Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: Synthesis and Translation to Medicine
Discussion Leader: Eric Jacobsen (Harvard University, United States)
7:40 pm - 8:25 pm
Sarah Reisman (California Institute of Technology, United States)
"Necessity is the Mother of Invention: Natural Products and the Chemistry They Inspire"
8:25 pm - 8:35 pm
Discussion
8:35 pm - 9:20 pm
Paul Wender (Stanford University, United States)
"Translational Science"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Stereochemistry of Radicals and Peptides
Discussion Leader: Alastair Lennox (University of Bristol, United Kingdom)
9:00 am - 9:35 am
Michelle Chang (University of California, Berkeley, United States)
"Synthetic Biology Approaches to New Amino Acid Chemistry"
9:35 am - 9:45 am
Discussion
9:45 am - 10:10 am
Song Lin (Cornell University, United States)
"The Fascinating Chemistry of Aminoxyl Radicals—From Asymmetric Catalysis to Site-Selective C–H Functionalization"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:25 am
Ivan Huc (Ludwig-Maximilians-University Munich, Germany)
"Aromatic Foldamer-Based Protein Mimicry and Recognition"
11:25 am - 11:35 am
Discussion
11:35 am - 12:00 pm
Alison Wendlandt (Massachusetts Institute of Technology, United States)
"Selective Catalytic Isomerization Reactions"
12:00 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
Alastair Lennox (University of Bristol, United Kingdom)
"Late-Breaking Topic"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hour™
The GRC Power Hour™ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
Organizers: Eric Ashley (Merck, United States) and Sarah Reisman (California Institute of Technology, United States)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Functionalization of Multiple Bonds
Discussion Leader: Santanu Mukherjee (Indian Institute of Science, Bangalore, India)
7:30 pm - 8:05 pm
Tomislav Rovis (Columbia University, United States)
"New Tools for Catalysis"
8:05 pm - 8:15 pm
Discussion
8:15 pm - 8:40 pm
Keary Engle (The Scripps Research Institute, United States)
"Catalytic Difunctionalization of Alkenes with Chiral Transient Directing Groups"
8:40 pm - 8:45 pm
Discussion
8:45 pm - 9:20 pm
Ryan Shenvi (Scripps Research, United States)
"Chemical Synthesis of Secondary Metabolites"
9:20 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Transition Metals in Asymmetric Catalysis
Discussion Leader: Robert Paton (Colorado State University, United States)
9:00 am - 9:35 am
Matthew Gaunt (University of Cambridge, United Kingdom)
"New Synthetic Chemistry to Probe the Biology of Modified Nucleic Acids"
9:35 am - 9:45 am
Discussion
9:45 am - 10:20 am
Daniele Leonori (RWTH-Aachen University, Germany)
"New Methods in Halogen-Atom Transfer"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:35 am
Kyle Mack (Genentech, United States)
"A New Framework for the Development and Optimization of Catalytic Asymmetric Transformations"
11:35 am - 11:45 am
Discussion
11:45 am - 12:20 pm
Gregory Fu (California Institute of Technology, United States)
"Nucleophilic Substitution Reactions: A Radical Alternative to SN1 and SN2 Reactions"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Functionalization of Strong Bonds
Discussion Leader: Shauna Paradine (University of Rochester, United States)
7:30 pm - 8:05 pm
Abigail Doyle (UCLA, United States)
"New Data Science Tools for Reaction Development"
8:05 pm - 8:15 pm
Discussion
8:15 pm - 8:40 pm
Bill Morandi (ETH Zurich, Switzerland)
"Recent Developments in Shuttle Catalysis"
8:40 pm - 8:45 pm
Discussion
8:45 pm - 9:20 pm
Corinna Schindler (University of Michigan, United States)
"New Strategies for Cycloaddition Reactions of Carbonyls, Imines, and Alkenes"
9:20 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Discovery and Synthesis of Medicinal Molecules
Discussion Leader: Tamas Benkovics (Loxo @ Lilly, United States)
9:00 am - 9:35 am
Jin Zhao (Sanofi, United States)
"Stereoselective Synthesis of a Substituted 3-methyl-2,3-dihydrobenzo[b ][1,4]dioxin-2-yl pyridine as a Drug Candidate"
9:35 am - 9:45 am
Discussion
9:45 am - 10:20 am
Cameron Cowden (Concert Pharmaceuticals, United States)
"An NDA Filing: A Process Chemists Final Exam"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:35 am
Andrew Neel (Merck and Co. Inc., United States)
"Sampling the Catalytic Spectrum to Deliver an Ideal Manufacturing Route to STING agonist MK-1454"
11:35 am - 11:45 am
Discussion
11:45 am - 12:20 pm
Robert Singer (Pfizer Inc, United States)
"Rapid Process Development of Lufotrelvir, PF-07304814 Hydrate, for Treatment of Covid-19"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Catalysis and Sustainability
Discussion Leader: Tian Qin (UT Southwestern Medical Center, United States)
7:30 pm - 8:05 pm
Alison Narayan (University of Michigan, United States)
"Building Molecules with Biocatalyst-Controlled Selectivity"
8:05 pm - 8:15 pm
Discussion
8:15 pm - 8:40 pm
Joseph Ready (UT Southwestern Medical Center, United States)
"Stereoselective multicomponent coupling reactions involving alkenyl boronates"
8:40 pm - 8:45 pm
Discussion
8:45 pm - 9:20 pm
Josep Cornella (Max-Planck-Institut für Kohlenforschung, Germany)
"Bismuth Redox Catalysis"
9:20 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Discuss Future Dates and Venue; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Asymmetric Catalysis and Mechanism
Discussion Leader: Christopher Sandford (Dartmouth College, United States)
9:00 am - 9:35 am
John Bower (University of Liverpool, United Kingdom)
"Electrophilic Amination Strategies for N-Heterocycle Synthesis"
9:35 am - 9:45 am
Discussion
9:45 am - 10:20 am
James Morken (Boston College, United States)
"Stereoselective Catalysis with Organoboron Reagents"
10:20 am - 10:30 am
Discussion
10:30 am - 11:05 am
Coffee Break
11:05 am - 11:20 am
Short Talk Selected from Poster Abstracts
11:20 am - 11:25 am
Discussion
11:25 am - 11:40 am
Short Talk Selected from Poster Abstracts
11:40 am - 11:45 am
Discussion
11:45 am - 12:20 pm
Viresh Rawal (University of Chicago, United States)
"Progress Toward Members of the Hapalindole Family of Alkaloids"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Keynote Session: De Novo Generation of Chirality
Discussion Leader: Tamas Benkovics (Loxo @ Lilly, United States)
7:30 pm - 8:20 pm
Michael Mcbride (Yale Univ., United States)
"Lessons from Viedma Ripening"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 9:20 pm
Richmond Sarpong (University of California, Berkeley, United States)
"A Core Remodeling Approach to the Chemical Synthesis of Natural Products and Attendant Stereochemical Considerations"
9:20 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure