SUNDAY |
2:00 pm - 9:00 pm | Arrival and Check-in |
6:00 pm | Dinner |
7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
7:40 pm - 9:30 pm | Frontiers in Stereoselective Catalysis |
| Discussion Leader: John Ragan (Pfizer) |
7:40 pm - 8:25 pm | Andreas Pfaltz (University of Basel)
"Screening and Mechanistic Studies of Chiral Catalysts Based on Mass Spectrometry"
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8:25 pm - 8:35 pm | Discussion |
8:35 pm - 9:20 pm | Alexander M. Cruickshank Award Lecture: Gregory Fu (California Institute of Technology)
"Metal-Catalyzed Cross-Coupling Reactions of Alkyl Electrophiles"
|
9:20 pm - 9:30 pm | Discussion |
MONDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Bioinspired Stereochemistry - Total Synthesis and Discovery |
| Discussion Leader: Mark Noe (Pfizer) |
9:00 am - 9:35 am | Wilfred van der Donk (University of Illinois, Urbana-Champaign)
"Understanding Phosphonate Biosynthesis Through Investigations of Stereochemistry"
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9:35 am - 9:45 am | Discussion |
9:45 am - 10:20 am | Michelle Chang (University of California, Berkeley)
"Synthetic Biology Approaches to New Fluorine Chemistry"
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10:20 am - 10:30 am | Discussion |
10:30 am | Coffee Break |
11:00 am - 11:35 am | André Beauchemin (University of Ottawa)
"Exploiting Intramolecularity: Reaction Development Using Aldehydes as Catalysts"
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11:35 am - 11:45 am | Discussion |
11:45 am - 12:20 pm | Emily Balskus (Harvard University)
"Gut Reactions: Exploring the Chemistry of the Human Microbiota"
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12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Asymmetric Catalysis and Stereoselective Synthesis |
| Discussion Leader: H. Peter Nestler (Sanofi Aventis) |
7:30 pm - 8:05 pm | Mikiko Sodeoka (RIKEN)
"Stereoselective Synthesis of Bioactive Molecules"
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8:05 pm - 8:10 pm | Discussion |
8:10 pm - 8:45 pm | Michael Martinelli (FibroGen)
"Pharmaceutical Development of Belviq"
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8:45 pm - 8:50 pm | Discussion |
8:50 pm - 9:25 pm | Hisashi Yamamoto (University of Chicago/Chubu University)
"Catalytic Asymmetric Oxidation"
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9:25 pm - 9:30 pm | Discussion |
TUESDAY |
7:30 am - 8:30 am | Breakfast |
8:30 am | Group Photo |
9:00 am - 12:30 pm | Stereocontrol on an Industrial Scale |
| Discussion Leader: Edward Grabowski (Merck Research Laboratories (Retired) and Consultants in Chemical Development)
|
9:00 am - 9:35 am | Thomas Razler (Bristol Myers Squibb)
"Development of the Commercial Synthesis of Gamma Secretase Inhibitor BMS-708163"
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9:35 am - 9:45 am | Discussion |
9:45 am - 10:20 am | Vittorio Farina (Johnson & Johnson)
"Stereoselective Synthesis of Therapeutic C-Glycosides"
|
10:20 am - 10:30 am | Discussion |
10:30 am | Coffee Break |
11:00 am - 11:35 am | James Leighton (Columbia University)
"In Pursuit of the Ideal in the Asymmetric Synthesis of Natural Products: How and Why"
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11:35 am - 11:45 am | Discussion |
11:45 am - 12:20 pm | David Collum (Cornell University)
"Method of Continuous Variations in Organometallic Chemistry"
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12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Stereochemistry at Interfaces |
| Discussion Leader: Cameron Cowden (Merck Research Laboratories) |
7:30 pm - 8:05 pm | Eric Anslyn (University of Texas, Austin)
"Supramolecular Methods for the Rapid Analysis of Enantiomeric Excess"
|
8:05 pm - 8:10 pm | Discussion |
8:10 pm - 8:45 pm | Milan Mrksich (Northwestern University)
"Using SAMDI Mass Spectrometry to Discover Chemical and Biochemical Reactions" |
8:45 pm - 8:50 pm | Discussion |
8:50 pm - 9:25 pm | M.G. Finn (Georgia Tech)
"Chemists Messing About with Biology: Functional Icosahedral 'Stereochemistry'"
|
9:25 pm - 9:30 pm | Discussion |
WEDNESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Stereoselective Catalysis - Experiment and Theory |
| Discussion Leader: Jon Lorenz (Boehringer Ingelheim) |
9:00 am - 9:35 am | Abigail Doyle (Princeton University)
"Methods and Mechanism in Asymmetric Catalysis"
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9:35 am - 9:45 am | Discussion |
9:45 am - 10:20 am | Takashi Ooi (Nagoya University)
"Catalytic Control of Anionic Intermediates by Chiral Organic Cations"
|
10:20 am - 10:30 am | Discussion |
10:30 am | Coffee Break |
11:00 am - 11:35 am | Cristina Nevado (University of Zurich)
"Radical and Cationic Mechanisms: A Fruitful Interplay"
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11:35 am - 11:45 am | Discussion |
11:45 am - 12:20 pm | Kendall Houk (University of California, Los Angeles)
"Theory and Modeling of Stereoselective Catalysis by Cinchona Amines"
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12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:00 pm - 7:30 pm | Business Meeting |
| Nominations for the Next Vice Chairs; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chairs |
7:30 pm - 9:30 pm | Asymmetric Catalysis |
| Discussion Leader: Chris Senanayake (Boehringer Ingelheim) |
7:30 pm - 8:05 pm | Sarah Reisman (California Institute of Technology)
"Development of Asymmetric Reductive Cross-Coupling Reactions"
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8:05 pm - 8:10 pm | Discussion |
8:10 pm - 8:45 pm | Eric Jacobsen (Harvard University)
"Enantioselective Reactions of Cationic Intermediates via Anion-Binding Catalysis"
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8:45 pm - 8:50 pm | Discussion |
8:50 pm - 9:25 pm | Erick Carreira (ETH Zürich)
"Recent Advances in Enantioselective Catalysis: Concepts and Applications"
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9:25 pm - 9:30 pm | Discussion |
THURSDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Asymmetric Synthetic Methods and Natural Products |
| Discussion Leader: Guido Koch (Novartis)
|
9:00 am - 9:35 am | William Roush (Scripps, Florida)
"Stereochemistry of Allylboration and Aldol Reactions of Chiral Allylboron and Enolborane Reagents Generated via Allene and Acrylamide Hydroboration Reactions" |
9:35 am - 9:45 am | Discussion |
9:45 am - 10:20 am | Laszlo Kürti (UT Southwestern Medical Center)
"Atroposelective Synthesis of Functionalized Biaryls and Stereospecific Olefin Bis-Functionalizations"
|
10:20 am - 10:30 am | Discussion |
10:30 am | Coffee Break |
11:00 am - 11:35 am | Nuno Maulide (University of Vienna)
"Asymmetric Rearrangements as Tools for C-C Bond Formation"
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11:35 am - 11:45 am | Discussion |
11:45 am - 12:20 pm | John Wood (Colorado State University)
"Recent Efforts in the Synthesis of Complex Natural Products" |
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Chemical Biology |
| Discussion Leader: Scott Denmark (University of Illinois, Urbana-Champaign) |
7:30 pm - 8:15 pm | Laura Kiessling (University of Wisconsin, Madison)
"Controlling Carbohydrate Stereochemistry to Probe Cell Wall Biosynthesis"
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8:15 pm - 8:25 pm | Discussion |
8:25 pm - 9:10 pm | Keynote Speaker: Ronald Breslow (Columbia University)
"How Prebiotic Homochirality Got Started"
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9:10 pm - 9:20 pm | Discussion |
9:20 pm - 9:30 pm | Closing Remarks (Chairs and Future Chairs) |
FRIDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am | Departure |