Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Vaccines, Treatment and Resistance
Discussion Leader: Andreas Baumler (University of California, Davis, USA)
7:40 pm - 7:55 pm
Introduction by Discussion Leader
7:55 pm - 8:20 pm
Ferric Fang (University of Washington, USA)
"Mechanisms of Salmonella typhi Virulence"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:40 pm
Dennis Ko (Duke University, USA)
"An Atlas of Human Genetic Variation Affecting Host-Pathogen Traits Reveals Regulatory Variants Modulating Salmonella Invasion and Typhoid Fever Risk"
8:40 pm - 8:45 pm
Discussion
8:45 pm - 9:10 pm
Calman MacLennan (University of Oxford, United Kingdom)
"Vaccines Against Nontyphoidal Salmonella: The Case, the Candidates and the Pathway Forward"
9:10 pm - 9:20 pm
Discussion
9:20 pm - 9:30 pm
General Discussion
Monday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Molecular Mechanisms of Virulence
Discussion Leader: Linda Kenney (Mechanobiology Institute, National University of Singapore, Singapore)
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:35 am
Jeongmin Song (Cornell University, USA)
"Sweet Interaction: A Key Determinant of Typhoid Toxin's Host and Tissue Tropism"
9:35 am - 9:45 am
Discussion
9:45 am - 9:55 am
Guntram Grassl (Hannover Medical School, Germany)
"Emerging Salmonella enterica Serovar Infantis Induces a Strong Pro-Inflammatory Response that Is Dependent on the pESI Virulence Plasmid"
9:55 am - 10:00 am
Discussion
10:00 am - 10:25 am
Melissa Kendall (University of Virginia School of Medicine, USA)
"Metabolite Signaling Influences Salmonella Systemic Infection"
10:25 am - 10:35 am
Discussion
10:35 am - 11:05 am
Coffee Break
11:05 am - 11:30 am
Cammie Lesser (Massachusetts General Hospital / Harvard Medical School, USA)
"High-Throughput Screening of Type III Secretion Determinants"
11:30 am - 11:40 am
Discussion
11:40 am - 11:50 am
Isabelle Hautefort (Earlham Institute, United Kingdom)
"When the Former Is Exploited by the Latter"
11:50 am - 11:55 am
Discussion
11:55 am - 12:20 pm
David Holden (Imperial College London, United Kingdom)
"Suppression of the Adaptive Immune Response"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hourâ„¢
The GRC Power Hourâ„¢ is designed to address challenges women face in science and issues of diversity and inclusion. The program supports the professional growth of all members of our communities by providing an open forum for discussion and mentoring.
Organizers: Leigh Knodler (Washington State University, USA) and Mary O'Riordan (University of Michigan Medical School, USA)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Interactions with Cells
Discussion Leader: Olivia Steele-Mortimer (National Institutes of Health, USA)
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:00 pm
Stefania Spano (University of Aberdeen, United Kingdom)
"Controlling Host-Membrane Trafficking to Establish Systemic Infection"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:20 pm
Moirangthem Kiran Singh (Mechanobiology Institute, National University of Singapore, Singapore)
"Visualization of Salmonella -Induced Filaments Through Site-Specific Fluorescent Labeling of SPI-2 SifA Effector Protein"
8:20 pm - 8:25 pm
Discussion
8:25 pm - 8:45 pm
Leigh Knodler (Washington State University, USA)
"Colonization of the Epithelial Cell Cytosol by Salmonella "
8:45 pm - 8:55 pm
Discussion
8:55 pm - 9:20 pm
Jorge Galan (Yale School of Medicine, USA)
"Interactions of Salmonella with Host Cells Through the SP1-T3SS"
9:20 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
The Innate Immune Response
Discussion Leader: Renee Tsolis (University of California, Davis, USA)
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:30 am
Igor Brodsky (University of Pennsylvania, USA)
"Sensing of Salmonella by Noncanonical Inflammasomes"
9:30 am - 9:40 am
Discussion
9:40 am - 10:05 am
Clare Bryant (University of Cambridge, United Kingdom)
"Pattern Recognition Receptor Redundancy Converges on Cell Death"
10:05 am - 10:15 am
Discussion
10:15 am - 10:25 am
Shai Bel (Bar-Ilan University, Israel)
"Paneth Cells Secrete Lysozyme via Secretory Autophagy During Bacterial Infection of the Intestine"
10:25 am - 10:30 am
Discussion
10:30 am - 10:55 am
Coffee Break
10:55 am - 11:15 am
Teresa Thurston (Imperial College London, United Kingdom)
"Innate Immune Inhibition by Salmonella Effector Proteins"
11:15 am - 11:25 am
Discussion
11:25 am - 11:45 am
Cagla Tukel (Lewis Katz School of Medicine, Temple University, USA)
"The Bacterial Amyloid Curli: Expression, Immune Recognition and Pathogenesis"
11:45 am - 11:55 am
Discussion
11:55 am - 12:20 pm
Samuel Miller (University of Washington, USA)
"Intracellular Salmonella and the Second Messenger c-di-GMP"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Metabolism and Pathogenesis
Discussion Leader: William Navarre (University of Toronto, Canada)
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:00 pm
Sebastian Winter (University of Texas Southwestern Medical Center, USA)
"Interaction of Salmonella typhimurium with the Gut Microbiota"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:20 pm
Mariana Byndloss (Vanderbilt University Medical Center, USA)
"Microbiota-Derived Aspartate Drives Salmonella Expansion During Colitis"
8:20 pm - 8:25 pm
Discussion
8:25 pm - 8:50 pm
Denise Monack (Stanford University, USA)
"The Interplay of Bacterial Pathogens, Host Metabolites and Immune Factors in the Ecosystem of the Mammalian Gut"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
Andres Vazquez-Torres (University of Colorado Denver, USA)
"Metabolic Adaptations to Oxidative Stress in Salmonella Pathogenesis"
9:20 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Gene Regulation
Discussion Leader: Eduardo Groisman (Yale School of Medicine, USA)
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:35 am
Lydia Bogomolnaya (Texas A&M University Health Science Center, USA)
"The Interplay Between Bacterial Genetics and Intestinal Colonization"
9:35 am - 9:45 am
Discussion
9:45 am - 9:55 am
Sanna Koskiniemi (Uppsala University, Sweden)
"RHS-Elements Function as Type II Toxin-Antitoxin Modules that Regulate Intra-Macrophage Replication of Salmonella "
9:55 am - 10:00 am
Discussion
10:00 am - 10:25 am
James Slauch (University of Illinois at Urbana-Champaign, USA)
"Regulation of the SPI1 Type Three Secretion System"
10:25 am - 10:35 am
Discussion
10:35 am - 11:05 am
Coffee Break
11:05 am - 11:30 am
Kelly Hughes (University of Utah, USA)
"The Type III Secretion Signal: Finally an Answer"
11:30 am - 11:40 am
Discussion
11:40 am - 11:50 am
Jeongjoon Choi (Yale University, USA)
"Salmonella Expresses Horizontally Acquired Genes by Degrading Their Silencer"
11:50 am - 11:55 am
Discussion
11:55 am - 12:20 pm
Sophie Helaine (Imperial College London, United Kingdom)
"Antibiotic Tolerant Salmonella During Infection"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
Adaptive Immune Response
Discussion Leader: Marcelo Sztein (University of Maryland, USA)
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:00 pm
Stephen McSorley (University of California, Davis, USA)
"Effective Protective Memory Responses to Salmonella Infection"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:20 pm
Zachary Dalebroux (University of Oklahoma Health Sciences Center, USA)
"Salmonella Lipid Homeostasis for Survival and Adaptation Within Host Tissues"
8:20 pm - 8:25 pm
Discussion
8:25 pm - 8:45 pm
Adrianus Van Der Velden (Stony Brook University, USA)
"Role of Inflammatory Monocytes in Salmonella Pathogenesis"
8:45 pm - 8:55 pm
Discussion
8:55 pm - 9:20 pm
Richard (Dick) Strugnell (Peter Doherty Institute for Infection and Immunity / The University of Melbourne, Australia)
"T-Cell Specificity and the Development of Immunity in the Murine Model of Invasive Salmonellosis"
9:20 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Complex Microbe-Host Interactions
Discussion Leader: Beth McCormick (University of Massachusetts Medical School, USA)
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:35 am
Mary O'Riordan (University of Michigan Medical School, USA)
"Infection of Organoids with Salmonella"
9:35 am - 9:45 am
Discussion
9:45 am - 10:10 am
John Gunn (The Research Institute at Nationwide Children's Hospital, USA)
"The Host-Pathogen Interface During Salmonella Chronic Carriage"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:15 am
Dirk Bumann (Biozentrum, University of Basel, Switzerland)
"Salmonella Single-Cell Biology During Infection: Subsets, Fates and Overall Impact on Disease Progression"
11:15 am - 11:25 am
Discussion
11:25 am - 11:45 am
Bärbel Stecher (Ludwig Maximilian University of Munich, Germany)
"Prepared for Every Eventuality: The Microbiota Blocks Salmonella Infection at Different Stages"
11:45 am - 11:55 am
Discussion
11:55 am - 12:20 pm
Wolf-Dietrich Hardt (ETH Zurich, Switzerland)
"Molecular Pathogenesis of Salmonella Diarrhea"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Evolution
Discussion Leader: Michael McClelland (University of California, Irvine, USA)
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:05 pm
Jay Hinton (University of Liverpool, United Kingdom)
"How Has African Salmonella Become So Dangerous?"
8:05 pm - 8:15 pm
Discussion
8:15 pm - 8:40 pm
Robert Kingsley (Quadram Institute Bioscience, United Kingdom)
"Salmonella Microevolution: Mechanisms and Consequences"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
Andreas Baumler (University of California, Davis, USA)
"Endogenous Enterobacteriaceae Underlie Variation in Susceptibility to Salmonella Infection"
9:20 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure