Sunday Evening

Drug Resistance, Targets, and Strategies

• 7:15-7:25 - Welcoming Comments
• 7:25-8:10 - Stuart Levy - "Problems and Opportunities Presented by Antibiotic-Resistant Microbes"
• 8:10-8:20 - Discussion
• 8:20-9:00 - Shahriar Mobashery - "Evolution of the Versatile ß-Lactam Hydrolase Activity: From Biosynthetic Enzymes to Drug Resistance Factors"
• 9:00-9:20 - Break
• 9:20-10:00 - Dudley Williams - "Glycopeptide Antibiotics: Structures and Mode of Action"
• 10:00-10:10 - Discussion

Monday Morning

Drug Resistance, Targets, and Strategies

• 8:25 - Convene
• 8:30-9:15 - David van Vranken - "2,2'-Biindoles in Peptides and Topoisomerase Inhibitors"
• 9:15-9:25 - Discussion
• 9:25-10:10 - Dan Littman - "Interactions of HIV Envelopes with Chemokine Receptors"
• 10:10-10:20 - Discussion
• 10:20-10:50 - Break / Photograph
• 10:50-11:10 - Brian Shoichet - "Structure-Based Discovery of Novel Inhibitors of Beta-Lactamases"
• 11:10-11:20 - Discussion
• 11:20-12:05 - Kevin Judice - "Constrained Helices as Probes of the HIV-1 Membrane Fusion Mechanism"
• 12:05-12:20 - Discussion
• 12:30 - Lunch

Monday Afternoon

• 4:00-6:00 - Poster Session I and Social

Monday Evening

Enzymes and Mechanisms - Protein Folding

• 7:25 - Convene
• 7:30-8:15 - Alan Fersht - "Protein Folding"
• 8:15-8:25 - Discussion
• 8:25-8:45 - Watson Lees - "Mechanistic Enzymology of Intermediate Steps in Peptidoglycan Biosynthesis"
• 8:45-8:55 - Discussion
• 8:55-9:05 - Break
• 9:05-9:50 - Ron Raines - "Catalysis of Oxidative Protein Folding in Vitro and in Vivo"
• 9:50-10:00 - Discussion

Tuesday Morning

Nucleic Acids And Genomics

• 8:35 - Convene
• 8:40-9:25 - Brian Metcalf - "The Impact of Genomics on Bioorganic Chemistry"
• 9:25-9:35 - Discussion
• 9:35-10:20 - Paul Schimmel - "RNA-Dependent Amino Acid Recognition in Translational Editing"
• 10:20-10:30 - Discussion
• 10:30-10:50 - Break
• 10:50-11:10 - Makoto Komiyama - "Molecular Design of Pinpoint and Hydrolytic Restriction Enzymes"
• 11:10-11:20 - Discussion
• 11:20-12:05 - Hiroshi Sugiyama - "Molecular Basis of Atom-Specific DNA Modification"
• 12:05-12:20 - Discussion
• 12:30 - Lunch

Tuesday Evening

Enzymes and Mechanisms - New Probes and Catalysts

• 7:25 - Convene
• 7:30-8:15 - Dale Drueckhammer - "Coenzyme A Analogs as Probes of Enzyme-Catalyzed Reactions"
• 8:15-8:25 - Discussion
• 8:25-8:45 - Dehua Pei - "Purification and Mechanistic Study of Esherichia coli Peptide Deformylase"
• 8:45-8:55 - Discussion
• 8:55-9:50 - Ikuo Fujii - "Evolving Catalytic Antibodies in Phage-Displayed Combinatorial Libraries"
• 9:50-10:00 - Discussion

Wednesday Morning

Molecular Diversity

• 8:35 - Convene
• 8:40-9:25 - Stephen Kaldor - "New Combinatorial Chemistry Methods for Pharmaceutical Lead Generation and Optimization"
• 9:25-9:35 - Discussion
• 9:35-10:20 - Klaus Gubernator - "3D-Structure Guided Evolutionary Discovery of Bioactive Molecules"
• 10:20-10:30 - Discussion
• 10:30-10:50 - Break
• 10:50-11:10 - Gerald Haaima - "PNA Combinatorial Libraries"
• 11:10-11:20 - Discussion
• 11:20-11:40 - H. Peter Nestler - "Sequence-Specific Receptors for Peptides from Combinatorial Libraries"
• 11:40-11:50 - Discussion
• 11:50-12:10 - Ben Miller - "Self-Assembled, Self-Amplified Combinatorial Libraries as a New Method for Ligand Synthesis"
• 12:10-12:20 - Discussion
• 12:30 - Lunch

Wednesday Afternoon

• 4:00-6:00 - Poster Session II and Social

Wednesday Evening

New Methods

• 7:25 - Convene
• 7:30-8:00 - Joe Loo - "Using Mass Spectrometry to Study Protein-DNA/RNA Interactions"
• 8:00-8:10 - Discussion
• 8:10-8:40 - Yen-Ho Chu - "Affinity Capillary Electrophoresis"
• 8:40-8:50 - Discussion
• 8:50-9:00 - Break
• 9:00-9:30 - Robert Flowers - "Calorimetric Investigations of Biologically Relevant Reaction Mechanisms"
• 9:30-9:40 - Discussion
• 9:40-10:10 - Peter Schuck - "Determination of Binding Affinity and Kinetics Using Evanescent Wave Biosensors"
• 10:10-10:20 - Discussion

Thursday Morning

Signals and Signal Transduction

• 8:35 - Convene
• 8:40-9:25 - Marc Snapper - "Ilimaquinone: A New Tool for Probing Intracellular Vesicular Trafficking"
• 9:25-9:35 - Discussion
• 9:35-10:20 - Linda Jolliffe - "Progress Towards Development of Small Molecule Mimetics of Erythropoietin"
• 10:20-10:30 - Discussion
• 10:30-10:50 - Break
• 10:50-11:10 - Daniel Sternbach - "The Design, Synthesis and X-Ray Analysis of a Ligand that forms a Covalent Complex with the SRC SH2 Domain"
• 11:10-11:20 - Discussion
• 11:20-12:05 - Kurt Deshayes - "Using Host-Guest Chemistry to Separate Rates of Energy Transfer from the Rate of Diffusion"
• 12:05-12:20 - Discussion
• 12:30 - Lunch

Thursday Evening

Molecular Recognition and Mimesis

• 7:25 - Convene
• 7:30-8:00 - Business Meeting - Discussion, Evaluation, and 1999 Election
• 8:00-8:45 - Lia Addadi - "Antibody Recognition of Molecular Organization at Specific Crystal Surfaces"
• 8:45-8:55 - Discussion
• 8:55-9:05 - Break
• 9:05-9:50 - Carlos Barbas - "Structure and Mechanism of Aldolase Catalytic Antibodies: Programming Covalent Catalysis"
• 9:50-10:00 - Discussion