Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Stereochemistry in Two and Three Dimensions
Discussion Leader: Varinder Aggarwal (University of Bristol, United Kingdom)
7:40 pm - 8:20 pm
Squire Booker (Pennsylvania State University, USA)
"Radical-Dependent Enzymatic Functionalization of Unactivated Carbon Centers with Sulfur and Methyl Groups"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 9:20 pm
Robert H. Grubbs (California Institute of Technology, USA)
"Catalysts to Control Stereochemistry in Olefin Metathesis"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Stereoselective Catalysis
Discussion Leader: Hosea Nelson (University of California, Los Angeles, USA)
9:00 am - 9:10 am
Alison Narayan (University of Michigan, USA)
"Biocatalysis and Complex Molecule Synthesis"
9:10 am - 9:15 am
Discussion
9:15 am - 9:25 am
Song Lin (Cornell University, USA)
"Taming Radicals for Selective Catalysis: An Electrochemical Approach to Alkene Difunctionalization"
9:25 am - 9:30 am
Discussion
9:30 am - 9:40 am
Mariola Tortosa (Universidad Autonoma de Madrid, Spain)
"Nucleophilic Boron for the Synthesis of Functionalized Small Rings"
9:40 am - 9:45 am
Discussion
9:45 am - 10:20 am
David Sarlah (University of Illinois at Urbana-Champaign, USA)
"Catalytic Dearomative Functionalization of Simple Arenes"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:35 am
Vy Dong (University of California, Irvine, USA)
"Enantioselective C-C Bond Construction via Rh-Hydride Catalysis"
11:35 am - 11:45 am
Discussion
11:45 am - 12:20 pm
Maria Christina White (University of Illinois at Urbana-Champaign, USA)
"Asymmetric C-H Oxidations"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
Power Hour
The GRC Power Hour is an optional informal gathering open to all meeting participants. It is designed to help address the challenges women face in science and support the professional growth of women in our communities by providing an open forum for discussion and mentoring.
Organizer: Rebecca Ruck (Merck & Co, Inc., USA)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Stereochemistry of Macromolecules
Discussion Leader: Julia Kalow (Northwestern University, USA)
7:30 pm - 8:05 pm
Michinori Suginome (Kyoto University, Japan)
"Catalytic Chirality Transfer Through Single-Handed Helical Macromolecules"
8:05 pm - 8:15 pm
Discussion
8:15 pm - 8:40 pm
Jeffery Byers (Boston College, USA)
"Controlling Stereoregularity in Polymers Through In Situ Catalyst Desymmetrization"
8:40 pm - 8:45 pm
Discussion
8:45 pm - 9:20 pm
Kyoko Nozaki (University of Tokyo, Japan)
"Stereocontrolled Propylene Insertion in Polymer Synthesis and Organic Synthesis"
9:20 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Biocatalysis and Chemical Biology
Discussion Leader: Alison Narayan (University of Michigan, USA)
9:00 am - 9:35 am
Suzanne Walker (Harvard Medical School, USA)
"Inhibiting O-GlcNAc Transferase"
9:35 am - 9:45 am
Discussion
9:45 am - 10:10 am
Todd Hyster (Princeton University, USA)
"Recent Advances in Photoenzyme Catalysis"
10:10 am - 10:15 am
Discussion
10:15 am - 10:45 am
Coffee Break
10:45 am - 11:20 am
Emily Balskus (Harvard University, USA)
"Chemical Discovery in the Microbial World"
11:20 am - 11:30 am
Discussion
11:30 am - 12:20 pm
Frances Arnold (California Institute of Technology, USA)
"Directed Evolution of Carbene Transferases: Bringing New Chemistry to Life"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Asymmetric Synthesis in Industry
Discussion Leader: Alison Wendlandt (Massachusetts Institute of Technology, USA)
7:30 pm - 8:00 pm
John Ragan (Pfizer Chemical R&D, USA)
"Stereochemical Challenges in the Synthesis of the SGLT2 Inhibitor Ertugliflozin"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
Rebecca Ruck (Merck & Co, Inc., USA)
"Asymmetric Catalysis to Solve Complex Chemical Problems at Merck"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
Chris Senanayake (AstaTech Biopharmaceutical Corporation, China)
"Sulfur and Phosphorus Containing Chiral Transfer Agents for Asymmetric Transformations"
9:20 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Enantioselective Reactions
Discussion Leader: Kimberly Petersen (University of North Carolina at Greensboro, USA)
9:00 am - 9:35 am
Cathleen Crudden (Queen's University, Canada)
"Sulfur in the Suzuki-Miyaura Reaction"
9:35 am - 9:45 am
Discussion
9:45 am - 10:20 am
Jin-Quan Yu (The Scripps Research Institute, USA)
"Enantioselective C-H Activation Reactions: Making Chiral Molecules from Bulky Chemicals"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:35 am
Michael Krische (University of Texas at Austin, USA)
"Enantioselective Alcohol-Mediated Carbonyl Reductive Coupling via Metal Catalyzed Hydrogen Transfer"
11:35 am - 11:45 am
Discussion
11:45 am - 12:20 pm
Scott Denmark (University of Illinois at Urbana-Champaign, USA)
"Demystifying the Mysterious Soai Reaction"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
Understanding Stereoselectivity and Mechanism
Discussion Leader: Daniel O'Leary (Pomona College, USA)
7:30 pm - 8:05 pm
Matthew Sigman (University of Utah, USA)
"Data Driven Methods to Identify and Exploit Non Covalent Interactions in Asymmetric Catalysis"
8:05 pm - 8:15 pm
Discussion
8:15 pm - 8:40 pm
Katherine Ryan (University of British Columbia, Canada)
"Biosynthetic Routes to Non-Proteinogenic Amino Acids"
8:40 pm - 8:45 pm
Discussion
8:45 pm - 9:20 pm
Ben Feringa (University of Groningen, The Netherlands)
"Control and Amplification of Chirality in Dynamic Molecular Systems"
9:20 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Enantioselective Synthesis of Natural Products
Discussion Leader: Sarah Wengryniuk (Temple University, USA)
9:00 am - 9:35 am
Seth Herzon (Yale University, USA)
"Total Synthesis of Diterpene Natural Products"
9:35 am - 9:45 am
Discussion
9:45 am - 10:00 am
Robert Phipps (University of Cambridge, United Kingdom)
"Catalytic Enantioselective Minisci-Type Addition to Heteroarenes"
10:00 am - 10:05 am
Discussion
10:05 am - 10:20 am
Laura Ackerman (Princeton University, USA)
"Transformation of C(sp3)-H Bonds to Ketones and Esters via Nickel and Photoredox Catalysis"
10:20 am - 10:25 am
Discussion
10:25 am - 11:00 am
Coffee Break
11:00 am - 11:35 am
Ang Li (Chinese Academy of Sciences, China)
"Total Synthesis of Polycyclic Natural Products"
11:35 am - 11:45 am
Discussion
11:45 am - 12:20 pm
Thomas Maimone (University of California, Berkeley, USA)
"Synthetic Studies Toward Complex Natural Products"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Stereochemistry: Structure and Function
Discussion Leader: Eric Ashley (Merck Research Laboratories, USA)
7:30 pm - 8:20 pm
Kendall Houk (University of California, Los Angeles, USA)
"Computational Explorations of Stereoselective Transition Metal, Organocatalytic and Enzyme Catalyzed Reactions"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 9:20 pm
Eric Jacobsen (Harvard University, USA)
"New Modes of H-Bond Donor Catalysis"
9:20 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure