Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
New Insights into Salmonella Epidemiology, Drug Resistance and Vaccines
Discussion Leader: Cal MacLennan (Bill & Melinda Gates Foundation, United Kingdom)
7:40 pm - 7:50 pm
Introduction by Discussion Leader
7:50 pm - 8:15 pm
Samuel Kariuki (Kenya Medical Research Institute, Kenya)
"Multidrug Resistant in Salmonella Infections in Africa and Role of Vaccine in Prevention and Control"
8:15 pm - 8:20 pm
Discussion
8:20 pm - 8:45 pm
Melita Gordon (University of Liverpool & Malawi-Liverpool-Wellcome Trust Programme, United Kingdom)
"Epidemiology of Invasive Non-Typhoidal Salmonella Infections in Malawi"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:00 pm
Kishore Alugupalli (Thomas Jefferson University, United States)
"Preclinical Mouse Model Systems to Identify the Basis for Effective Typhoid Vaccines"
9:00 pm - 9:05 pm
Discussion
9:05 pm - 9:15 pm
Fermin Guerra (University of Washington, United States)
"Determinants of the Susceptibility of Nontyphoidal and Enteric Fever Salmonella Serovars to Serum Antibodies and Complement"
9:15 pm - 9:20 pm
Discussion
9:20 pm - 9:30 pm
General Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Molecular Mechanisms of Host-Pathogen Interactions
Discussion Leader: Andres Vazquez-Torres (University of Colorado School of Medicine, United States)
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:35 am
William Navarre (University of Toronto, Canada)
"The Xenogeneic Silencing and the Maintenance of Conjugative Plasmids like pSLT"
9:35 am - 9:40 am
Discussion
9:40 am - 9:50 am
Olivia Steele-Mortimer (National Institute of Allergy and Infectious Diseases , United States)
"SPI1-Induced Changes in Motility and Chemotaxis"
9:50 am - 9:55 am
Discussion
9:55 am - 10:05 am
Fabienne Chevance (University of Utah, United States)
"A Comparison of Flagellar and SPI1 Type 3 Secretion Systems"
10:05 am - 10:10 am
Discussion
10:10 am - 10:20 am
Ethel Bayer Santos (University of Sao Paulo, Brazil)
"New Weapons in (Micro)Biological Conflicts: T6SS Effectors with Structure-Specific Nuclease Activity"
10:20 am - 10:25 am
Discussion
10:25 am - 10:55 am
Coffee Break
10:55 am - 11:20 am
Marc Erhardt (Humboldt-Universität zu Berlin, Germany)
"Cost-Benefit Tradeoffs in Flagellum Assembly"
11:20 am - 11:25 am
Discussion
11:25 am - 11:35 am
Ines Diaz del Olmo (Imperial College London, United Kingdom)
"Non-Canonical Reprogramming of Host Transcriptional Pathways by Salmonella Typhimurium"
11:35 am - 11:40 am
Discussion
11:40 am - 11:50 am
Virginie Stévenin (Leiden University Medical Center, The Netherlands)
"Salmonella Manipulates a Host DUB to Orchestrate the Rab-Mediated SCV Maturation"
11:50 am - 11:55 am
Discussion
11:55 am - 12:05 pm
General Discussion
12:05 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hour™
The GRC Power Hour™ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
Organizer: Sophie Helaine (Harvard Medical School, United States)
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Session in Memory of Josep (Pepe) Casadesus and Stefania Spanó: Interactions Between Salmonella and Host Cells
Discussion Leader: Leigh Knodler (University of Vermont, United States)
6:00 pm - 6:10 pm
Introduction by Discussion Leader
6:10 pm - 6:35 pm
Jost Enninga (Institut Pasteur, France)
"Multimodular Imaging to Decipher the Different Intracellular Niches of Entero-Invasive Bacteria"
6:35 pm - 6:40 pm
Discussion
6:40 pm - 7:05 pm
John Brumell (Hospital for Sick Children, Canada)
"Salmonella Effector SopD Promotes Plasma Membrane Scission by Inhibiting RAB10."
7:05 pm - 7:10 pm
Discussion
7:10 pm - 7:35 pm
Emmanuel Saliba (Helmholtz Institute for RNA-based infection research (HIRI), Germany)
"Identifying Host Vulnerabilities to Infections Using Single-Cell Genomics"
7:35 pm - 7:40 pm
Discussion
7:40 pm - 7:50 pm
Leigh Knodler (University of Vermont, United States) and Francisco Garcia-Del Portillo (Centro Nacional de Biotecnologia (CNB)-CSIC, Spain)
"Salmonella Genetics and Interactions with Host Cells"
7:50 pm - 7:55 pm
Discussion
7:55 pm - 8:00 pm
General Discussion
8:00 pm - 9:00 pm
Dinner
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Salmonella Interactions in the Intestine
Discussion Leader: Cagla Tukel (Lewis Katz School of Medicine, Temple University, United States)
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:35 am
Shipra Vaishnava (Brown University, United States)
"Micronutrients at the Host-Microbe Interface"
9:35 am - 9:40 am
Discussion
9:40 am - 10:05 am
Manuela Raffatellu (University of California, San Diego, United States)
"New Insights on Mucosal Immunity During Salmonella Infection"
10:05 am - 10:10 am
Discussion
10:10 am - 10:20 am
Mengru Yang (University of Liverpool, United Kingdom)
"Decoding the Assembly and Biogenesis of Bacterial Microcompartments in Salmonella "
10:20 am - 10:25 am
Discussion
10:25 am - 10:55 am
Coffee Break
10:55 am - 11:20 am
Mikael Sellin (Uppsala Universitet, Sweden)
"Salmonella at the Intestinal Epithelial Surface - Insights from Imaging in Enteroids and Colonoids"
11:20 am - 11:25 am
Discussion
11:25 am - 11:50 am
Judith Behnsen (University of Illinois Chicago, United States)
"Modulation of Salmonella Typhimurium Virulence by Commensal Intestinal Fungi"
11:50 am - 11:55 am
Discussion
11:55 am - 12:05 pm
Philipp Walch (University of Lausanne, Switzerland)
"Dissecting the Impact of Enteric Viral-Bacterial Co-Infection on the Host Innate Immune Response and its Implications for Pathogenicity"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:20 pm
Wenhan Zhu (Vanderbilt University Medical Center, United States)
"Commensal Iron Acquisition Promotes Salmonella Evasion of Nutritional Immunity"
12:20 pm - 12:25 pm
Discussion
12:25 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Innate Immunity During Bacterial Infection
Discussion Leader: Denise Monack (Stanford University, United States)
6:00 pm - 6:10 pm
Introduction by Discussion Leader
6:10 pm - 6:35 pm
Sunny Shin (University of Pennsylvania Perelman School of Medicine, United States)
"Human inflammasome Responses to Salmonella Typhimurium"
6:35 pm - 6:40 pm
Discussion
6:40 pm - 7:05 pm
Mathias Hornef (RWTH Aachen University, Germany)
"Interaction of Salmonella with the Neonatal Intestinal Epithelium"
7:05 pm - 7:10 pm
Discussion
7:10 pm - 7:35 pm
Edward Miao (Duke University, United States)
"Caspase-7 Helps Intestinal Epithelial Cells Complete Extrusion Bucket Lists"
7:35 pm - 7:40 pm
Discussion
7:40 pm - 7:50 pm
Marijke Keestra-Gounder (University of Colorado, Denver, United States)
"Nitrate-Mediated Luminal Expansion of Salmonella Typhimurium is Dependent on CHOP"
7:50 pm - 7:55 pm
Discussion
7:55 pm - 8:00 pm
General Discussion
8:00 pm - 9:00 pm
Dinner
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Gene Regulation and Bacterial Signaling Networks
Discussion Leader: James Slauch (University of Illinois at Urbana-Champaign, United States)
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:35 am
Ute Romling (Karolinska Institutet, Sweden)
"Cyclic di-GMP Signaling in Salmonella Typhimurium"
9:35 am - 9:40 am
Discussion
9:40 am - 9:50 am
Vivian Rojas (UC Davis, United States)
"Gene Regulation of Tartrate Metabolism in Salmonella Typhimurium"
9:50 am - 9:55 am
Discussion
9:55 am - 10:05 am
Johanna Elfenbein (University of Wisconsin-Madison, United States)
"Regulation of the Sulfite Stress Response in Salmonella "
10:05 am - 10:10 am
Discussion
10:10 am - 10:20 am
Craig Altier (Cornell University, United States)
"Control of Salmonella Virulence by Diffusible Signal Factors of the Intestine"
10:20 am - 10:25 am
Discussion
10:25 am - 10:55 am
Coffee Break
10:55 am - 11:20 am
Mederic Diard (University of Basel, Switzerland)
"Steering Salmonella Within-Host Evolution"
11:20 am - 11:25 am
Discussion
11:25 am - 11:35 am
Ohad Gal-Mor (Sheba Medical Center and Tel-Aviv University Israel, Israel)
"Persistent Salmonella Infections in Humans are Associated with Mutations in the BarA/SirA Regulatory Pathway"
11:35 am - 11:40 am
Discussion
11:40 am - 11:50 am
Joshua Newson (ETH Zürich, Switzerland)
"Antibiotic-Tolerant Reservoirs of Salmonella are Determined by Bacterial Secretion Machinery"
11:50 am - 11:55 am
Discussion
11:55 am - 12:05 pm
Camila Valenzuela (Institut Pasteur, France)
"The Salmonella Typhimurium Effector SifA Controls Bacterial Dormancy in Epithelial Cells"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:15 pm
General Discussion
12:15 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Novel Approaches to Antimicrobial Resistance
Discussion Leader: Wolf-Dietrich Hardt (ETH Zurich, Switzerland)
6:00 pm - 6:10 pm
Introduction by Discussion Leader
6:10 pm - 6:35 pm
Corrella Detweiler (University of Colorado, United States)
"Rethinking Antimicrobial Discovery"
6:35 pm - 6:40 pm
Discussion
6:40 pm - 7:05 pm
Brian Coombes (McMaster University, Canada)
"Drug Screening Under Infection-Relevant Conditions Reveals Chemical Sensitivity in Multi-Drug Resistant Non-Typhoidal Salmonella (iNTS)"
7:05 pm - 7:10 pm
Discussion
7:10 pm - 7:35 pm
Beth McCormick (University of Massachusetts Chan Medical School, United States)
"Salmonella Typhimurium, Multidrug Resistance, and Cancer"
7:35 pm - 7:40 pm
Discussion
7:40 pm - 7:50 pm
Laurent Aussel (Aix-Marseille University, France)
"Dual Regulatory Mechanism to Cope with Copper and Oxidative Stress in Salmonella Enterica "
7:50 pm - 7:55 pm
Discussion
7:55 pm - 8:00 pm
General Discussion
8:00 pm - 9:00 pm
Dinner
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Discuss Future Dates and Venue; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Evolution and Genomics of Salmonella- Host Interactions
Discussion Leader: Robert Kingsley (Quadram Institute Bioscience, United Kingdom)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:30 am
Helene Andrews-Polymenis (Texas A&M University School of Medicine, United States)
"The Role of Host Genetics in Salmonella Pathogenesis"
9:30 am - 9:35 am
Discussion
9:35 am - 9:55 am
Nara Figueroa-Bossi (Institute for Integrative Biology of the Cell, I2BC, CNRS, France)
"Interplay Between Transcription and H-NS Silencing: Source of Phenotypic Heterogeneity in Genetically Identical Salmonellae "
9:55 am - 10:05 am
Discussion
10:05 am - 10:30 am
Alexander Herbig (MPI for Evolutionary Anthropology, Germany)
"Evolution of Human-Adapted Salmonella enterica from an Archaeogenetic Perspective"
10:30 am - 10:35 am
Discussion
10:35 am - 11:05 am
Coffee Break
11:05 am - 11:15 am
Blanca Perez-Sepulveda (University of Liverpool, United Kingdom)
"Metabolism of Carbon Sources as Key Clade-Specific Determinants of Salmonella Enteritidis Associated with iNTS Disease"
11:15 am - 11:20 am
Discussion
11:20 am - 11:30 am
Laure Simoens (Ghent University, Belgium)
"Unveiling the Small Protein Load of Salmonella "
11:30 am - 11:35 am
Discussion
11:35 am - 12:00 pm
Francisco Garcia-Del Portillo (Centro Nacional de Biotecnologia (CNB)-CSIC, Spain)
"New Actors Control the Shape of Intraphagosomal Salmonella "
12:00 pm - 12:05 pm
Discussion
12:05 pm - 12:15 pm
Benjamin Wang (Stanford University, United States)
"Finding the Weak Link: High-Throughput Fitness Experiments Reveal Specific Vulnerabilities of Human-Adapted Salmonella Isolates During Stress and Infection"
12:15 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Emerging Technologies and New Challenges
Discussion Leader: Jay Hinton (University of Liverpool, United Kingdom)
6:00 pm - 6:10 pm
Introduction by Discussion Leader
6:10 pm - 6:35 pm
Athanasios Typas (European Molecular Biology Laboratory, Germany)
"Systems-Based Approaches to Dissect Salmonella 's Functions and Physiology"
6:35 pm - 6:40 pm
Discussion
6:40 pm - 6:50 pm
Branch Moody (Brigham and Women's Hospital, Harvard Medical School, United States)
"A New Lipidomic Tool Identifies Previously Unknown Virulence Associated Salmonella Lipids"
6:50 pm - 6:55 pm
Discussion
6:55 pm - 7:05 pm
Sven Engel (The Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Australia)
"Cytotoxic CD4+ T Cells and IFN-gamma Orchestrate the Induction of Apoptosis During Salmonella Typhimurium Infection"
7:05 pm - 7:10 pm
Discussion
7:10 pm - 7:35 pm
Roi Avraham (Weizmann Institute of Science, Israel)
"Characterizing Host-Pathogen Encounters at Early Stages of Infection"
7:35 pm - 7:40 pm
Discussion
7:40 pm - 7:50 pm
General Discussion
7:50 pm - 8:00 pm
Closing Remarks
8:00 pm - 9:00 pm
Dinner
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure