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Sunday Afternoon, June 17
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Arrival and Check-in
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Sunday Evening
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Molecular Recognition (Kevin
Dalby, U of Texas)
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7:15 - 7:30
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Welcome and Introductory Remark
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7:30 - 8:05
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Andrew Hamilton (Yale)
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New Synthetic Approaches
to Disrupting Protein-Protein Interactions
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8:05 - 8:15
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Discussion
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8:15 - 8:50
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Milan Mrksich (Chicago)
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Model Substrates for Studying
and Controlling Cell Adhesion
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8:50 - 9:00
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Discussion
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9:00 - 9:35
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Greg Petsko (Brandeis)
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Structure-Based Drug Discovery
in the Age of Genomics
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9:35 - 9:45
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Discussion
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Monday Morning
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Chemical Biology (Anna Mapp, Michigan)
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8:30 - 9:00
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Conference Photograph
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9:00 - 9:35
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Eric Kool (Stanford)
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Hydrophobic bases and base pairs as probes of DNA structure and function
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9:35 - 9:45
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Discussion
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9:45 - 10:20
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Jun Liu (MIT)
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Probing Signal Transduction
Pathways and Cell Cycle Regulation with Natural Products
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10:20 - 10:30
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Discussion
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10:30 - 10:50
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Coffee Break
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10:50 - 11:25
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Floyd Romseberg (Scripps)
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Evolution and Function of Biological
Systems: Efforts to Expand the Genetic Code and Understand
Protein Dynamics
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11:25 - 11:35
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Discussion
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11:35 - 12:10
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Chris Sander (MIT)
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Bioinformatics
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12:10 - 12:20
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Discussion
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12:20 - 12:30
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Poster Talk I: David Liu (Harvard)
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The Generality of DNA-templated Synthesis as a Basis for Evolving Non-natural Molecules
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Monday Evening
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Learning Nature’s Strategies for
Making Molecules (Seiichi
Matsuda, Rice)
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7:30 - 8:05
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David Sherman (Minnesota)
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Novel Biocatalysts and Metabolic
Systems from Natural Product Biosynthetic Pathways
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8:05 - 8:15
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Discussion
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8:15 - 8:50
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Ben Shen (UC Davis)
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Lessons from Natural Product
Biosynthesis and Prospects of
Engineering Microorganisms
for Chemical Structural Diversity
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8:50 - 9:00
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Discussion
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9:00 - 9:35 |
Chris Farnet (Ecopia
BioSciences)
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Genomics and Natural Products:
Deducing Nature's Strategies for Chemical Synthesis
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9:35 - 9:45 |
Discussion
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Tuesday Morning
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Combinatorial Chemistry and Biology (Mark
Distefano, Minnesota)
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8:40 -9:15
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David Austin (Yale)
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Combining Chemical and Biological
Diversity for the Investigation of Small Molecule / Protein Interactions
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9:15 - 9:25
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Discussion
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9:25 - 10:00
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Karen Lackey (Glaxo
Wellcome)
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Synthesis of Oxindole libraries for rapid generation of SAR for kinase inhibition
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10:00
-10:10
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Discussion
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10:10 - 10:30
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Coffee Break
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| 10:30 -
11:05 |
Jon Thorson
(Sloan-Kettering) |
The Application
of Structure-Based Engineering and Chemo-Enzymatic Synthesis Toward the
Generation of Nucleotide Sugar Libraries |
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11:05 - 11:15
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Discussion
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11:15 - 11:50
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Sachdev Sidhu (Genentech)
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High throughput phage display
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11:50 - 12:00
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Discussion
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12:00 - 12:15
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Poster Talk II: Seiichi Matsuda (Rice)
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The Origins of Triterpene Structural Diversity
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12:15 - 12:30
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Poster Talk III: George Wang (Wayne State)
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Superbugs and Superbeads: Following Nature’s Way to Make Natural Products
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Tuesday
Evening
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Genomics and Proteomics (David
Liu, Harvard)
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7:30 - 8:05
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Tom Kodadek (UT Southwestern)
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Second Generation Proteomics
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8:05 - 8:15
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Discussion
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8:15 - 8:50 |
Virginia
Cornish
(Columbia)
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Genetic Screen for Protein
Evolution and Proteomics |
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8:50 - 9:00
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Discussion
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9:00 - 9:35 |
Peter Schultz
(Scripps) |
New Opportunities
at the Interface of Chemistry and Biology |
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9:35 - 9:45 |
Discussion
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Wednesday Morning
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Structure Based Drug Design (Neera
Borkakoti, Roche)
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8:40 -9:15
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Wim Hol (U.
Washington)
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Protein structures and tropical diseases
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9:15 - 9:25
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Discussion
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9:25 - 10:00
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David Banner
(Hoffmann-La Roche)
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Protein structure based ligand design
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10:00
-10:10
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Discussion
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10:10 - 10:30
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Coffee Break
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10:30 - 11:05
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Nenad Ban
(ETH Zuerich)
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The atomic resolution structure of the large ribosomal subunit and its role in protein synthesis
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11:05 - 11:15
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Discussion
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11:15 - 11:50
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Mike Rosen (Sloan-Kettering)
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Structural and Dynamic Regulation
of the Wiskott-Aldrich
Syndrome Protein
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11:50 - 12:00
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Discussion
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12:00 - 12:15
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PosterTalk IV: Marcey Waters (Chapel Hill)
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Influence of Aromatic Interactions on Peptide Secondary Structure
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12:15 - 12:30
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PosterTalk V: Timothy Glass (Penn State)
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Cooperative Molecular Recognition and Applications to Fluorescent Chemical Sensors
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Wednesday Evening
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Drug Interactions and Inhibitor
Design (George
Wang, Wayne State)
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7:00 - 7:30
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Business Meeting
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7:30 - 8:05
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Laurence Hurley (Arizona)
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G-Quadruplexes and Associated
Gene Targets for Drug Design
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8:05 - 8:15
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Discussion
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8:15 - 8:50
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Youla Tsantrizos (Boehringer
Ingelheim)
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Peptidomimetic Inhibitors for the Viral NS3 Protease of Hepatitis C
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8:50 - 9:00
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Discussion
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9:00 - 9:35 |
Chi-Huey
Wong (Scripps) |
RNA-Small
Molecule Interaction and Programmed One-Pot normal Synthesis |
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9:35 - 9:45 |
Discussion
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Thursday Morning
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Frontiers in Enzymology (Wilfred van der Donk, University of Illinois)
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8:40 - 9:15
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Chris Whitman (U. Texas)
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Nature's Way of Making New Enzymes
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9:15 - 9:25
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Discussion
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9:25 -10:00 |
Ming-Daw
Tsai (Ohio State) |
Structure,
Function, and Specificity of FHA, a New
Phosphoprotein Binding Domain
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| 10:00 - 10:10
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Discussion |
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10:10 - 10:30
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Coffee Break
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10:30 - 11:05
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George
Reed (Wisconsin) |
Radical
Intermediates in Enzyme Catalyses
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11:05 - 11:15
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Discussion
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11:15 - 11:50
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Peter
Beal |
The
Chemistry of Enzymes that Bind Duplex RNA
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11:50 - 12:00
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Discussion
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12:00 - 12:15
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Poster Talk VI: Kevin Dalby (Texas)
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Phosphorylation within MAPK Signal Transdution Cascades
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12:15 - 12:30
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Poster Talk VII: Brain Shoichet (Northwestern)
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A Relationship Between Activity and Protein Stability in Beta- Lactamase
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Thursday Evening
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Light,
Vision, and Magic (Adrian
Whitty, Biogen)
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7:30 - 8:05
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Kazuya Kikuchi
(Tokyo U.)
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Visualization and Manipulation
of Cellular Events using Fluorescence Probes and Laser Inactivation Probes
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8:05 - 8:15
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Discussion
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8:15 - 8:50
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Ron Stenkamp
(U. Washington)
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Crystal
Structure of Rhodopsin, A G-Protein Coupled Receptor
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8:50 - 9:00
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Discussion
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9:00 - 9:35 |
Koji Nakanishi
(Columbia) |
Bioorganic
Studies on Vision |
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9:35 - 9:45 |
Discussion
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