Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: Synthesis and Translation to Medicine
7:40 pm - 8:25 pm
"Necessity is the Mother of Invention: Natural Products and the Chemistry They Inspire"
8:25 pm - 8:35 pm
Discussion
8:35 pm - 9:20 pm
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Stereochemistry of Radicals and Peptides
9:00 am - 9:35 am
"Synthetic Biology Approaches to New Amino Acid Chemistry"
9:35 am - 9:45 am
Discussion
9:45 am - 10:10 am
"The Fascinating Chemistry of Aminoxyl Radicals—From Asymmetric Catalysis to Site-Selective C–H Functionalization"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:25 am
"Aromatic Foldamer-Based Protein Mimicry and Recognition"
11:25 am - 11:35 am
Discussion
11:35 am - 12:00 pm
"Selective Catalytic Isomerization Reactions"
12:00 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hour™
The GRC Power Hour™ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Functionalization of Multiple Bonds
7:30 pm - 8:05 pm
"New Tools for Catalysis"
8:05 pm - 8:15 pm
Discussion
8:15 pm - 8:40 pm
"Catalytic Difunctionalization of Alkenes with Chiral Transient Directing Groups"
8:40 pm - 8:45 pm
Discussion
8:45 pm - 9:20 pm
"Chemical Synthesis of Secondary Metabolites"
9:20 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Transition Metals in Asymmetric Catalysis
9:00 am - 9:35 am
"New Synthetic Chemistry to Probe the Biology of Modified Nucleic Acids"
9:35 am - 9:45 am
Discussion
9:45 am - 10:20 am
"New Methods in Halogen-Atom Transfer"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:35 am
"A New Framework for the Development and Optimization of Catalytic Asymmetric Transformations"
11:35 am - 11:45 am
Discussion
11:45 am - 12:20 pm
"Nucleophilic Substitution Reactions: A Radical Alternative to SN1 and SN2 Reactions"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Functionalization of Strong Bonds
7:30 pm - 8:05 pm
"New Data Science Tools for Reaction Development"
8:05 pm - 8:15 pm
Discussion
8:15 pm - 8:40 pm
"Recent Developments in Shuttle Catalysis"
8:40 pm - 8:45 pm
Discussion
8:45 pm - 9:20 pm
"New Strategies for Cycloaddition Reactions of Carbonyls, Imines, and Alkenes"
9:20 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Discovery and Synthesis of Medicinal Molecules
9:00 am - 9:35 am
"Stereoselective Synthesis of a Substituted 3-methyl-2,3-dihydrobenzo[b ][1,4]dioxin-2-yl pyridine as a Drug Candidate"
9:35 am - 9:45 am
Discussion
9:45 am - 10:20 am
"An NDA Filing: A Process Chemists Final Exam"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:35 am
"Sampling the Catalytic Spectrum to Deliver an Ideal Manufacturing Route to STING agonist MK-1454"
11:35 am - 11:45 am
Discussion
11:45 am - 12:20 pm
"Rapid Process Development of Lufotrelvir, PF-07304814 Hydrate, for Treatment of Covid-19"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Catalysis and Sustainability
7:30 pm - 8:05 pm
"Building Molecules with Biocatalyst-Controlled Selectivity"
8:05 pm - 8:15 pm
Discussion
8:15 pm - 8:40 pm
"Stereoselective multicomponent coupling reactions involving alkenyl boronates"
8:40 pm - 8:45 pm
Discussion
8:45 pm - 9:20 pm
"Bismuth Redox Catalysis"
9:20 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Discuss Future Dates and Venue; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Asymmetric Catalysis and Mechanism
9:00 am - 9:35 am
"Electrophilic Amination Strategies for N-Heterocycle Synthesis"
9:35 am - 9:45 am
Discussion
9:45 am - 10:20 am
"Stereoselective Catalysis with Organoboron Reagents"
10:20 am - 10:30 am
Discussion
10:30 am - 11:05 am
Coffee Break
11:05 am - 11:20 am
Short Talk Selected from Poster Abstracts
11:20 am - 11:25 am
Discussion
11:25 am - 11:40 am
Short Talk Selected from Poster Abstracts
11:40 am - 11:45 am
Discussion
11:45 am - 12:20 pm
"Progress Toward Members of the Hapalindole Family of Alkaloids"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Keynote Session: De Novo Generation of Chirality
7:30 pm - 8:20 pm
"Lessons from Viedma Ripening"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 9:20 pm
"A Core Remodeling Approach to the Chemical Synthesis of Natural Products and Attendant Stereochemical Considerations"
9:20 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure