Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
The Leading Edge: Emerging Themes in Streptococcal Research
Discussion Leader: Kelly Doran (University of Colorado School of Medicine, USA)
7:40 pm - 8:10 pm
Jan-Willem Veening (University of Lausanne, Switzerland)
"Coordination of DNA Replication with Cell Division in Streptococcus pneumoniae "
8:10 pm - 8:20 pm
Discussion
8:20 pm - 8:50 pm
Howard Hang (The Rockefeller University, USA)
"Chemical Dissection of Enterococcus faecium Protection Mechanisms"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
Jennifer Dan (La Jolla Institute for Allergy and Immunology, USA)
"The Immunology of Group A Streptococcus Tonsillitis"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Streptococcal Manipulation of Macrophage and Neutrophil Function
Discussion Leader: Michael Wessels (Harvard Medical School, USA)
9:00 am - 9:25 am
Carlos Orihuela (The University of Alabama at Birmingham, USA)
"Intracellular Replication of Streptococcus pneumoniae Within the Heart"
9:25 am - 9:35 am
Discussion
9:35 am - 10:00 am
Birgitta Henriques-Normark (Karolinska Institutet, Sweden)
"Pneumococcal Interactions with the Host"
10:00 am - 10:10 am
Discussion
10:10 am - 10:40 am
Coffee Break
10:40 am - 11:05 am
Jennifer Gaddy (Vanderbilt University Medical Center, USA)
"Placental Macrophages Release Macrophage Extracellular Traps and Matrix Metalloproteinases in Response to Streptococcus agalactiae Infection"
11:05 am - 11:15 am
Discussion
11:15 am - 11:40 am
George Liu (Cedars-Sinai Medical Center, USA)
"Bacterial Manipulation of Hyaluronan Size as a Strategy for Immune Evasion"
11:40 am - 11:50 am
Discussion
11:50 am - 12:05 pm
Arnaud Firon (Institut Pasteur, France)
"Cyclic di-AMP in GBS Physiology and Host-Pathogen Interaction"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
Alex McCarthy (University Medical Centre Utrecht, The Netherlands)
"Streptococcal Pathogens Engage Human CEACAM1 Receptor"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
Power Hour
The GRC Power Hour is an optional informal gathering open to all meeting participants. It is designed to help address the challenges women face in science and support the professional growth of women in our communities by providing an open forum for discussion and mentoring.
Organizer: Kelly Doran (University of Colorado School of Medicine, USA)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Immune Responses to Streptococcal Infection: A Balancing Act
Discussion Leader: Annelies Zinkernagel (University of Zurich, Switzerland)
7:30 pm - 7:55 pm
Mariela Segura (University of Montreal, Canada)
"Strategies Used by Streptococcus suis to Defy the Host Adaptive Immune Response"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:30 pm
Anna Norrby-Teglund (Karolinska Institute, Sweden)
"Skewed Macrophage Phenotypes in Streptococcal Necrotizing Soft Tissue Infections"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 8:50 pm
Sarah Hobdey (Idaho Veterans Research and Education Foundation, USA)
"Enrichment of Antigen-Specific Class-Switched B-Cells from Individuals Naturally Immunized by Infection with Group A Streptococcus"
8:50 pm - 8:55 pm
Discussion
8:55 pm - 9:05 pm
Hsiang-Chi Tseng (Rutgers, the State University of New Jersey, USA)
"Type I and Type III Interferons Inhibit Bacterial Clearance Following Influenza Virus Infection"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:20 pm
David Ermert (Lund University, Sweden)
"C4BP-Mediated Complement Evasion in Streptococcal Infections: How the Good Guys Turn Bad"
9:20 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Finding a Niche: Streptococcal Colonization of Host Mucosal Barriers
Discussion Leader: Paul Sullam (University of California, San Francisco, USA)
9:00 am - 9:25 am
Anthony Flores (McGovern Medical School, University of Texas Health Science Center at Houston, USA)
"Tale of Two Phenotypes: Group A Streptococcal Mechanisms to Persist in the Absence of Symptoms"
9:25 am - 9:35 am
Discussion
9:35 am - 10:00 am
Katharina Ribbeck (Massachusetts Institute of Technology, USA)
"Probing the Influence of Salivary Mucins on Oral Streptococci Physiology"
10:00 am - 10:10 am
Discussion
10:10 am - 10:40 am
Coffee Break
10:40 am - 11:05 am
Jeffrey Weiser (New York University School of Medicine, USA)
"Transmission of the Pneumococcus"
11:05 am - 11:15 am
Discussion
11:15 am - 11:40 am
Shaynoor Dramsi (Institut Pasteur, France)
"Competitive Advantage of Streptococcus gallolyticus in Colon Cancer Microbiota"
11:40 am - 11:50 am
Discussion
11:50 am - 12:05 pm
Samantha King (Nationwide Children's Hospital, USA)
"Multiple Serine Rich Repeat Proteins of Streptococcus oralis : Roles in Surface Fibril Formation, Adhesion and Pathogenesis"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
Angharad Green (University of Liverpool, United Kingdom)
"Transcriptional Profiles of Streptococcus pneumoniae Adapted to the Lung Environment"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Polymicrobial Interactions: Life Among the Microbiome
Discussion Leader: Michael Gilmore (Harvard Medical School, USA)
7:30 pm - 8:00 pm
Kimberly Kline (Nanyang Technological University, Singapore)
"Mechanisms of Synergy During Enterococcal Polymicrobial Infection"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
Marvin Whiteley (Georgia Institute of Technology, USA)
"Biogeography of In Vivo Polymicrobial Biofilms"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:05 pm
Breck Duerkop (University of Colorado School of Medicine, USA)
"Enterococcal-Bacteriophage Interactions Reveal Mechanisms of Phage Resistance and Community Behaviour"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
Jason Rosch (St. Jude Children's Research Hospital, USA)
"New Insights into Influenza-Pneumococcal Synergy"
9:25 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
New Paradigms in Streptococcal Virulence Factor Action
Discussion Leader: Gunnar Lindahl (Lund University, Sweden)
9:00 am - 9:25 am
Christopher LaRock (Emory University School of Medicine, USA)
"Group A Streptococcus Fuels the Fire"
9:25 am - 9:35 am
Discussion
9:35 am - 10:00 am
Lakshmi Rajagopal (University of Washington, USA)
"Importance of Polyenes for GBS Hemolysis"
10:00 am - 10:10 am
Discussion
10:10 am - 10:40 am
Group Photo / Coffee Break
10:40 am - 11:05 am
John McCormick (University of Western Ontario, Canada)
"Molecular Correlates of Nasopharyngeal Infection by Streptococcus pyogenes "
11:05 am - 11:15 am
Discussion
11:15 am - 11:40 am
Liangfang Zhang (University of California, San Diego, USA)
"Biomimetic Nanoparticles for Broad-Spectrum Antivirulence Therapy"
11:40 am - 11:50 am
Discussion
11:50 am - 12:05 pm
Anne Botteaux (Université Libre de Bruxelles, Belgium)
"A Novel Interaction Between C4BP and the Enn Protein of Group A Streptococcus "
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
Matthew Siggins (Imperial College London, United Kingdom)
"Early Extracellular Long-Distance Lymphatic Metastasis Is a Route of Systemic Invasion for Virulent Streptococcus pyogenes "
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 5:30 pm
Poster Session
5:30 pm - 7:30 pm
Streptococci and the Nervous System
Discussion Leader: James Dale (University of Tennessee Health Science Center, USA)
5:30 pm - 5:55 pm
Elaine Tuomanen (St. Jude Children's Research Hospital, USA)
"Bacterial Communication with the Brain"
5:55 pm - 6:05 pm
Discussion
6:05 pm - 6:30 pm
Isaac Chiu (Harvard Medical School, USA)
"Pain and Neuro-Immune Regulation of Streptococcal Host Defense"
6:30 pm - 6:40 pm
Discussion
6:40 pm - 6:50 pm
Liwen Deng (University of Colorado Anschutz Medical Campus, USA)
"The Group B Streptococcal Adhesin BspC Interacts with Vimentin to Promote Meningitis"
6:50 pm - 6:55 pm
Discussion
6:55 pm - 7:05 pm
Alexa Lauer (Heidelberg University, Germany)
"A Comparative Transcriptome Analysis of Human and Porcine Choroid Plexus Cells Infected with Streptococcus suis "
7:05 pm - 7:10 pm
Discussion
7:10 pm - 7:25 pm
Anirban Banerjee (Indian Institute of Technology Bombay, India)
"Role of Stochastic Pneumolysin Expression in Pneumococcal Trafficking Across Host Barriers"
7:25 pm - 7:30 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
9:00 am - 12:30 pm
"Streptococcomics": Big Data Approaches to Streptococcal Pathogens
Discussion Leader: Debra Bessen (New York Medical College, USA)
9:00 am - 9:25 am
Johan Malmström (Lund University, Sweden)
"Structural Proteomics in Host-Bacterial Interactions"
9:25 am - 9:35 am
Discussion
9:35 am - 10:00 am
Andrew Waller (Animal Health Trust, United Kingdom)
"Defining Streptococcus equi Gene Essentiality in a Susceptible Natural Host"
10:00 am - 10:10 am
Discussion
10:10 am - 10:40 am
Coffee Break
10:40 am - 11:05 am
Kevin McIver (University of Maryland / Maryland Pathogen Research Institute, USA)
"Dissecting Fitness at the Host-Streptococcal Interface"
11:05 am - 11:15 am
Discussion
11:15 am - 11:40 am
Mark Walker (The University of Queensland, Australia)
"China Scarlet Fever Outbreak: From Genomics to Function"
11:40 am - 11:50 am
Discussion
11:50 am - 12:05 pm
Federico Rosconi (Boston College, USA)
"Deciphering Streptococcus pneumoniae -Host Interactions Considering the Pathogen's Large Pan-Genome"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
Claire Turner (University of Sheffield, United Kingdom)
"Divergence Within Genotypes of Streptococcus pyogenes : A Comparison of UK and USA Genome Sequence Data"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Young Investigator Presentations
Discussion Leader: Shiranee Sriskandan (Imperial College London, United Kingdom)
7:30 pm - 7:40 pm
Poshmaal Dhar (Deakin University, Australia)
"MUC1 Protects Against Severe Streptococcus pneumoniae Infection"
7:40 pm - 7:45 pm
Discussion
7:45 pm - 7:55 pm
Thomas Hooven (Columbia University, USA)
"A Couterselectable Sucrose Sensitivity Cassette Enhances Targeted Mutagenesis in Group B Streptococcus "
7:55 pm - 8:00 pm
Discussion
8:00 pm - 8:10 pm
Artemis Gogos (University of Illinois at Chicago, USA)
"A GAS Quorum-Sensing System Enhances Oropharyngeal Colonization and Resistance to Host Factors via Alterations of the Bacterial Cell Surface"
8:10 pm - 8:15 pm
Discussion
8:15 pm - 8:25 pm
Tanya Puccio (Virginia Commonwealth University School of Dentistry, USA)
"A ZIP Family Protein Contributes to Infective Endocarditis Virulence in Streptococcus sanguinis "
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:40 pm
Andreas Naegeli (Lund University, Sweden)
"Streptococcus pyogenes Evades Adaptive Immunity Through Specific Modification of Host IgG Glycosylation"
8:40 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
Vicky Sender (Karolinska Institutet, Sweden)
"The Pneumococcal Surface Protease HtrA Contributes to Enhances Bacterial Burden During Influenza/Pneumococcal Confection"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
Kees van der Ark (Amsterdam UMC, University of Amsterdam, The Netherlands)
"Phase Variation in Streptococcus suis "
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Lina Zarate Bonilla (Max Planck Institute for Infection Biology, Germany)
"Characterization of a Novel Toxin-Antitoxin System from Streptococcus Progenies"
9:25 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure