SUNDAY |
2:00 pm - 11:00 pm | Arrival and Check-in |
6:00 pm | Dinner |
7:30 pm - 7:40 pm | Chair's Welcome / Introductory Comments by GRC Site Staff |
7:40 pm - 9:30 pm | NEW REAGENTS AND METHODOLOGIES |
| Discussion Leader: Carl Johnson (Wayne State University) |
7:40 pm - 8:10 pm | Franklin Davis (Temple University) "Asymmetric Synthesis of Nitrogen Heterocycles using Sulfinimines" |
8:10 pm - 8:20 pm | Discussion |
8:20 pm - 8:50 pm | Ian Lennon (Dowpharma) "The Quest for Phenyl-DuPhos" |
8:50 pm - 8:55 pm | Discussion |
8:55 pm - 9:25 pm | Erick Carreira (ETH, Zurich) "Discovery and Surprises in Synthesis" |
9:25 pm - 9:30 pm | Discussion |
MONDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | NOVEL STRATEGIES |
| Discussion Leader: Vittorio Farina (Johnson & Johnson Pharmaceutical R&D) |
9:00 am - 9:30 am | Peter Seeberger (ETH, Zurich) "Automated Assembly of Oligosaccharides Using Sugars Derived by de novo Synthesis" |
9:30 am - 9:40 am | Discussion |
9:40 am - 10:20 am | Donna Blackmond (Imperial College London) "Crystallization Models for the Origin of Biological Homochirality" |
10:20 am - 10:30 am | Discussion |
10:30 am - 11:10 am | Coffee Break / Group Photo |
11:10 am - 11:40 am | Colin Nuckolls (Columbia University) "Spring-Loaded Mobius Topology" |
11:40 am - 11:50 am | Discussion |
11:50 am - 12:20 pm | Bart Kahr (Washington University) "Chiroptics of Achiral Compounds" |
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 6:00 pm | Free Time |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | STEREOSELECTIVE SYNTHESIS |
| Discussion Leader: Chris McWilliams (Wyeth) |
7:30 pm - 8:00 pm | Jeffrey Bode (University of Pennsylvania) "Stereochemical Aspects of New Reactions and Processes" |
8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:40 pm | Glenn Micalizio (Yale University) "Metal-Mediated Reactions for Carbon-Carbon Bond Formation: Fragment Assembly via Carbometalation" |
8:40 pm - 8:50 pm | Discussion |
8:50 pm - 9:20 pm | Peter Wipf (University of Pittsburgh) "The Bicyclobutane Gateway to Heterocycles" |
9:20 pm - 9:30 pm | Discussion |
TUESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | ORGANIC PROCESSES |
| Discussion Leader: Roger Bakale (Cephalon, Inc.) |
9:00 am - 9:30 am | Xumu Zhang (Rutgers University) "Practical Asymmetric Hydrogenation and Hydroformylation Reactions" |
9:30 am - 9:40 am | Discussion |
9:40 am - 10:10 am | Mike Martinelli (Arena Pharmaceuticals) "Development of an Asymmetric Alkylation Based Chemical Process" |
10:10 am - 10:20 am | Discussion |
10:20 am - 10:40 am | Coffee Break |
10:40 am - 11:10 am | William Clark (GlaxoSmithKline) "The Development of a Manufacturing Route to a Cathepsin K Inhibitor" |
11:10 am - 11:20 am | Discussion |
| Discussion Leader: Dhileep Krishnamurthy (Boehringer Ingelheim Pharmaceuticals, Inc) |
11:20 am - 11:50 am | Stephane Caron (Pfizer) "Process Research and Development of a Factor Xa Inhibitor" |
11:50 am - 11:55 am | Discussion |
11:55 am - 12:25 pm | Ohyun Kwon (University of California, Los Angeles) "Phosphine Catalysis of Allenes" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 6:00 pm | Free Time |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | CATALYSIS |
| Discussion Leader: Kai Rossen (Sanofi Aventis) |
7:30 pm - 8:00 pm | Melanie Sanford (University of Michigan) "Development of New Palladium-Catalyzed Reactions for Organic Synthesis" |
8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:40 pm | Carl Busacca (Boehringer Ingelheim Pharmaceuticals, Inc.) "Asymmetric Catalysis with the BIPI Ligands" |
8:40 pm - 8:50 pm | Discussion |
8:50 pm - 9:20 pm | Andreas Pfaltz (University of Basel) "Recent Progress in Asymmetric Hydrogenation" |
9:20 pm - 9:30 pm | Discussion |
WEDNESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | NOVEL METHODOLOGY |
| Discussion Leader: Robert Waltermire (Bristol-Myers Squibb Company) |
9:00 am - 9:30 am | David Barnes (Abbott Laboratories) "A Scaleable Asymmetric Synthesis of a PARP Inhibitor, Employing a Memory of Chirality Cyclization" |
9:30 am - 9:40 am | Discussion |
9:40 am - 10:10 am | Joerg Deerberg (Bristol-Myers Squibb Company) "Practical Asymmetric Synthesis of a Challenging Drug Candidate" |
10:10 am - 10:20 am | Discussion |
10:20 am - 10:40 am | Coffee Break |
| Discussion Leader: Terry Rathman (T-Links) |
10:40 am - 11:10 am | Yoshitaka Hamashima (RIKEN) "Enantioselective Catalysis Based On Transition Metal Enolate Chemistry" |
11:10 am - 11:20 am | Discussion |
11:20 am - 11:50 am | Mark Huffman (Merck Research Laboratories) "Diels-Alder-Based Asymmetric Synthesis of a Drug Candidate" |
11:50 am - 12:00 pm | Discussion |
12:00 pm - 12:30 pm | Business Meeting |
| (Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair) |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session A: Scott Miller (Co-Vice Chair, Yale University) |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | SELECTIVE REACTIONS AND CATALYTIC PROCESSES |
| Discussion Leader: Amy Howell (University of Connecticut) |
7:30 pm - 8:00 pm | Mohammad Movassaghi (Massachusetts Institute of Technology) "Cascade Reactions in Complex Alkaloid Synthesis" |
8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:40 pm | Christina White (University of Illinois) "Streamlining Synthesis via C-H Oxidation" |
8:40 pm - 8:50 pm | Discussion |
8:50 pm - 9:20 pm | Eric Jacobsen (Harvard University) "Cooperative Asymmetric Catalysis" |
9:20 pm - 9:30 pm | Discussion |
THURSDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | BIOLOGICAL SYSTEMS |
| Discussion Leader: Janine Cossy (ESPCI, Paris) |
9:00 am - 9:30 am | Brian Stoltz (California Institute of Technology) "Stereochemically Rich Natural Products as a Driving Force for Discovery in Organic Chemistry" |
9:30 am - 9:40 am | Discussion |
9:40 am - 10:10 am | Arun Ghosh (Purdue University) "Chemistry and biology of novel microtubule-stabilizing agents" |
10:10 am - 10:20 am | Discussion |
10:20 am - 10:40 am | Coffee Break |
| Discussion Leader: Nicola Pohl (Iowa State University) |
10:40 am - 11:10 am | Marco Ciufolini (University of British Columbia) "Synthetic Studies on Heterocyclic Natural Products" |
11:10 am - 11:20 am | Discussion |
11:20 am - 11:50 am | Louis Jungheim (Lilly and Company) "Multidrug Resistance Pump Inhibitors, the Stereochemistry Matters" |
11:50 am - 11:55 am | Discussion |
11:55 am - 12:25 pm | Timothy Jamison (Massachusetts Institute of Technology) "Epoxide-Opening Cascades" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session B: Jay Siegel (Co-Vice Chair, Universität Zürich) |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | STATERGIES AND TACTICS OF ORGANIC SYNTHESIS |
| Discussion Leader: Steve King (Abbott Laboratories) |
7:30 pm - 8:20 pm | Larry Overman (University of California, Irvine) "Recent Studies in Stereocontrolled Synthesis" |
8:20 pm - 8:30 pm | Discussion |
8:30 pm - 9:20 pm | Barry Trost (Stanford University) "On the Design of Chiral Space for Asymmetric Induction in a Catalytic Synthetic Reactions" |
9:20 pm - 9:25 pm | Discussion |
9:25 pm - 9:30 pm | Chairs Closing Remarks Co-Vice Chairs Remarks: Scott Miller and Jay Siegel |
FRIDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am | Departure |