9:30 pmDiscussion
Thursday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmInnovations in the Synthesis of Biologically Active Natural Products
Discussion Leader: Matthew Lamarche (Novartis, USA)
9:00 am - 9:25 amAlexander Kornienko (Texas State University, USA)
"Total Synthesis and Medicinal Chemistry of Marine Alkaloid Rigidins"
9:25 am - 9:35 amDiscussion
9:35 am - 10:10 amKevin Brown (Indiana University, USA)
"Total Synthesis of Unusual Polyketides: Development and Application of [2+2] Cycloadditions and Late-Stage C-H Oxidations"
10:10 am - 10:20 amDiscussion
10:20 am - 10:50 amCoffee Break
10:50 am - 11:30 amMartin Lear (University of Lincoln, United Kingdom)
"Routes to Nine-Membered Enediynes: Not Such a Walk in the Park"
11:30 am - 11:40 amDiscussion
11:40 am - 12:20 pmBaudouin Gerard (H3 Biomedicine, USA)
"Total Synthesis of 6-Deoxypladienolide D and Assessment of Splicing Inhibitory Activity in a Mutant SF3B1 Cancer Cell Line"
12:20 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmThe Impact of Natural Products from Chemical Discovery to Human Health
Discussion Leader: Mingji Dai (Purdue University, USA)
7:30 pm - 8:10 pmJeffrey Johnston (Vanderbilt University, USA)
"Natural Products and Other Therapeutics at the Intersection of Reaction Discovery and Reagent Development"
8:10 pm - 8:30 pmDiscussion
8:30 pm - 9:10 pmKim Lewis (Northeastern University, USA)
"Antimicrobials with Surprising Properties from Natural Products"
9:10 pm - 9:30 pmDiscussion
Friday
7:30 am - 8:30 amBreakfast
9:00 amDeparture

Contributors

Conference Links

Conference History
Additional Fee Info

Bioorganic Chemistry
June 15 - 20, 2025
Carbohydrates
June 15 - 20, 2025
Heterocyclic Compounds
June 22 - 27, 2025
High Throughput Chemistry and Chemical Biology
July 27 - August 1, 2025
Medicinal Chemistry
August 3 - 8, 2025
Medicinal Chemistry
August 11 - 16, 2024
Mycotoxins and Phycotoxins
June 15 - 20, 2025
Natural Products and Bioactive Compounds (GRS)
July 26 - 27, 2025
Natural Products and Bioactive Compounds (GRS)
July 27 - 28, 2024
Organic Reactions and Processes
July 21 - 26, 2024
Organic Reactions and Processes
July 20 - 25, 2025
Stereochemistry
July 21 - 26, 2024
Venom Evolution, Function and Biomedical Applications
August 11 - 16, 2024


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